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Aliases for ZNF2 Gene

Aliases for ZNF2 Gene

  • Zinc Finger Protein 2 2 3 5
  • Zinc Finger Protein 2.2 3 4
  • Zinc Finger Protein 661 3 4
  • ZNF661 3 4
  • Zinc Finger Protein 2 (A1-5) 2
  • Zfp661 3
  • A1-5 3

External Ids for ZNF2 Gene

Previous GeneCards Identifiers for ZNF2 Gene

  • GC02P093728
  • GC02P094264
  • GC02P095299
  • GC02P095315
  • GC02P095162
  • GC02P095253
  • GC02P095194
  • GC02P095831
  • GC02P089859

Summaries for ZNF2 Gene

Entrez Gene Summary for ZNF2 Gene

  • The protein encoded by this gene belongs to the C2H2-type zinc-finger protein family. The exact function of this gene is not known, however, zinc-finger proteins are known to interact with DNA and function as transcription regulators. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

GeneCards Summary for ZNF2 Gene

ZNF2 (Zinc Finger Protein 2) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF789.

UniProtKB/Swiss-Prot for ZNF2 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF2 Gene

Genomics for ZNF2 Gene

Regulatory Elements for ZNF2 Gene


Promoters for ZNF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001544364 283 2600 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for ZNF2 Gene

Chromosome:
2
Start:
95,165,417 bp from pter
End:
95,184,317 bp from pter
Size:
18,901 bases
Orientation:
Plus strand

Genomic View for ZNF2 Gene

Genes around ZNF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF2 Gene

Proteins for ZNF2 Gene

  • Protein details for ZNF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSG1-ZNF2_HUMAN
    Recommended name:
    Zinc finger protein 2
    Protein Accession:
    Q9BSG1
    Secondary Accessions:
    • A8MWV7
    • B4DIR4
    • Q4ZFY6
    • Q96G44
    • Q9UMC5

    Protein attributes for ZNF2 Gene

    Size:
    426 amino acids
    Molecular mass:
    48863 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX88982.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF2 Gene

Post-translational modifications for ZNF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for ZNF2
  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF2

No data available for DME Specific Peptides for ZNF2 Gene

Domains & Families for ZNF2 Gene

Gene Families for ZNF2 Gene

Protein Domains for ZNF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BSG1

UniProtKB/Swiss-Prot:

ZNF2_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF2: view

Function for ZNF2 Gene

Molecular function for ZNF2 Gene

GENATLAS Biochemistry:
zinc finger protein 2 (A1-5) with Kruppel type C2H2 finger motif,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0008270 zinc ion binding NAS 1945843
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF2: view
genes like me logo Genes that share phenotypes with ZNF2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF2 Gene

Localization for ZNF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF2 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF2: view

Pathways & Interactions for ZNF2 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF2: view

Pathways by source for ZNF2 Gene

2 Reactome pathways for ZNF2 Gene

Gene Ontology (GO) - Biological Process for ZNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 1945843
genes like me logo Genes that share ontologies with ZNF2: view

No data available for SIGNOR curated interactions for ZNF2 Gene

Transcripts for ZNF2 Gene

Unigene Clusters for ZNF2 Gene

Zinc finger protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF2 Gene

No ASD Table

Relevant External Links for ZNF2 Gene

GeneLoc Exon Structure for
ZNF2
ECgene alternative splicing isoforms for
ZNF2

Expression for ZNF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF2 Gene

Protein differential expression in normal tissues from HIPED for ZNF2 Gene

This gene is overexpressed in Heart (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF2 Gene



Protein tissue co-expression partners for ZNF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF2 Gene:

ZNF2

SOURCE GeneReport for Unigene cluster for ZNF2 Gene:

Hs.590916
genes like me logo Genes that share expression patterns with ZNF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF2 Gene

Orthologs for ZNF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF2 34
  • 99.45 (n)
cow
(Bos Taurus)
Mammalia ZNF2 34
  • 85.93 (n)
dog
(Canis familiaris)
Mammalia LOC100856076 34
  • 85.33 (n)
rat
(Rattus norvegicus)
Mammalia LOC100909998 34
  • 80.52 (n)
mouse
(Mus musculus)
Mammalia Zfp661 34 16
  • 79.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18555 36
  • 44 (a)
CG17803 36
  • 36 (a)
Species where no ortholog for ZNF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF2 Gene

ENSEMBL:
Gene Tree for ZNF2 (if available)
TreeFam:
Gene Tree for ZNF2 (if available)

Paralogs for ZNF2 Gene

Paralogs for ZNF2 Gene

(527) SIMAP similar genes for ZNF2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNF2 Gene

genes like me logo Genes that share paralogs with ZNF2: view

Variants for ZNF2 Gene

Sequence variations from dbSNP and Humsavar for ZNF2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs111737364 -- 95,165,925(+) GACAT(A/G)AGAAC intron-variant, upstream-variant-2KB
rs112155629 -- 95,164,257(+) CTTAG(C/T)ACAAC intron-variant, upstream-variant-2KB
rs112239855 -- 95,168,113(+) GTGGA(A/G)AATGC intron-variant
rs112887855 -- 95,181,299(+) CGGCG(A/G)CGACG reference, synonymous-codon
rs112945567 -- 95,179,901(+) AAAAT(-/A)CAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF2 Gene

Variant ID Type Subtype PubMed ID
nsv1160825 CNV duplication 26073780
esv3591652 OTHER inversion 21293372
dgv4007n100 CNV gain 25217958

Variation tolerance for ZNF2 Gene

Residual Variation Intolerance Score: 47.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF2 Gene

Disorders for ZNF2 Gene

Relevant External Links for ZNF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF2

No disorders were found for ZNF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF2 Gene

Publications for ZNF2 Gene

  1. Members of the zinc finger protein gene family sharing a conserved N- terminal module. (PMID: 1945843) Rosati M. … Grimaldi G. (Nucleic Acids Res. 1991) 2 3 4 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The KrA1ppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. (PMID: 8183940) Witzgall R. … Bonventre J.V. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 64

Products for ZNF2 Gene

Sources for ZNF2 Gene

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