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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF214 Gene

protein-coding GIFtS: 48
GCID: GC11M007020

zinc finger protein 214

Explore 2 diseases affiliated with
ZNF214 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 214¹ ²
BAZ-1² ³
BAZ1² ³
BWSCR2-Associated Zinc Finger Protein 1² ³
BAZ 1²

External Ids:	HGNC: 13006¹	Entrez Gene: 7761²	Ensembl: ENSG00000149050⁷	OMIM: 605015⁵	UniProtKB: Q9UL59³

Export aliases for ZNF214 gene to outside databases

Previous GC identifers: GC11M007763 GC11M007481 GC11M006979 GC11M006984 GC11M006977 GC11M006679

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN214_HUMAN, Q9UL59

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF214 gene promoter:
NRSF form 1 FOXO3a FOXO3 NRSF form 2 FOXO3b
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF214 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF214

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF214

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4

ZNF214 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF214 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M007020: view genomic region (about GC identifiers)

Start:	7,020,549 bp from pter	End:	7,041,599 bp from pter
Size:	21,051 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN214_HUMAN, Q9UL59 (See protein sequence)

Recommended Name: Zinc finger protein 214

Size: 606 amino acids; 70992 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: B2R8Q1

Explore the universe of human proteins at neXtProt for ZNF214: NX_Q9UL59

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UL59

ZNF214 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_037381.2

ENSEMBL proteins:

ENSP00000278314 ENSP00000445373

Reactome Protein details: Q9UL59
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	Uscn Proteins for ZNF214

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	--

ZNF214 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF214 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9UL59

ProtoNet protein and cluster: Q9UL59

2 Blocks protein families:

IPB001909 KRAB box

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN214_HUMAN, Q9UL59

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 11 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN214_HUMAN, Q9UL59

Function: May be involved in transcriptional regulation

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	NAS	--
GO:0008270	zinc ion binding	NAS	10762538

ZNF214 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF214

	Generic Transcription Pathway
	Gene Expression

ZNF214 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF214

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	NAS	--

ZNF214 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Search CenterWatch for drugs/clinical trials and news about ZNF214 / ZN214

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ZNF214 gene:

NM_013249.2

Unigene Cluster for ZNF214:

Zinc finger protein 214

Hs.733636 [show with all ESTs]

Unigene Representative Sequence: NM_013249

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000278314(uc001mfa.2 uc010ray.1 uc009yfh.1) ENST00000531083

ENST00000525017 ENST00000536068

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Additional cDNA sequence:

AF056617.1 AK313462.1 BC136772.1 BC144405.1

1 DOTS entry:

DT.40122876

15 AceView cDNA sequences:

BX117436 AA678604 AI792275 AI273720 AW182291 AF056617 AW450792 AI383932

NM_013249 BQ576016 BX096368 AA442251 AL703077 BV185926 AU149800

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF214 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	·	5c	·	5d
SP1:											-
SP2:									-		-
SP3:									-		-
SP4:
SP5:									-		-

ECgene alternative splicing isoforms for ZNF214

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF214 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ZNF214 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZNF214 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF214

SOURCE GeneReport for Unigene cluster: Hs.733636

SABiosciences Custom PCR Arrays for ZNF214

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF214 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	56(a) 48(a) (see all 3)	many ↔ many many ↔ many (see all 3)	GL343520.1(33049-35524) GL343626.1(93308-95281)
zebrafish (Danio rerio)	Actinopterygii	BX649556.3⁶ si:ch211-231i17.4⁶ (see all 4)	si:ch211-231i17.4 (see all 4)	50(a) 40(a) (see all 4)	many ↔ many many ↔ many (see all 4)	Zv9_scaffold3530(37025-100672) 4(29133676-29138334)

ENSEMBL Gene Tree for ZNF214 (if available)
TreeFam Gene Tree for ZNF214 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF214 gene

ZNF229² ZNF223² ZNF230² ENSG00000062370² ZNF155² ZNF664² ZNF227² ZNF234²

ZNF239² ZNF224² ZNF225² ZNF226² ZNF222² ZNF284² ENSG00000267173² ZNF45²

ZNF235² ZNF221² ENSG00000267022² ZNF285² ZNF233²

18/491 SIMAP similar genes for ZNF214 using alignment to 2 protein entries: ZN214_HUMAN (see all proteins) (see all similar genes):

ZNF78L1 kr-znf3 MGC12518 ZNF664 ZNF818P DKFZp762K012

ZSCAN22 ZNF DKFZp666C237 ZNF232 ZNF436 DKFZp686M04222

HZF16 HZF36 ZFP41 ZFS-5 ZNF32 ZNF702P

ZNF214 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2857931^1,2	C,F,H	--	7020123(-)	`TACACA/CGTCTT`	1	--	ds500¹		20		NS EA NA WA	2346
rs2638088^1,2	C,F,H	--	7020135(+)	`TCCGAT/CTAACT`	1	--	ds500¹		16		NS EA NA WA CSA	793
rs187712735^1,2		--	7020281(+)	`ATTCTA/CCTGCT`	1	--	ds500¹		0	--	--	--	--
rs192688154^1,2		--	7020340(+)	`TTGTCC/TATACC`	1	--	ds500¹		0	--	--	--	--
rs78845975^1,2	F	--	7020342(+)	`GTCCAT/CACCCT`	1	--	ds500¹		1		WA	118
rs184080821^1,2		--	7020397(+)	`GAACCC/TATTAT`	1	--	ds500¹		0	--	--	--	--
rs187695622^1,2		--	7020408(+)	`TAAGCA/GTGGAA`	1	--	ds500¹		0	--	--	--	--
rs142917055^1,2		--	7020432(+)	`AGGGAC/TGAGTG`	1	--	ds500¹		0	--	--	--	--
rs192226907^1,2		--	7020443(+)	`CACTGC/TAGTCA`	1	--	ds500¹		0	--	--	--	--
rs2857930^1,2	C,F,O,A,H	--	7020454(-)	`TCACTT/CTGAGG`	1	--	ds500¹		30		EA NA NS WA CSA	2928

HapMap Linkage Disequilibrium report for ZNF214 (7020549 - 7041599 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF214: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF214 for disorders           About GeneDecksing

OMIM gene information: 605015    OMIM disorders: --

2 diseases for ZNF214:    About MalaCards

beckwith-wiedemann syndrome cryptorchidism

2 diseases from the University of Copenhagen DISEASES database for ZNF214:

Beckwith-Wiedemann syndrome Cryptorchidism

Export disorders for ZNF214 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF214 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF214)

Utopia: connect your pdf to the dynamic
world of online information

Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. (PubMed id 10762538)^{1, 2} Alders M.... Mannens M. (2000)
Reduced transcript expression of genes affected by in herited and de novo CNVs in autism. (PubMed id 21448237)¹ Nord A.S....McClellan J.M. (2011)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
An integrated physical map of 210 markers assigned to the short arm of human chromosome 11. (PubMed id 7959730)¹ Redeker E....van den Bogaard R. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7761	HGNC: 13006	AceView: ZNF214	Ensembl:ENSG00000149050	euGenes: HUgn7761
ECgene: ZNF214	H-InvDB: ZNF214

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF214	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF214 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF214 gene:
Search GeneIP for patents involving ZNF214

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF214
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	GenScript Custom Purified and Recombinant Proteins Services for ZNF214		GenScript cDNA clones with any tag delivered in your preferred vector for ZNF214
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF214

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZNF214

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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ZNF214 Gene

zinc finger protein 214

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ZNF214 Gene

zinc finger protein 214

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