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Aliases for ZNF213 Gene

Aliases for ZNF213 Gene

  • Zinc Finger Protein 213 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 21 3 4
  • Putative Transcription Factor CR53 3 4
  • ZKSCAN21 3 4
  • ZSCAN53 3
  • CR53 3

External Ids for ZNF213 Gene

Previous GeneCards Identifiers for ZNF213 Gene

  • GC16P003205
  • GC16P003185
  • GC16P003124
  • GC16P003126
  • GC16P003156
  • GC16P003179
  • GC16P003182
  • GC16P003231

Summaries for ZNF213 Gene

Entrez Gene Summary for ZNF213 Gene

  • C2H2 zinc finger proteins, such as ZNF213, have bipartite structures in which one domain binds DNA or RNA and the other modulates target gene expression.[supplied by OMIM, Apr 2004]

GeneCards Summary for ZNF213 Gene

ZNF213 (Zinc Finger Protein 213) is a Protein Coding gene. Diseases associated with ZNF213 include Perinatal Necrotizing Enterocolitis. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF75A.

UniProtKB/Swiss-Prot for ZNF213 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF213 Gene

Genomics for ZNF213 Gene

Regulatory Elements for ZNF213 Gene

Enhancers for ZNF213 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF213 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF213 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF213 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF213 Gene

3,129,777 bp from pter
3,142,805 bp from pter
13,029 bases
Plus strand

Genomic View for ZNF213 Gene

Genes around ZNF213 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF213 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF213 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF213 Gene

Proteins for ZNF213 Gene

  • Protein details for ZNF213 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 213
    Protein Accession:
    Secondary Accessions:
    • A8K1B9
    • B4DMG6
    • Q96IS1

    Protein attributes for ZNF213 Gene

    459 amino acids
    Molecular mass:
    51263 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB70531.1; Type=Frameshift; Positions=400, 405, 457; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF213 Gene


neXtProt entry for ZNF213 Gene

Proteomics data for ZNF213 Gene at MOPED

Post-translational modifications for ZNF213 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF213 Gene

Domains & Families for ZNF213 Gene

Gene Families for ZNF213 Gene

Suggested Antigen Peptide Sequences for ZNF213 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF213: view

Function for ZNF213 Gene

Molecular function for ZNF213 Gene

GENATLAS Biochemistry:
zinc finger protein 213 (C2H2 type,Kruppel-like),ubiquitously expressed
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF213: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF213 Gene

Localization for ZNF213 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF213 Gene

Subcellular locations from

Jensen Localization Image for ZNF213 Gene COMPARTMENTS Subcellular localization image for ZNF213 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF213 Gene

Pathways & Interactions for ZNF213 Gene

SuperPathways for ZNF213 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF213: view

Pathways by source for ZNF213 Gene

2 Reactome pathways for ZNF213 Gene

Interacting Proteins for ZNF213 Gene

Gene Ontology (GO) - Biological Process for ZNF213 Gene


No data available for SIGNOR curated interactions for ZNF213 Gene

Drugs & Compounds for ZNF213 Gene

No Compound Related Data Available

Transcripts for ZNF213 Gene

Unigene Clusters for ZNF213 Gene

Zinc finger protein 213:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF213 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: -
SP4: - -

Relevant External Links for ZNF213 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF213 Gene

mRNA expression in normal human tissues for ZNF213 Gene

Protein differential expression in normal tissues from HIPED for ZNF213 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF213 Gene

SOURCE GeneReport for Unigene cluster for ZNF213 Gene Hs.115284

mRNA Expression by UniProt/SwissProt for ZNF213 Gene

Tissue specificity: Widely expressed with highest levels in testis.
genes like me logo Genes that share expression patterns with ZNF213: view

Protein tissue co-expression partners for ZNF213 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF213 Gene

Orthologs for ZNF213 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF213 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF213 35
  • 85.89 (n)
  • 82.68 (a)
ZNF213 36
  • 81 (a)
(Canis familiaris)
Mammalia ZNF213 35
  • 85.01 (n)
  • 81.66 (a)
(Mus musculus)
Mammalia Zfp213 35
  • 80.24 (n)
  • 75.88 (a)
Zfp213 16
Zfp213 36
  • 73 (a)
(Pan troglodytes)
Mammalia ZNF213 35
  • 99.35 (n)
  • 98.91 (a)
ZNF213 36
  • 99 (a)
(Monodelphis domestica)
Mammalia ZNF213 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF213 36
  • 69 (a)
Species with no ortholog for ZNF213:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF213 Gene

Gene Tree for ZNF213 (if available)
Gene Tree for ZNF213 (if available)

Paralogs for ZNF213 Gene

Paralogs for ZNF213 Gene

(297) SIMAP similar genes for ZNF213 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF213: view

Variants for ZNF213 Gene

Sequence variations from dbSNP and Humsavar for ZNF213 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3888697 -- 3,139,728(+) GTGAC(A/G)GTTGG intron-variant
rs3891045 -- 3,139,530(+) CGTCA(G/T)AACTG intron-variant
rs3891046 -- 3,139,583(+) CATCA(G/T)GGATC intron-variant
rs3891047 -- 3,139,614(+) CARGA(A/G)GATGG intron-variant
rs172792 -- 3,139,444(+) AGGCA(C/T)AGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF213 Gene

Variant ID Type Subtype PubMed ID
nsv905170 CNV Loss 21882294
nsv905185 CNV Loss 21882294
nsv509589 CNV Insertion 20534489
dgv2580n71 CNV Loss 21882294
nsv457355 CNV Gain 19166990
dgv2581n71 CNV Loss 21882294
dgv2582n71 CNV Loss 21882294
nsv905207 CNV Loss 21882294
nsv905208 CNV Loss 21882294
esv1496729 CNV Insertion 17803354
nsv103291 CNV Insertion 16902084

Variation tolerance for ZNF213 Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF213 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF213 Gene

Disorders for ZNF213 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF213 Gene - From: DISEASES

Disorder Aliases PubMed IDs
perinatal necrotizing enterocolitis
  • enterocolitis necrotizing
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF213

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZNF213: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF213 Gene

Publications for ZNF213 Gene

  1. Identification and characterization of a zinc finger gene (ZNF213) from 16p13.3. (PMID: 10023065) Chen X. … Fischel-Ghodsian N. (Biochim. Biophys. Acta 1999) 2 3 4 67
  2. A transcriptional map of the FMF region. (PMID: 9653642) Bernot A. … Weissenbach J. (Genomics 1998) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  5. Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. (PMID: 23934736) Yu B. … Boerwinkle E. (Genet. Epidemiol. 2013) 3

Products for ZNF213 Gene

Sources for ZNF213 Gene