Aliases for ZNF212 Gene
Aliases for ZNF212 Gene
External Ids for ZNF212 Gene
- HGNC: 13004
- Entrez Gene: 7988
- Ensembl: ENSG00000170260
- OMIM: 602386
- UniProtKB: Q9UDV6
Previous GeneCards Identifiers for ZNF212 Gene
- GC07P147194
- GC07P148251
- GC07P148328
- GC07P148374
- GC07P148567
- GC07P148936
- GC07P143014
Summaries for ZNF212 Gene
-
This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZNF212 Gene
ZNF212 (Zinc Finger Protein 212) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription cofactor activity. An important paralog of this gene is ZNF783.
UniProtKB/Swiss-Prot for ZNF212 Gene
-
May be involved in transcriptional regulation.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF212 Gene
Genomics for ZNF212 Gene
Regulatory Elements for ZNF212 Gene
Enhancers for ZNF212 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ZNF212 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ZNF212 gene promoter:
Regulatory Element Products
Genomic Location for ZNF212 Gene
- Chromosome:
- 7
- Start:
- 149,239,648 bp from pter
- End:
- 149,255,609 bp from pter
- Size:
- 15,962 bases
- Orientation:
- Plus strand
Genomic View for ZNF212 Gene
Genes around ZNF212 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q36.1 by Ensembl
- 7q36.1 by Entrez Gene
- 7q36.1 by HGNC
ZNF212 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF212 Gene
Proteins for ZNF212 Gene
-
Protein details for ZNF212 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UDV6-ZN212_HUMAN
- Recommended name:
- Zinc finger protein 212
- Protein Accession:
- Q9UDV6
- B2RCF4
- Q13396
- Q8N664
Protein attributes for ZNF212 Gene
- Size:
- 495 amino acids
- Molecular mass:
- 55447 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAC51296.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAD45826.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ZNF212 Gene
Post-translational modifications for ZNF212 Gene
Other Protein References for ZNF212 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZNF212
-
Abcam antibodies for ZNF212
- Invitrogen Antibodies for ZNF212
- antibodies-online Antibodies for ZNF212: See all 27
- GeneTex ZNF212 antibody for ZNF212
Protein Products
-
OriGene Purified Proteins for ZNF212
- Search Origene for MassSpec and Protein Over-expression Lysates for ZNF212
- Origene Custom Protein Services for ZNF212
- Search GeneTex for Proteins for ZNF212
-
Abcam proteins for ZNF212
No data available for DME Specific Peptides for ZNF212 Gene
Domains & Families for ZNF212 Gene
Gene Families for ZNF212 Gene
Protein Domains for ZNF212 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF212 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UDV6- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF212 Gene
Molecular function for ZNF212 Gene
- GENATLAS Biochemistry:
- zinc finger protein 122,KRAB subfamily (C2H2 Kruppel-like)
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 18255255 |
| GO:0008270 | zinc ion binding | NAS | 7633419 |
| GO:0042802 | identical protein binding | IPI | 18255255 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF212 Gene
- GenomeRNAi human phenotypes for ZNF212:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZNF212
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ZNF212 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF212 gene
- Search ViGene Biosciences for ZNF212
CRISPR Products
-
OriGene CRISPR knockouts for ZNF212
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF212
- GenScript: Design CRISPR guide RNA sequences for ZNF212
miRNA for ZNF212 Gene
- miRTarBase miRNAs that target ZNF212
-
- hsa-mir-744-5p (MIRT037645)
- hsa-mir-125b-5p (MIRT045981)
- hsa-mir-4646-5p (MIRT457905)
- hsa-mir-5196-5p (MIRT457906)
- hsa-mir-4747-5p (MIRT457907)
- hsa-mir-6851-5p (MIRT457908)
- hsa-mir-3689d (MIRT457909)
- hsa-mir-765 (MIRT457910)
- hsa-mir-6077 (MIRT457911)
- hsa-mir-6134 (MIRT457912)
- hsa-mir-6738-5p (MIRT457913)
- hsa-mir-5194 (MIRT457914)
- hsa-mir-1914-3p (MIRT457915)
- hsa-mir-4784 (MIRT457916)
- hsa-mir-3150b-3p (MIRT457917)
- hsa-mir-665 (MIRT457918)
- hsa-mir-103b (MIRT457919)
- hsa-mir-4459 (MIRT457920)
- hsa-mir-575 (MIRT457921)
- hsa-mir-4676-5p (MIRT457922)
- hsa-mir-6858-3p (MIRT457923)
- hsa-mir-4715-3p (MIRT723189)
- hsa-mir-6887-3p (MIRT723190)
- hsa-mir-361-3p (MIRT723191)
- hsa-mir-6729-3p (MIRT723192)
miRNA Products
- Search ViGene Biosciences for ZNF212
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ZNF212
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-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF212 gene
Clone Products
-
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- VectorBuilder custom plasmid, inducible vectors for ZNF212
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF212
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ZNF212
-
ViGene Biosciences adenoviral particle packaged cDNA for ZNF212 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ZNF212 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF212 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF212 Gene
Localization for ZNF212 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF212 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IEA,IDA | -- |
Pathways & Interactions for ZNF212 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
