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Aliases for ZNF217 Gene

Aliases for ZNF217 Gene

  • Zinc Finger Protein 217 2 3
  • ZABC1 3 4

External Ids for ZNF217 Gene

Previous GeneCards Identifiers for ZNF217 Gene

  • GC20M051912
  • GC20M052822
  • GC20M052869
  • GC20M051617
  • GC20M052183
  • GC20M048929

Summaries for ZNF217 Gene

GeneCards Summary for ZNF217 Gene

ZNF217 (Zinc Finger Protein 217) is a Protein Coding gene. Diseases associated with ZNF217 include ovarian cystadenocarcinoma and ovarian serous cystadenocarcinoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is ZNF219.

UniProtKB/Swiss-Prot for ZNF217 Gene

  • Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at Ser-473.

Gene Wiki entry for ZNF217 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF217 Gene

Genomics for ZNF217 Gene

Regulatory Elements for ZNF217 Gene

Genomic Location for ZNF217 Gene

Start:
53,567,065 bp from pter
End:
53,609,907 bp from pter
Size:
42,843 bases
Orientation:
Minus strand

Genomic View for ZNF217 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF217 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF217 Gene

Proteins for ZNF217 Gene

  • Protein details for ZNF217 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75362-ZN217_HUMAN
    Recommended name:
    Zinc finger protein 217
    Protein Accession:
    O75362
    Secondary Accessions:
    • E1P5Y6
    • Q14DB8

    Protein attributes for ZNF217 Gene

    Size:
    1048 amino acids
    Molecular mass:
    115272 Da
    Quaternary structure:
    • Component of a histone deacetylase complex that contains HDAC2, KDM1A, CTBP1 and ZNF217. May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with CTBP1 and CTBP2.

    Three dimensional structures from OCA and Proteopedia for ZNF217 Gene

neXtProt entry for ZNF217 Gene

Proteomics data for ZNF217 Gene at MOPED

Post-translational modifications for ZNF217 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF217 Gene

No data available for DME Specific Peptides for ZNF217 Gene

Domains for ZNF217 Gene

Gene Families for ZNF217 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF217 Gene

Graphical View of Domain Structure for InterPro Entry

O75362

UniProtKB/Swiss-Prot:

ZN217_HUMAN :
  • O75362
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF217: view

Function for ZNF217 Gene

Molecular function for ZNF217 Gene

GENATLAS Biochemistry: zinc finger protein 217 (C2H2 type Kruppel-like) with two alternatively spliced isoforms amplified and overexpressed in breast carcinoma
UniProtKB/Swiss-Prot Function: Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at Ser-473.

Gene Ontology (GO) - Molecular Function for ZNF217 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 17130829
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 17130829
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9671742
GO:0005515 protein binding IPI 16940172
GO:0044212 transcription regulatory region DNA binding IDA 18625718
genes like me logo Genes that share ontologies with ZNF217: view

Phenotypes for ZNF217 Gene

GenomeRNAi human phenotypes for ZNF217:
genes like me logo Genes that share phenotypes with ZNF217: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF217

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF217 Gene

Localization for ZNF217 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF217 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF217 Gene COMPARTMENTS Subcellular localization image for ZNF217 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF217 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IDA 18625718
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF217: view

Pathways for ZNF217 Gene

SuperPathways for ZNF217 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF217 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 17130829
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 18625718
GO:0045892 negative regulation of transcription, DNA-templated IDA 16940172
genes like me logo Genes that share ontologies with ZNF217: view

No data available for Pathways by source for ZNF217 Gene

Compounds for ZNF217 Gene

(1) Novoseek inferred chemical compound relationships for ZNF217 Gene

Compound -log(P) Hits PubMed IDs
zinc 60.1 5
genes like me logo Genes that share compounds with ZNF217: view

Transcripts for ZNF217 Gene

Unigene Clusters for ZNF217 Gene

Zinc finger protein 217:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF217

