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Aliases for ZNF208 Gene

Aliases for ZNF208 Gene

  • Zinc Finger Protein 208 2 3
  • Zinc Finger Protein 95 2 3
  • ZNF95 3 6
  • Zinc Finger Protein 91-Like 4
  • ZNF91L 4
  • PMIDP 3

External Ids for ZNF208 Gene

Previous GeneCards Identifiers for ZNF208 Gene

  • GC19M022601
  • GC19M022483
  • GC19M021683
  • GC19M021782
  • GC19M022148
  • GC19M021686
  • GC19M022115

Summaries for ZNF208 Gene

Entrez Gene Summary for ZNF208 Gene

  • Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998 [PubMed 9724325]). See ZNF91 (MIM 603971) for further information on ZNFs.[supplied by OMIM, Aug 2009]

GeneCards Summary for ZNF208 Gene

ZNF208 (Zinc Finger Protein 208) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF729.

UniProtKB/Swiss-Prot for ZNF208 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF208 Gene

Genomics for ZNF208 Gene

Genomic Location for ZNF208 Gene

Start:
21,932,958 bp from pter
End:
22,010,949 bp from pter
Size:
77,992 bases
Orientation:
Minus strand

Genomic View for ZNF208 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF208 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF208 Gene

No data available for Regulatory Elements for ZNF208 Gene

Proteins for ZNF208 Gene

  • Protein details for ZNF208 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43345-ZN208_HUMAN
    Recommended name:
    Zinc finger protein 208
    Protein Accession:
    O43345
    Secondary Accessions:

    Protein attributes for ZNF208 Gene

    Size:
    1280 amino acids
    Molecular mass:
    147487 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF208 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF208 Gene

Proteomics data for ZNF208 Gene at MOPED

Post-translational modifications for ZNF208 Gene

  • Ubiquitination at Lys97 and Lys684
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF208 Gene

No data available for DME Specific Peptides for ZNF208 Gene

Domains for ZNF208 Gene

Gene Families for ZNF208 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF208 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43345

UniProtKB/Swiss-Prot:

ZN208_HUMAN :
  • O43345
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 39 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF208: view

Function for ZNF208 Gene

Molecular function for ZNF208 Gene

GENATLAS Biochemistry: zinc finger protein 208,ubiquitously expressed,located in a cluster of Kruppel associated box zinc finger
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS 9724325
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF208: view

Animal Model Products

CRISPR Products

miRNA for ZNF208 Gene

miRTarBase miRNAs that target ZNF208

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF208 Gene

Localization for ZNF208 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF208 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF208 Gene COMPARTMENTS Subcellular localization image for ZNF208 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZNF208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF208: view

Pathways for ZNF208 Gene

SuperPathways for ZNF208 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF208: view

Pathways by source for ZNF208 Gene

2 Reactome pathways for ZNF208 Gene

Gene Ontology (GO) - Biological Process for ZNF208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF208: view

Transcripts for ZNF208 Gene

mRNA/cDNA for ZNF208 Gene

(15) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF208 Gene

Zinc finger protein 208:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF208

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF208 Gene

No ASD Table

Relevant External Links for ZNF208 Gene

GeneLoc Exon Structure for
ZNF208
ECgene alternative splicing isoforms for
ZNF208

Expression for ZNF208 Gene

mRNA expression in normal human tissues for ZNF208 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF208 Gene

SOURCE GeneReport for Unigene cluster for ZNF208 Gene Hs.732975

mRNA Expression by UniProt/SwissProt for ZNF208 Gene

O43345-ZN208_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with ZNF208: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF208 Gene

