ZNF212 Gene
protein-coding GIFtS: 50
GCID: GC07P148936
|
|
zinc finger protein 212
| |
Aliases
for ZNF212 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 2121 2 | | ZNFC1502 3 5 | | C2H2-1501 2 | | Zinc Finger Protein C2H2-1502 3 | | ZNF1822 5 |
Export aliases for ZNF212 gene to outside databasesPrevious GC identifers: GC07P147194 GC07P148251 GC07P148328 GC07P148374 GC07P148567 GC07P143014 |
Summaries
for ZNF212 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF212:
This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulationand development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc fingerproteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-proteininteractions. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ZN212_HUMAN, Q9UDV6Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF212 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF212 gene promoter:
AP-2alpha isoform 3 Lmo2 Nkx2-5 AP-2alpha isoform 2 STAT3 AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF212
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF212 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q36.1 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36.1ZNF212 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P148936: view genomic region
(about GC identifiers)
Start:
|
148,936,742 bp from pter |
End:
|
148,952,700 bp from pter |
Size:
|
15,959 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 148,274,750-148,290,707 |
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Proteins
for ZNF212 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN212_HUMAN, Q9UDV6 (See
protein sequence)Recommended Name: Zinc finger protein 212 Size: 495 amino acids; 55447 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAC51296.1; Type=Erroneous initiation; Sequence=AAD45826.2; Type=Erroneous initiation;
Secondary accessions: B2RCF4 Q13396 Q8N664Explore the universe of human proteins at neXtProt for ZNF212: NX_Q9UDV6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UDV6
ZNF212 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036388.2
ENSEMBL proteins: ENSP00000338572 ENSP00000418281 ENSP00000418167 ENSP00000419419 ENSP00000419261 Reactome Protein details: Q9UDV6
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
NAS | -- |
ZNF212 for ontologies About GeneDecksing
ZNF212 Antibody Products:
Assay Products for ZNF212: |
Protein
Domains /
Families
for ZNF212 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF212 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UDV6ProtoNet protein and cluster: Q9UDV6 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN212_HUMAN, Q9UDV6Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 4 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF212 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN212_HUMAN, Q9UDV6Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF212:zinc finger protein 122,KRAB subfamily (C2H2 Kruppel-like)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF212 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF212
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Synthesis Service for ZNF212 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF212 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF212 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZNF212 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF212 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF212
ZNF212 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF212
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
5/20 Interacting proteins for ZNF212 (Q9UDV61, 3 ENSP000003385724) via UniProtKB, MINT, STRING, and/or I2D (see all 20)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | 7633419 |
ZNF212 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF212 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF212
Search CenterWatch for drugs/clinical trials and news about ZNF212 / ZN212
|
Transcripts
for ZNF212 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF212 gene: NM_012256.3 Unigene Cluster for ZNF212: Zinc finger protein 212 Hs.490510 [show with all ESTs]Unigene Representative Sequence: NM_0122565 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000335870(uc003wfp.3) ENST00000486371 ENST00000462724 ENST00000481584
ENST00000488917
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF212 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF212
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF212 (NM_012256) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF212 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF212 |
Additional cDNA sequence: AK074821.1 AK315086.1 BC022785.2 U38864.1 14 DOTS entries: DT.446324 DT.91950902 DT.121050997 DT.91683890 DT.95096988 DT.102834071 DT.95268179 DT.100804303 DT.121050913 DT.95268177 DT.97845530 DT.40240589 DT.95134411 DT.99935364 3 AceView cDNA sequences: CB988192 BV186394 CF593491
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF212 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF212
|
Expression
for ZNF212 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF212 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTCCCACG
About this image
See ZNF212 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF212
SOURCE GeneReport for Unigene cluster: Hs.490510
SABiosciences Custom PCR Arrays for ZNF212
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF212
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF212 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF212 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF212 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF212 |
Orthologs
for ZNF212 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF212 (if available)
TreeFam Gene Tree for ZNF212 (if available) |
Paralogs
for ZNF212 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF212 gene
- ZNF2822 ZNF7772 ZNF7462 ZNF3982 ZNF7832
18/93 SIMAP similar genes for ZNF212 using alignment to 4 protein entries: ZN212_HUMAN (see all proteins)
(see all similar genes):ZNF767 EML2 CLUL1 DCTN5 FAM175A NF2
AURA2 BTBD2 CHID1 FAM3A RNF217 RUFY1
TMEM14B ZNF564 ZNF585B ZNF74 LYRM4 NXPE2
ZNF212 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF212 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF212 (148936742 - 148952700 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF212
1 Indel: 59394 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF212 |
|
Disorders
/ Diseases
for ZNF212 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF212 for disorders About MalaCards
ZNF212 for disorders About GeneDecksing
OMIM gene information: 602386
OMIM disorders: --
Export disorders for ZNF212 gene to outside databases
|
Publications
for ZNF212 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF212 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF212) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and mapping of a novel human KRAB domain-containing C2H2-type zinc finger to chromosome 7q36.1. (PubMed id 9169157)1, 2, 3 Becker K.G.... Drew P.D. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain. (PubMed id 7633419)1, 2 Becker K.G....Drew P.D. (1995)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- A protein-protein interaction network of transcription factors acting during liver cell proliferation. (PubMed id 18255255)1 Gao J....Yu Y. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)
|
External Searches for ZNF212 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF212 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF212 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF212 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF212 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF212 gene:
Search GeneIP for patents involving ZNF212
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF212 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF212 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF212 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF212 | | | OriGene Protein Over-expression Lysate for ZNF212 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF212 | | OriGene 3'-UTR Clone for ZNF212 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF212 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF212 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| |  |  |  |  | | | | |
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 | | | ZNF212 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF212 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF212 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF212 |
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