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Aliases for ZNF213 Gene

Aliases for ZNF213 Gene

  • Zinc Finger Protein 213 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 21 3 4
  • Putative Transcription Factor CR53 3 4
  • ZKSCAN21 3 4
  • ZSCAN53 3
  • CR53 3

External Ids for ZNF213 Gene

Previous GeneCards Identifiers for ZNF213 Gene

  • GC16P003205
  • GC16P003185
  • GC16P003124
  • GC16P003126
  • GC16P003156
  • GC16P003179
  • GC16P003182
  • GC16P003231
  • GC16P003234
  • GC16P003287
  • GC16P003324

Summaries for ZNF213 Gene

Entrez Gene Summary for ZNF213 Gene

  • C2H2 zinc finger proteins, such as ZNF213, have bipartite structures in which one domain binds DNA or RNA and the other modulates target gene expression.[supplied by OMIM, Apr 2004]

GeneCards Summary for ZNF213 Gene

ZNF213 (Zinc Finger Protein 213) is a Protein Coding gene. Diseases associated with ZNF213 include Perinatal Necrotizing Enterocolitis. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF500.

UniProtKB/Swiss-Prot for ZNF213 Gene

  • May be involved in transcriptional regulation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF213 Gene

Genomics for ZNF213 Gene

Regulatory Elements for ZNF213 Gene

Enhancers for ZNF213 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G003069 2 FANTOM5 Ensembl ENCODE dbSUPER 7.1 -55.4 -55398 9.8 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A YBX1 ZNF2 ZBTB7B ZNF205 LOC105371058 MMP25 IL32 FLYWCH2 BICDL2 LOC100128770 CLDN6 THOC6 HCFC1R1
GH16G003156 1.7 FANTOM5 ENCODE dbSUPER 7.6 +29.0 29017 3.8 CREB3L1 DMAP1 YY1 ZNF263 SP3 NFYC TBX21 MEF2D SSRP1 ZNF610 ZNF213-AS1 ZNF205 CLUAP1 RNPS1 MTCO1P28 ZNF174 ZNF263 MTND1P8 TIGD7 MTRNR2L4
GH16G003148 1.7 Ensembl ENCODE dbSUPER 6.7 +21.4 21409 4.9 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZNF213-AS1 THOC6 ZNF263 ZNF205 LOC105371055 CREBBP SNORD60 TRAF7 ERVK13-1 RNPS1
GH16G003097 2 FANTOM5 Ensembl ENCODE dbSUPER 4.6 -29.7 -29677 6.2 CREB3L1 MLX ZFP64 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF205 ZNF263 SNHG19 SNORD60 ZNF213-AS1 THOC6 ZNF597 ERVK13-1 LOC105371055 CREBBP
GH16G003182 1.4 ENCODE dbSUPER 5.3 +53.7 53694 2.0 PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZNF2 FOS ZHX2 MXD4 REST ZNF213-AS1 THOC6 LOC105371055 CREBBP RNPS1 ZNF263 PDPK2P LOC652276 ZNF213 ENSG00000262521
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF213 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF213 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082607 -77 201 PKNOX1 ATF1 WRNIP1 ARID4B SIN3A ZNF2 YY1 ELK1 ZNF143 DEK

Genomic Location for ZNF213 Gene

Chromosome:
16
Start:
3,129,777 bp from pter
End:
3,142,805 bp from pter
Size:
13,029 bases
Orientation:
Plus strand

Genomic View for ZNF213 Gene

Genes around ZNF213 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF213 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF213 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF213 Gene

Proteins for ZNF213 Gene

  • Protein details for ZNF213 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14771-ZN213_HUMAN
    Recommended name:
    Zinc finger protein 213
    Protein Accession:
    O14771
    Secondary Accessions:
    • A8K1B9
    • B4DMG6
    • Q96IS1

    Protein attributes for ZNF213 Gene

    Size:
    459 amino acids
    Molecular mass:
    51263 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB70531.1; Type=Frameshift; Positions=400, 405, 457; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF213 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF213 Gene

Post-translational modifications for ZNF213 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF213 Gene

Domains & Families for ZNF213 Gene

Gene Families for ZNF213 Gene

Suggested Antigen Peptide Sequences for ZNF213 Gene

Graphical View of Domain Structure for InterPro Entry

O14771

UniProtKB/Swiss-Prot:

