Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF217 Gene

protein-coding   GIFtS: 53
GCID: GC20M052183

Zinc Finger Protein 217

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 2171 2
ZABC12 3

External Ids:    HGNC: 130091   Entrez Gene: 77642   Ensembl: ENSG000001719407   OMIM: 6029675   UniProtKB: O753623   

Export aliases for ZNF217 gene to outside databases

Previous GC identifers: GC20M051912 GC20M052822 GC20M052869 GC20M051617 GC20M048929


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF217 Gene: 
ZNF217 (zinc finger protein 217) is a protein-coding gene. Diseases associated with ZNF217 include cystadenocarcinoma, and serous cystadenocarcinoma. GO annotations related to this gene include transcription regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF219.

UniProtKB/Swiss-Prot: ZN217_HUMAN, O75362
Function: Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and
antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'

Gene Wiki entry for ZNF217 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF217 gene promoter:
         p53   E4BP4   Evi-1   AREB6   E2F   E2F-1   FOXO1a   FOXJ2   Ik-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF217 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF217

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF217


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2   Ensembl cytogenetic band:  20q13.2   HGNC cytogenetic band: 20q13.2

ZNF217 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF217 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M052183:  view genomic region     (about GC identifiers)

Start:
52,183,604 bp from pter      End:
52,226,446 bp from pter
Size:
42,843 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN217_HUMAN, O75362 (See protein sequence)
Recommended Name: Zinc finger protein 217  
Size: 1048 amino acids; 115272 Da
Subunit: Component of a histone deacetylase complex that contains HDAC2, KDM1A, CTBP1 and ZNF217. May be a
component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST,
PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with CTBP1 and CTBP2
Subcellular location: Nucleus (Probable)
4 PDB 3D structures from and Proteopedia for ZNF217:
2HU2 (3D)        3UK3 (3D)        4F2J (3D)        4IS1 (3D)    
Secondary accessions: E1P5Y6 Q14DB8

Explore the universe of human proteins at neXtProt for ZNF217: NX_O75362

Explore proteomics data for ZNF217 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75362

  • ZNF217 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF217 Protein Expression
    REFSEQ proteins: NP_006517.1  
    ENSEMBL proteins: 
     ENSP00000360526   ENSP00000394010   ENSP00000399672   ENSP00000304308  

    Human Recombinant Protein Products for ZNF217: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ZNF217
    OriGene Protein Over-expression Lysate for ZNF217
    OriGene MassSpec for ZNF217 
    OriGene Custom Protein Services for ZNF217
    GenScript Custom Purified and Recombinant Proteins Services for ZNF217
    Novus Biologicals ZNF217 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF217 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118histone deacetylase complex IDA18625718
    GO:0005654nucleoplasm IDA18625718

    ZNF217 for ontologies           About GeneDecksing



    ZNF217 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ZNF217
    OriGene Custom Antibody Services for ZNF217
    GenScript Custom Superior Antibodies Services for ZNF217
    Novus Biologicals ZNF217 Antibodies
    Abcam antibodies for ZNF217
    Cloud-Clone Corp. Antibodies for ZNF217 
    ThermoFisher Antibodies for ZNF217
    LSBio Antibodies in human, mouse, rat for ZNF217 

    Assay Products for ZNF217: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZNF217
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZNF217
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZNF217 
    Cloud-Clone Corp. CLIAs for ZNF217


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O75362

    ProtoNet protein and cluster: O75362

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN217_HUMAN, O75362
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers


    ZNF217 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN217_HUMAN, O75362
    Function: Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and
    antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'

         Genatlas biochemistry entry for ZNF217:
    zinc finger protein 217 (C2H2 type Kruppel-like) with two alternatively spliced isoforms amplified and
    overexpressed in breast carcinoma

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9671742
    GO:0005515protein binding IPI16940172
    GO:0008270zinc ion binding ----
    GO:0044212transcription regulatory region DNA binding IDA18625718
    GO:0046872metal ion binding IEA--
         
    ZNF217 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF217:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF217 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNF217

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF217 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF217 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF217
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF217 (see all 98):
    hsa-miR-549 hsa-miR-607 hsa-miR-106a hsa-miR-199a-3p hsa-miR-374a hsa-miR-3074-3p hsa-miR-519a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidZNF217 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF217
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF217

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZNF217
    Sirion Biotech Customized adenovirus for overexpression of ZNF217

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ZNF217 (see all 8)
    OriGene ORF clones in mouse, rat for ZNF217
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZNF217 (NM_006526)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF217
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF217
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF217 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF217 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZNF217
    Search LifeMap BioReagents cell lines for ZNF217
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF217


