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Aliases for ZNF212 Gene

Aliases for ZNF212 Gene

  • Zinc Finger Protein 212 2 3 5
  • Zinc Finger Protein C2H2-150 3 4
  • ZNFC150 3 4
  • C2H2-150 3
  • ZNF182 3

External Ids for ZNF212 Gene

Previous GeneCards Identifiers for ZNF212 Gene

  • GC07P147194
  • GC07P148251
  • GC07P148328
  • GC07P148374
  • GC07P148567
  • GC07P148936
  • GC07P143014

Summaries for ZNF212 Gene

Entrez Gene Summary for ZNF212 Gene

  • This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF212 Gene

ZNF212 (Zinc Finger Protein 212) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription cofactor activity. An important paralog of this gene is ZNF282.

UniProtKB/Swiss-Prot for ZNF212 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF212 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF212 Gene

Genomics for ZNF212 Gene

GeneHancer (GH) Regulatory Elements for ZNF212 Gene

Promoters and enhancers for ZNF212 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I149238 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 577.1 +0.4 361 2.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF212 ZNF783 ZNF398 LOC155060 ZNF777 ENSG00000271664 ZNF786 ATP6V0E2-AS1 ENSG00000273419 ZNF746
GH07I149237 Enhancer 0.7 ENCODE 550.8 -1.4 -1387 0.8 HDGF NCOA3 PKNOX1 NEUROD1 BMI1 RFX5 CTBP1 GATA3 FOS FOSL2 ZNF212 ZNF282
GH07I149124 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 54.2 -112.8 -112822 3.8 CLOCK MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZFP41 ZNF398 ZNF425 GC07M149126 RN7SL521P ZNF212 ZNF282 ZNF783 ENSG00000271664 ZNF767P CUL1
GH07I149143 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 41.7 -93.1 -93124 7 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A ZNF2 YY1 POLR2B ZNF398 GC07P149147 GC07P149148 ZNF282 ZNF783 ZNF212 ZNF425 ENSG00000271664 ZNF786 LOC155060
GH07I149714 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 42.5 +476.2 476204 3.4 HDGF PKNOX1 ATF1 ARID4B GLI4 ZNF2 ETS1 ZNF766 ZNF213 ZNF143 KRBA1 ZNF212 ZNF783 ZNF398 ENSG00000271664 LOC155060 ZNF282 ZNF777 ZNF767P ZNF746
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF212 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF212 gene promoter:

Genomic Locations for ZNF212 Gene

Genomic Locations for ZNF212 Gene
chr7:149,239,648-149,255,609
(GRCh38/hg38)
Size:
15,962 bases
Orientation:
Plus strand
chr7:148,936,742-148,952,700
(GRCh37/hg19)

Genomic View for ZNF212 Gene

Genes around ZNF212 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF212 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF212 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF212 Gene

Proteins for ZNF212 Gene

  • Protein details for ZNF212 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDV6-ZN212_HUMAN
    Recommended name:
    Zinc finger protein 212
    Protein Accession:
    Q9UDV6
    Secondary Accessions:
    • B2RCF4
    • Q13396
    • Q8N664

    Protein attributes for ZNF212 Gene

    Size:
    495 amino acids
    Molecular mass:
    55447 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC51296.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAD45826.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF212 Gene

Post-translational modifications for ZNF212 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF212 Gene

Domains & Families for ZNF212 Gene

Gene Families for ZNF212 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF212 Gene

Suggested Antigen Peptide Sequences for ZNF212 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UDV6

UniProtKB/Swiss-Prot:

ZN212_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF212: view

Function for ZNF212 Gene

Molecular function for ZNF212 Gene

GENATLAS Biochemistry:
zinc finger protein 122,KRAB subfamily (C2H2 Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF212 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 18255255
GO:0008270 zinc ion binding NAS 7633419
GO:0042802 identical protein binding IPI 18255255
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF212: view
genes like me logo Genes that share phenotypes with ZNF212: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF212 Gene

Localization for ZNF212 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF212 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF212 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF212 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with ZNF212: view

Pathways & Interactions for ZNF212 Gene

SuperPathways for ZNF212 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF212: view

Pathways by source for ZNF212 Gene

2 Reactome pathways for ZNF212 Gene

Gene Ontology (GO) - Biological Process for ZNF212 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 7633419
genes like me logo Genes that share ontologies with ZNF212: view

No data available for SIGNOR curated interactions for ZNF212 Gene

Drugs & Compounds for ZNF212 Gene

No Compound Related Data Available

Transcripts for ZNF212 Gene

Unigene Clusters for ZNF212 Gene

Zinc finger protein 212:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF212 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - - -
SP6:
SP7: - - -
SP8: - - - -
SP9: - - -

Relevant External Links for ZNF212 Gene

GeneLoc Exon Structure for
ZNF212
ECgene alternative splicing isoforms for
ZNF212

Expression for ZNF212 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF212 Gene

Protein differential expression in normal tissues from HIPED for ZNF212 Gene

This gene is overexpressed in Liver, secretome (57.2) and Peripheral blood mononuclear cells (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF212 Gene



Protein tissue co-expression partners for ZNF212 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF212 Gene:

ZNF212

SOURCE GeneReport for Unigene cluster for ZNF212 Gene:

Hs.490510

Evidence on tissue expression from TISSUES for ZNF212 Gene

  • Nervous system(4.7)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with ZNF212: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF212 Gene

Orthologs for ZNF212 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF212 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF212 33 34
  • 99.19 (n)
dog
(Canis familiaris)
Mammalia ZNF212 33
  • 87.07 (n)
cow
(Bos Taurus)
Mammalia ZNF212 33 34
  • 83.19 (n)
mouse
(Mus musculus)
Mammalia Zfp212 33 16 34
  • 82.21 (n)
rat
(Rattus norvegicus)
Mammalia Zfp212 33
  • 81.33 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF212 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF212 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ZNF212 34
  • 29 (a)
OneToOne
Species where no ortholog for ZNF212 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF212 Gene

ENSEMBL:
Gene Tree for ZNF212 (if available)
TreeFam:
Gene Tree for ZNF212 (if available)

Paralogs for ZNF212 Gene

Paralogs for ZNF212 Gene

genes like me logo Genes that share paralogs with ZNF212: view

Variants for ZNF212 Gene

Sequence variations from dbSNP and Humsavar for ZNF212 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000037160 -- 149,240,821(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000095419 -- 149,242,354(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000128124 -- 149,242,007(+) TTTTCTTTTCTTTTCTTTT/TTTTCTTTTCTTTT genic_upstream_transcript_variant, intron_variant
rs1000267570 -- 149,252,610(+) C/T intron_variant
rs1000318756 -- 149,239,865(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF212 Gene

Variant ID Type Subtype PubMed ID
dgv11712n54 CNV loss 21841781
nsv465196 CNV loss 19166990
nsv819456 CNV gain 19587683

Variation tolerance for ZNF212 Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.77; 73.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF212 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF212

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF212 Gene

Disorders for ZNF212 Gene

Additional Disease Information for ZNF212

No disorders were found for ZNF212 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF212 Gene

Publications for ZNF212 Gene

  1. Molecular cloning and mapping of a novel human KRAB domain-containing C2H2-type zinc finger to chromosome 7q36.1. (PMID: 9169157) Becker KG … Drew PD (Genomics 1997) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  4. Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain. (PMID: 7633419) Becker KG … Drew PD (Human molecular genetics 1995) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF212 Gene

Sources for ZNF212 Gene

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