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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF200 Gene

protein-coding   GIFtS: 51
GCID: GC16M003242

zinc finger protein 200

 Explore 4 diseases affiliated with
ZNF200 via our new
 Human Malady Compendium 
Biological research products
for ZNF200
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 2001 2
ZNFMF3

External Ids:    HGNC: 129931   Entrez Gene: 77522   Ensembl: ENSG000000105397   OMIM: 6032315   UniProtKB: P981823   

Export aliases for ZNF200 gene to outside databases

Previous GC identifers: GC16M003292 GC16M003272 GC16M003212


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN200_HUMAN, P98182
Function: Could have a role in spermatogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF200 gene promoter:
         PPAR-gamma1   AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF200 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF200

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF200


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

ZNF200 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF200 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M003242:  view genomic region     (about GC identifiers)

Start:
3,272,325 bp from pter      End:
3,286,221 bp from pter
Size:
13,897 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN200_HUMAN, P98182 (See protein sequence)
Recommended Name: Zinc finger protein 200  
Size: 395 amino acids; 45534 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAC70008.1; Type=Erroneous initiation;
Secondary accessions: D3DUB8 O15361 Q5XKM5
Alternative splicing: 2 isoforms:  P98182-1   P98182-2   

Explore the universe of human proteins at neXtProt for ZNF200: NX_P98182

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P98182

  • ZNF200 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins (6 alternative transcripts): 
    NP_001138918.1  NP_001138919.1  NP_001138920.1  NP_003445.2  NP_932353.1  NP_932354.1  

    ENSEMBL proteins: 
     ENSP00000380077   ENSP00000405786   ENSP00000380080   ENSP00000395723   ENSP00000380079  
     ENSP00000458508   ENSP00000458777  
    Reactome Protein details: P98182
    Human Recombinant Protein Products for ZNF200: 
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    Novus Biologicals ZNF200 Proteins
    Novus Biologicals ZNF200 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF200

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus NAS--

    ZNF200 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF200 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P98182

    ProtoNet protein and cluster: P98182

    UniProtKB/Swiss-Prot: ZN200_HUMAN, P98182
    Similarity: Contains 5 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN200_HUMAN, P98182
    Function: Could have a role in spermatogenesis

         Genatlas biochemistry entry for ZNF200:
    zinc finger protein 200,C2H2 type,predominantly expressed in testis

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding IEA--
         
    ZNF200 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF200:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZNF200 

    miRNA
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    hsa-miR-548j hsa-miR-3607-3p hsa-let-7d hsa-miR-3651 hsa-miR-30d hsa-let-7g hsa-miR-30a hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidZNF200 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF200


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF200
        Generic Transcription Pathway
    Gene Expression



    ZNF200 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF200

    3 Interacting proteins for ZNF200 (P981822, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPARGC1BQ86YN63I2D: score=1 
    UBCP0CG483I2D: score=1 
    --P310162MINT-8105167
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0008150biological_process ND--

    ZNF200 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF200
    Search CenterWatch for drugs/clinical trials and news about ZNF200 / ZN200 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF200 gene (6 alternative transcripts): 
    NM_001145446.1  NM_001145447.1  NM_001145448.1  NM_003454.3  NM_198087.2  NM_198088.2  

    Unigene Cluster for ZNF200:

    Zinc finger protein 200
    Hs.632222  [show with all ESTs]
    Unigene Representative Sequence: NM_003454
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396868 ENST00000414144(uc002cuk.2 uc010bti.2 uc002cui.2 uc002cul.3)
    ENST00000396871 ENST00000431561(uc002cuj.2 uc002cum.3) ENST00000396870
    ENST00000575285 ENST00000575948 ENST00000575630 ENST00000575617 ENST00000577015


    miRNA
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF200 (see all 44):
    hsa-miR-548j hsa-miR-3607-3p hsa-let-7d hsa-miR-3651 hsa-miR-30d hsa-let-7g hsa-miR-30a hsa-let-7a
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF060866.1 AK056010.1 AK315036.1 BC012909.1 BC025293.1 BC032575.1 BC054005.1 Y14443.1 