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF217

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for ZNF217 (O753622, 3 ENSP000003043084) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000227333Q96KQ73, ENSP000003973234I2D: score=1 STRING: ENSP00000397323
    EHMT2Q96KQ73I2D: score=1 
    ENSG00000206376Q96KQ73I2D: score=1 
    ENSG00000232045Q96KQ73I2D: score=1 
    ENSG00000236759Q96KQ73I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA18625718
    GO:0045892negative regulation of transcription, DNA-dependent IDA16940172

    ZNF217 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZNF217 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF217 (ZN217)

    1 Novoseek inferred chemical compound relationship for ZNF217 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 60.1 6 15745248 (1), 16793610 (1), 17160949 (1), 19242095 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about ZNF217 / ZN217

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF217 gene: 
    NM_006526.2  

    Unigene Clusters for ZNF217:

    Zinc finger protein 217
    Hs.155040  [show with all ESTs], Hs.711564  [show with all ESTs]
    Unigene Representative Sequences: NM_006526, AK290350
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371471(uc002xwq.4 uc010gij.1) ENST00000437222 ENST00000431687
    ENST00000540425 ENST00000302342
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF217
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF217 (see all 98):
    hsa-miR-549 hsa-miR-607 hsa-miR-106a hsa-miR-199a-3p hsa-miR-374a hsa-miR-3074-3p hsa-miR-519a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidZNF217 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF217
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF217
    Clone
    Products:
         
    OriGene clones in human, mouse for ZNF217 (see all 8)
    OriGene ORF clones in mouse, rat for ZNF217
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZNF217 (NM_006526)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF217
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF217
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF217 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF217 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF217
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF217
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF217
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF217

    Additional mRNA sequence: AK290350.1 

    6 DOTS entries:

    DT.112015  DT.100751266  DT.120838356  DT.120838360  DT.91733753  DT.91917842 

    24/93 AceView cDNA sequences (see all 93):

    AA353699 BM834501 BX350697 AA460802 CD644465 AW600304 BP366481 AA451924 
    AA563911 CA449440 BG010798 BX955300 NM_006526 AA460368 BP366185 AW298383 
    D17016 BX119280 CR598126 AA513383 BC039055 AF041259 BF944766 BU508213 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF217 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTTAGTGA
    ZNF217 Expression
    About this image


    See ZNF217 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF217

    SOURCE GeneReport for Unigene clusters: Hs.155040 Hs.711564
        SABiosciences Custom PCR Arrays for ZNF217
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF217
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF217
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF217
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF217
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF217

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF217 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp2171 , 5 zinc finger protein 2171, 5 75(n)1
    71.96(a)1
      2 (89.91 cM)5
    2289131  NM_001033299.31  NP_001028471.11 
     1701086465 
    chicken
    (Gallus gallus)
    Aves ZNF2171 zinc finger protein 217 65.68(n)
    59.58(a)
      419340  XM_417505.3  XP_417505.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF2176
    zinc finger protein 217
    49(a)
    1 ↔ 1
    GL343226.1(228257-264560)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3983812 mitotic phosphoprotein 140 75.61(n)    AF419155.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.263962 Transcribed sequence with weak similarity to protein spO75362 (H.sapiens) Z217_HUMAN Zinc finger protein 217 less 75.22(n)    AL719606.1 


    ENSEMBL Gene Tree for ZNF217 (if available)
    TreeFam Gene Tree for ZNF217 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF217 gene
    ZNF2192  ZNF5362  ZNF5162  
    14 SIMAP similar genes for ZNF217 using alignment to 4 protein entries:     ZN217_HUMAN (see all proteins):
    HZF16    ZNF78L1    kr-znf3    DKFZp434J0650    ZFX    ZNF844
    A-328A3.4    DKFZp686N0199    PLZF    ZFS-5    ZNF    OVOL3
    ZNF697    ZNF72

    ZNF217 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/540 SNPs in ZNF217 are shown (see all 540)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355724
    A colorectal cancer sample4--see VAR_0355722 D N mis40--------
    rs2018103591,2
    C--52183138(+) CTGGCA/GCAATC 1 -- ds50010--------
    rs1139929671,2
    C,F--52183167(+) TGCCTC/TCCGGG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1817342891,2
    --52183240(+) ACTCAA/GCTAAT 1 -- ds50010--------
    rs1872209951,2
    --52183276(+) TTTCGC/TCATGT 1 -- ds50010--------
    rs1411996631,2
    C--52183326(+) ACCCGC/TCTTGG 1 -- ds50010--------
    rs1117847701,2
    C,F--52183384(+) AAATTG/CTGTTT 1 -- ds50012Minor allele frequency- C:0.06CSA WA 120
    rs107154321,2
    C--52183526(+) ATCTC-/AAAAAA 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs758390441,2
    C,F--52183600(+) CACTAA/TAACTC 1 -- ds50012Minor allele frequency- T:0.08WA 120
    rs10569491,2
    C,F--52183689(-) ATTACT/GTGTTT 1 -- ut31 ese33Minor allele frequency- G:0.19MN NA 306

