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Aliases for ZNF20 Gene

Aliases for ZNF20 Gene

  • Zinc Finger Protein 20 2 3 5
  • Zinc Finger Protein KOX13 3 4
  • KOX13 3 4
  • Zinc Finger Protein 20 (KOX 13) 2

External Ids for ZNF20 Gene

Previous GeneCards Identifiers for ZNF20 Gene

  • GC19M012374
  • GC19M012465
  • GC19M012089
  • GC19M012241
  • GC19M011818

Summaries for ZNF20 Gene

GeneCards Summary for ZNF20 Gene

ZNF20 (Zinc Finger Protein 20) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF433.

UniProtKB/Swiss-Prot for ZNF20 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF20 Gene

Genomics for ZNF20 Gene

Regulatory Elements for ZNF20 Gene

Enhancers for ZNF20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G012139 1 ENCODE 6.1 +0.2 151 2.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 CBX5 ELK1 ZNF143 ZNF207 ZNF433 RNA5SP464 LOC101928464 ZNF20 GC19M012133
GH19G012288 1.3 Ensembl ENCODE 4.3 -148.8 -148768 2.1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 ZNF44 WDR83OS ZNF788 ZNF700 TRMT1 ZNF136 ZNF564 ZNF791 ZNF625-ZNF20 ZNF440
GH19G012155 1 ENCODE 5.4 -15.9 -15919 2.2 HDGF PKNOX1 ZNF133 ARID4B SIN3A GLI4 ZNF2 ZNF48 GLIS2 ZNF143 FBXW9 ZNF627 PRKCSH ENSG00000248406 ZNF709 RPL18AP13 ZNF700 ZNF44 ZNF20 ZNF625-ZNF20
GH19G012091 0.9 ENCODE 5.3 +48.0 48026 2.0 HDAC1 TBP PKNOX1 ARID4B ZBTB40 RAD21 NFYA SMAD5 GTF2B NFYC C19orf43 PRKCSH ZNF700 WDR83OS ZNF136 ZNF799 ZNF564 ZNF433 ZNF791 ZNF44
GH19G012137 0.7 ENCODE 6.2 +2.7 2677 0.1 SOX13 DRAP1 CTCF SAP130 ARID4B CEBPG RAD21 TEAD3 ZNF143 SMC3 ZNF20 GC19M012133
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF20 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107248 507 1401 PKNOX1 ARID4B SIN3A DMAP1 ELK1 ZNF143 ZNF207 FOS NFYC REST

Genomic Location for ZNF20 Gene

Chromosome:
19
Start:
12,092,843 bp from pter
End:
12,140,407 bp from pter
Size:
47,565 bases
Orientation:
Minus strand

Genomic View for ZNF20 Gene

Genes around ZNF20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF20 Gene

Proteins for ZNF20 Gene

  • Protein details for ZNF20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17024-ZNF20_HUMAN
    Recommended name:
    Zinc finger protein 20
    Protein Accession:
    P17024
    Secondary Accessions:
    • Q8N457
    • Q9UG41

    Protein attributes for ZNF20 Gene

    Size:
    532 amino acids
    Molecular mass:
    61567 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF20 Gene

Post-translational modifications for ZNF20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF20 Gene

No data available for DME Specific Peptides for ZNF20 Gene

Domains & Families for ZNF20 Gene

Gene Families for ZNF20 Gene

Protein Domains for ZNF20 Gene

Suggested Antigen Peptide Sequences for ZNF20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17024

UniProtKB/Swiss-Prot:

ZNF20_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF20: view

Function for ZNF20 Gene

Molecular function for ZNF20 Gene

GENATLAS Biochemistry:
zinc finger protein 20 (KOX13) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF20: view
genes like me logo Genes that share phenotypes with ZNF20: view

Animal Model Products

CRISPR Products

miRNA for ZNF20 Gene

miRTarBase miRNAs that target ZNF20

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF20 Gene

Localization for ZNF20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF20 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF20 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF20: view

Pathways & Interactions for ZNF20 Gene

SuperPathways for ZNF20 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF20: view

Pathways by source for ZNF20 Gene

2 Reactome pathways for ZNF20 Gene

Gene Ontology (GO) - Biological Process for ZNF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF20: view

No data available for SIGNOR curated interactions for ZNF20 Gene

Drugs & Compounds for ZNF20 Gene

No Compound Related Data Available

Transcripts for ZNF20 Gene

Unigene Clusters for ZNF20 Gene

Zinc finger protein 20:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF20 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6:
SP7: - -
SP8: -
SP9: - - - -

Relevant External Links for ZNF20 Gene

GeneLoc Exon Structure for
ZNF20
ECgene alternative splicing isoforms for
ZNF20

Expression for ZNF20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF20 Gene

This gene is overexpressed in Testis (x13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF20 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF20 Gene:

ZNF20

SOURCE GeneReport for Unigene cluster for ZNF20 Gene:

Hs.512823

Evidence on tissue expression from TISSUES for ZNF20 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF20: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF20 Gene

Orthologs for ZNF20 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF20 34
  • 99.75 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 50 (a)
ManyToMany
Species where no ortholog for ZNF20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF20 Gene

ENSEMBL:
Gene Tree for ZNF20 (if available)
TreeFam:
Gene Tree for ZNF20 (if available)

Paralogs for ZNF20 Gene

(521) SIMAP similar genes for ZNF20 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNF20 Gene

genes like me logo Genes that share paralogs with ZNF20: view

Variants for ZNF20 Gene

Sequence variations from dbSNP and Humsavar for ZNF20 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000003116 -- 12,131,343(+) ACATA(A/C)CCCAA intron-variant, downstream-variant-500B
rs1000102253 -- 12,142,358(+) ATTTT(C/G)TTTTG intron-variant, upstream-variant-2KB
rs1000557516 -- 12,142,062(+) CAGTC(C/T)ACATG intron-variant, upstream-variant-2KB
rs1000749406 -- 12,136,439(+) CACTT(G/T)GGGAG intron-variant
rs1000951901 -- 12,134,614(+) CTCCC(A/G)CCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF20 Gene

Variant ID Type Subtype PubMed ID
esv2665806 CNV deletion 23128226
nsv578619 CNV loss 21841781
nsv833753 CNV loss 17160897
nsv961178 CNV duplication 23825009

Variation tolerance for ZNF20 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF20 Gene

Disorders for ZNF20 Gene

Relevant External Links for ZNF20

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF20

No disorders were found for ZNF20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF20 Gene

Publications for ZNF20 Gene

  1. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4 64
  2. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart A.E. … Wells C.M. (J. Cell Biol. 2015) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for ZNF20 Gene

Sources for ZNF20 Gene

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