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ZNF214 Gene

protein-coding   GIFtS: 47
GCID: GC11M007020

Zinc Finger Protein 214

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 2141 2
BAZ-12 3
BAZ12 3
BWSCR2-Associated Zinc Finger Protein 12 3
BAZ 12

External Ids:    HGNC: 130061   Entrez Gene: 77612   Ensembl: ENSG000001490507   OMIM: 6050155   UniProtKB: Q9UL593   

Export aliases for ZNF214 gene to outside databases

Previous GC identifers: GC11M007763 GC11M007481 GC11M006979 GC11M006984 GC11M006977 GC11M006679


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF214 Gene:
ZNF214 (zinc finger protein 214) is a protein-coding gene. Diseases associated with ZNF214 include beckwith-wiedemann syndrome, and cryptorchidism. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot: ZN214_HUMAN, Q9UL59
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF214 gene promoter:
         NRSF form 1   FOXO3a   FOXO3   NRSF form 2   FOXO3b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF214 promoter sequence
   Search Chromatin IP Primers for ZNF214

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF214


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

ZNF214 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF214 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M007020:  view genomic region     (about GC identifiers)

Start:
7,020,549 bp from pter      End:
7,041,599 bp from pter
Size:
21,051 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN214_HUMAN, Q9UL59 (See protein sequence)
Recommended Name: Zinc finger protein 214  
Size: 606 amino acids; 70992 Da
Secondary accessions: B2R8Q1

Explore the universe of human proteins at neXtProt for ZNF214: NX_Q9UL59

Explore proteomics data for ZNF214 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF214 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037381.2  
    ENSEMBL proteins: 
     ENSP00000278314   ENSP00000445373  
    Reactome Protein details: Q9UL59

    ZNF214 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UL59

    ProtoNet protein and cluster: Q9UL59

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN214_HUMAN, Q9UL59
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF214 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN214_HUMAN, Q9UL59
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding NAS10762538
    GO:0046872metal ion binding ----
         
    ZNF214 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF214
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    miRNA
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    miRTarBase miRNAs that target ZNF214:
    hsa-mir-186-5p (MIRT045263)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN214_HUMAN, Q9UL59: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF214 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF214 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF214
        Generic Transcription Pathway



    ZNF214 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF214
    Interactions:

        Search GeneGlobe Interaction Network for ZNF214

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF214 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF214 (ZN214)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF214 gene: 
    NM_013249.2  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278314(uc001mfa.2 uc010ray.1 uc009yfh.1) ENST00000531083
    ENST00000525017 ENST00000536068
    miRNA
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    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF214
      QuantiFast Probe-based Assays in human, mouse, rat ZNF214

    15 AceView cDNA sequences:

    AA678604 BX117436 AI273720 AI792275 BX096368 BQ576016 AW450792 NM_013249 
    AW182291 AI383932 AF056617 BV185926 AA442251 AL703077 AU149800 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF214    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
    SP1:                                -                                 
    SP2:                          -     -                                 
    SP3:                          -     -                                 
    SP4:                                                                  
    SP5:                          -     -                                 


    ECgene alternative splicing isoforms for ZNF214

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF214 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF214 Expression
    About this image

    ZNF214 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF214 Protein Expression
        Custom PCR Arrays for ZNF214
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF214

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF214 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    43(a)
    many ↔ many
    16(478531-480245) ENSGALG00000024335
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    36(a)
    1 → many
    2(192616857-192618623)
    zebrafish
    (Danio rerio)
    Actinopterygii ZNF2146
    zinc finger protein 214
    11(a)
    1 → many
    16(27346625-27354753) ENSDARG00000022952
    fruit fly
    (Drosophila melanogaster)
    Insecta CG21203   -- 35(a)
    (best of 2)
      7D15   --
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1466
    C27A12.26
    Protein C27A12.2 (C27A12.2) mRNA, complete cds
    21(a)
    18(a)
    many ↔ many
    many ↔ many
    I(6038406-6041265) WBGene00006492
    I(6041670-6046176) WBGene00016154
            Species with no ortholog for ZNF214

