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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF217 Gene

protein-coding   GIFtS: 53
GCID: GC20M052183

zinc finger protein 217

 Explore 14 diseases affiliated with
ZNF217 via our new
 Human Malady Compendium 
Biological research products
for ZNF217
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 2171 2
ZABC11 2 3

External Ids:    HGNC: 130091   Entrez Gene: 77642   Ensembl: ENSG000001719407   OMIM: 6029675   UniProtKB: O753623   

Export aliases for ZNF217 gene to outside databases

Previous GC identifers: GC20M051912 GC20M052822 GC20M052869 GC20M051617 GC20M048929


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN217_HUMAN, O75362
Function: Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and
antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'

Gene Wiki entry for ZNF217


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF217 gene promoter:
         p53   E4BP4   Evi-1   AREB6   E2F   E2F-1   FOXO1a   FOXJ2   Ik-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF217 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF217

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF217


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2   Ensembl cytogenetic band:  20q13.2   HGNC cytogenetic band: 20q13.2

ZNF217 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF217 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M052183:  view genomic region     (about GC identifiers)

Start:
52,183,604 bp from pter      End:
52,226,446 bp from pter
Size:
42,843 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN217_HUMAN, O75362 (See protein sequence)
Recommended Name: Zinc finger protein 217  
Size: 1048 amino acids; 115272 Da
Subunit: Component of a histone deacetylase complex that contains HDAC2, KDM1A, CTBP1 and ZNF217. May be a component of
a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2,
ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with CTBP1 and CTBP2
Subcellular location: Nucleus (Probable)
2 PDB 3D structures from and Proteopedia for ZNF217:
2HU2 (3D)        3UK3 (3D)    
Secondary accessions: E1P5Y6 Q14DB8

Explore the universe of human proteins at neXtProt for ZNF217: NX_O75362

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75362

  • ZNF217 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006517.1  
    ENSEMBL proteins: 
     ENSP00000360526   ENSP00000394010   ENSP00000399672   ENSP00000304308  

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    Novus Biologicals ZNF217 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF217

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118histone deacetylase complex IDA18625718
    GO:0005622intracellular ----
    GO:0005654nucleoplasm IDA18625718


    ZNF217 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZNF217


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF217 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O75362

    ProtoNet protein and cluster: O75362

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN217_HUMAN, O75362
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN217_HUMAN, O75362
    Function: Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and
    antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'

         Genatlas biochemistry entry for ZNF217:
    zinc finger protein 217 (C2H2 type Kruppel-like) with two alternatively spliced isoforms amplified and overexpressed in
    breast carcinoma

    miRNA
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    hsa-miR-549 hsa-miR-607 hsa-miR-106a hsa-miR-199a-3p hsa-miR-374a hsa-miR-3074-3p hsa-miR-519a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidZNF217 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9671742
    GO:0005515protein binding IPI16940172
    GO:0008270zinc ion binding IEA--
    GO:0044212transcription regulatory region DNA binding IDA18625718


    ZNF217 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZNF217:
     Increased cell death HMECs cel 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF217

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for ZNF217 (O753622, 3 ENSP000003043084) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RCOR1Q9UKL03, ENSP000002622414I2D: score=1 STRING: ENSP00000262241
    KDM1AO603413, ENSP000003490494I2D: score=1 STRING: ENSP00000349049
    CTBP1Q133633, ENSP000002909214I2D: score=1 STRING: ENSP00000290921
    CTBP2P565453, ENSP000003118254I2D: score=1 STRING: ENSP00000311825
    HDAC2Q927693, ENSP000003813314I2D: score=1 STRING: ENSP00000381331
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA18625718
    GO:0045892negative regulation of transcription, DNA-dependent IDA16940172


    ZNF217 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZNF217 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF217
    1 Novoseek chemical compound relationship for ZNF217 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 60.1 6 15745248 (1), 16793610 (1), 17160949 (1), 19242095 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about ZNF217 / ZN217 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF217 gene: 
    NM_006526.2  

    Unigene Clusters for ZNF217:

    Zinc finger protein 217
    Hs.155040  [show with all ESTs], Hs.711564  [show with all ESTs]
    Unigene Representative Sequences: NM_006526, AK290350
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371471(uc002xwq.4 uc010gij.1) ENST00000437222 ENST00000431687
    ENST00000540425 ENST00000302342

    miRNA
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    hsa-miR-549 hsa-miR-607 hsa-miR-106a hsa-miR-199a-3p hsa-miR-374a hsa-miR-3074-3p hsa-miR-519a hsa-miR-93
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF217
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF217

    Additional cDNA sequence: AK290350.1 

    6 DOTS entries:

    DT.112015  DT.100751266  DT.120838356  DT.120838360  DT.91733753  DT.91917842 

    24/93 AceView cDNA sequences (see all 93):

