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Aliases for ZNF200 Gene

Aliases for ZNF200 Gene

  • Zinc Finger Protein 200 2 3 5
  • ZNFMF 4

External Ids for ZNF200 Gene

Previous GeneCards Identifiers for ZNF200 Gene

  • GC16M003292
  • GC16M003272
  • GC16M003212

Summaries for ZNF200 Gene

GeneCards Summary for ZNF200 Gene

ZNF200 (Zinc Finger Protein 200) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF597.

UniProtKB/Swiss-Prot for ZNF200 Gene

  • Could have a role in spermatogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF200 Gene

Genomics for ZNF200 Gene

Regulatory Elements for ZNF200 Gene

Promoters for ZNF200 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF200 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF200 Gene

Chromosome:
16
Start:
3,222,325 bp from pter
End:
3,236,221 bp from pter
Size:
13,897 bases
Orientation:
Minus strand

Genomic View for ZNF200 Gene

Genes around ZNF200 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF200 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF200 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF200 Gene

Proteins for ZNF200 Gene

  • Protein details for ZNF200 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98182-ZN200_HUMAN
    Recommended name:
    Zinc finger protein 200
    Protein Accession:
    P98182
    Secondary Accessions:
    • D3DUB7
    • D3DUB8
    • O15361
    • Q5XKM5
    • Q7Z5V1

    Protein attributes for ZNF200 Gene

    Size:
    395 amino acids
    Molecular mass:
    45534 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC70008.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH54005.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF200 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF200 Gene

Proteomics data for ZNF200 Gene at MOPED

Post-translational modifications for ZNF200 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF200 Gene

Domains & Families for ZNF200 Gene

Gene Families for ZNF200 Gene

Protein Domains for ZNF200 Gene

Graphical View of Domain Structure for InterPro Entry

P98182

UniProtKB/Swiss-Prot:

ZN200_HUMAN :
  • Contains 5 C2H2-type zinc fingers.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF200: view

Function for ZNF200 Gene

Molecular function for ZNF200 Gene

GENATLAS Biochemistry:
zinc finger protein 200,C2H2 type,predominantly expressed in testis
UniProtKB/Swiss-Prot Function:
Could have a role in spermatogenesis.

Gene Ontology (GO) - Molecular Function for ZNF200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with ZNF200: view
genes like me logo Genes that share phenotypes with ZNF200: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF200 Gene

Localization for ZNF200 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF200 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF200 Gene COMPARTMENTS Subcellular localization image for ZNF200 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF200 Gene

Pathways & Interactions for ZNF200 Gene

SuperPathways for ZNF200 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF200: view

Pathways by source for ZNF200 Gene

2 Reactome pathways for ZNF200 Gene

Gene Ontology (GO) - Biological Process for ZNF200 Gene

None

No data available for SIGNOR curated interactions for ZNF200 Gene

Drugs & Compounds for ZNF200 Gene

No Compound Related Data Available

Transcripts for ZNF200 Gene

Unigene Clusters for ZNF200 Gene

Zinc finger protein 200:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF200 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: - - -
SP3: -
SP4: -
SP5: - -
SP6: - - - -
SP7:

Relevant External Links for ZNF200 Gene

GeneLoc Exon Structure for
ZNF200
ECgene alternative splicing isoforms for
ZNF200

Expression for ZNF200 Gene

mRNA expression in normal human tissues for ZNF200 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF200 Gene

This gene is overexpressed in Testis (x5.1) and Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for ZNF200 Gene

This gene is overexpressed in Esophagus (47.8) and Saliva (21.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF200 Gene



SOURCE GeneReport for Unigene cluster for ZNF200 Gene Hs.632222

mRNA Expression by UniProt/SwissProt for ZNF200 Gene

P98182-ZN200_HUMAN
Tissue specificity: Highly expressed in testis, weakly expressed in spleen, thymus, prostate, ovary, small intestine colon and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with ZNF200: view

Protein tissue co-expression partners for ZNF200 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ZNF200 Gene

Orthologs for ZNF200 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF200 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF200 35
  • 88.01 (n)
  • 86.73 (a)
ZNF200 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF200 35
  • 87.44 (n)
  • 83.33 (a)
ZNF200 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF200 35
  • 99.41 (n)
  • 98.98 (a)
ZNF200 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF200 36
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CR352258.1 36
  • 35 (a)
OneToMany
Species with no ortholog for ZNF200:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF200 Gene

ENSEMBL:
Gene Tree for ZNF200 (if available)
TreeFam:
Gene Tree for ZNF200 (if available)

Paralogs for ZNF200 Gene

Paralogs for ZNF200 Gene

genes like me logo Genes that share paralogs with ZNF200: view

Variants for ZNF200 Gene

Sequence variations from dbSNP and Humsavar for ZNF200 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs9302870 - 3,232,468(+) CTGAC(A/G)TGAGT nc-transcript-variant, reference, missense
rs11228 -- 3,222,391(+) ACCAA(C/G)AAACT utr-variant-3-prime
rs224235 -- 3,226,444(+) CAAAA(A/G)CAGCT intron-variant
rs224236 -- 3,227,298(+) tttga(A/G)tctta intron-variant
rs442387 -- 3,236,118(+) GCCCA(C/T)TCCAG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF200 Gene

Variant ID Type Subtype PubMed ID
nsv457355 CNV Gain 19166990
nsv905208 CNV Loss 21882294
nsv833127 CNV Gain+Loss 17160897
nsv471074 CNV Gain 18288195
nsv905209 CNV Gain 21882294
nsv516280 CNV Gain 19592680
nsv509592 CNV Insertion 20534489
dgv2583n71 CNV Loss 21882294

Variation tolerance for ZNF200 Gene

Residual Variation Intolerance Score: 71.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF200 Gene

HapMap Linkage Disequilibrium report
ZNF200

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF200 Gene

Disorders for ZNF200 Gene

Relevant External Links for ZNF200

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF200

No disorders were found for ZNF200 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF200 Gene

Publications for ZNF200 Gene

  1. Identification of two Kruppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3. (PMID: 9787081) Deng Z. … Kastner D.L. (Genomics 1998) 2 3 4 67
  2. A candidate gene for familial Mediterranean fever. (PMID: 9288094) Bernot A. … Grateau G. (Nat. Genet. 1997) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3

Products for ZNF200 Gene

Sources for ZNF200 Gene

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