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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF205 Gene

protein-coding   GIFtS: 53
GCID: GC16P003162

zinc finger protein 205


(Previous symbol: ZNF210)
 Explore 4 diseases affiliated with
ZNF205 via our new
 Human Malady Compendium 
Biological research products
for ZNF205
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 2051 2
ZNF2101 2 3 5
Zfp131 2
Zinc Finger Protein 2102 3
RhitH2
Transcriptional Repressor RhitH2

External Ids:    HGNC: 129961   Entrez Gene: 77552   Ensembl: ENSG000001223867   OMIM: 6034365   UniProtKB: O952013   

Export aliases for ZNF205 gene to outside databases

Previous GC identifers: GC16P003183 GC16P003104 GC16P003105 GC16P003133


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN205_HUMAN, O95201
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF205 gene promoter:
         NRSF form 1   Nkx2-2   HSF1 (long)   Nkx2-5   NRSF form 2   Ik-3   LCR-F1   HSF1short   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF205 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF205

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF205


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

ZNF205 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF205 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P003162:  view genomic region     (about GC identifiers)

Start:
3,162,561 bp from pter      End:
3,170,518 bp from pter
Size:
7,958 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN205_HUMAN, O95201 (See protein sequence)
Recommended Name: Zinc finger protein 205  
Size: 554 amino acids; 60630 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAC70007.1; Type=Erroneous initiation;
Secondary accessions: A8MZK0 D3DUB4 Q9BU95

Explore the universe of human proteins at neXtProt for ZNF205: NX_O95201

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95201

  • ZNF205 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035893.1  NP_003447.2  

    ENSEMBL proteins: 
     ENSP00000371627   ENSP00000219091   ENSP00000394360   ENSP00000403306   ENSP00000460890  
    Reactome Protein details: O95201
    Human Recombinant Protein Products: 
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    Novus Biologicals ZNF205 Protein
    Novus Biologicals ZNF205 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF205

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus NAS--


    ZNF205 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZNF205


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF205 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O95201

    ProtoNet protein and cluster: O95201

    1 Blocks protein family: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN205_HUMAN, O95201
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 8 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN205_HUMAN, O95201
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF205:
    zinc finger protein 205,C2H2 type,with an alternative transcript ZNF210,ubiquitously expressed

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF205:
    hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidZNF205 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF205 (see all 7)
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    OriGene siRNA: ZNF205
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF205

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding NAS--
    GO:0005515protein binding IPI16713569
    GO:0008270zinc ion binding NAS9787081


    ZNF205 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZNF205:
     Wnt reporter downregulated 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zfp13):
     hematopoietic system  immune system 

    ZNF205 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF205
        Generic Transcription Pathway
    Gene Expression



    ZNF205 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF205

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/17 Interacting proteins for ZNF205 (O952011, 2, 3 ENSP000002190914) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-67040 I2D: score=5 STRING: ENSP00000311695
    C8orf33Q9H7E92, 3MINT-8250600 I2D: score=2 
    CDC37Q165432, 3MINT-8251021 I2D: score=2 
    HDAC6Q9UBN72, 3MINT-8258109 I2D: score=2 
    ILKQ134182, 3MINT-8258690 I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS9787081
    GO:0010729positive regulation of hydrogen peroxide biosynthetic process IMP--
    GO:1901030positive regulation of mitochondrial outer membrane permeabilization IMP--


    ZNF205 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF205
    Search CenterWatch for drugs/clinical trials and news about ZNF205 / ZN205 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF205 gene (2 alternative transcripts): 
    NM_001042428.1  NM_003456.2  

    Unigene Cluster for ZNF205:

    Zinc finger protein 205
    Hs.592088  [show with all ESTs]
    Unigene Representative Sequence: AB672633
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382192(uc002cub.3 uc002cua.3) ENST00000219091 ENST00000444510
    ENST00000414351 ENST00000570935

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF205:
    hsa-miR-3142
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    Inhib. RNA
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    OriGene shRNA RFP: ZNF205
    OriGene siRNA: ZNF205
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF205 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF205
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF205

    Additional cDNA sequence: 