    5 DOTS entries:

    DT.91752272  DT.92419243  DT.100776978  DT.120674488  DT.120674507 

    24/80 AceView cDNA sequences (see all 80):

    BU632258 BM840505 Y14443 BC025293 AU123793 AA916398 AA262064 NM_198088 
    BC012909 AA732442 AW291609 AA593878 NM_003454 AA338573 CA418180 BM747840 
    BE886797 AK056010 CR609782 CB157925 AA255747 NM_198087 AA291304 AF060866 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF200 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                                      -     -     -                                                   
    SP2:                                      -     -     -                                                   
    SP3:                                                  -                                                   
    SP4:                                                  -                                                   
    SP5:                                            -     -                                                   


    ECgene alternative splicing isoforms for ZNF200

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF200 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAAAACCCA
    ZNF200 Expression
    About this image
    Genevestigator expression for ZNF200

    SOURCE GeneReport for Unigene cluster: Hs.632222

    UniProtKB/Swiss-Prot: ZN200_HUMAN, P98182
    Tissue specificity: Highly expressed in testis, weakly expressed in spleen, thymus, prostate, ovary, small intestine
    colon and peripheral blood leukocytes

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ZNF200 (if available)
    TreeFam Gene Tree for ZNF200 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF200 gene
    ZNF5972  
    18/169 SIMAP similar genes for ZNF200 using alignment to 5 protein entries:     ZN200_HUMAN (see all proteins) (see all similar genes):
    kr-znf3    ZNF818P    ZFS-5    ZNF78L1    ZNF55    ZFS-4
    ZNF567    ZNF    DKFZp434J0650    ZNF391    ZNF663    ZNF774
    DKFZp686O111    ZFS-1    ZNF132    ZNF286B    ZNF418    ZNF546

    ZNF200 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/389 NCBI SNPs in ZNF200 are shown (see all 389    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs767679291,2
    F--3256807(+) GCATAA/TTTATA 2 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1121759891,2
    F--3256887(+) TACTCC/ATGGGA 2 -- us2k12Minor allele frequency- A:0.50CSA 4
    rs286995131,2
    C--3256918(+) TGCCTG/ATAATC 2 -- us2k13Minor allele frequency- A:0.17NA WA 6
    rs727744671,2
    --3271887(+) ATACCC/TGACTC 6 -- ds50010--------
    rs1458066501,2
    --3271894(+) ACTCTG/TGGCAG 6 -- ds50010--------
    rs2010350901,2
    --3271938(+) CACTC-/AACTTC 6 -- ds50010--------
    rs1489890571,2
    --3271956(+) CTACTC/TTTCTG 6 -- ds50010--------
    rs1861789661,2
    --3272039(+) TAGTGC/TACTGG 6 -- ds50010--------
    rs1152181881,2
    --3272102(+) TGCTGG/ACTTTA 6 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1174502341,2
    F--3272140(+) CAATGT/GTGGTA 6 -- ds50011Minor allele frequency- G:0.04NA 120

    HapMap Linkage Disequilibrium report for ZNF200 (3272325 - 3286221 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ZNF200
         2 CNVs: 49690 4921

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF200 for disorders           About GeneDecksing

    OMIM gene information: 603231    OMIM disorders: --

    4 diseases for ZNF200:    About MalaCards
    familial mediterranean fever    fanconi's anemia    anemia    prostatitis


    Export disorders for ZNF200 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF200 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with ZNF200)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two Kruppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3. (PubMed id 9787081)1, 2, 3 Deng Z....Kastner D.L. (1998)
    2. A candidate gene for familial Mediterranean fever. (PubMed id 9288094)1, 2, 3 Bernot A.... Grateau G. (1997)
    3. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    4. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    6. Identification of ZNF200 as a novel binding partner of histone H3 methyltransferase G9a. (PubMed id 17584299)1 Nishida M....Yamaguchi M. (2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7752 HGNC: 12993 AceView: ZNF200 Ensembl:ENSG00000010539 euGenes: HUgn7752
    ECgene: ZNF200 H-InvDB: ZNF200

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF200 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF200 gene:
    Search GeneIP for patents involving ZNF200

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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