ZNF213 Gene
protein-coding GIFtS: 49
GCID: GC16P003179
|
|
zinc finger protein 213
| |
Aliases
for ZNF213 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 2131 2 | | ZKSCAN211 2 3 | | CR531 2 5 | | ZSCAN531 2 | | Putative Transcription Factor CR532 3 | | Zinc Finger Protein With KRAB And SCAN Domains 212 3 |
Export aliases for ZNF213 gene to outside databasesPrevious GC identifers: GC16P003205 GC16P003185 GC16P003124 GC16P003126 GC16P003156 |
Summaries
for ZNF213 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF213:
C2H2 zinc finger proteins, such as ZNF213, have bipartite structures in which one domain binds DNA or RNA and the othermodulates target gene expression.(supplied by OMIM, Apr 2004)
UniProtKB/Swiss-Prot: ZN213_HUMAN, O14771Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF213 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF213 gene promoter:
Nkx2-5 NF-E2 NF-E2 p45 AP-2alpha LCR-F1 AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF213
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF213 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3ZNF213 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P003179: view genomic region
(about GC identifiers)
Start:
|
3,179,778 bp from pter |
End:
|
3,192,806 bp from pter |
Size:
|
13,029 bases |
Orientation:
|
plus strand |
|
Proteins
for ZNF213 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN213_HUMAN, O14771 (See
protein sequence)Recommended Name: Zinc finger protein 213 Size: 459 amino acids; 51263 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAB70531.1; Type=Frameshift; Positions=400, 405, 457;
Secondary accessions: A8K1B9 Q96IS1Explore the universe of human proteins at neXtProt for ZNF213: NX_O14771
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14771
ZNF213 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins (2 alternative transcripts):
NP_001128127.1 NP_004211.1
ENSEMBL proteins: ENSP00000459967 ENSP00000460157 ENSP00000380087 ENSP00000459177 ENSP00000461024 ENSP00000459233 ENSP00000459293 ENSP00000403892 Reactome Protein details: O14771
Human Recombinant Protein Products for ZNF213:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF213 for ontologies About GeneDecksing
ZNF213 Antibody Products:
Assay Products for ZNF213: |
Protein
Domains /
Families
for ZNF213 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF213 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry O14771ProtoNet protein and cluster: O14771 2 Blocks protein families: IPB001909 KRAB box IPB003309 Transcriptional regulator SCAN
UniProtKB/Swiss-Prot: ZN213_HUMAN, O14771Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 5 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domainSimilarity: Contains 1 SCAN box domain |
Function
for ZNF213 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN213_HUMAN, O14771Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF213:zinc finger protein 213 (C2H2 type,Kruppel-like),ubiquitously expressed
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
-- | -- | | GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZNF213 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF213 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF213 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF213 (NM_004220) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF213 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF213 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF213 |
|
Pathways & Interactions
for ZNF213 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF213
ZNF213 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF213
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0016032 | viral reproduction |
IEA | -- |
ZNF213 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF213 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF213
Search CenterWatch for drugs/clinical trials and news about ZNF213 / ZN213
|
Transcripts
for ZNF213 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF213 gene (2 alternative transcripts): NM_001134655.1 NM_004220.2 Unigene Cluster for ZNF213: Zinc finger protein 213 Hs.115284 [show with all ESTs]Unigene Representative Sequence: AK0553379 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000573771 ENST00000574902 ENST00000396878(uc010uws.2 uc002cud.3 uc010bth.3)
ENST00000576416 ENST00000574928(uc010btf.3) ENST00000576863(uc010uwt.2)
ENST00000572647 ENST00000574575 ENST00000416391
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF213 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF213 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF213 (NM_004220) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF213 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF213 |
Additional cDNA sequence: AF017433.1 AK055337.1 AK289834.1 AK291789.1 AK297454.1 BC007287.1 BC007598.1 BC012772.2 BC080572.1 7 DOTS entries: DT.100789991 DT.99953934 DT.95327378 DT.97845601 DT.105522 DT.120661143 DT.95297638 24/83 AceView cDNA sequences (see all 83): BX280382 BM705589 BG574413 BF916366 BM974318 BU734878 BQ930371 BQ931481 AI474497 BF510572 BE274943 BM461723 BM916949 BC080572 BE794194 BI063489 BI918411 BM822988 BI063710 BM552256 AA861582 BF932282 BI063866 AI197807
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF213 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | | |
ECgene alternative splicing isoforms for ZNF213
|
Expression
for ZNF213 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF213 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACAGGGACA
About this image
Genevestigator expression for ZNF213
SOURCE GeneReport for Unigene cluster: Hs.115284
UniProtKB/Swiss-Prot: ZN213_HUMAN, O14771Tissue specificity: Widely expressed with highest levels in testis
SABiosciences Custom PCR Arrays for ZNF213
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF213
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF213 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF213 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF213 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF213 |
Orthologs
for ZNF213 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF213 gene from 1/7 species (see all 7) About this table
ENSEMBL Gene Tree for ZNF213 (if available)
TreeFam Gene Tree for ZNF213 (if available) |
Paralogs
for ZNF213 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF213 gene
- ZNF4962 ZNF4492 ZNF4462 ZSCAN92 ZKSCAN12 ZNF3972 ZNF5002 ZSCAN302
- ZNF2322 ZNF2022 ZNF2632 ZKSCAN42 ZNF1742 ZSCAN252 ZNF3962 ZSCAN122
- ZNF3942 ZSCAN212 ZSCAN232 ZNF1652 ZSCAN162 ZKSCAN82 ZSCAN312 ZSCAN222
- ZKSCAN32 ZNF242 ZNF182
18/298 SIMAP similar genes for ZNF213 using alignment to 7 protein entries: ZN213_HUMAN (see all proteins)
(see all similar genes):kr-znf3 ZSCAN29 ZNF396 SCAND1 ZNF818P HZF36
ZNF774 ZNF78L1 ZNF852 ZNF665 ZNF501 ZNF630
ZNF883 ZSCAN10 HZF30 ZIK1 ZNF189 ZNF286A
ZNF213 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF213 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF213 (3179778 - 3192806 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF213: --
Human Gene Mutation Database (HGMD): ZNF213
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF213 |
|
Disorders
/ Diseases
for ZNF213 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF213 for disorders About GeneDecksing
OMIM gene information: 608387
OMIM disorders: --
2  diseases for ZNF213: About MalaCardsperinatal necrotizing enterocolitis familial mediterranean fever
1 disease from the University of Copenhagen DISEASES database for ZNF213:Patent ductus arteriosus Export disorders for ZNF213 gene to outside databases
|
Publications
for ZNF213 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF213 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF213) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of a zinc finger gene (ZNF213) from 16p13.3. (PubMed id 10023065)1, 2, 3 Chen X....Fischel-Ghodsian N. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A transcriptional map of the FMF region. (PubMed id 9653642)1, 3 Bernot A.... Weissenbach J. (1998)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for ZNF213 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF213 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF213 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF213 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF213 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF213 gene:
Search GeneIP for patents involving ZNF213
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF213 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF213 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF213 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF213 | | | OriGene Protein Over-expression Lysate for ZNF213 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF213 | | OriGene 3'-UTR Clone for ZNF213 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF213 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF213 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ZNF213 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF213 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF213 |
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