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Aliases for ZNF214 Gene

Aliases for ZNF214 Gene

  • Zinc Finger Protein 214 2 3 5
  • BWSCR2-Associated Zinc Finger Protein 1 3 4
  • BAZ-1 3 4
  • BAZ1 3 4
  • BAZ 1 3

External Ids for ZNF214 Gene

Previous GeneCards Identifiers for ZNF214 Gene

  • GC11M007763
  • GC11M007481
  • GC11M006979
  • GC11M006984
  • GC11M006977
  • GC11M006679

Summaries for ZNF214 Gene

GeneCards Summary for ZNF214 Gene

ZNF214 (Zinc Finger Protein 214) is a Protein Coding gene. Diseases associated with ZNF214 include Beckwith-Wiedemann Syndrome. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF285.

UniProtKB/Swiss-Prot for ZNF214 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF214 Gene

Genomics for ZNF214 Gene

Regulatory Elements for ZNF214 Gene

Enhancers for ZNF214 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F007962 0.6 Ensembl ENCODE 18.9 -946.4 -946357 8.2 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 TMEM9B-AS1 EIF3F OLFML1 TUB ZNF214 NLRP10 OR10A3 AKIP1 CASC23 GC11M007966
GH11F007985 0.2 ENCODE 18.9 -966.8 -966813 2.7 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 EIF3F OLFML1 TMEM9B-AS1 ZNF214 SNORA3B CASC23 TUB COX6CP5 PIR63023
GH11F006991 0.5 Ensembl ENCODE 11.3 +28.0 27972 2.5 PKNOX1 ZNF146 ZNF792 BHLHE40 MAFG ZNF407 ZIC2 ZNF843 ZNF316 ZFP3 NLRP14 ZNF214 GVINP1 ZNF215 LOC102724711 GC11M006969
GH11F007071 0.2 ENCODE 10.8 -52.8 -52813 3.3 NR2F1 ZEB2 NR2F6 NLRP14 ZNF214 OVCH2 OLFML1 GC11M006985 GC11P007052
GH11F006680 0.6 ENCODE 9.7 +337.8 337827 3.4 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143 OLFML1 TIMM10B MRPL17 ZNF214 ILK GC11P006674
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF214 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF214 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000557780 175 1999 ZFP64 INSM2 ARID4B YY1 MIXL1 SP3 SP5 NFYC NR2F2 KAT8

Genomic Location for ZNF214 Gene

Chromosome:
11
Start:
6,996,613 bp from pter
End:
7,020,376 bp from pter
Size:
23,764 bases
Orientation:
Minus strand

Genomic View for ZNF214 Gene

Genes around ZNF214 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF214 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF214 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF214 Gene

Proteins for ZNF214 Gene

  • Protein details for ZNF214 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL59-ZN214_HUMAN
    Recommended name:
    Zinc finger protein 214
    Protein Accession:
    Q9UL59
    Secondary Accessions:
    • B2R8Q1

    Protein attributes for ZNF214 Gene

    Size:
    606 amino acids
    Molecular mass:
    70992 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF214 Gene

Post-translational modifications for ZNF214 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF214 Gene

Domains & Families for ZNF214 Gene

Gene Families for ZNF214 Gene

Suggested Antigen Peptide Sequences for ZNF214 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UL59

UniProtKB/Swiss-Prot:

ZN214_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF214: view

Function for ZNF214 Gene

Molecular function for ZNF214 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS 10762538
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF214: view
genes like me logo Genes that share phenotypes with ZNF214: view

Animal Model Products

miRNA for ZNF214 Gene

miRTarBase miRNAs that target ZNF214

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF214 Gene

Localization for ZNF214 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF214 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF214 Gene COMPARTMENTS Subcellular localization image for ZNF214 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF214: view

Pathways & Interactions for ZNF214 Gene

SuperPathways for ZNF214 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF214: view

