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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF20 Gene

protein-coding   GIFtS: 52
GCID: GC19M012241

zinc finger protein 20

(Previous name: zinc finger protein 20 (KOX 13) )
 Explore 4 diseases affiliated with
ZNF20 via our new
 Human Malady Compendium 
Biological research products
for ZNF20
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 201 2
KOX131 2 3 5
Zinc Finger Protein KOX132 3
Zinc Finger Protein 20 (KOX 13)1

External Ids:    HGNC: 129921   Entrez Gene: 75682   Ensembl: ENSG000001320107   OMIM: 1945575   UniProtKB: P170243   

Export aliases for ZNF20 gene to outside databases

Previous GC identifers: GC19M012374 GC19M012465 GC19M012089 GC19M012103 GC19M011818


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZNF20_HUMAN, P17024
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF20 gene promoter:
         SRF   POU2F1   POU2F1a   SRF (504 AA)   p300   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF20 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF20 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M012241:  view genomic region     (about GC identifiers)

Start:
12,241,300 bp from pter      End:
12,251,222 bp from pter
Size:
9,923 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZNF20_HUMAN, P17024 (See protein sequence)
Recommended Name: Zinc finger protein 20  
Size: 532 amino acids; 61567 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q8N457 Q9UG41

Explore the universe of human proteins at neXtProt for ZNF20: NX_P17024

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17024

  • ZNF20 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001190179.1  NP_066966.2  

    ENSEMBL proteins: 
     ENSP00000335437   ENSP00000390115   ENSP00000402483  
    Reactome Protein details: P17024
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF20

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--


    ZNF20 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZNF20


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF20 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17024

    ProtoNet protein and cluster: P17024

    2 Blocks protein families:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZNF20_HUMAN, P17024
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 15 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZNF20_HUMAN, P17024
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF20:
    zinc finger protein 20 (KOX13) (C2H2 type,Kruppel-like)

    miRNA
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    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    ZNF20 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF20
        Generic Transcription Pathway
    Gene Expression



    ZNF20 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF20

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/15 Interacting proteins for ZNF20 (P170242, 3 ENSP000003354374) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF174Q156973, ENSP000002686554I2D: score=1 STRING: ENSP00000268655
    HAP1P542573I2D: score=3 
    FBLP220872MINT-8373408
    HEMGNQ9BXL52MINT-8373408
    HNRNPA3P519912MINT-8373408
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    ZNF20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF20
    Search CenterWatch for drugs/clinical trials and news about ZNF20 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF20 gene (2 alternative transcripts): 
    NM_001203250.1  NM_021143.3  

    Unigene Cluster for ZNF20:

    Zinc finger protein 20
    Hs.512823  [show with all ESTs]
    Unigene Representative Sequence: NR_037802
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480770 ENST00000334213(uc002mte.2 uc002mtf.2 uc021upm.1 uc002mtg.2)
    ENST00000418866 ENST00000454949 ENST00000485451 ENST00000478942 ENST00000480477


    miRNA
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    Inhib. RNA
    Products:
         
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    Additional cDNA sequence: 

    AK023094.1 AL080125.1 BC036714.2 BC045814.1 NR_037802.1 X52344.1 

    8 DOTS entries:

    DT.100018881  DT.208702  DT.91917588  DT.99981643  DT.121449763  DT.121449783  DT.121449778  DT.40291078 

    24/78 AceView cDNA sequences (see all 78):

    AK096560 BC045814 BX440069 BE219250 AL080125 CB152168 BF062327 AI936844 
    BC036714 AU133067 AI968718 AI085836 AA860133 BE551497 BX100736 X52344 
    T16780 CA441751 BE408214 BE729270 W32055 NM_021143 AA868931 BE877366 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF20 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d
    SP1:                    -           -     -     -     -           -     -     -                             -     -                           
    SP2:                                                              -     -     -                             -     -                           
    SP3:                                                              -     -     -     -                       -     -                           
    SP4:                                                              -     -     -     -                       -                                 
    SP5:                                                                    -     -     -                       -     -                           


    ECgene alternative splicing isoforms for ZNF20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCACTTTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF20

