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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF200 Gene

protein-coding   GIFtS: 51
GCID: GC16M003242

Zinc Finger Protein 200

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 2001 2
ZNFMF3

External Ids:    HGNC: 129931   Entrez Gene: 77522   Ensembl: ENSG000000105397   OMIM: 6032315   UniProtKB: P981823   

Export aliases for ZNF200 gene to outside databases

Previous GC identifers: GC16M003292 GC16M003272 GC16M003212


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF200 Gene: 
ZNF200 (zinc finger protein 200) is a protein-coding gene. Diseases associated with ZNF200 include familial mediterranean fever, and fanconi's anemia, and among its related super-pathways are Gene Expression. GO annotations related to this gene include molecular_function and nucleic acid binding. An important paralog of this gene is ZNF597.

UniProtKB/Swiss-Prot: ZN200_HUMAN, P98182
Function: Could have a role in spermatogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF200 gene promoter:
         PPAR-gamma1   AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF200 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF200

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF200


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

ZNF200 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF200 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M003242:  view genomic region     (about GC identifiers)

Start:
3,272,325 bp from pter      End:
3,286,221 bp from pter
Size:
13,897 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN200_HUMAN, P98182 (See protein sequence)
Recommended Name: Zinc finger protein 200  
Size: 395 amino acids; 45534 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAC70008.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH54005.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: D3DUB7 D3DUB8 O15361 Q5XKM5 Q7Z5V1
Alternative splicing: 3 isoforms:  P98182-1   P98182-2   P98182-3   

Explore the universe of human proteins at neXtProt for ZNF200: NX_P98182

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P98182

  • ZNF200 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (6 alternative transcripts): 
    NP_001138918.1  NP_001138919.1  NP_001138920.1  NP_003445.2  NP_932353.1  NP_932354.1  

    ENSEMBL proteins: 
     ENSP00000380077   ENSP00000405786   ENSP00000380080   ENSP00000395723   ENSP00000380079  
     ENSP00000458508   ENSP00000458777  
    Reactome Protein details: P98182
    Human Recombinant Protein Products for ZNF200: 
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    Novus Biologicals ZNF200 Proteins
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    Cloud-Clone Corp. Proteins for ZNF200 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--

    ZNF200 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P98182

    ProtoNet protein and cluster: P98182

    UniProtKB/Swiss-Prot: ZN200_HUMAN, P98182
    Similarity: Contains 5 C2H2-type zinc fingers


    ZNF200 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN200_HUMAN, P98182
    Function: Could have a role in spermatogenesis

         Genatlas biochemistry entry for ZNF200:
    zinc finger protein 200,C2H2 type,predominantly expressed in testis

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF200 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF200:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF200 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF200 
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    miRNA
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF200 (see all 44):
    hsa-miR-548j hsa-miR-3607-3p hsa-let-7d hsa-miR-3651 hsa-miR-30d hsa-let-7g hsa-miR-30a hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidZNF200 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF200 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF200
        Generic Transcription Pathway
    Gene Expression



    ZNF200 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF200

    3 Interacting proteins for ZNF200 (P981822, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPARGC1BQ86YN63I2D: score=1 
    UBCP0CG483I2D: score=1 
    --P310162MINT-8105167
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0008150biological_process ND--

    ZNF200 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF200 (ZN200)

    Search CenterWatch for drugs/clinical trials and news about ZNF200 / ZN200

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF200 gene (6 alternative transcripts): 
    NM_001145446.1  NM_001145447.1  NM_001145448.1  NM_003454.3  NM_198087.2  NM_198088.2  

    Unigene Cluster for ZNF200:

    Zinc finger protein 200
    Hs.632222  [show with all ESTs]
    Unigene Representative Sequence: NM_003454
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396868 ENST00000414144(uc002cuk.2 uc010bti.2 uc002cui.2 uc002cul.3)
    ENST00000396871 ENST00000431561(uc002cuj.2 uc002cum.3) ENST00000396870
    ENST00000575285 ENST00000575948 ENST00000575630 ENST00000575617 ENST00000577015

    miRNA
    Products:
         
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF200 (see all 44):
    hsa-miR-548j hsa-miR-3607-3p hsa-let-7d hsa-miR-3651 hsa-miR-30d hsa-let-7g hsa-miR-30a hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidZNF200 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF060866.1 AK056010.1 AK315036.1 BC012909.1 BC025293.1 BC032575.1 BC054005.1 Y14443.1 

