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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF208 Gene

protein-coding   GIFtS: 45
GCID: GC19M022148

Zinc Finger Protein 208

  Search for ZNF208
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 2081 2
Zinc Finger Protein 951 2
ZNF952 5
PMIDP2
ZNF91L3
Zinc Finger Protein 91-Like3

External Ids:    HGNC: 129991   Entrez Gene: 77572   Ensembl: ENSG000001603217   OMIM: 6039775   UniProtKB: O433453   

Export aliases for ZNF208 gene to outside databases

Previous GC identifers: GC19M022601 GC19M022483 GC19M021683 GC19M021782 GC19M021945 GC19M021686


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF208 Gene:
Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most
ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif,
termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998
(PubMed 9724325)). See ZNF91 (MIM 603971) for further information on ZNFs.(supplied by OMIM, Aug 2009)

GeneCards Summary for ZNF208 Gene: 
ZNF208 (zinc finger protein 208) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF91.

UniProtKB/Swiss-Prot: ZN208_HUMAN, O43345
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF208
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF208

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF208


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF208 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF208 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M022148:  view genomic region     (about GC identifiers)

Start:
22,115,760 bp from pter      End:
22,193,751 bp from pter
Size:
77,992 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN208_HUMAN, O43345 (See protein sequence)
Recommended Name: Zinc finger protein 208  
Size: 1167 amino acids; 134353 Da
Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for ZNF208: NX_O43345

Explore proteomics data for ZNF208 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43345

  • ZNF208 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF208 Protein Expression
    REFSEQ proteins: NP_009084.2  
    ENSEMBL proteins: 
     ENSP00000469254   ENSP00000469887   ENSP00000380315   ENSP00000473026   ENSP00000472406  
     ENSP00000471831  
    Reactome Protein details: O43345
    Human Recombinant Protein Products for ZNF208: 
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    Cloud-Clone Corp. Proteins for ZNF208 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus NAS--

    ZNF208 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O43345

    ProtoNet protein and cluster: O43345

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN208_HUMAN, O43345
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 34 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF208 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN208_HUMAN, O43345
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF208:
    zinc finger protein 208,ubiquitously expressed,located in a cluster of Kruppel associated box zinc finger

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding NAS--
    GO:0008270zinc ion binding NAS9724325
    GO:0046872metal ion binding ----
         
    ZNF208 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target ZNF208:
    hsa-mir-197 (MIRT004214)

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF208 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF208
        Generic Transcription Pathway
    Gene Expression



    ZNF208 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF208

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF208 (O433453 ENSP000003803154) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRYQ050663, ENSP000003725474I2D: score=1 STRING: ENSP00000372547
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--

    ZNF208 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF208 (ZN208)

    Search CenterWatch for drugs/clinical trials and news about ZNF208 / ZN208

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF208 gene: 
    NM_007153.3  

    Unigene Cluster for ZNF208:

    Zinc finger protein 208
    Hs.732975  [show with all ESTs]
    Unigene Representative Sequence: NM_007153
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000599916 ENST00000601773 ENST00000397126(uc002nqo.1 uc021urr.1 uc002nqq.3)
    ENST00000599723 ENST00000597040 ENST00000601993
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF208
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF208
    Clone
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    Primer
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    Additional mRNA sequence: 

    AK096236.1 AK124313.1 BC038199.1 D70833.1 D70834.1 

    9 DOTS entries:

    DT.75166542  DT.95312637  DT.99936277  DT.121421683  DT.100775080  DT.100799832  DT.101976780  DT.121496522 
    DT.91654015 

    15 AceView cDNA sequences:

    BE164637 BX281273 BQ011212 AA904003 AK096236 AA135608 BF530154 NM_007153 
    BC038199 AW196217 AA911264 AA904167 CB997649 AA135651 BF893899 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF208 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCTTAAAT
    ZNF208 Expression
    About this image


    See ZNF208 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF208

    SOURCE GeneReport for Unigene cluster: Hs.732975

    UniProtKB/Swiss-Prot: ZN208_HUMAN, O43345
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for ZNF208
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF208

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF208 gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia A530054K11Rik1 RIKEN cDNA A530054K11 gene 70.17(n)
    63.09(a)
      212281  NM_183146.3  NP_898969.2 


    ENSEMBL Gene Tree for ZNF208 (if available)
    TreeFam Gene Tree for ZNF208 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF208 gene
    ZNF7291 2  ZNF912  ZNF7212  ZNF5212  ZNF6462  ZNF8502  ZNF4232  
    18/380 SIMAP similar genes for ZNF208 using alignment to 6 protein entries:     ZN208_HUMAN (see all proteins) (see all similar genes):
    ZNF56    ZNF728    ZNF525    ZNF676    ZNF726    ZNF468
    ZNF98    ZNF90    ZNF420    ZNF415    ZNF320    ZNF776
    ZNF888    ZNF675    ZNF724P    ZNF616    MGC12518    ZNF559

    ZNF208 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZNF208
    PGOHUM00000234257 PGOHUM00000260513


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1145 SNPs in ZNF208 are shown (see all 1145)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105924301,2
    C--21696519(+) AAAAA-/AC/C  
            
    AACTT
    1 -- int10--------
    rs342340401,2
    C--22099271(+) ATCTC-/AAAAAA 1 -- int10--------
    rs1905151011,2
    --22148491(+) TTTGGA/GATACA 1 -- ds50010--------
    rs1142117541,2
    C,F--22148578(+) GTCTCA/TCCCAT 1 -- ds50011Minor allele frequency- T:0.15WA 118
    rs110855041,2
    C,F,A,H--22148582(+) CACCCT/ATTCAC 1 -- ds500111Minor allele frequency- A:0.31NA WA CSA EA 376
    rs1412023751,2
    C--22148602(+) TTCTG-/AAAAAA 1 -- ds50010--------
    rs110855051,2
    C,F,A,H--22148671(+) ATAGTC/GTAGTG 1 -- ds500118Minor allele frequency- G:0.29NA NS EA WA CSA 873
    rs1384501621,2
    C--22148674(+) GTGTAA/GTGTAC 1 -- ds50010--------
    rs1822237311,2
    --22148703(+) AAAGGC/TGTAAT 1 -- ds50010--------
    rs1492559331,2
    --22148807(+) AGAAAC/TATTCA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZNF208 (22115760 - 22193751 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for ZNF208 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv436253CNV Deletion17901297
    dgv554e201CNV Deletion23290073
    dgv552e201CNV Deletion23290073
    dgv553e201CNV Deletion23290073
    dgv633e199CNV Deletion23128226
    esv2718335CNV Deletion23290073
    nsv436853CNV Insertion17901297
    esv34340CNV Loss17911159
    dgv3808n71CNV Gain21882294
    nsv833785CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF208
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF208

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF208 for disorders           About MalaCards
    OMIM gene information: 603977    OMIM disorders: --


    ZNF208 for disorders           About GeneDecksing


    Export disorders for ZNF208 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF208 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF208)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complex beta-satellite repeat structures and the expansion of the zinc finger gene cluster in 19p12. (PubMed id 9724325)1, 2, 3 Eichler E.E.... Mohrenweiser H.W. (1998)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. (PubMed id 15469996)1 Oh H.J.... Lau Y.-F.C. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PubMed id 8467795)1 Bellefroid E.J.... Martial J.A. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7757 HGNC: 12999 AceView: ZNF208 Ensembl:ENSG00000160321 euGenes: HUgn7757
    ECgene: ZNF208 H-InvDB: ZNF208

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF208 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF208 gene:
    Search GeneIP for patents involving ZNF208

    GeneCards and IP:
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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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