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Aliases for ZNF207 Gene

Aliases for ZNF207 Gene

  • Zinc Finger Protein 207 2 3 4 5
  • HBuGZ 3 4
  • BuGZ 3 4
  • BUB3-Interacting And GLEBS Motif-Containing Protein ZNF207 3

External Ids for ZNF207 Gene

Previous GeneCards Identifiers for ZNF207 Gene

  • GC17P030443
  • GC17P032712
  • GC17P030525
  • GC17P030822
  • GC17P027636
  • GC17P027414
  • GC17P030678
  • GC17P026863
  • GC17P030679
  • GC17P030681
  • GC17P030683
  • GC17P032351
  • GC17P032353
  • GC17P032354

Summaries for ZNF207 Gene

GeneCards Summary for ZNF207 Gene

ZNF207 (Zinc Finger Protein 207) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and microtubule binding.

UniProtKB/Swiss-Prot for ZNF207 Gene

  • Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF207 Gene

Genomics for ZNF207 Gene

Regulatory Elements for ZNF207 Gene

Enhancers for ZNF207 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G032288 1.2 Ensembl ENCODE dbSUPER 11.1 -60.7 -60691 2.4 BCOR TEAD4 ZMYM3 CHD7 ZNF664 NR2F6 SMARCA5 RNF2 HLF NR2F1 RHBDL3 C17orf75 ZNF207 MIR632 LOC105371730 LOC105371732 PIR39108
GH17G032323 1 Ensembl ENCODE 12.3 -25.9 -25917 0.8 CTCF ESRRA ZFP64 NR2F1 ZEB2 EBF1 ZIC2 RELA YY1 ZEB1 RHBDL3 ZNF207 C17orf75 MIR632 ENSG00000265794 PIR39108
GH17G032443 1.1 ENCODE 10.3 +95.4 95358 3.3 HDGF HNRNPUL1 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 PSMD11 UTP6 SUZ12 ENSG00000265139 CDK5R1 TMEM98 RHBDL3 C17orf75 ZNF207 MIR632
GH17G032268 0.8 dbSUPER 11.2 -81.0 -81001 3.5 FOXA2 KLF17 DMAP1 RARA MIXL1 ZNF263 NFIL3 NFIC SMARCA4 ZNF580 RHBDL3 MIR632 ZNF207 C17orf75 GC17M032239
GH17G031752 1.3 Ensembl ENCODE dbSUPER 4.8 -596.2 -596151 3.1 BCOR FOXA2 JUN ZMYM3 CEBPG THRB RAD21 RARA TEAD3 GATA2 ZNF207 LOC100420482 RNU6-1134P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF207 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF207 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093226 362 3001 HDGF PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for ZNF207 Gene

Chromosome:
17
Start:
32,350,117 bp from pter
End:
32,408,085 bp from pter
Size:
57,969 bases
Orientation:
Plus strand

Genomic View for ZNF207 Gene

Genes around ZNF207 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF207 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF207 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF207 Gene

Proteins for ZNF207 Gene

  • Protein details for ZNF207 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43670-ZN207_HUMAN
    Recommended name:
    BUB3-interacting and GLEBS motif-containing protein ZNF207
    Protein Accession:
    O43670
    Secondary Accessions:
    • A8K6Y6
    • E1P660
    • E1P661
    • E1P662
    • Q53XS9
    • Q96HW5
    • Q9BUQ7

    Protein attributes for ZNF207 Gene

    Size:
    478 amino acids
    Molecular mass:
    50751 Da
    Quaternary structure:
    • Interacts (via GLEBS region) with BUB3.

    Alternative splice isoforms for ZNF207 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF207 Gene

Post-translational modifications for ZNF207 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF207 Gene

Domains & Families for ZNF207 Gene

Gene Families for ZNF207 Gene

Protein Domains for ZNF207 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF207 Gene

Graphical View of Domain Structure for InterPro Entry

O43670

UniProtKB/Swiss-Prot:

ZN207_HUMAN :
  • The GLEBS region mediates interaction with BUB3 (PubMed:24462186, PubMed:24462187).
Domain:
  • The GLEBS region mediates interaction with BUB3 (PubMed:24462186, PubMed:24462187).
  • The microtubule-binding region is required for efficient loading of BUB3 onto kinetochores and proper mitosis.
  • Mainly composed of disordered low-complexity regions outside of the C2H2-type zinc fingers. Coacervation depends on hydrophobic and aromatic Phe and Tyr in the disordered low-complexity region, that may promote coacervation by forming intermolecular hydrophobic interactions.
genes like me logo Genes that share domains with ZNF207: view

Function for ZNF207 Gene

Molecular function for ZNF207 Gene

GENATLAS Biochemistry:
zinc finger protein 207 (C2H2 type Kruppel like),ubiquitously expressed
UniProtKB/Swiss-Prot Function:
Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).

