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Aliases for ZNF214 Gene

Aliases for ZNF214 Gene

  • Zinc Finger Protein 214 2 3
  • BWSCR2-Associated Zinc Finger Protein 1 3 4
  • BAZ-1 3 4
  • BAZ1 3 4
  • BAZ 1 3

External Ids for ZNF214 Gene

Previous GeneCards Identifiers for ZNF214 Gene

  • GC11M007763
  • GC11M007481
  • GC11M006979
  • GC11M006984
  • GC11M006977
  • GC11M006679

Summaries for ZNF214 Gene

GeneCards Summary for ZNF214 Gene

ZNF214 (Zinc Finger Protein 214) is a Protein Coding gene. Diseases associated with ZNF214 include beckwith-wiedemann syndrome. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF155.

UniProtKB/Swiss-Prot for ZNF214 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF214 Gene

Genomics for ZNF214 Gene

Regulatory Elements for ZNF214 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF214 Gene

Chromosome:
11
Start:
6,996,613 bp from pter
End:
7,020,376 bp from pter
Size:
23,764 bases
Orientation:
Minus strand

Genomic View for ZNF214 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF214 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF214 Gene

Proteins for ZNF214 Gene

  • Protein details for ZNF214 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL59-ZN214_HUMAN
    Recommended name:
    Zinc finger protein 214
    Protein Accession:
    Q9UL59
    Secondary Accessions:
    • B2R8Q1

    Protein attributes for ZNF214 Gene

    Size:
    606 amino acids
    Molecular mass:
    70992 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF214 Gene

Proteomics data for ZNF214 Gene at MOPED

Post-translational modifications for ZNF214 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF214 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF214

No data available for DME Specific Peptides for ZNF214 Gene

Domains & Families for ZNF214 Gene

Gene Families for ZNF214 Gene

Protein Domains for ZNF214 Gene

Suggested Antigen Peptide Sequences for ZNF214 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UL59

UniProtKB/Swiss-Prot:

ZN214_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF214: view

Function for ZNF214 Gene

Molecular function for ZNF214 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS 10762538
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF214: view

Phenotypes for ZNF214 Gene

GenomeRNAi human phenotypes for ZNF214:
genes like me logo Genes that share phenotypes with ZNF214: view

Animal Model Products

CRISPR Products

miRNA for ZNF214 Gene

miRTarBase miRNAs that target ZNF214

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF214

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF214 Gene

Localization for ZNF214 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF214 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF214 Gene COMPARTMENTS Subcellular localization image for ZNF214 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF214: view

Pathways & Interactions for ZNF214 Gene

SuperPathways for ZNF214 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF214: view

Pathways by source for ZNF214 Gene

2 Reactome pathways for ZNF214 Gene

Interacting Proteins for ZNF214 Gene

Gene Ontology (GO) - Biological Process for ZNF214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF214: view

No data available for SIGNOR curated interactions for ZNF214 Gene

Drugs & Compounds for ZNF214 Gene

No Compound Related Data Available

Transcripts for ZNF214 Gene

mRNA/cDNA for ZNF214 Gene

Unigene Clusters for ZNF214 Gene

Zinc finger protein 214:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF214

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF214 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1: -
SP2: - -
SP3: - -
SP4:
SP5: - -

Relevant External Links for ZNF214 Gene

GeneLoc Exon Structure for
ZNF214
ECgene alternative splicing isoforms for
ZNF214

Expression for ZNF214 Gene

mRNA expression in normal human tissues for ZNF214 Gene

Protein differential expression in normal tissues from HIPED for ZNF214 Gene

This gene is overexpressed in Monocytes (40.4), Pancreatic juice (11.8), Fetal Brain (7.5), and CD4 Tcells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF214 Gene



SOURCE GeneReport for Unigene cluster for ZNF214 Gene Hs.733636

genes like me logo Genes that share expression patterns with ZNF214: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF214 Gene

Orthologs for ZNF214 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF214 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF214 35
  • 86.67 (n)
  • 80 (a)
ZNF214 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF214 35
  • 88.5 (n)
  • 84.49 (a)
ZNF214 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF214 35
  • 99.34 (n)
  • 98.84 (a)
ZNF214 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 30 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm13242 36
  • 33 (a)
ManyToMany
Gm14443 36
  • 38 (a)
ManyToMany
Gm26919 36
  • 27 (a)
ManyToMany
Rex2 36
  • 32 (a)
ManyToMany
Zfp109 36
  • 35 (a)
ManyToMany
Zfp229 36
  • 32 (a)
ManyToMany
Zfp53 36
  • 35 (a)
ManyToMany
Zfp54 36
  • 32 (a)
ManyToMany
Zfp677 36
  • 35 (a)
ManyToMany
Zfp760 36
  • 33 (a)
ManyToMany
Zfp948 36
  • 30 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 43 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF214 36
  • 11 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11695 37
  • 29 (a)
CG2120 37
  • 35 (a)
CG5245 36
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C27A12.2 36
  • 18 (a)
ManyToMany
tag-146 36
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
Species with no ortholog for ZNF214:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF214 Gene

ENSEMBL:
Gene Tree for ZNF214 (if available)
TreeFam:
Gene Tree for ZNF214 (if available)

Paralogs for ZNF214 Gene

(497) SIMAP similar genes for ZNF214 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF214: view

Variants for ZNF214 Gene

Sequence variations from dbSNP and Humsavar for ZNF214 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2035845 -- 7,017,019(-) CATTT(C/G)TCATA intron-variant
rs2087719 -- 7,008,610(+) agaaa(G/T)aaaag intron-variant
rs2346004 -- 7,012,907(+) ggtca(C/G)aaatt intron-variant
rs4757982 -- 7,008,910(+) attac(A/C)aagca intron-variant
rs6578818 -- 7,009,055(+) cattc(A/C/T)tcact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF214 Gene

Variant ID Type Subtype PubMed ID
nsv832061 CNV Loss 17160897

Variation tolerance for ZNF214 Gene

Residual Variation Intolerance Score: 86.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.41; 77.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF214 Gene

HapMap Linkage Disequilibrium report
ZNF214

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF214 Gene

Disorders for ZNF214 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF214 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • wiedemann-beckwith syndrome
- elite association

Relevant External Links for ZNF214

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF214
genes like me logo Genes that share disorders with ZNF214: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF214 Gene

Publications for ZNF214 Gene

  1. Reduced transcript expression of genes affected by inherited and de novo CNVs in autism. (PMID: 21448237) Nord A.S. … McClellan J.M. (Eur. J. Hum. Genet. 2011) 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for ZNF214 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF214
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF214
    • Block miRNA regulation of ZNF214 using miScript Target Protectors

    Sources for ZNF214 Gene

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