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Aliases for ZNF217 Gene

Aliases for ZNF217 Gene

  • Zinc Finger Protein 217 2 3 5
  • ZABC1 3 4

External Ids for ZNF217 Gene

Previous GeneCards Identifiers for ZNF217 Gene

  • GC20M051912
  • GC20M052822
  • GC20M052869
  • GC20M051617
  • GC20M052183
  • GC20M048929

Summaries for ZNF217 Gene

GeneCards Summary for ZNF217 Gene

ZNF217 (Zinc Finger Protein 217) is a Protein Coding gene. Diseases associated with ZNF217 include ovarian serous cystadenocarcinoma and ovarian cystadenocarcinoma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is ZNF219.

UniProtKB/Swiss-Prot for ZNF217 Gene

  • Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at Ser-473.

Gene Wiki entry for ZNF217 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF217 Gene

Genomics for ZNF217 Gene

Regulatory Elements for ZNF217 Gene

Promoters for ZNF217 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF217 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF217 Gene

Chromosome:
20
Start:
53,567,065 bp from pter
End:
53,609,907 bp from pter
Size:
42,843 bases
Orientation:
Minus strand

Genomic View for ZNF217 Gene

Genes around ZNF217 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF217 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF217 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF217 Gene

Proteins for ZNF217 Gene

  • Protein details for ZNF217 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75362-ZN217_HUMAN
    Recommended name:
    Zinc finger protein 217
    Protein Accession:
    O75362
    Secondary Accessions:
    • E1P5Y6
    • Q14DB8

    Protein attributes for ZNF217 Gene

    Size:
    1048 amino acids
    Molecular mass:
    115272 Da
    Quaternary structure:
    • Component of a histone deacetylase complex that contains HDAC2, KDM1A, CTBP1 and ZNF217. May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with CTBP1 and CTBP2.

    Three dimensional structures from OCA and Proteopedia for ZNF217 Gene

neXtProt entry for ZNF217 Gene

Proteomics data for ZNF217 Gene at MOPED

Post-translational modifications for ZNF217 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF217 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF217 Gene

Domains & Families for ZNF217 Gene

Gene Families for ZNF217 Gene

Protein Domains for ZNF217 Gene

Graphical View of Domain Structure for InterPro Entry

O75362

UniProtKB/Swiss-Prot:

ZN217_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF217: view

Function for ZNF217 Gene

Molecular function for ZNF217 Gene

GENATLAS Biochemistry:
zinc finger protein 217 (C2H2 type Kruppel-like) with two alternatively spliced isoforms amplified and overexpressed in breast carcinoma
UniProtKB/Swiss-Prot Function:
Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at Ser-473.

Gene Ontology (GO) - Molecular Function for ZNF217 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044212 transcription regulatory region DNA binding IDA 18625718
genes like me logo Genes that share ontologies with ZNF217: view
genes like me logo Genes that share phenotypes with ZNF217: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF217 Gene

Localization for ZNF217 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF217 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF217 Gene COMPARTMENTS Subcellular localization image for ZNF217 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF217 Gene

Pathways & Interactions for ZNF217 Gene

SuperPathways for ZNF217 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF217 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 18625718
GO:0007165 signal transduction IBA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 16940172
genes like me logo Genes that share ontologies with ZNF217: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF217 Gene

Drugs & Compounds for ZNF217 Gene

(1) Drugs for ZNF217 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF217: view

Transcripts for ZNF217 Gene

Unigene Clusters for ZNF217 Gene

Zinc finger protein 217:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF217 Gene

No ASD Table

Relevant External Links for ZNF217 Gene

GeneLoc Exon Structure for
ZNF217
ECgene alternative splicing isoforms for
ZNF217

Expression for ZNF217 Gene

mRNA expression in normal human tissues for ZNF217 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF217 Gene

This gene is overexpressed in Breast (48.9) and CD8 Tcells (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF217 Gene



