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Aliases for ZNF207 Gene

Aliases for ZNF207 Gene

  • Zinc Finger Protein 207 2 3 4
  • BuGZ 3 4
  • BUB3-Interacting And GLEBS Motif-Containing Protein ZNF207 3

External Ids for ZNF207 Gene

Previous GeneCards Identifiers for ZNF207 Gene

  • GC17P030443
  • GC17P032712
  • GC17P030525
  • GC17P030822
  • GC17P027636
  • GC17P027414
  • GC17P030678
  • GC17P026863
  • GC17P030679
  • GC17P030681
  • GC17P030683

Summaries for ZNF207 Gene

GeneCards Summary for ZNF207 Gene

ZNF207 (Zinc Finger Protein 207) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and heparin binding.

UniProtKB/Swiss-Prot for ZNF207 Gene

  • Kinetochore-binding protein involved in spindle-assembly checkpoint signaling by regulating mitotic chromosome alignment and mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF207 Gene

Genomics for ZNF207 Gene

Regulatory Elements for ZNF207 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF207 Gene

Start:
32,350,117 bp from pter
End:
32,381,886 bp from pter
Size:
31,770 bases
Orientation:
Plus strand

Genomic View for ZNF207 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF207 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF207 Gene

Proteins for ZNF207 Gene

  • Protein details for ZNF207 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43670-ZN207_HUMAN
    Recommended name:
    BUB3-interacting and GLEBS motif-containing protein ZNF207
    Protein Accession:
    O43670
    Secondary Accessions:
    • A8K6Y6
    • E1P660
    • E1P661
    • E1P662
    • Q53XS9
    • Q96HW5
    • Q9BUQ7

    Protein attributes for ZNF207 Gene

    Size:
    478 amino acids
    Molecular mass:
    50751 Da
    Quaternary structure:
    • Interacts (via GLEBS region) with BUB3.

    Alternative splice isoforms for ZNF207 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF207 Gene

Proteomics data for ZNF207 Gene at MOPED

Post-translational modifications for ZNF207 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ZNF207 Gene

Domains for ZNF207 Gene

Gene Families for ZNF207 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF207 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF207 Gene

Graphical View of Domain Structure for InterPro Entry

O43670

UniProtKB/Swiss-Prot:

ZN207_HUMAN :
  • O43670
Domain:
  • The GLEBS region mediates interaction with BUB3 (PubMed:24462186, PubMed:24462187).
  • The microtubule-binding region is required for efficient loading of BUB3 onto kinetochores and proper mitosis.
Similarity:
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF207: view

Function for ZNF207 Gene

Molecular function for ZNF207 Gene

GENATLAS Biochemistry: zinc finger protein 207 (C2H2 type Kruppel like),ubiquitously expressed
UniProtKB/Swiss-Prot Function: Kinetochore-binding protein involved in spindle-assembly checkpoint signaling by regulating mitotic chromosome alignment and mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).

Gene Ontology (GO) - Molecular Function for ZNF207 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 9799612
GO:0005515 protein binding IPI 24462186
GO:0008017 microtubule binding IDA 24462186
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with ZNF207: view

Phenotypes for ZNF207 Gene

genes like me logo Genes that share phenotypes with ZNF207: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF207

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF207 Gene

Localization for ZNF207 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF207 Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF207 Gene COMPARTMENTS Subcellular localization image for ZNF207 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF207 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IMP 24462186
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus NAS 9799612
GO:0005730 nucleolus IDA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with ZNF207: view

Pathways for ZNF207 Gene

SuperPathways for ZNF207 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF207 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IMP 24462186
GO:0006355 regulation of transcription, DNA-templated NAS 9799612
GO:0007094 mitotic spindle assembly checkpoint IMP 24462186
GO:0008608 attachment of spindle microtubules to kinetochore IMP 24462186
GO:0050821 protein stabilization IMP 24462186
genes like me logo Genes that share ontologies with ZNF207: view