Orthologs for ZNF208 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF208 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF208 36
  • 99 (a)
OneToOne
ZNF493 35
  • 80.87 (n)
  • 66.61 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 55 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 17 (a)
ManyToMany
ZNF208 35
  • 54.54 (n)
  • 45.17 (a)
mouse
(Mus musculus)
Mammalia Zfp619 35
  • 55.26 (n)
  • 45.34 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC102548231 35
  • 55.29 (n)
  • 45.26 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii AL935044.2 36
  • 46 (a)
ManyToMany
BX005085.3 36
  • 50 (a)
ManyToMany
BX321873.2 36
  • 49 (a)
ManyToMany
BX321887.1 36
  • 44 (a)
ManyToMany
BX324216.1 36
  • 43 (a)
ManyToMany
BX510909.2 36
  • 45 (a)
ManyToMany
BX510909.3 36
  • 47 (a)
ManyToMany
BX571760.1 36
  • 47 (a)
ManyToMany
BX942815.1 36
  • 50 (a)
ManyToMany
CABZ01021450.1 36
  • 43 (a)
ManyToMany
CABZ01084613.2 36
  • 44 (a)
ManyToMany
CR356223.5 36
  • 45 (a)
ManyToMany
CR847941.1 36
  • 45 (a)
ManyToMany
CR927215.1 36
  • 49 (a)
ManyToMany
CU467646.2 36
  • 45 (a)
ManyToMany
CU929391.1 36
  • 45 (a)
ManyToMany
LOC101884857 35
  • 62.65 (n)
  • 52.77 (a)
si:ch211-208f21.5 36
  • 48 (a)
ManyToMany
si:ch211-209p16.3 36
  • 50 (a)
ManyToMany
si:ch211-245n8.1 36
  • 49 (a)
ManyToMany
si:ch73-40a17.5 36
  • 39 (a)
ManyToMany
si:dkey-111k8.1 36
  • 48 (a)
ManyToMany
si:dkey-14o6.6 36
  • 51 (a)
ManyToMany
si:dkey-15h8.4 36
  • 45 (a)
ManyToMany
si:dkey-196n19.7 36
  • 46 (a)
ManyToMany
si:dkey-240n22.7 36
  • 45 (a)
ManyToMany
si:dkey-77f5.7 36
  • 20 (a)
ManyToMany
si:dkey-92c21.3 36
  • 48 (a)
ManyToMany
zgc:113100 36
  • 50 (a)
ManyToMany
zgc:113381 36
  • 41 (a)
ManyToMany
zgc:171418 36
  • 51 (a)
ManyToMany
zgc:171570 36
  • 44 (a)
ManyToMany
zgc:174234 36
  • 44 (a)
ManyToMany
znf770 36
  • 18 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Oaz 36
  • 13 (a)
OneToMany
CG10147 37
  • 36 (a)
l(2)35Ea 37
  • 36 (a)
CG3032 37
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
CSA.11281 36
  • 39 (a)
ManyToMany
Species with no ortholog for ZNF208:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF208 Gene

ENSEMBL:
Gene Tree for ZNF208 (if available)
TreeFam:
Gene Tree for ZNF208 (if available)

Paralogs for ZNF208 Gene

Paralogs for ZNF208 Gene

Selected SIMAP similar genes for ZNF208 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZNF208 Gene

genes like me logo Genes that share paralogs with ZNF208: view

Variants for ZNF208 Gene

Sequence variations from dbSNP and Humsavar for ZNF208 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1018912 -- 21,973,783(-) GAGGT(A/C)ATTCA synonymous-codon, reference
rs1057132 -- 22,006,655(-) GCCCA(G/T)TTAGT intron-variant
rs1057133 -- 22,006,511(-) agaag(A/G)ggttt intron-variant
rs1057134 -- 22,006,443(-) TTAAA(C/G)AGTAA intron-variant
rs1057135 -- 22,006,416(-) GGCAG(A/T)TTCGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF208 Gene

Variant ID Type Subtype PubMed ID
esv4924 CNV Complex 18987735
esv2718335 CNV Deletion 23290073
dgv552e201 CNV Deletion 23290073
nsv7306 OTHER Inversion 18451855
dgv3808n71 CNV Gain 21882294
dgv1066e1 CNV Complex 17122850
esv731 CNV CNV 17122850
esv34340 CNV Loss 17911159
nsv833785 CNV Gain 17160897
dgv553e201 CNV Deletion 23290073
dgv633e199 CNV Deletion 23128226
nsv436853 CNV Insertion 17901297
dgv554e201 CNV Deletion 23290073
nsv469674 CNV Complex 16826518
nsv436253 CNV Deletion 17901297

Relevant External Links for ZNF208 Gene

HapMap Linkage Disequilibrium report
ZNF208

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF208 Gene

Disorders for ZNF208 Gene

No disorders were found for ZNF208 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF208 Gene

Publications for ZNF208 Gene

  1. Complex beta-satellite repeat structures and the expansion of the zinc finger gene cluster in 19p12. (PMID: 9724325) Eichler E.E. … Mohrenweiser H.W. (Genome Res. 1998) 2 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  3. Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. (PMID: 15469996) Oh H.J. … Lau Y.-F.C. (Biol. Reprod. 2005) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for ZNF208 Gene

Sources for ZNF208 Gene

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