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Aliases for ZNF215 Gene

Aliases for ZNF215 Gene

  • Zinc Finger Protein 215 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 11 3 4
  • BWSCR2-Associated Zinc Finger Protein 2 3 4
  • ZKSCAN11 3 4
  • BAZ-2 3 4
  • BAZ2 3 4
  • ZSCAN43 3
  • BAZ 2 3

External Ids for ZNF215 Gene

Previous GeneCards Identifiers for ZNF215 Gene

  • GC11P007690
  • GC11P007408
  • GC11P006906
  • GC11P006911
  • GC11P006904
  • GC11P006606

Summaries for ZNF215 Gene

GeneCards Summary for ZNF215 Gene

ZNF215 (Zinc Finger Protein 215) is a Protein Coding gene. Diseases associated with ZNF215 include Beckwith-Wiedemann Syndrome. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF274.

UniProtKB/Swiss-Prot for ZNF215 Gene

  • May be involved in transcriptional regulation.

Tocris Summary for ZNF215 Gene

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF215 Gene

Genomics for ZNF215 Gene

Regulatory Elements for ZNF215 Gene

Enhancers for ZNF215 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF215 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF215 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF215 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF215 Gene

6,926,404 bp from pter
7,005,354 bp from pter
78,951 bases
Plus strand

Genomic View for ZNF215 Gene

Genes around ZNF215 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF215 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF215 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF215 Gene

Proteins for ZNF215 Gene

  • Protein details for ZNF215 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 215
    Protein Accession:
    Secondary Accessions:
    • Q96C84

    Protein attributes for ZNF215 Gene

    517 amino acids
    Molecular mass:
    60034 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF215 Gene


neXtProt entry for ZNF215 Gene

Proteomics data for ZNF215 Gene at MOPED

Post-translational modifications for ZNF215 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF215 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF215 Gene

Domains & Families for ZNF215 Gene

Gene Families for ZNF215 Gene

Suggested Antigen Peptide Sequences for ZNF215 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF215: view

Function for ZNF215 Gene

Molecular function for ZNF215 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF215 Gene

genes like me logo Genes that share phenotypes with ZNF215: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF215 Gene

Localization for ZNF215 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF215 Gene

Subcellular locations from

Jensen Localization Image for ZNF215 Gene COMPARTMENTS Subcellular localization image for ZNF215 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF215 Gene

Pathways & Interactions for ZNF215 Gene

SuperPathways for ZNF215 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF215: view

Pathways by source for ZNF215 Gene

2 Reactome pathways for ZNF215 Gene

Interacting Proteins for ZNF215 Gene

Gene Ontology (GO) - Biological Process for ZNF215 Gene


No data available for SIGNOR curated interactions for ZNF215 Gene

Drugs & Compounds for ZNF215 Gene

No Compound Related Data Available

Transcripts for ZNF215 Gene

Unigene Clusters for ZNF215 Gene

Zinc finger protein 215:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF215 Gene

No ASD Table

Relevant External Links for ZNF215 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF215 Gene

mRNA expression in normal human tissues for ZNF215 Gene

SOURCE GeneReport for Unigene cluster for ZNF215 Gene Hs.523457

genes like me logo Genes that share expression patterns with ZNF215: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF215 Gene

Orthologs for ZNF215 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF215 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF215 35
  • 85.12 (n)
  • 74.66 (a)
ZNF215 36
  • 73 (a)
(Canis familiaris)
Mammalia ZNF215 35
  • 84.6 (n)
  • 72.43 (a)
ZNF215 36
  • 69 (a)
(Pan troglodytes)
Mammalia ZNF215 35
  • 99.23 (n)
  • 98.26 (a)
ZNF215 36
  • 98 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
Species with no ortholog for ZNF215:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF215 Gene

Gene Tree for ZNF215 (if available)
Gene Tree for ZNF215 (if available)

Paralogs for ZNF215 Gene

Paralogs for ZNF215 Gene Pseudogenes for ZNF215 Gene

genes like me logo Genes that share paralogs with ZNF215: view

Variants for ZNF215 Gene

Sequence variations from dbSNP and Humsavar for ZNF215 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2239729 - 6,956,103(-) ATTCA(C/T)TGTAG intron-variant, reference, missense
rs11041108 - 6,932,627(+) AAGAT(A/G)TGGTG nc-transcript-variant, reference, missense
rs11041107 - 6,932,379(+) AACCA(A/G)CCCCG nc-transcript-variant, reference, missense
rs35111903 - 6,932,384(-) CACGA(C/T)GGGGT nc-transcript-variant, reference, missense
rs11041115 - 6,955,765(+) CCCTT(C/T)TTCAG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF215 Gene

Variant ID Type Subtype PubMed ID
nsv832061 CNV Loss 17160897
nsv896973 CNV Loss 21882294
esv2557168 CNV Deletion 19546169
nsv896974 CNV Loss 21882294

Variation tolerance for ZNF215 Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.50; 64.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF215 Gene

Disorders for ZNF215 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF215 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • wiedemann-beckwith syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF215

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZNF215: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF215 Gene

Publications for ZNF215 Gene

  1. Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. (PMID: 10762538) Alders M. … Mannens M. (Am. J. Hum. Genet. 2000) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines. (PMID: 24483146) Li L. … Wang L. (BMC Genomics 2014) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for ZNF215 Gene

Sources for ZNF215 Gene