    BX119280 AW600304 NM_006526 CD644465 BM834501 AA353699 AA563911 BX955300 
    BP366481 AW298383 AA513383 BX350697 D17016 AA460368 BP366185 CR598126 
    CA449440 AA451924 AF041259 BG010798 BC039055 AA460802 BU508213 BM818130 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF217 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCTTAGTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF217 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF217

    SOURCE GeneReport for Unigene clusters: Hs.155040 Hs.711564
        SABiosciences Custom PCR Arrays for ZNF217
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF217

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF217 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ZNF2171 zinc finger protein 217 65.68(n)
    59.58(a)
      419340  XM_417505.3  XP_417505.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF2176
    --
    49(a)
    1 ↔ 1
    GL343226.1(248723-264544)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3983812 mitotic phosphoprotein 140 75.61(n)    AF419155.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.263962 Transcribed sequence with weak similarity to protein more 75.22(n)    AL719606.1 


    ENSEMBL Gene Tree for ZNF217 (if available)
    TreeFam Gene Tree for ZNF217 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF217 gene
    ZNF2192  ZNF5362  ZNF5162  
    14 SIMAP similar genes for ZNF217 using alignment to 4 protein entries:     ZN217_HUMAN (see all proteins):
    HZF16    ZNF78L1    kr-znf3    DKFZp434J0650    ZFX    ZNF844
    A-328A3.4    DKFZp686N0199    PLZF    ZFS-5    ZNF    OVOL3
    ZNF697    ZNF72

    ZNF217 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/437 NCBI SNPs in ZNF217 are shown (see all 437    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1139929671,2
    --52183167(+) TGCCTC/TCCGGG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1817342891,2
    --52183240(+) ACTCAA/GCTAAT 1 -- ds50010--------
    rs1872209951,2
    --52183276(+) TTTCGC/TCATGT 1 -- ds50010--------
    rs1411996631,2
    --52183326(+) ACCCGC/TCTTGG 1 -- ds50010--------
    rs1117847701,2
    --52183384(+) AAATTG/CTGTTT 1 -- ds50012Minor allele frequency- C:0.06CSA WA 120
    rs107154321,2
    C--52183526(+) ATCTC-/AAAAAA 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs758390441,2
    C,--52183600(+) CACTAA/TAACTC 1 -- ds50012Minor allele frequency- T:0.08WA 120
    rs10569491,2
    C,--52183689(-) ATTACT/GTGTTT 1 -- ut31 ese33Minor allele frequency- G:0.19MN NA 306
    rs10569481,2
    C,--52183705(-) TTGTCG/AAACAG 1 -- ut31 ese33Minor allele frequency- A:0.15MN NA 306
    rs1421720041,2
    --52183713(+) CAACT-/TAAG  
            
    TATCA
    1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF217 (52183604 - 52226446 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZNF217
         1 CNV: 5142

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing ZNF217:
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF217 for disorders           About GeneDecksing

    OMIM gene information: 602967    OMIM disorders: --

    14 diseases for ZNF217:    About MalaCards
    serous cystadenocarcinoma    ovarian serous cystadenocarcinoma    cystadenocarcinoma    ovarian cancer
    gastric adenocarcinoma    noma    cervical cancer    cervicitis
    breast carcinoma    adenocarcinoma    breast cancer    glioblastoma
    hypoxia    carcinoma

    3 Novoseek disease relationships for ZNF217 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian serous cystadenocarcinoma 94.4 1 17160949 (1)
    ovarian cancer 53.4 1 16793610 (1)
    cancer 12.6 5 17130829 (1), 19242095 (1), 17572303 (1), 18425333 (1)


    Export disorders for ZNF217 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF217 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with ZNF217)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. (PubMed id 9671742)1, 2, 3 Collins C.... Gray J.W. (1998)
    2. Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex. (PubMed id 18625718)1, 2 Thillainadesan G....Torchia J. (2008)
    3. Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins. (PubMed id 16940172)1, 2 Quinlan K.G.R.... Crossley M. (2006)
    4. ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction. (PubMed id 16203743)1, 2 Huang G....Collins C. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. (PubMed id 12493763)1, 2 Hakimi M.A....Shiekhattar R. (2003)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    8. Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence. (PubMed id 17130829)1, 9 Cowger J.J....Torchia J. (2007)
    9. The ZNF217 oncogene is a candidate organizer of repressive histone modifiers. (PubMed id 19242095)1, 9 Banck M.S....Walsh M.J. (2009)
    10. Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line. (PubMed id 18425333)1, 9 Sun G....Zhong M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7764 HGNC: 13009 AceView: ZNF217 Ensembl:ENSG00000171940 euGenes: HUgn7764
    ECgene: ZNF217 H-InvDB: ZNF217

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF217 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZNF217 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF217 gene:
    Search GeneIP for patents involving ZNF217

    GeneCards and IP:
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