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ZNF208 Gene

protein-coding   GIFtS: 43
GCID: GC19M022115

Zinc Finger Protein 208

  Search for ZNF208
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 2081 2
Zinc Finger Protein 951 2
ZNF952 5
PMIDP2
ZNF91L3
Zinc Finger Protein 91-Like3

External Ids:    HGNC: 129991   Entrez Gene: 77572   Ensembl: ENSG000001603217   OMIM: 6039775   UniProtKB: O433453   

Export aliases for ZNF208 gene to outside databases

Previous GC identifers: GC19M022601 GC19M022483 GC19M021683 GC19M021782 GC19M021945 GC19M022148 GC19M021686


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF208 Gene:
Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most
ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif,
termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998
(PubMed 9724325)). See ZNF91 (MIM 603971) for further information on ZNFs.(supplied by OMIM, Aug 2009)

GeneCards Summary for ZNF208 Gene:
ZNF208 (zinc finger protein 208) is a protein-coding gene. An important paralog of this gene is ZNF91.

UniProtKB/Swiss-Prot: ZN208_HUMAN, O43345
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF208
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF208

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF208


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF208 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF208 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M022115:  view genomic region     (about GC identifiers)

Start:
22,115,760 bp from pter      End:
22,193,751 bp from pter
Size:
77,992 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN208_HUMAN, O43345 (See protein sequence)
Recommended Name: Zinc finger protein 208  
Size: 1280 amino acids; 147487 Da
Alternative splicing: 2 isoforms:  O43345-1   O43345-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF208: NX_O43345

Explore proteomics data for ZNF208 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys97, Lys684
  • Modification sites at PhosphoSitePlus

  • See ZNF208 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009084.2  
    ENSEMBL proteins: 
     ENSP00000469254   ENSP00000469887   ENSP00000380315   ENSP00000473026   ENSP00000472406  
     ENSP00000471831  
    Reactome Protein details: O43345

    ZNF208 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O43345

    ProtoNet protein and cluster: O43345

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN208_HUMAN, O43345
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 39 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF208 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN208_HUMAN, O43345
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF208:
    zinc finger protein 208,ubiquitously expressed,located in a cluster of Kruppel associated box zinc finger

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding NAS9724325
    GO:0046872metal ion binding ----
         
    ZNF208 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF208
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF208
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    miRNA
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    miRTarBase miRNAs that target ZNF208:
    hsa-mir-197-3p (MIRT004214)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN208_HUMAN, O43345: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF208 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF208 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF208
        Generic Transcription Pathway



    ZNF208 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF208
    Interactions:

        Search GeneGlobe Interaction Network for ZNF208

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF208 (O433453 ENSP000003803154) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRYQ050663, ENSP000003725474I2D: score=1 STRING: ENSP00000372547
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF208 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF208 (ZN208)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF208 gene: 
    NM_007153.3  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000599916 ENST00000601773 ENST00000397126(uc002nqo.1 uc021urr.1 uc002nqq.3)
    ENST00000599723 ENST00000597040 ENST00000601993
    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF208
    Clone
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    GenScript: all cDNA clones in your preferred vector: ZNF208 (NM_007153)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF208
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    15 AceView cDNA sequences:

    BE164637 BX281273 AA135608 AA904003 BF530154 AW196217 NM_007153 BQ011212 
    BC038199 AK096236 AA904167 AA911264 CB997649 AA135651 BF893899 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF208 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCTTAAAT
    ZNF208 Expression
    About this image

    ZNF208 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF208 Protein Expression

    UniProtKB/Swiss-Prot: ZN208_HUMAN, O43345
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for ZNF208
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF208

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF208 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6191 zinc finger protein 619 55.26(n)
    45.34(a)
      70227  NM_001004139.2  NP_001004139.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 63)
    Uncharacterized protein
    (see all 63)
    56(a)
    55(a)
    (see all 63)
    many ↔ many
    many ↔ many
    (see all 63)
    GL343676.1(133636-262720)
    GL343434.1(88139-103400)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018848571 zinc finger protein 91-like 62.65(n)
    52.77(a)
      101884857  XM_005164356.1  XP_005164413.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG101473   -- 36(a)
    (best of 3)
      65B3   --


