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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF2 Gene

protein-coding   GIFtS: 51
GCID: GC02P095831

Zinc Finger Protein 2

(Previous name: zinc finger protein 2 (A1-5))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 21 2     Zinc Finger Protein 2 (A1-5)1
Zinc Finger Protein 2.22 3     A1-52
Zinc Finger Protein 6612 3     Zfp6612
ZNF6612 3     

External Ids:    HGNC: 129911   Entrez Gene: 75492   Ensembl: ENSG000001630677   OMIM: 1945005   UniProtKB: Q9BSG13   

Export aliases for ZNF2 gene to outside databases

Previous GC identifers: GC02P093728 GC02P094264 GC02P095299 GC02P095315 GC02P095162 GC02P095253 GC02P095194 GC02P089859


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF2 Gene:
The protein encoded by this gene belongs to the krueppel C2H2-type zinc-finger protein family. The exact function
of this gene is not known, however, zinc-finger proteins are known to interact with DNA and function as
transcription regulators. Alternatively spliced transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Sep 2013)

GeneCards Summary for ZNF2 Gene: 
ZNF2 (zinc finger protein 2) is a protein-coding gene. Diseases associated with ZNF2 include cryptococcosis, and hypoparathyroidism, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF707.

UniProtKB/Swiss-Prot: ZNF2_HUMAN, Q9BSG1
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022171.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF2 gene promoter:
         STAT1   HTF   p300   STAT1beta   STAT5A   STAT1alpha   FAC1   Ik-2   c-Myb   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.1   HGNC cytogenetic band: 2q11.1

ZNF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P095831:  view genomic region     (about GC identifiers)

Start:
95,831,177 bp from pter      End:
95,850,065 bp from pter
Size:
18,889 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZNF2_HUMAN, Q9BSG1 (See protein sequence)
Recommended Name: Zinc finger protein 2  
Size: 426 amino acids; 48863 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAX88982.1; Type=Erroneous gene model prediction;
Secondary accessions: A8MWV7 Q4ZFY6 Q96G44 Q9UMC5
Alternative splicing: 3 isoforms:  Q9BSG1-1   Q9BSG1-2   Q9BSG1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF2: NX_Q9BSG1

Explore proteomics data for ZNF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BSG1

  • ZNF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001017396.1  NP_001269327.1  NP_066574.2  

    ENSEMBL proteins: 
     ENSP00000381178   ENSP00000345392   ENSP00000406017   ENSP00000295210   ENSP00000411051  
    Reactome Protein details: Q9BSG1
    Human Recombinant Protein Products for ZNF2: 
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    Novus Biologicals ZNF2 Lysates
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    Cloud-Clone Corp. Proteins for ZNF2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus NAS--

    ZNF2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BSG1

    ProtoNet protein and cluster: Q9BSG1

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZNF2_HUMAN, