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Aliases for ZNF208 Gene

Aliases for ZNF208 Gene

  • Zinc Finger Protein 208 2 3 5
  • Zinc Finger Protein 95 2 3
  • Zinc Finger Protein 91-Like 4
  • ZNF91L 4
  • PMIDP 3
  • ZNF95 3

External Ids for ZNF208 Gene

Previous GeneCards Identifiers for ZNF208 Gene

  • GC19M022601
  • GC19M022483
  • GC19M021683
  • GC19M021782
  • GC19M022148
  • GC19M021686
  • GC19M022115

Summaries for ZNF208 Gene

Entrez Gene Summary for ZNF208 Gene

  • Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998 [PubMed 9724325]). See ZNF91 (MIM 603971) for further information on ZNFs.[supplied by OMIM, Aug 2009]

GeneCards Summary for ZNF208 Gene

ZNF208 (Zinc Finger Protein 208) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF729.

UniProtKB/Swiss-Prot for ZNF208 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF208 Gene

Genomics for ZNF208 Gene

Regulatory Elements for ZNF208 Gene

Promoters for ZNF208 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF208 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF208 Gene

Chromosome:
19
Start:
21,932,958 bp from pter
End:
22,010,949 bp from pter
Size:
77,992 bases
Orientation:
Minus strand

Genomic View for ZNF208 Gene

Genes around ZNF208 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF208 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF208 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF208 Gene

Proteins for ZNF208 Gene

  • Protein details for ZNF208 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43345-ZN208_HUMAN
    Recommended name:
    Zinc finger protein 208
    Protein Accession:
    O43345

    Protein attributes for ZNF208 Gene

    Size:
    1280 amino acids
    Molecular mass:
    147487 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF208 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF208 Gene

Proteomics data for ZNF208 Gene at MOPED

Post-translational modifications for ZNF208 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF208 Gene

No data available for DME Specific Peptides for ZNF208 Gene

Domains & Families for ZNF208 Gene

Gene Families for ZNF208 Gene

Protein Domains for ZNF208 Gene

Suggested Antigen Peptide Sequences for ZNF208 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43345

UniProtKB/Swiss-Prot:

ZN208_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 39 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 39 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF208: view

Function for ZNF208 Gene

Molecular function for ZNF208 Gene

GENATLAS Biochemistry:
zinc finger protein 208,ubiquitously expressed,located in a cluster of Kruppel associated box zinc finger
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF208: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF208 Gene

Localization for ZNF208 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF208 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF208 Gene COMPARTMENTS Subcellular localization image for ZNF208 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for ZNF208 Gene

Pathways & Interactions for ZNF208 Gene

SuperPathways for ZNF208 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF208: view

Pathways by source for ZNF208 Gene

2 Reactome pathways for ZNF208 Gene

Gene Ontology (GO) - Biological Process for ZNF208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF208: view

No data available for SIGNOR curated interactions for ZNF208 Gene

Drugs & Compounds for ZNF208 Gene

No Compound Related Data Available

Transcripts for ZNF208 Gene

mRNA/cDNA for ZNF208 Gene

Unigene Clusters for ZNF208 Gene

Zinc finger protein 208:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF208 Gene

No ASD Table

Relevant External Links for ZNF208 Gene

GeneLoc Exon Structure for
ZNF208
ECgene alternative splicing isoforms for
ZNF208

Expression for ZNF208 Gene

mRNA expression in normal human tissues for ZNF208 Gene

Protein differential expression in normal tissues from HIPED for ZNF208 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF208 Gene



SOURCE GeneReport for Unigene cluster for ZNF208 Gene Hs.732975

mRNA Expression by UniProt/SwissProt for ZNF208 Gene

O43345-ZN208_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ZNF208: view

Protein tissue co-expression partners for ZNF208 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF208 Gene

Orthologs for ZNF208 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF208 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF493 35
  • 80.87 (n)
  • 66.61 (a)
ZNF208 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 55 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 17 (a)
ManyToMany
ZNF208 35
  • 54.54 (n)
  • 45.17 (a)
mouse
(Mus musculus)
Mammalia Zfp619 16
Zfp619 35
  • 55.26 (n)
  • 45.34 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC102548231 35
  • 55.29 (n)
  • 45.26 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii AL935044.2 36
  • 46 (a)
ManyToMany
BX005085.3 36
  • 50 (a)
ManyToMany
BX321873.2 36
  • 49 (a)
ManyToMany
BX321887.1 36
  • 44 (a)
ManyToMany
BX324216.1 36
  • 43 (a)
ManyToMany
BX510909.2 36
  • 45 (a)
ManyToMany
BX510909.3 36
  • 47 (a)
ManyToMany
BX571760.1 36
  • 47 (a)
ManyToMany
BX942815.1 36
  • 50 (a)
ManyToMany
CABZ01021450.1 36
  • 43 (a)
ManyToMany
CABZ01084613.2 36
  • 44 (a)
ManyToMany
CR356223.5 36
  • 45 (a)
ManyToMany
CR847941.1 36
  • 45 (a)
ManyToMany
CR927215.1 36
  • 49 (a)
ManyToMany
CU467646.2 36
  • 45 (a)
ManyToMany
CU929391.1 36
  • 45 (a)
ManyToMany
si:ch211-208f21.5 36
  • 48 (a)
ManyToMany
si:ch211-209p16.3 36
  • 50 (a)
ManyToMany
si:ch211-245n8.1 36
  • 49 (a)
ManyToMany
si:ch73-40a17.5 36
  • 39 (a)
ManyToMany
si:dkey-111k8.1 36
  • 48 (a)
ManyToMany
si:dkey-14o6.6 36
  • 51 (a)
ManyToMany
si:dkey-15h8.4 36
  • 45 (a)
ManyToMany
si:dkey-196n19.7 36
  • 46 (a)
ManyToMany
si:dkey-240n22.7 36
  • 45 (a)
ManyToMany
si:dkey-77f5.7 36
  • 20 (a)
ManyToMany
si:dkey-92c21.3 36
  • 48 (a)
ManyToMany
zgc:113100 36
  • 50 (a)
ManyToMany
zgc:113381 36
  • 41 (a)
ManyToMany
zgc:171418 36
  • 51 (a)
ManyToMany
zgc:171570 36
  • 44 (a)
ManyToMany
zgc:174234 36
  • 44 (a)
ManyToMany
znf770 36
  • 18 (a)
ManyToMany
LOC101884857 35
  • 62.65 (n)
  • 52.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10147 37
  • 36 (a)
CG3032 37
  • 31 (a)
l(2)35Ea 37
  • 36 (a)
Oaz 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
CSA.11281 36
  • 39 (a)
ManyToMany
Species with no ortholog for ZNF208:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF208 Gene

ENSEMBL:
Gene Tree for ZNF208 (if available)
TreeFam:
Gene Tree for ZNF208 (if available)

Paralogs for ZNF208 Gene

(382) SIMAP similar genes for ZNF208 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZNF208 Gene

genes like me logo Genes that share paralogs with ZNF208: view

Variants for ZNF208 Gene

Sequence variations from dbSNP and Humsavar for ZNF208 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2007506 - 21,974,190(-) CTGGA(A/G)AGAAA reference, missense
rs12462668 - 21,974,141(+) GAGTC(A/G)AGACC reference, missense
rs7255075 - 21,973,668(+) TTCTT(C/G)ACATT reference, missense
rs10425763 - 21,973,116(+) TTCTT(C/T)ACATT reference, missense
rs8108957 - 21,971,930(+) CTTTG(C/T)CACAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF208 Gene

Variant ID Type Subtype PubMed ID
esv4924 CNV Complex 18987735
esv2718335 CNV Deletion 23290073
dgv552e201 CNV Deletion 23290073
nsv7306 OTHER Inversion 18451855
dgv3808n71 CNV Gain 21882294
dgv1066e1 CNV Complex 17122850
esv731 CNV CNV 17122850
esv34340 CNV Loss 17911159
nsv833785 CNV Gain 17160897
dgv553e201 CNV Deletion 23290073
dgv633e199 CNV Deletion 23128226
nsv436853 CNV Insertion 17901297
dgv554e201 CNV Deletion 23290073
nsv469674 CNV Complex 16826518
nsv436253 CNV Deletion 17901297

Variation tolerance for ZNF208 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.93; 93.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF208 Gene

HapMap Linkage Disequilibrium report
ZNF208

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF208 Gene

Disorders for ZNF208 Gene

Relevant External Links for ZNF208

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF208

No disorders were found for ZNF208 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF208 Gene

Publications for ZNF208 Gene

  1. Complex beta-satellite repeat structures and the expansion of the zinc finger gene cluster in 19p12. (PMID: 9724325) Eichler E.E. … Mohrenweiser H.W. (Genome Res. 1998) 2 3 4 67
  2. Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. (PMID: 15469996) Oh H.J. … Lau Y.-F.C. (Biol. Reprod. 2005) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF208 Gene

Sources for ZNF208 Gene

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