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF217

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF217 Gene

No ASD Table

Relevant External Links for ZNF217 Gene

GeneLoc Exon Structure for
ZNF217
ECgene alternative splicing isoforms for
ZNF217

Expression for ZNF217 Gene

mRNA expression in normal human tissues for ZNF217 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF217 Gene

SOURCE GeneReport for Unigene cluster for ZNF217 Gene Hs.155040

genes like me logo Genes that share expressions with ZNF217: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF217 Gene

Orthologs for ZNF217 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF217 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF217 35
  • 99.55 (n)
  • 99.52 (a)
ZNF217 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF217 35
  • 70.13 (n)
  • 67.88 (a)
ZNF217 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF217 35
  • 76.71 (n)
  • 73.57 (a)
ZNF217 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp217 35
  • 75.03 (n)
  • 72.06 (a)
Zfp217 16
Zfp217 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF217 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF217 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp217 35
  • 75.07 (n)
  • 72.65 (a)
chicken
(Gallus gallus)
Aves ZNF217 35
  • 66.04 (n)
  • 60.12 (a)
ZNF217 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF217 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398381 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10081 35
znf217 35
  • 53.73 (n)
  • 44.55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4604 35
zebrafish
(Danio rerio)
Actinopterygii CABZ01070579.1 36
  • 39 (a)
OneToOne
Dr.26396 35
LOC100537540 35
  • 51.16 (n)
  • 43.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3642 36
  • 27 (a)
OneToMany
Species with no ortholog for ZNF217:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF217 Gene

ENSEMBL:
Gene Tree for ZNF217 (if available)
TreeFam:
Gene Tree for ZNF217 (if available)

Paralogs for ZNF217 Gene

Paralogs for ZNF217 Gene

Selected SIMAP similar genes for ZNF217 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF217: view

Variants for ZNF217 Gene

Sequence variations from dbSNP and Humsavar for ZNF217 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs204760 -- 53,609,632(+) GCCAC(C/G)AGAAG upstream-variant-2KB
rs204761 -- 53,607,469(+) aaaaa(A/T)atata intron-variant
rs887285 -- 53,604,104(+) CACAG(G/T)AGGTG intron-variant
rs1075390 -- 53,592,299(+) TGATT(C/G)AGGAA intron-variant
rs1326862 -- 53,582,428(+) TGCCC(A/G)CATAC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for ZNF217 Gene

Variant ID Type Subtype PubMed ID
nsv834006 CNV Gain+Loss 17160897
nsv3417 CNV Insertion 18451855

Relevant External Links for ZNF217 Gene

HapMap Linkage Disequilibrium report
ZNF217

PCR Panel Products

  • Copy Number PCR Panels: for ZNF217

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF217 Gene

Disorders for ZNF217 Gene

(3) Novoseek inferred disease relationships for ZNF217 Gene

Disease -log(P) Hits PubMed IDs
ovarian serous cystadenocarcinoma 94.4 1
ovarian cancer 53.4 1
cancer 12.6 4
genes like me logo Genes that share disorders with ZNF217: view

No data available for UniProtKB/Swiss-Prot for ZNF217 Gene

Publications for ZNF217 Gene

  1. Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. (PMID: 9671742) Collins C. … Gray J.W. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. (PMID: 12493763) Hakimi M.-A. … Shiekhattar R. (J. Biol. Chem. 2003) 3 4
  4. Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence. (PMID: 17130829) Cowger J.J. … Torchia J. (Oncogene 2007) 3 23
  5. Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad. (PMID: 17572303) Quinlan K.G. … Crossley M. (Biochim. Biophys. Acta 2007) 3 23

Products for ZNF217 Gene

  • antibodies-online peptides for ZNF217
  • antibodies-online antibodies for ZNF217
  • antibodies-online kits for ZNF217

Sources for ZNF217 Gene

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