    HapMap Linkage Disequilibrium report for ZNF217 (52183604 - 52226446 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF217:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3417CNV Insertion18451855
    nsv834006CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing ZNF217:
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing ZNF217
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF217

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602967    OMIM disorders: --

    14 diseases for ZNF217:    About MalaCards
    cystadenocarcinoma    serous cystadenocarcinoma    ovarian serous cystadenocarcinoma    noma
    gastric adenocarcinoma    hypoxia    cervical cancer    ovarian cancer
    glioblastoma    mental retardation    cervicitis    adenocarcinoma
    breast cancer    prostatitis


    ZNF217 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for ZNF217 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian serous cystadenocarcinoma 94.4 1 17160949 (1)
    ovarian cancer 53.4 1 16793610 (1)
    cancer 12.6 5 17130829 (1), 19242095 (1), 17572303 (1), 18425333 (1)


    Export disorders for ZNF217 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF217 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with ZNF217)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. (PubMed id 9671742)1, 2, 3 Collins C.... Gray J.W. (1998)
    2. Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex. (PubMed id 18625718)1, 2 Thillainadesan G....Torchia J. (2008)
    3. Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins. (PubMed id 16940172)1, 2 Quinlan K.G.R.... Crossley M. (2006)
    4. ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction. (PubMed id 16203743)1, 2 Huang G....Collins C. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. (PubMed id 12493763)1, 2 Hakimi M.A....Shiekhattar R. (2003)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    8. Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence. (PubMed id 17130829)1, 9 Cowger J.J....Torchia J. (2007)
    9. The ZNF217 oncogene is a candidate organizer of repressive histone modifiers. (PubMed id 19242095)1, 9 Banck M.S....Walsh M.J. (2009)
    10. Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line. (PubMed id 18425333)1, 9 Sun G....Zhong M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7764 HGNC: 13009 AceView: ZNF217 Ensembl:ENSG00000171940 euGenes: HUgn7764
    ECgene: ZNF217 H-InvDB: ZNF217

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF217 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZNF217 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF217 gene:
    Search GeneIP for patents involving ZNF217

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ZNF217   OriGene RNAi products in human, mouse, rat for ZNF217  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ZNF217  
     OriGene MassSpec something-or-other for ZNF217   OriGene clones in human, mouse for ZNF217  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZNF217   OriGene Purified Protein for ZNF217  
     OriGene ORF clones in mouse, rat for ZNF217   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZNF217   OriGene Custom Protein Services for ZNF217  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF217
     QIAGEN SeqTarget long-range PCR primers for resequencing ZNF217
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF217
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF217
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF217
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF217
     GenScript Custom Purified and Recombinant Proteins Services for ZNF217 GenScript cDNA clones with any tag delivered in your preferred vector for ZNF217
     GenScript Custom Assay Services for ZNF217 GenScript Custom Superior Antibodies Services for ZNF217
     GenScript Custom overexpressing Cell Line Services for ZNF217 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ZNF217 promoter
     Search Chromatin IP Primers for ZNF217
     RT2 qPCR Primer Assay in human, mouse, rat ZNF217
     Search GNC Networks for ZNF217
     SABiosciences Custom PCR Arrays for ZNF217
     Search Tocris compounds for ZNF217 (ZN217)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ZNF217 antibodies
     ZNF217 lysates
     Antibodies for ZNF217
     See all of Abcam's Antibodies, Kits and Proteins for ZNF217
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ZNF217
     Antibodies for ZNF217
     ELISAs for ZNF217
     CLIAs for ZNF217
     Search LifeMap BioReagents cell lines for ZNF217
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF217
     SwitchGear 3'UTR luciferase reporter plasmids for ZNF217
     SwitchGear Promoter luciferase reporter plasmids for ZNF217
     ThermoFisher Antibodies for ZNF217
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF217
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF217
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNF217
    Customized:
     lentivirus for stable overexpression of ZNF217
     lentivirus expression plasmids for stable overexpression of ZNF217
     adenovirus for overexpression of ZNF217
     LSBio Antibodies in human, mouse, rat for ZNF217
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZNF217 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4