Pathways by source for ZNF212 Gene
2 Reactome pathways for ZNF212 Gene
Interacting Proteins for ZNF212 Gene
Selected Interacting proteins:
ENSP00000338572
Q9UDV6-ZN212_HUMAN
for ZNF212 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | NAS,IEA | 7633419 |
No data available for SIGNOR curated interactions for ZNF212 Gene
Transcripts for ZNF212 Gene
mRNA/cDNA for ZNF212 Gene
- (7) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (3) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZNF212 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZNF212
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF212
- GenScript: Design CRISPR guide RNA sequences for ZNF212
miRNA Products
- Search ViGene Biosciences for ZNF212
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ZNF212
- Browse OriGene Inhibitory RNA Products For ZNF212
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF212 gene
Clone Products
-
OriGene ORF clones in human for ZNF212
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZNF212
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF212
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP9: | - | - | - |
Expression for ZNF212 Gene
This gene is overexpressed in Liver, secretome (57.2) and Peripheral blood mononuclear cells (10.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF212 Gene
NURSA nuclear receptor signaling pathways regulating expression of ZNF212 Gene:
ZNF212SOURCE GeneReport for Unigene cluster for ZNF212 Gene:
Hs.490510Evidence on tissue expression from TISSUES for ZNF212 Gene
- Nervous system(4.7)
- Intestine(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for ZNF212
-
OriGene qPCR primer pairs for ZNF212
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF212 Gene
Orthologs for ZNF212 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF212 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ZNF212 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ZNF212 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Zfp212 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Zfp212 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZNF212 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZNF212 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | ZNF212 35 |
|
OneToOne |
- Species where no ortholog for ZNF212 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for ZNF212 Gene
(107) SIMAP similar genes for ZNF212 Gene using alignment to 4 proteins:
- ZNF767
- EML2
- DCTN5
- CLUL1
- NF2
- FAM175A
- ZNF74
- ZNF564
- ZNF585B
- TMEM14B
- RUFY1
- RNF217
- CHID1
- BTBD2
- FAM3A
- AURA2
- UBIAD1
- TNFRSF17
- LYRM4
- C18orf8
- VPS33A
- TSEN2
- MEFV
- ZNF420
- ZNF135
- RBMS2
- LAMB4
- EDRF1
- CHD5
- B3GALNT1
- ZNF763
- ZFP30
- PKN1
- ERBB2
- DNMT1
- ZNF737
- ZNF547
- USP38
- DCK
- AEBP2
- SHANK2
- LOC155060
- ZNF850
- ZNF75A
- ZNF738
- USP10
- TCF4
- SNX31
- NUP88
- NSRP1
- NPLOC4
- MPP4
- IMPA1
- DNAPTP3
- HKR1
- SEPT2
- ZNF573
- ZNF28
- QRICH2
- APOPT1
- LEPROTL1
- FAM129C
- ZNF81
- ZNF721
- FAM210A
- DAPL1
- CATSPERG
- CRCP
- ZNF746
- ZNF790
- ZNF766
- ZNF540
- ZNF468
- ZNF283
- ZFP14
- NEK4
- HAUS1
- ZNF816
- ZNF611
- WARS
- TMEM135
- GCDH
- ASB11
- ZNF783
- ZNF83
- SH3PXD2A
- PLEKHH2
- PHC3
- KLHL2
- ATP6V0A1
- ZNF761
- TMSB15B
- FAT3
- ZNF780B
- CFLAR
- C4orf21
- BECN1
- KDM5B
- FKBP3
- ZNF702P
- RBBP4
- ZNF677
- ZNF282
- ZNF844
- ZNF571
- ZNF20
- ZNF777
Variants for ZNF212 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000037160 | -- | 149,240,821(+) | TGACC(A/G)TGAGC | intron-variant | |
| rs1000095419 | -- | 149,242,354(+) | AACCA(A/G)AAAAA | intron-variant | |
| rs1000128124 | -- | 149,242,007(+) | CTTCT(-/TTTTC)TTTTC | intron-variant | |
| rs1000267570 | -- | 149,252,610(+) | ATTTC(C/T)TCCCT | intron-variant | |
| rs1000318756 | -- | 149,239,865(+) | CCGGG(C/G)GCGGG | intron-variant, utr-variant-5-prime |
Residual Variation Intolerance Score:
68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.77;
73.50% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ZNF212 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF212
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF212 Gene
Disorders for ZNF212 Gene
Relevant External Links for ZNF212
No disorders were found for ZNF212 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF212 Gene
Publications for ZNF212 Gene
- Molecular cloning and mapping of a novel human KRAB domain-containing C2H2-type zinc finger to chromosome 7q36.1. (PMID: 9169157) Becker K.G. … Drew P.D. (Genomics 1997) 2 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
- Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain. (PMID: 7633419) Becker K.G. … Drew P.D. (Hum. Mol. Genet. 1995) 3 4 64
- Repression of rRNA transcription by PARIS contributes to Parkinson's disease. (PMID: 25315684) Kang H. … Shin J.H. (Neurobiol. Dis. 2015) 3 64
Products for ZNF212 Gene
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- Horizon Cell Lines for ZNF212
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZNF212
- VectorBuilder custom plasmid, inducible vectors for ZNF212
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF212
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ZNF212 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
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