SOURCE GeneReport for Unigene cluster for ZNF217 Gene Hs.155040

genes like me logo Genes that share expression patterns with ZNF217: view

Protein tissue co-expression partners for ZNF217 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF217 Gene

Orthologs for ZNF217 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF217 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF217 35
  • 99.55 (n)
  • 99.52 (a)
ZNF217 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF217 36
  • 67 (a)
OneToOne
ZNF217 35
  • 70.13 (n)
  • 67.88 (a)
dog
(Canis familiaris)
Mammalia ZNF217 35
  • 76.71 (n)
  • 73.57 (a)
ZNF217 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp217 36
  • 71 (a)
OneToOne
Zfp217 16
Zfp217 35
  • 75.03 (n)
  • 72.06 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF217 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF217 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp217 35
  • 75.07 (n)
  • 72.65 (a)
chicken
(Gallus gallus)
Aves ZNF217 36
  • 55 (a)
OneToOne
ZNF217 35
  • 66.04 (n)
  • 60.12 (a)
lizard
(Anolis carolinensis)
Reptilia ZNF217 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398381 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10081 35
znf217 35
  • 53.73 (n)
  • 44.55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4604 35
zebrafish
(Danio rerio)
Actinopterygii CABZ01070579.1 36
  • 39 (a)
OneToOne
Dr.26396 35
LOC100537540 35
  • 51.16 (n)
  • 43.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3642 36
  • 27 (a)
OneToMany
Species with no ortholog for ZNF217:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF217 Gene

ENSEMBL:
Gene Tree for ZNF217 (if available)
TreeFam:
Gene Tree for ZNF217 (if available)

Paralogs for ZNF217 Gene

Paralogs for ZNF217 Gene

genes like me logo Genes that share paralogs with ZNF217: view

Variants for ZNF217 Gene

Sequence variations from dbSNP and Humsavar for ZNF217 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_035572 A colorectal cancer sample
rs6063966 - 53,576,549(+) ATGAA(C/T)GTCAG reference, missense
rs34323943 - 53,576,098(-) GAACG(A/G/T)CAGCC reference, missense
rs1819286 -- 53,590,048(+) GGTAG(A/C)TGTTC intron-variant
rs1326862 -- 53,582,428(+) TGCCC(A/G)CATAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF217 Gene

Variant ID Type Subtype PubMed ID
nsv834006 CNV Gain+Loss 17160897
nsv3417 CNV Insertion 18451855

Variation tolerance for ZNF217 Gene

Residual Variation Intolerance Score: 3.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.16; 69.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF217 Gene

HapMap Linkage Disequilibrium report
ZNF217
Human Gene Mutation Database (HGMD)
ZNF217

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF217 Gene

Disorders for ZNF217 Gene

MalaCards: The human disease database

(11) MalaCards diseases for ZNF217 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian serous cystadenocarcinoma
  • serous cystadenoma
ovarian cystadenocarcinoma
  • cystadenocarcinoma of ovary
ovary serous adenocarcinoma
  • malignant ovarian serous tumor
ovarian clear cell carcinoma
  • clear-cell ovarian carcinoma
serous cystadenocarcinoma
  • serous adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF217

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF217
genes like me logo Genes that share disorders with ZNF217: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF217 Gene

Publications for ZNF217 Gene

  1. Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. (PMID: 9671742) Collins C. … Gray J.W. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 67
  2. The ZNF217 oncogene is a candidate organizer of repressive histone modifiers. (PMID: 19242095) Banck M.S. … Walsh M.J. (Epigenetics 2009) 3 23
  3. Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line. (PMID: 18425333) Sun G. … Zhong M. (Int. J. Oncol. 2008) 3 23
  4. Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence. (PMID: 17130829) Cowger J.J. … Torchia J. (Oncogene 2007) 3 23
  5. Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad. (PMID: 17572303) Quinlan K.G. … Crossley M. (Biochim. Biophys. Acta 2007) 3 23

Products for ZNF217 Gene

Sources for ZNF217 Gene

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