Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF205 Gene

Aliases for ZNF205 Gene

  • Zinc Finger Protein 205 2 3 5
  • Zinc Finger Protein 210 3 4
  • ZNF210 3 4
  • Transcriptional Repressor RhitH 3
  • RhitH 3
  • Zfp13 3

External Ids for ZNF205 Gene

Previous HGNC Symbols for ZNF205 Gene

  • ZNF210

Previous GeneCards Identifiers for ZNF205 Gene

  • GC16P003183
  • GC16P003162
  • GC16P003104
  • GC16P003105
  • GC16P003133
  • GC16P003147
  • GC16P003171
  • GC16P003259
  • GC16P003294

Summaries for ZNF205 Gene

GeneCards Summary for ZNF205 Gene

ZNF205 (Zinc Finger Protein 205) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF691.

UniProtKB/Swiss-Prot for ZNF205 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF205 Gene

Genomics for ZNF205 Gene

Regulatory Elements for ZNF205 Gene

Enhancers for ZNF205 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F003097 1.8 FANTOM5 Ensembl ENCODE 47 -12.5 -12474 6.2 MLX CREB3L1 ZFP64 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF205 CREBBP THOC6 ZNF263 ZNF597 SNHG19 LOC105371055 SNORD60 ZNF213-AS1 ENSG00000200059
GH16F003105 1.6 FANTOM5 ENCODE 36.4 -6.2 -6194 2.2 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF302 ZNF143 FOS KLF13 ZNF205 ZNF213-AS1 CREBBP THOC6 LOC105371055 TRAF7 OR2C1 OR1F1 CLUAP1 PAQR4
GH16F003148 1.4 Ensembl ENCODE 30.5 +38.6 38626 4.9 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC CREBBP THOC6 ZNF213-AS1 ZNF263 LOC105371055 ZNF205 TRAF7 TIGD7 ZNF597 CLUAP1
GH16F003156 1.5 FANTOM5 ENCODE 27.2 +46.2 46234 3.8 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 FOS KLF13 CREBBP THOC6 ZNF213-AS1 CLUAP1 LOC105371055 ZNF263 ZNF597 ZNF205 ENSG00000279473 RNPS1
GH16F003123 1.1 ENCODE 35.8 +12.1 12073 2.1 PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF205 ZNF213-AS1 ENSG00000200059 ZNF205-AS1 ERVK13-1 GC16M003129 PIR58259
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF205 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF205 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000502700 340 1801 HDGF PKNOX1 ARNT ZFP64 SIN3A ARID4B FEZF1 DMAP1 ZNF2 ZNF143

Genomic Location for ZNF205 Gene

Chromosome:
16
Start:
3,112,560 bp from pter
End:
3,120,527 bp from pter
Size:
7,968 bases
Orientation:
Plus strand

Genomic View for ZNF205 Gene

Genes around ZNF205 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF205 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF205 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF205 Gene

Proteins for ZNF205 Gene

  • Protein details for ZNF205 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95201-ZN205_HUMAN
    Recommended name:
    Zinc finger protein 205
    Protein Accession:
    O95201
    Secondary Accessions:
    • A8MZK0
    • D3DUB4
    • Q9BU95

    Protein attributes for ZNF205 Gene

    Size:
    554 amino acids
    Molecular mass:
    60630 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC70007.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF205 Gene

Post-translational modifications for ZNF205 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF205 Gene

Domains & Families for ZNF205 Gene

Gene Families for ZNF205 Gene

Protein Domains for ZNF205 Gene

Suggested Antigen Peptide Sequences for ZNF205 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95201

UniProtKB/Swiss-Prot:

ZN205_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF205: view

Function for ZNF205 Gene

Molecular function for ZNF205 Gene

GENATLAS Biochemistry:
zinc finger protein 205,C2H2 type,with an alternative transcript ZNF210,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 16713569
GO:0008270 zinc ion binding NAS 9787081
genes like me logo Genes that share ontologies with ZNF205: view
genes like me logo Genes that share phenotypes with ZNF205: view