Pathways by source for ZNF214 Gene

2 Reactome pathways for ZNF214 Gene

Interacting Proteins for ZNF214 Gene

Gene Ontology (GO) - Biological Process for ZNF214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF214: view

No data available for SIGNOR curated interactions for ZNF214 Gene

Transcripts for ZNF214 Gene

mRNA/cDNA for ZNF214 Gene

Unigene Clusters for ZNF214 Gene

Zinc finger protein 214:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF214 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1: -
SP2: - -
SP3: - -
SP4:
SP5: - -

Relevant External Links for ZNF214 Gene

GeneLoc Exon Structure for
ZNF214
ECgene alternative splicing isoforms for
ZNF214

Expression for ZNF214 Gene

mRNA expression in normal human tissues for ZNF214 Gene

Protein differential expression in normal tissues from HIPED for ZNF214 Gene

This gene is overexpressed in Monocytes (40.4), Pancreatic juice (11.8), Fetal Brain (7.5), and CD4 Tcells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF214 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF214 Gene:

ZNF214

SOURCE GeneReport for Unigene cluster for ZNF214 Gene:

Hs.733636
genes like me logo Genes that share expression patterns with ZNF214: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF214 Gene

Orthologs for ZNF214 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF214 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF214 34 35
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia ZNF214 34 35
  • 88.5 (n)
cow
(Bos Taurus)
Mammalia ZNF214 34 35
  • 86.67 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 48 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm14443 35
  • 38 (a)
ManyToMany
Zfp109 35
  • 35 (a)
ManyToMany
Zfp53 35
  • 35 (a)
ManyToMany
Zfp677 35
  • 35 (a)
ManyToMany
Gm13242 35
  • 33 (a)
ManyToMany
Zfp760 35
  • 33 (a)
ManyToMany
Rex2 35
  • 32 (a)
ManyToMany
Zfp229 35
  • 32 (a)
ManyToMany
Zfp54 35
  • 32 (a)
ManyToMany
Zfp948 35
  • 30 (a)
ManyToMany
Gm26919 35
  • 27 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 43 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF214 35
  • 11 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG2120 36
  • 35 (a)
CG5245 35
  • 32 (a)
ManyToMany
CG11695 36
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea tag-146 35
  • 21 (a)
ManyToMany
C27A12.2 35
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
Species where no ortholog for ZNF214 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF214 Gene

ENSEMBL:
Gene Tree for ZNF214 (if available)
TreeFam:
Gene Tree for ZNF214 (if available)

Paralogs for ZNF214 Gene

Paralogs for ZNF214 Gene

(497) SIMAP similar genes for ZNF214 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF214: view

Variants for ZNF214 Gene

Sequence variations from dbSNP and Humsavar for ZNF214 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10732506 -- 7,010,213(+) TACAC(A/G)TATAC intron-variant
rs10769748 -- 6,997,347(+) AGCAC(A/G)TAATT utr-variant-3-prime
rs10769749 -- 7,002,220(+) ACCTC(C/T)ACTGA intron-variant
rs10769750 -- 7,002,310(+) GATAA(A/G)AGATC intron-variant
rs10769751 -- 7,009,729(+) TAACA(A/G)GCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF214 Gene

Variant ID Type Subtype PubMed ID
esv3417932 CNV insertion 20981092
nsv832061 CNV loss 17160897

Variation tolerance for ZNF214 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.41; 77.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF214 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF214

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF214 Gene

Disorders for ZNF214 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF214 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • wiedemann-beckwith syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF214

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF214
genes like me logo Genes that share disorders with ZNF214: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF214 Gene

Publications for ZNF214 Gene

  1. Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. (PMID: 10762538) Alders M. … Mannens M. (Am. J. Hum. Genet. 2000) 3 4 64
  2. Reduced transcript expression of genes affected by inherited and de novo CNVs in autism. (PMID: 21448237) Nord A.S. … McClellan J.M. (Eur. J. Hum. Genet. 2011) 3 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for ZNF214 Gene

Sources for ZNF214 Gene

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