    AB672633.1 AF060865.1 AK313009.1 BC002810.2 

    8 DOTS entries:

    DT.442144  DT.40245264  DT.75153320  DT.91737732  DT.95187232  DT.120661128  DT.91727494  DT.92059100 

    24/57 AceView cDNA sequences (see all 57):

    BC002810 CR623188 BU501927 BX112788 AF060865 BU528378 BI826058 NM_003456 
    BM716860 BM924378 N59892 BM924902 BX332784 BX376263 BX354179 BM854569 
    BQ068590 BX376264 BX419101 BX401230 BX337472 BQ925778 BI194439 BX440712 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF205    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                    -     -                                                                     
    SP2:                    -     -     -                                                               
    SP3:                                -                                                               
    SP4:                    -     -                 -                                                   
    SP5:                                                                                                


    ECgene alternative splicing isoforms for ZNF205

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF205 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCGATGGGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF205 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF205

    SOURCE GeneReport for Unigene cluster: Hs.592088

    UniProtKB/Swiss-Prot: ZN205_HUMAN, O95201
    Tissue specificity: Expressed in heart, skeletal muscle, pancreas and brain. Weakly expressed in placenta, lung, liver,
    kidney and thymus

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF205

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF205 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    25(a)
    possible ortholog
    Un(38586535-38588178)


    ENSEMBL Gene Tree for ZNF205 (if available)
    TreeFam Gene Tree for ZNF205 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF205 gene
    ZSCAN22  ZNF4362  ZNF7742  ZNF6912  ZNF6292  ZNF5722  ZNF6972  
    18/413 SIMAP similar genes for ZNF205 using alignment to 4 protein entries:     ZN205_HUMAN (see all proteins) (see all similar genes):
    RhitH    ZNF669    ZNF789    ZNF818P    kr-znf3    ZNF625
    PRDM9    PRMD9    ZNF214    DKFZp686M04222    ZNF844    DKFZp666C237
    ZNF268    ZNF492    ZNF551    ZNF761    ZNF78L1    ZFS-1

    ZNF205 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/200 NCBI SNPs in ZNF205 are shown (see all 200    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1490983141,2
    --3160645(+) GTAAAG/TGTTCT 4 -- us2k1 nc-transcript-variant0--------
    rs99250601,2
    C,F,H,--3160655(+) TAATTT/ATTTTT 4 -- us2k1 nc-transcript-variant5Minor allele frequency- A:0.04NS EA WA 530
    rs1858793141,2
    --3160688(+) GGCGCA/GGTGGC 4 -- us2k1 nc-transcript-variant0--------
    rs1898169421,2
    --3160698(+) CTCACA/GCCTGT 4 -- nc-transcript-variantus2k10--------
    rs1421693521,2
    --3160702(+) CGCCTA/GTAATC 4 -- us2k1 nc-transcript-variant0--------
    rs1824415631,2
    --3160874(+) GAATCC/GCTTGA 4 -- nc-transcript-variantus2k10--------
    rs1870648321,2
    --3160964(+) AAAAAA/TTAAAA 4 -- int1 us2k10--------
    rs1467147381,2
    --3161041(+) TGGGCA/GCGGTG 4 -- int1 us2k10--------
    rs1911331901,2
    --3161092(+) GGTGGA/GTCACT 4 -- int1 us2k10--------
    rs1404236571,2
    --3161134(+) ACACGG/TTGAAA 4 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for ZNF205 (3162561 - 3170518 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNF205: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF205 for disorders           About GeneDecksing

    OMIM gene information: 603436    OMIM disorders: --

    4 diseases for ZNF205:    About MalaCards
    familial mediterranean fever    intrahepatic cholangiocarcinoma    cholangiocarcinoma    ataxia

    1 disease from the University of Copenhagen DISEASES database for ZNF205:
    Familial Mediterranean fever

    Export disorders for ZNF205 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF205 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF205)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two Kruppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3. (PubMed id 9787081)1, 2, 3 Deng Z....Kastner D.L. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
    6. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    8. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7755 HGNC: 12996 AceView: ZNF205 Ensembl:ENSG00000122386 euGenes: HUgn7755
    ECgene: ZNF205 H-InvDB: ZNF205

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF205 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF205 gene:
    Search GeneIP for patents involving ZNF205

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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