No data available for Pathways by source for ZNF207 Gene

Transcripts for ZNF207 Gene

Unigene Clusters for ZNF207 Gene

Zinc finger protein 207:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF207

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF207 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ·
SP1: - - - - - - - - - - -
SP2:
SP3: -
SP4:
SP5:
SP6: - - -
SP7: -
SP8: -
SP9: - - -
SP10: - - -
SP11: -
SP12: - -
SP13:
SP14:

ExUns: 13d ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16
SP1:
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:

Relevant External Links for ZNF207 Gene

GeneLoc Exon Structure for
ZNF207
ECgene alternative splicing isoforms for
ZNF207

Expression for ZNF207 Gene

mRNA expression in normal human tissues for ZNF207 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF207 Gene

SOURCE GeneReport for Unigene cluster for ZNF207 Gene Hs.500775

mRNA Expression by UniProt/SwissProt for ZNF207 Gene

O43670-ZN207_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with ZNF207: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZNF207 Gene

Orthologs for ZNF207 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF207 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF207 35
  • 99.8 (n)
  • 100 (a)
ZNF207 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF207 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp207 35
  • 93.95 (n)
  • 98.92 (a)
Zfp207 16
Zfp207 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF207 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF207 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp207 35
  • 93.74 (n)
  • 99.35 (a)
chicken
(Gallus gallus)
Aves ZNF207 35
  • 83.3 (n)
  • 89.66 (a)
ZNF207 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF207 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia 4m77-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75627 35
zebrafish
(Danio rerio)
Actinopterygii znf207 35
znf207a 36
  • 70 (a)
OneToMany
znf207b 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17912 36
  • 26 (a)
OneToOne
CG17912 37
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea B0035.1 36
  • 35 (a)
OneToOne
B0035.1b 37
  • 68 (a)
B0035.1a 37
  • 68 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.237 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10678 36
  • 47 (a)
OneToOne
Species with no ortholog for ZNF207:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF207 Gene

ENSEMBL:
Gene Tree for ZNF207 (if available)
TreeFam:
Gene Tree for ZNF207 (if available)

Paralogs for ZNF207 Gene

Selected SIMAP similar genes for ZNF207 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF207 Gene

genes like me logo Genes that share paralogs with ZNF207: view

No data available for Paralogs for ZNF207 Gene

Variants for ZNF207 Gene

Sequence variations from dbSNP and Humsavar for ZNF207 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1802230 -- 32,370,223(+) AATGT(A/G)TAACA utr-variant-3-prime
rs1802231 -- 32,369,318(+) TTACC(A/T)AAGTA synonymous-codon, reference
rs1802232 -- 32,369,892(+) GGAAC(A/T)ATTGG utr-variant-3-prime
rs1802233 -- 32,369,669(+) CAGGG(A/G)CCGCC reference, synonymous-codon
rs1860411 -- 32,354,800(+) tagta(C/G)agatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF207 Gene

Variant ID Type Subtype PubMed ID
nsv908068 CNV Gain 21882294
nsv908069 CNV Gain 21882294

Relevant External Links for ZNF207 Gene

HapMap Linkage Disequilibrium report
ZNF207

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF207 Gene

Disorders for ZNF207 Gene

No disorders were found for ZNF207 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF207 Gene

Publications for ZNF207 Gene

  1. ZNF207, a ubiquitously expressed zinc finger gene on chromosome 6p21.3. (PMID: 9799612) Pahl P.M.B. … Horwitz L.D. (Genomics 1998) 2 3 4
  2. A microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targeting. (PMID: 24462186) Jiang H. … Zheng Y. (Dev. Cell 2014) 3 4
  3. BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignment. (PMID: 24462187) Toledo C.M. … Paddison P.J. (Dev. Cell 2014) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers. (PMID: 15576338) Rosas-Acosta G. … Wilson V.G. (Mol. Cell Proteomics 2005) 3

Products for ZNF207 Gene

Sources for ZNF207 Gene

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