    ENSEMBL Gene Tree for ZNF214 (if available)
    TreeFam Gene Tree for ZNF214 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF214 gene
    ZNF2292  ZNF2232  ZNF2302  ZNF1552  ZNF2272  ZNF2242  ZNF2342  ZNF2252  
    ZNF2262  ZNF2222  ZNF2842  ENSG000002671732  ZNF452  ZNF2352  ZNF2212  ZNF2852  
    ENSG000002670222  ZNF1122  ZNF2332  
    Selected SIMAP similar genes for ZNF214 using alignment to 2 protein entries:     ZN214_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    kr-znf3    MGC12518    ZNF664    ZNF818P    DKFZp762K012
    ZSCAN22    ZNF    DKFZp666C237    ZNF169    ZNF232    DKFZp686M04222
    HZF16    HZF36    ZFP41    ZFS-5    ZNF32    ZNF702P

    ZNF214 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF214 (see all 450)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs28579311,2
    C,F,H--7020123(-) TACACA/CGTCTT 1 -- ds500120Minor allele frequency- C:0.10NS EA NA WA 2346
    rs26380881,2
    C,F,H--7020135(+) TCCGAT/CTAACT 1 -- ds500116Minor allele frequency- C:0.05NS EA NA WA CSA 793
    rs1877127351,2
    --7020281(+) ATTCTA/CCTGCT 1 -- ds50010--------
    rs1926881541,2
    --7020340(+) TTGTCC/TATACC 1 -- ds50010--------
    rs788459751,2
    C,F--7020342(+) GTCCAT/CACCCT 1 -- ds50011Minor allele frequency- C:0.10WA 118
    rs1840808211,2
    --7020397(+) GAACCC/TATTAT 1 -- ds50010--------
    rs1876956221,2
    --7020408(+) TAAGCA/GTGGAA 1 -- ds50010--------
    rs1429170551,2
    --7020432(+) AGGGAC/TGAGTG 1 -- ds50010--------
    rs1922269071,2
    --7020443(+) CACTGC/TAGTCA 1 -- ds50010--------
    rs28579301,2
    C,F,O,A,H--7020454(-) TCACTT/CTGAGG 1 -- ds500130Minor allele frequency- C:0.22EA NA NS WA CSA 2928

    HapMap Linkage Disequilibrium report for ZNF214 (7020549 - 7041599 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF214:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832061CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF214
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF214

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605015    OMIM disorders: --

    2 diseases for ZNF214:    
    About MalaCards
    beckwith-wiedemann syndrome    cryptorchidism

    2 diseases from the University of Copenhagen DISEASES database for ZNF214:
    Beckwith-Wiedemann syndrome     Cryptorchidism

    ZNF214 for disorders           About GeneDecksing


    Export disorders for ZNF214 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF214 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF214)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. (PubMed id 10762538)1, 2 Alders M.... Mannens M. (Am. J. Hum. Genet. 2000)
    2. Reduced transcript expression of genes affected by inherited and de novo CNVs in autism. (PubMed id 21448237)1 Nord A.S....McClellan J.M. (Eur. J. Hum. Genet. 2011)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. An integrated physical map of 210 markers assigned to the short arm of human chromosome 11. (PubMed id 7959730)1 Redeker E....van den Bogaard R. (Genomics 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7761 HGNC: 13006 AceView: ZNF214 Ensembl:ENSG00000149050 euGenes: HUgn7761
    ECgene: ZNF214 H-InvDB: ZNF214

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF214 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF214 gene:
    Search GeneIP for patents involving ZNF214

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZNF214  
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     Block miRNA regulation of human, mouse, rat ZNF214 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZNF214
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF214 Predesigned siRNA for gene silencing in human, mouse, rat ZNF214
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     Custom PCR Arrays for ZNF214 Search Chromatin IP Primers for ZNF214
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF214
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