    5 DOTS entries:

    DT.91752272  DT.92419243  DT.100776978  DT.120674488  DT.120674507 

    24/80 AceView cDNA sequences (see all 80):

    AI859128 NM_198088 AA291304 BM783614 CR609782 BE886797 Y14443 NM_198087 
    BU632258 BC012909 BC032575 AW291609 AA255747 AA338573 BM747840 AF060866 
    AA732442 CB157925 NM_003454 AU123793 BM840692 CA418180 BM784349 AA593878 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF200 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                                      -     -     -                                                   
    SP2:                                      -     -     -                                                   
    SP3:                                                  -                                                   
    SP4:                                                  -                                                   
    SP5:                                            -     -                                                   


    ECgene alternative splicing isoforms for ZNF200

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF200 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAAACCCA
    ZNF200 Expression
    About this image


    Genevestigator expression for ZNF200

    SOURCE GeneReport for Unigene cluster: Hs.632222

    UniProtKB/Swiss-Prot: ZN200_HUMAN, P98182
    Tissue specificity: Highly expressed in testis, weakly expressed in spleen, thymus, prostate, ovary, small
    intestine colon and peripheral blood leukocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF200 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF2001 zinc finger protein 200 87.18(n)
    83.33(a)
      490042  XM_547162.3  XP_547162.3 


    ENSEMBL Gene Tree for ZNF200 (if available)
    TreeFam Gene Tree for ZNF200 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF200 gene
    ZNF5972  
    18/106 SIMAP similar genes for ZNF200 using alignment to 3 protein entries:     ZN200_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    ZNF567    ZNF391    ZNF663    ZNF774    DKFZp686O111
    ZFS-1    ZNF132    ZNF286B    ZNF418    ZNF667    ZFP37
    ZNF12    ZNF16    ZNF180    ZNF544    ZNF85    ZNF93

    ZNF200 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/466 SNPs in ZNF200 are shown (see all 466)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1163675471,2
    F--3256771(+) TATTAC/TATGAA 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs767679291,2
    F--3256807(+) GCATAA/TTTATA 2 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1464392501,2
    --3256828(+) AAACAA/CAACAC 2 -- us2k10--------
    rs1121759891,2
    F--3256887(+) TACTCC/ATGGGA 2 -- us2k12Minor allele frequency- A:0.50CSA 4
    rs1398641961,2
    C--3256891(+) CATGGC/GATGGC 2 -- us2k10--------
    rs1167731331,2
    F--3256899(+) GGCCAG/AGCGCA 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs286995131,2
    C,F--3256918(+) TGCCTG/ATAATC 2 -- us2k13Minor allele frequency- A:0.17NA WA 6
    rs1511387811,2
    --3256970(+) TTAGGA/TGTTCA 2 -- us2k10--------
    rs1859480501,2
    --3256997(+) CATGGG/TGAAAC 2 -- us2k10--------
    rs1401196531,2
    C--3257045(+) GGTGGC/TGGGTG 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF200 (3272325 - 3286221 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZNF200:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509592CNV Insertion20534489
    nsv905208CNV Loss21882294
    dgv2583n71CNV Loss21882294
    nsv905209CNV Gain21882294
    nsv471074CNV Gain18288195
    nsv457355CNV Gain19166990
    nsv516280CNV Gain19592680
    nsv833127CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603231    OMIM disorders: --

    4 diseases for ZNF200:    About MalaCards
    familial mediterranean fever    fanconi's anemia    anemia    prostatitis


    ZNF200 for disorders           About GeneDecksing


    Export disorders for ZNF200 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF200 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ZNF200)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two Kruppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3. (PubMed id 9787081)1, 2, 3 Deng Z....Kastner D.L. (1998)
    2. A candidate gene for familial Mediterranean fever. (PubMed id 9288094)1, 2, 3 Bernot A.... Grateau G. (1997)
    3. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    4. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
    5. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    6. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    8. Identification of ZNF200 as a novel binding partner of histone H3 methyltransferase G9a. (PubMed id 17584299)1 Nishida M....Yamaguchi M. (2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7752 HGNC: 12993 AceView: ZNF200 Ensembl:ENSG00000010539 euGenes: HUgn7752
    ECgene: ZNF200 H-InvDB: ZNF200

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF200 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF200 gene:
    Search GeneIP for patents involving ZNF200

    GeneCards and IP:
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