    ENSEMBL Gene Tree for ZNF208 (if available)
    TreeFam Gene Tree for ZNF208 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF208 gene
    ZNF912  ZNF5212  PEG32  ZNF8502  ZNF7292  ZNF4232  
    Selected SIMAP similar genes for ZNF208 using alignment to 6 protein entries:     ZN208_HUMAN (see all proteins) (see all similar genes):
    ZNF56    ZNF728    ZNF525    ZNF676    ZNF726    ZNF468
    ZNF98    ZNF90    ZNF415    ZNF320    ZNF776    ZNF888
    ZNF675    ZNF724P    ZNF616    MGC12518    ZNF257    ZNF519

    ZNF208 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZNF208
    PGOHUM00000234257 PGOHUM00000260513


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF208 (see all 1144)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105924301,2
    C--21696519(+) AAAAA-/AC/C  
            
    AACTT
    1 -- int10--------
    rs342340401,2
    C--22099271(+) ATCTC-/AAAAAA 1 -- int10--------
    rs1905151011,2
    --22148491(+) TTTGGA/GATACA 1 -- ds50010--------
    rs1142117541,2
    C,F--22148578(+) GTCTCA/TCCCAT 1 -- ds50011Minor allele frequency- T:0.15WA 118
    rs110855041,2
    C,F,A,H--22148582(+) CACCCT/ATTCAC 1 -- ds500111Minor allele frequency- A:0.31NA WA CSA EA 376
    rs1412023751,2
    C--22148602(+) TTCTG-/AAAAAA 1 -- ds50010--------
    rs110855051,2
    C,F,A,H--22148671(+) ATAGTC/GTAGTG 1 -- ds500118Minor allele frequency- G:0.29NA NS EA WA CSA 873
    rs1384501621,2
    C--22148674(+) GTGTAA/GTGTAC 1 -- ds50010--------
    rs1822237311,2
    --22148703(+) AAAGGC/TGTAAT 1 -- ds50010--------
    rs1492559331,2
    --22148807(+) AGAAAC/TATTCA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZNF208 (22115760 - 22193751 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF208 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436253CNV Deletion17901297
    dgv554e201CNV Deletion23290073
    dgv552e201CNV Deletion23290073
    dgv553e201CNV Deletion23290073
    dgv633e199CNV Deletion23128226
    esv2718335CNV Deletion23290073
    nsv436853CNV Insertion17901297
    esv34340CNV Loss17911159
    dgv3808n71CNV Gain21882294
    nsv833785CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF208
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603977    OMIM disorders: --


    ZNF208 for disorders           About GeneDecksing


    Export disorders for ZNF208 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF208 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF208)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complex beta-satellite repeat structures and the expansion of the zinc finger gene cluster in 19p12. (PubMed id 9724325)1, 2, 3 Eichler E.E.... Mohrenweiser H.W. (Genome Res. 1998)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    5. Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. (PubMed id 15469996)1 Oh H.J.... Lau Y.-F.C. (Biol. Reprod. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PubMed id 8467795)1 Bellefroid E.J.... Martial J.A. (EMBO J. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7757 HGNC: 12999 AceView: ZNF208 Ensembl:ENSG00000160321 euGenes: HUgn7757
    ECgene: ZNF208 H-InvDB: ZNF208

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF208 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF208 gene:
    Search GeneIP for patents involving ZNF208

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZNF208  
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     Block miRNA regulation of human, mouse, rat ZNF208 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZNF208
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF208 Predesigned siRNA for gene silencing in human, mouse, rat ZNF208
     QuantiFast Probe-based Assays in human, mouse, rat ZNF208 QuantiTect SYBR Green Assays in human, mouse, rat ZNF208
     Custom PCR Arrays for ZNF208 Search Chromatin IP Primers for ZNF208
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     Search ThermoFisher Antibodies for ZNF208
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF208
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