ZNF217 Gene
protein-coding GIFtS: 53
GCID: GC20M052183
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zinc finger protein 217
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Aliases for ZNF217 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 2171 2 | | ZABC11 2 3 |
Export aliases for ZNF217 gene to outside databasesPrevious GC identifers: GC20M051912 GC20M052822 GC20M052869 GC20M051617 GC20M048929 |
Summaries for ZNF217 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ZN217_HUMAN, O75362Function: Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation andantagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473' Gene Wiki entry for ZNF217
|
Genomic Views for ZNF217 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF217 gene promoter: p53 E4BP4 Evi-1 AREB6 E2F E2F-1 FOXO1a FOXJ2 Ik-1 FOXO1 Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF217
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF217 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.2 Ensembl cytogenetic band: 20q13.2 HGNC cytogenetic band: 20q13.2ZNF217 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M052183: view genomic region
(about GC identifiers)
Start:
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52,183,604 bp from pter |
End:
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52,226,446 bp from pter |
Size:
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42,843 bases |
Orientation:
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minus strand |
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Proteins for ZNF217 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZN217_HUMAN, O75362 (See
protein sequence)Recommended Name: Zinc finger protein 217 Size: 1048 amino acids; 115272 Da
Subunit: Component of a histone deacetylase complex that contains HDAC2, KDM1A, CTBP1 and ZNF217. May be a component ofa BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2,ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with CTBP1 and CTBP2
Subcellular location: Nucleus (Probable)
2 PDB 3D structures from and Proteopedia for ZNF217:2HU2 (3D)
  3UK3 (3D)
 
Secondary accessions: E1P5Y6 Q14DB8Explore the universe of human proteins at neXtProt for ZNF217: NX_O75362
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75362 ZNF217 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006517.1 ENSEMBL proteins: ENSP00000360526 ENSP00000394010 ENSP00000399672 ENSP00000304308 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZNF217 for ontologies About GeneDecksing
ZNF217 Antibody Products: Assay Products for ZNF217: |
Protein
Domains / Families for ZNF217 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF217 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75362ProtoNet protein and cluster: O75362 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN217_HUMAN, O75362Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 7 C2H2-type zinc fingers |
Function for ZNF217 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ZN217_HUMAN, O75362Function: Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation andantagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473' Genatlas biochemistry entry for ZNF217:zinc finger protein 217 (C2H2 type Kruppel-like) with two alternatively spliced isoforms amplified and overexpressed inbreast carcinoma
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF217 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF217 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF217 (NM_006526) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF217 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF217  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF217 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZNF217 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF217:
|
Pathways & Interactions for ZNF217 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF217
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/48 Interacting proteins for ZNF217 (O753622, 3 ENSP000003043084) via UniProtKB, MINT, STRING, and/or I2D (see all 48)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
ZNF217 for ontologies About GeneDecksing
|
Drugs & Compounds for ZNF217 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ZNF217 for compounds About GeneDecksing
Browse Tocris compounds for ZNF217 1 Novoseek chemical compound relationship for ZNF217 gene About this table
Search CenterWatch for drugs/clinical trials and news about ZNF217 / ZN217 
|
Transcripts for ZNF217 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZNF217 gene: NM_006526.2 Unigene Clusters for ZNF217: Zinc finger protein 217 Hs.155040 [show with all ESTs], Hs.711564 [show with all ESTs]Unigene Representative Sequences: NM_006526, AK2903505 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371471(uc002xwq.4 uc010gij.1) ENST00000437222 ENST00000431687 ENST00000540425 ENST00000302342
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF217 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF217 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF217 (NM_006526) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF217 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF217  |
Additional cDNA sequence: AK290350.1 6 DOTS entries: DT.112015 DT.100751266 DT.120838356 DT.120838360 DT.91733753 DT.91917842 24/93 AceView cDNA sequences (see all 93): BX119280 AW600304 NM_006526 CD644465 BM834501 AA353699 AA563911 BX955300 BP366481 AW298383 AA513383 BX350697 D17016 AA460368 BP366185 CR598126 CA449440 AA451924 AF041259 BG010798 BC039055 AA460802 BU508213 BM818130 GeneLoc Exon Structure
