ZNF208 Gene
protein-coding GIFtS: 47
GCID: GC19M022148
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|
zinc finger protein 208
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Aliases
for ZNF208 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 2081 2 | | ZNF951 2 5 | | PMIDP1 2 | | Zinc Finger Protein 952 | | ZNF91L3 | | Zinc Finger Protein 91-Like3 |
Export aliases for ZNF208 gene to outside databasesPrevious GC identifers: GC19M022601 GC19M022483 GC19M021683 GC19M021782 GC19M021945 GC19M021686 |
Summaries
for ZNF208 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF208:
Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFscontain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed theKruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998 (PubMed 9724325)).See ZNF91 (MIM 603971) for further information on ZNFs.(supplied by OMIM, Aug 2009)
UniProtKB/Swiss-Prot: ZN208_HUMAN, O43345Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF208 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZNF208
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF208
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF208 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p12 Ensembl cytogenetic band: 19p12 HGNC cytogenetic band: 19p12ZNF208 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M022148: view genomic region
(about GC identifiers)
Start:
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22,148,897 bp from pter |
End:
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22,193,745 bp from pter |
Size:
|
44,849 bases |
Orientation:
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minus strand |
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Proteins
for ZNF208 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN208_HUMAN, O43345 (See
protein sequence)Recommended Name: Zinc finger protein 208 Size: 1167 amino acids; 134353 Da
Subcellular location: Nucleus (Probable)Explore the universe of human proteins at neXtProt for ZNF208: NX_O43345
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43345
ZNF208 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009084.2
ENSEMBL proteins: ENSP00000380315 Reactome Protein details: O43345
Human Recombinant Protein Products for ZNF208:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
NAS | -- |
ZNF208 for ontologies About GeneDecksing
ZNF208 Antibody Products:
Assay Products for ZNF208: |
Protein
Domains /
Families
for ZNF208 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF208 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43345ProtoNet protein and cluster: O43345 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN208_HUMAN, O43345Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 34 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF208 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN208_HUMAN, O43345Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF208:zinc finger protein 208,ubiquitously expressed,located in a cluster of Kruppel associated box zinc finger
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF208 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF208 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF208 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF208 (NM_007153) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF208 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF208 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF208 |
|
Pathways & Interactions
for ZNF208 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF208
ZNF208 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF208
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZNF208 (O433453 ENSP000003803154) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | -- |
ZNF208 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF208 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF208
Search CenterWatch for drugs/clinical trials and news about ZNF208 / ZN208
|
Transcripts
for ZNF208 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF208 gene: NM_007153.3 Unigene Cluster for ZNF208: Zinc finger protein 208 Hs.732975 [show with all ESTs]Unigene Representative Sequence: NM_0071531 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000397126(uc002nqo.1 uc021urr.1 uc002nqq.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF208 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF208 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF208 (NM_007153) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF208 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF208 |
Additional cDNA sequence: AK096236.1 AK124313.1 BC038199.1 D70833.1 D70834.1 9 DOTS entries: DT.75166542 DT.95312637 DT.99936277 DT.121421683 DT.100775080 DT.100799832 DT.101976780 DT.121496522 DT.91654015 15 AceView cDNA sequences: BX281273 BE164637 AK096236 BQ011212 BF530154 AW196217 AA904003 BC038199 AA135608 NM_007153 AA911264 AA904167 CB997649 AA135651 BF893899
GeneLoc Exon Structure
|
Expression
for ZNF208 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF208 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACCTTAAAT
About this image
See ZNF208 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF208
SOURCE GeneReport for Unigene cluster: Hs.732975
UniProtKB/Swiss-Prot: ZN208_HUMAN, O43345Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for ZNF208
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF208 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF208 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF208 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF208 |
Orthologs
for ZNF208 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF208 gene from 3/16 species (see all 16) About this table
ENSEMBL Gene Tree for ZNF208 (if available)
TreeFam Gene Tree for ZNF208 (if available) |
Paralogs
for ZNF208 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF208 gene
- ZNF7291 2 ZNF6162 ZNF1602 ZNF8502 ZNF992 ZNF5462 ZNF6652 ZNF7212
- ZNF8362 ZNF8412 ZNF912 ZNF432 ZNF780B2 ZNF1972 ZNF585A2 ZNF8082
- ZNF3472 ZNF8452 ZNF1842 ZNF585B2 ZNF6582 ZNF6242
18/301 SIMAP similar genes for ZNF208 using alignment to 6 protein entries: ZN208_HUMAN (see all proteins)
(see all similar genes):ZNF676 ZFS-1 ZNF737 ZNF85 ZNF430 ZNF92
ZNF232 ZNF665 ZNF726 ZNF98 ZNF100 ZNF254
ZNF257 ZNF323 ZNF492 ZNF675 ZNF679 ZNF680
ZNF208 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ZNF208
PGOHUM00000234257 PGOHUM00000260513
|
Genomic Variants
for ZNF208 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF208 (22148897 - 22193745 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for ZNF208
4 CNVs: 22951 3184 9304 4071
1 Indel: 40271
1 Inversion: 37202 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF208 |
|
Disorders
/ Diseases
for ZNF208 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF208 for disorders About MalaCards
ZNF208 for disorders About GeneDecksing
OMIM gene information: 603977
OMIM disorders: --
Export disorders for ZNF208 gene to outside databases
|
Publications
for ZNF208 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF208 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF208) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complex beta-satellite repeat structures and the expansion of the zinc finger gene cluster in 19p12. (PubMed id 9724325)1, 2, 3 Eichler E.E.... Mohrenweiser H.W. (1998)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. (PubMed id 15469996)1 Oh H.J.... Lau Y.-F.C. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PubMed id 8467795)1 Bellefroid E.J.... Martial J.A. (1993)
|
External Searches for ZNF208 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF208 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF208 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF208 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF208 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF208 gene:
Search GeneIP for patents involving ZNF208
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF208 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF208 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF208 | | Browse OriGene genome-wide validated SYBR primer pairs | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF208 | | OriGene 3'-UTR Clone for ZNF208 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF208 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF208 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 |  |  |  | |
| | | | Search Tocris compounds for ZNF208 |
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 | | | ZNF208 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF208 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ZNF208 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF208 |
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