ZN213_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF213: view

Function for ZNF213 Gene

Molecular function for ZNF213 Gene

GENATLAS Biochemistry:
zinc finger protein 213 (C2H2 type,Kruppel-like),ubiquitously expressed
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF213 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF213: view
genes like me logo Genes that share phenotypes with ZNF213: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF213 Gene

Localization for ZNF213 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF213 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF213 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF213 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF213: view

Pathways & Interactions for ZNF213 Gene

SuperPathways for ZNF213 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF213: view

Pathways by source for ZNF213 Gene

2 Reactome pathways for ZNF213 Gene

Gene Ontology (GO) - Biological Process for ZNF213 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF213: view

No data available for SIGNOR curated interactions for ZNF213 Gene

Drugs & Compounds for ZNF213 Gene

No Compound Related Data Available

Transcripts for ZNF213 Gene

Unigene Clusters for ZNF213 Gene

Zinc finger protein 213:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF213 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: -
SP3:
SP4: - -

Relevant External Links for ZNF213 Gene

GeneLoc Exon Structure for
ZNF213
ECgene alternative splicing isoforms for
ZNF213

Expression for ZNF213 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF213 Gene

Protein differential expression in normal tissues from HIPED for ZNF213 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF213 Gene



Protein tissue co-expression partners for ZNF213 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF213 Gene:

ZNF213

SOURCE GeneReport for Unigene cluster for ZNF213 Gene:

Hs.115284

mRNA Expression by UniProt/SwissProt for ZNF213 Gene:

O14771-ZN213_HUMAN
Tissue specificity: Widely expressed with highest levels in testis.

Evidence on tissue expression from TISSUES for ZNF213 Gene

  • Nervous system(4.5)
  • Kidney(4.2)
  • Blood(4)
genes like me logo Genes that share expression patterns with ZNF213: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF213 Gene

Orthologs for ZNF213 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF213 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF213 34 35
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia ZNF213 34 35
  • 85.89 (n)
dog
(Canis familiaris)
Mammalia ZNF213 34
  • 85.01 (n)
mouse
(Mus musculus)
Mammalia Zfp213 34 16 35
  • 80.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF213 35
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF213 35
  • 68 (a)
OneToOne
Species where no ortholog for ZNF213 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF213 Gene

ENSEMBL:
Gene Tree for ZNF213 (if available)
TreeFam:
Gene Tree for ZNF213 (if available)

Paralogs for ZNF213 Gene

Paralogs for ZNF213 Gene

(297) SIMAP similar genes for ZNF213 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF213: view

Variants for ZNF213 Gene

Sequence variations from dbSNP and Humsavar for ZNF213 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000267260 -- 3,139,962(+) GGTCT(C/T)GAACT intron-variant
rs1000445393 -- 3,133,235(+) AAGTG(C/G)AAGTT intron-variant, upstream-variant-2KB
rs1000486670 -- 3,134,851(+) AGCCT(C/T)GCCTT nc-transcript-variant, upstream-variant-2KB
rs1000570780 -- 3,134,575(+) GAGGC(C/T)AGAAA intron-variant, upstream-variant-2KB
rs1000773259 -- 3,143,024(+) GAGCA(C/T)CGTCG intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF213 Gene

Variant ID Type Subtype PubMed ID
esv1496729 CNV insertion 17803354
nsv103291 CNV insertion 16902084
nsv1117154 CNV tandem duplication 24896259
nsv1148275 CNV insertion 26484159
nsv457355 CNV gain 19166990
nsv509589 CNV insertion 20534489
nsv571248 CNV loss 21841781
nsv571249 CNV gain 21841781

Variation tolerance for ZNF213 Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF213 Gene

Human Gene Mutation Database (HGMD)
ZNF213
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF213

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF213 Gene

Disorders for ZNF213 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF213 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
perinatal necrotizing enterocolitis
  • enterocolitis necrotizing
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF213

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF213
genes like me logo Genes that share disorders with ZNF213: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF213 Gene

Publications for ZNF213 Gene

  1. Identification and characterization of a zinc finger gene (ZNF213) from 16p13.3. (PMID: 10023065) Chen X. … Fischel-Ghodsian N. (Biochim. Biophys. Acta 1999) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A transcriptional map of the FMF region. (PMID: 9653642) Bernot A. … Weissenbach J. (Genomics 1998) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for ZNF213 Gene

Sources for ZNF213 Gene

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