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Expression for ZNF217 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF217 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GGCTTAGTGA
About this image See ZNF217 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF217
SOURCE GeneReport for Unigene clusters: Hs.155040 Hs.711564 SABiosciences Custom PCR Arrays for ZNF217
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF217 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF217 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF217 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF217 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF217 |
Orthologs for ZNF217 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF217 gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
ZNF2171 |
zinc finger protein 217 |
65.68(n) 59.58(a) |
  |
419340 XM_417505.3 XP_417505.3 |
lizard (Anolis carolinensis) |
Reptilia |
ZNF2176 |
-- |
49(a) |
1 ↔ 1 |
GL343226.1(248723-264544) |
African clawed frog (Xenopus laevis) |
Amphibia |
LOC3983812 |
mitotic phosphoprotein 140 |
75.61(n) |
  |
AF419155.1 |
zebrafish (Danio rerio) |
Actinopterygii |
Dr.263962 |
Transcribed sequence with weak similarity to protein more |
75.22(n) |
  |
AL719606.1 |
ENSEMBL Gene Tree for ZNF217 (if available) TreeFam Gene Tree for ZNF217 (if available)  |
Paralogs for ZNF217 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ZNF217 gene
- ZNF2192 ZNF5362 ZNF5162
14 SIMAP similar genes for ZNF217 using alignment to 4 protein entries: ZN217_HUMAN (see all proteins):HZF16 ZNF78L1 kr-znf3 DKFZp434J0650 ZFX ZNF844 A-328A3.4 DKFZp686N0199 PLZF ZFS-5 ZNF OVOL3 ZNF697 ZNF72
ZNF217 for paralogs About GeneDecksing
|
Genomic Variants for ZNF217 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 20 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF217 (52183604 - 52226446 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for ZNF217 1 CNV: 5142  | SABiosciences Cancer Mutation PCR Assays |
 | 1 SABiosciences qBiomarker Copy Number PCR Array containing ZNF217: |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF217 |
|
Disorders
/ Diseases for ZNF217 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF217 for disorders About GeneDecksing
OMIM gene information: 602967
OMIM disorders: --
14 diseases for ZNF217: About MalaCardsserous cystadenocarcinoma ovarian serous cystadenocarcinoma cystadenocarcinoma ovarian cancer gastric adenocarcinoma noma cervical cancer cervicitis breast carcinoma adenocarcinoma breast cancer glioblastoma hypoxia carcinoma
3 Novoseek disease relationships for ZNF217 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ovarian serous cystadenocarcinoma |
94.4 |
1 |
17160949 (1) |
| ovarian cancer |
53.4 |
1 |
16793610 (1) |
| cancer |
12.6 |
5 |
17130829 (1), 19242095 (1), 17572303 (1), 18425333 (1) |
Export disorders for ZNF217 gene to outside databases
|
Publications for ZNF217 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF217 gene, integrated from 9 sources (see all 44): (articles sorted by number of sources associating them with ZNF217) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. (PubMed id 9671742)1, 2, 3 Collins C.... Gray J.W. (1998)
- Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex. (PubMed id 18625718)1, 2 Thillainadesan G....Torchia J. (2008)
- Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins. (PubMed id 16940172)1, 2 Quinlan K.G.R.... Crossley M. (2006)
- ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction. (PubMed id 16203743)1, 2 Huang G....Collins C. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. (PubMed id 12493763)1, 2 Hakimi M.A....Shiekhattar R. (2003)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence. (PubMed id 17130829)1, 9 Cowger J.J....Torchia J. (2007)
- The ZNF217 oncogene is a candidate organizer of repressive histone modifiers. (PubMed id 19242095)1, 9 Banck M.S....Walsh M.J. (2009)
- Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line. (PubMed id 18425333)1, 9 Sun G....Zhong M. (2008)
|
External Searches for ZNF217 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZNF217 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF217 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF217 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for ZNF217 gene: Search GeneIP for patents involving ZNF217
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZNF217 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | OriGene Custom Antibody Services for ZNF217 | | OriGene Custom Protein Services for ZNF217 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF217 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF217 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF217 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF217 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF217 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF217 |
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| | | Search Tocris compounds for ZNF217 |
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 | | ZNF217 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF217 |
|  |  |  | | | Search ThermoFisher Antibodies for ZNF217 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF217 |
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