Gene Ontology (GO) - Molecular Function for ZNF207 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 9799612
GO:0003723 RNA binding IDA 22681889
GO:0005515 protein binding IPI 24462186
GO:0008017 microtubule binding IDA 24462186
genes like me logo Genes that share ontologies with ZNF207: view
genes like me logo Genes that share phenotypes with ZNF207: view

Animal Models for ZNF207 Gene

MGI Knock Outs for ZNF207:

Animal Model Products

CRISPR Products

miRNA for ZNF207 Gene

miRTarBase miRNAs that target ZNF207

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF207 Gene

Localization for ZNF207 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF207 Gene

Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding. {ECO:0000269 PubMed:24462186, ECO:0000269 PubMed:24462187}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF207 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF207 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IMP 24462186
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus NAS,IDA 9799612
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF207: view

Pathways & Interactions for ZNF207 Gene

SuperPathways for ZNF207 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF207 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IMP 24462186
GO:0001578 microtubule bundle formation ISS --
GO:0006355 regulation of transcription, DNA-templated NAS 9799612
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IEA --
genes like me logo Genes that share ontologies with ZNF207: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF207 Gene

Transcripts for ZNF207 Gene

Unigene Clusters for ZNF207 Gene

Zinc finger protein 207:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF207 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ·
SP1: - - - - - - - - - - -
SP2:
SP3: -
SP4:
SP5:
SP6: - - -
SP7: -
SP8: -
SP9: - - -
SP10: - - -
SP11: -
SP12: - -
SP13:
SP14:

ExUns: 13d ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16
SP1:
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:

Relevant External Links for ZNF207 Gene

GeneLoc Exon Structure for
ZNF207
ECgene alternative splicing isoforms for
ZNF207

Expression for ZNF207 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF207 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF207 Gene

This gene is overexpressed in Fetal Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF207 Gene



Protein tissue co-expression partners for ZNF207 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF207 Gene:

ZNF207

SOURCE GeneReport for Unigene cluster for ZNF207 Gene:

Hs.500775

mRNA Expression by UniProt/SwissProt for ZNF207 Gene:

O43670-ZN207_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ZNF207 Gene

  • Nervous system(5)
  • Lung(4.8)
  • Kidney(4.3)
  • Skin(4.3)
  • Intestine(4)
  • Liver(3.4)
  • Blood(3.1)
  • Spleen(2.9)
  • Adrenal gland(2.8)
  • Bone marrow(2.8)
  • Gall bladder(2.8)
  • Pancreas(2.8)
  • Stomach(2.8)
  • Thyroid gland(2.8)
  • Eye(2.1)
  • Lymph node(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with ZNF207: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF207 Gene

Orthologs for ZNF207 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF207 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 100 (a)
OneToMany
-- 35
  • 93 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZNF207 34 35
  • 99.8 (n)
cow
(Bos Taurus)
Mammalia ZNF207 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF207 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF207 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp207 34 16 35
  • 93.95 (n)
rat
(Rattus norvegicus)
Mammalia Zfp207 34
  • 93.74 (n)
chicken
(Gallus gallus)
Aves ZNF207 34 35
  • 83.3 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF207 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75627 34
African clawed frog
(Xenopus laevis)
Amphibia 4m77-prov 34
zebrafish
(Danio rerio)
Actinopterygii znf207a 35
  • 70 (a)
OneToMany
znf207b 35
  • 69 (a)
OneToMany
znf207 34
fruit fly
(Drosophila melanogaster)
Insecta CG17912 36 35
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea B0035.1a 36
  • 68 (a)
B0035.1b 36
  • 68 (a)
B0035.1 35
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10678 35
  • 47 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.237 34
Species where no ortholog for ZNF207 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF207 Gene

ENSEMBL:
Gene Tree for ZNF207 (if available)
TreeFam:
Gene Tree for ZNF207 (if available)

Paralogs for ZNF207 Gene

(1) SIMAP similar genes for ZNF207 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF207 Gene

genes like me logo Genes that share paralogs with ZNF207: view

No data available for Paralogs for ZNF207 Gene

Variants for ZNF207 Gene

Sequence variations from dbSNP and Humsavar for ZNF207 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000097005 -- 32,378,629(+) AGATT(C/G)TTTAT nc-transcript-variant
rs1000121677 -- 32,357,358(+) TTTTT(A/T)TTTTT intron-variant
rs1000181486 -- 32,376,901(+) GTGTG(-/CT)GTGTT intron-variant
rs1000200727 -- 32,373,857(+) CTCAA(A/G)GATAA intron-variant
rs1000210740 -- 32,370,654(+) ATAGA(C/T)ACTTA intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF207 Gene

Variant ID Type Subtype PubMed ID
esv3640380 CNV loss 21293372

Variation tolerance for ZNF207 Gene

Residual Variation Intolerance Score: 10.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.11; 61.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF207 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF207

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF207 Gene

Disorders for ZNF207 Gene

Relevant External Links for ZNF207

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF207

No disorders were found for ZNF207 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF207 Gene

Publications for ZNF207 Gene

  1. ZNF207, a ubiquitously expressed zinc finger gene on chromosome 6p21.3. (PMID: 9799612) Pahl P.M.B. … Horwitz L.D. (Genomics 1998) 2 3 4 64
  2. Phase Transition of Spindle-Associated Protein Regulate Spindle Apparatus Assembly. (PMID: 26388440) Jiang H. … Zheng Y. (Cell 2015) 3 4 64
  3. A microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targeting. (PMID: 24462186) Jiang H. … Zheng Y. (Dev. Cell 2014) 3 4 64
  4. BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignment. (PMID: 24462187) Toledo C.M. … Paddison P.J. (Dev. Cell 2014) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ZNF207 Gene

Sources for ZNF207 Gene

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