Animal Models for ZNF205 Gene

MGI Knock Outs for ZNF205:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF205 Gene

Localization for ZNF205 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF205 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF205 gene
Compartment Confidence
nucleus 5
mitochondrion 3
plasma membrane 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ZNF205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ZNF205: view

Pathways & Interactions for ZNF205 Gene

SuperPathways for ZNF205 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF205: view

Pathways by source for ZNF205 Gene

2 Reactome pathways for ZNF205 Gene

Gene Ontology (GO) - Biological Process for ZNF205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 22306510
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 9787081
GO:0010729 positive regulation of hydrogen peroxide biosynthetic process IMP 22306510
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IMP 22306510
genes like me logo Genes that share ontologies with ZNF205: view

No data available for SIGNOR curated interactions for ZNF205 Gene

Transcripts for ZNF205 Gene

Unigene Clusters for ZNF205 Gene

Zinc finger protein 205:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF205 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - -
SP3: -
SP4: - - -
SP5:

Relevant External Links for ZNF205 Gene

GeneLoc Exon Structure for
ZNF205
ECgene alternative splicing isoforms for
ZNF205

Expression for ZNF205 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF205 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZNF205 Gene:

ZNF205

SOURCE GeneReport for Unigene cluster for ZNF205 Gene:

Hs.592088

mRNA Expression by UniProt/SwissProt for ZNF205 Gene:

O95201-ZN205_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, pancreas and brain. Weakly expressed in placenta, lung, liver, kidney and thymus.
genes like me logo Genes that share expression patterns with ZNF205: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZNF205 Gene

Orthologs for ZNF205 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF205 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF205 34 35
  • 98.92 (n)
cow
(Bos Taurus)
Mammalia ZNF205 34 35
  • 84.52 (n)
dog
(Canis familiaris)
Mammalia ZNF205 34 35
  • 83.8 (n)
rat
(Rattus norvegicus)
Mammalia Zfp13 34
  • 81.76 (n)
mouse
(Mus musculus)
Mammalia Zfp13 34 16 35
  • 79.39 (n)
Species where no ortholog for ZNF205 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF205 Gene

ENSEMBL:
Gene Tree for ZNF205 (if available)
TreeFam:
Gene Tree for ZNF205 (if available)

Paralogs for ZNF205 Gene

Paralogs for ZNF205 Gene

(400) SIMAP similar genes for ZNF205 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF205: view

Variants for ZNF205 Gene

Sequence variations from dbSNP and Humsavar for ZNF205 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1075972 -- 3,113,967(+) AGTCA(G/T)CGACA intron-variant
rs111388627 -- 3,117,798(+) TAATA(C/T)GGAAA intron-variant
rs111474527 -- 3,119,150(+) GCGCT(C/T)TCTGG intron-variant
rs111515073 -- 3,115,746(+) GGGCC(A/G)GGGGT intron-variant, upstream-variant-2KB
rs111531242 -- 3,116,960(+) CGGCT(A/T)ATTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF205 Gene

Variant ID Type Subtype PubMed ID
nsv833125 CNV loss 17160897
nsv571249 CNV gain 21841781
nsv571248 CNV loss 21841781
nsv509589 CNV insertion 20534489
nsv457355 CNV gain 19166990

Variation tolerance for ZNF205 Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF205 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF205

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF205 Gene

Disorders for ZNF205 Gene

Relevant External Links for ZNF205

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF205

No disorders were found for ZNF205 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF205 Gene

Publications for ZNF205 Gene

  1. Identification of two Kruppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3. (PMID: 9787081) Deng Z. … Kastner D.L. (Genomics 1998) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. SUMO-2 orchestrates chromatin modifiers in response to DNA damage. (PMID: 25772364) Hendriks I.A. … Vertegaal A.C. (Cell Rep. 2015) 4 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP. (PMID: 22306510) Iida R. … Yasuda T. (Free Radic. Biol. Med. 2012) 3 64

Products for ZNF205 Gene

Sources for ZNF205 Gene

Content
Loading form....