    SOURCE GeneReport for Unigene cluster: Hs.512823
        SABiosciences Custom PCR Arrays for ZNF20
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ZNF20 (if available)
    TreeFam Gene Tree for ZNF20 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF20 gene
    ZNF6692  ZNF4902  ZNF5642  ZNF4412  ZNF8782  ENSG000002671792  ZNF142  ENSG000001968262  
    ZNF7002  ZNF692  ZNF4402  ZNF4432  ZNF442  ZNF4392  ZNF8232  ZNF4912  
    ENSG000001884742  ZNF5552  ZNF7092  ZNF6252  ZNF7992  ZNF1012  ZNF7912  ZNF4422  
    ZNF4332  ZNF572  ZNF5632  ZNF6272  ENSG000002573552  ZNF1362  ZNF5562  ZNF6702  
    ZNF7632  ZNF1242  ZNF6992  ZNF8442  ZNF772  
    18/450 SIMAP similar genes for ZNF20 using alignment to 5 protein entries:     ZNF20_HUMAN (see all proteins) (see all similar genes):
    ZNF625    POM121C    ZNF433    ZNF833P    ZNF491    ZNF627
    HZF36    ZNF124    ZNF69    MGC12518    ZFP41    ZNF791
    ZNF443    ZNF283    ZNF669    DKFZp666C237    DKFZp666M039    ZNF232

    ZNF20 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF20
    PGOHUM00000234500


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/181 NCBI SNPs in ZNF20 are shown (see all 181    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs72459761,2
    C,F,A,H,--12241806(+) GCAGGG/ACACAG 3 -- int1 ds50018Minor allele frequency- A:0.06NS NA WA CSA 795
    rs65117671,2
    C,F,A,--12241866(+) CACGAA/GGTCAG 3 -- int1 ds50014Minor allele frequency- G:0.25NA WA CSA 8
    rs1423619601,2
    --12241952(+) TAGTCA/CCAGTT 3 -- int1 ds50010--------
    rs1460162891,2
    --12241986(+) ATGGCA/GTGAAC 3 -- ds5001 int10--------
    rs1865653751,2
    --12242098(+) AAAACC/TTCATT 3 -- int1 ds50010--------
    rs1482787441,2
    --12242155(+) CAAACA/GTACCC 3 -- ds5001 int10--------
    rs1910173781,2
    --12242179(+) TCTCAC/TGAAAT 3 -- ut31 nc-transcript-variant0--------
    rs1830776211,2
    --12242276(+) TTTGAC/TGACAC 3 -- ut31 nc-transcript-variant0--------
    rs104163771,2
    C,F,H,--12242300(+) GGTCTT/CTGGTC 3 -- ut31 nc-transcript-variant10Minor allele frequency- C:0.03NS EA WA NA 1210
    rs10365931,2
    C,F,O,A,H,--12242460(-) GGTGGT/ACACTG 3 -- nc-transcript-variantut3121Minor allele frequency- A:0.25MN NS EA NA WA CSA 2530

    HapMap Linkage Disequilibrium report for ZNF20 (12241300 - 12251222 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNF20: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF20 for disorders           About GeneDecksing

    OMIM gene information: 194557    OMIM disorders: --

    4 diseases for ZNF20:    About MalaCards
    papillary thyroid carcinoma    thyroid carcinoma    thyroiditis    carcinoma


    Export disorders for ZNF20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF20 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
    2. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. The KOX zinc finger genes: genome wide mapping of 368 ZNF PAC clones with zinc finger gene clusters predominantly in 23 chromosomal loci are confirmed by human sequences annotated in EnsEMBL. (PubMed id 12697996)1 Rousseau-Merck M.F....Thiesen H.J. (2002)
    10. The zinc finger-associated SCAN box is a conserved oligomerization domain. (PubMed id 10567577)1 Williams A.J....Collins T. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7568 HGNC: 12992 AceView: ZNF20andZNF625andLOC388508 Ensembl:ENSG00000132010 euGenes: HUgn7568
    ECgene: ZNF20 H-InvDB: ZNF20

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF20 gene:
    Search GeneIP for patents involving ZNF20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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