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Aliases for ZNF202 Gene

Aliases for ZNF202 Gene

  • Zinc Finger Protein 202 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 10 3 4
  • ZKSCAN10 3 4
  • ZSCAN42 3

External Ids for ZNF202 Gene

Previous GeneCards Identifiers for ZNF202 Gene

  • GC11M125595
  • GC11M125107
  • GC11M123628
  • GC11M123132
  • GC11M123099
  • GC11M123594
  • GC11M119536

Summaries for ZNF202 Gene

GeneCards Summary for ZNF202 Gene

ZNF202 (Zinc Finger Protein 202) is a Protein Coding gene. Diseases associated with ZNF202 include colonic benign neoplasm. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF500.

UniProtKB/Swiss-Prot for ZNF202 Gene

  • Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.

Gene Wiki entry for ZNF202 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF202 Gene

Genomics for ZNF202 Gene

Regulatory Elements for ZNF202 Gene

Promoters for ZNF202 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF202 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF202 Gene

Chromosome:
11
Start:
123,723,927 bp from pter
End:
123,741,683 bp from pter
Size:
17,757 bases
Orientation:
Minus strand

Genomic View for ZNF202 Gene

Genes around ZNF202 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF202 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF202 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF202 Gene

Proteins for ZNF202 Gene

  • Protein details for ZNF202 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95125-ZN202_HUMAN
    Recommended name:
    Zinc finger protein 202
    Protein Accession:
    O95125
    Secondary Accessions:
    • B0LPH9
    • Q4JG21
    • Q9H1B9
    • Q9NSM4

    Protein attributes for ZNF202 Gene

    Size:
    648 amino acids
    Molecular mass:
    74720 Da
    Quaternary structure:
    • Interacts with SDP1.

    Alternative splice isoforms for ZNF202 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF202 Gene

Proteomics data for ZNF202 Gene at MOPED

Post-translational modifications for ZNF202 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ZNF202 Gene

Domains & Families for ZNF202 Gene

Gene Families for ZNF202 Gene

Suggested Antigen Peptide Sequences for ZNF202 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95125

UniProtKB/Swiss-Prot:

ZN202_HUMAN :
  • Contains 1 KRAB domain.
  • Contains 8 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF202: view

Function for ZNF202 Gene

Molecular function for ZNF202 Gene

GENATLAS Biochemistry:
zinc finger protein C2H2 type,specifically expressed in testis with two alternatively spliced isoforms alpha and beta
UniProtKB/Swiss-Prot Function:
Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.

Gene Ontology (GO) - Molecular Function for ZNF202 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF202: view
genes like me logo Genes that share phenotypes with ZNF202: view

Animal Models for ZNF202 Gene

MGI Knock Outs for ZNF202:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF202 Gene

Localization for ZNF202 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF202 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF202 Gene COMPARTMENTS Subcellular localization image for ZNF202 gene
Compartment Confidence
mitochondrion 5
nucleus 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZNF202 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF202: view

Pathways & Interactions for ZNF202 Gene

SuperPathways for ZNF202 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF202: view

Pathways by source for ZNF202 Gene

2 Reactome pathways for ZNF202 Gene

Gene Ontology (GO) - Biological Process for ZNF202 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 10748193
genes like me logo Genes that share ontologies with ZNF202: view

No data available for SIGNOR curated interactions for ZNF202 Gene

Drugs & Compounds for ZNF202 Gene

(3) Drugs for ZNF202 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for ZNF202 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZNF202: view

Transcripts for ZNF202 Gene

Unigene Clusters for ZNF202 Gene

Zinc finger protein 202:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF202 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - - -
SP2: - - - - - -
SP3:
SP4: - - -
SP5: - - - -
SP6: - -
SP7: - -
SP8: - - - - -
SP9:

Relevant External Links for ZNF202 Gene

GeneLoc Exon Structure for
ZNF202
ECgene alternative splicing isoforms for
ZNF202

Expression for ZNF202 Gene

mRNA expression in normal human tissues for ZNF202 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF202 Gene



SOURCE GeneReport for Unigene cluster for ZNF202 Gene Hs.112556

mRNA Expression by UniProt/SwissProt for ZNF202 Gene

O95125-ZN202_HUMAN
Tissue specificity: Highly expressed in testis. Also expressed in breast carcinoma cell lines.
genes like me logo Genes that share expression patterns with ZNF202: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for ZNF202 Gene

Orthologs for ZNF202 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF202 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF202 35
  • 85.39 (n)
  • 87.96 (a)
ZNF202 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF202 35
  • 89.04 (n)
  • 90.12 (a)
ZNF202 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp202 35
  • 81.59 (n)
  • 79.81 (a)
Zfp202 16
Zfp202 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF202 35
  • 99.18 (n)
  • 99.23 (a)
ZNF202 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp202 35
  • 81.74 (n)
  • 80.13 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF202 36
  • 73 (a)
OneToOne
Species with no ortholog for ZNF202:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF202 Gene

ENSEMBL:
Gene Tree for ZNF202 (if available)
TreeFam:
Gene Tree for ZNF202 (if available)

Paralogs for ZNF202 Gene

Paralogs for ZNF202 Gene

genes like me logo Genes that share paralogs with ZNF202: view

Variants for ZNF202 Gene

Sequence variations from dbSNP and Humsavar for ZNF202 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1144507 - 123,729,767(+) GCTCC(A/C/G/T)CTCCT reference, missense, utr-variant-5-prime
rs34111365 - 123,726,346(+) CCTGG(C/G)AGGCA reference, missense
rs10904 -- 123,725,347(-) CCAGC(A/G)TCAAA utr-variant-3-prime
rs481168 -- 123,723,532(+) TGCCA(A/C)TTCTG downstream-variant-500B
rs546218 -- 123,728,897(+) CATTT(G/T)GTTAG intron-variant

Variation tolerance for ZNF202 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF202 Gene

HapMap Linkage Disequilibrium report
ZNF202
Human Gene Mutation Database (HGMD)
ZNF202

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF202 Gene

Disorders for ZNF202 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF202 Gene - From: DISEASES

Disorder Aliases PubMed IDs
colonic benign neoplasm
  • colon neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF202

Genetic Association Database (GAD)
ZNF202
Human Genome Epidemiology (HuGE) Navigator
ZNF202
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF202
genes like me logo Genes that share disorders with ZNF202: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF202 Gene

Publications for ZNF202 Gene

  1. Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins. (PMID: 9790754) Monaco C. … Negrini M. (Genomics 1998) 2 3 4 67
  2. Functional promoter variant in zinc finger protein 202 predicts severe atherosclerosis and ischemic heart disease. (PMID: 18652945) Stene M.C. … Tybjaerg-Hansen A. (J. Am. Coll. Cardiol. 2008) 3 23
  3. Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study. (PMID: 16289551) Stene M.C. … Tybjaerg-Hansen A. (Atherosclerosis 2006) 3 23
  4. Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population. (PMID: 16467280) Stene M.C. … Tybjaerg-Hansen A. (J. Lipid Res. 2006) 3 23
  5. The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux. (PMID: 11279031) Porsch-Oezcueruemez M. … Schmitz G. (J. Biol. Chem. 2001) 3 23

Products for ZNF202 Gene

Sources for ZNF202 Gene

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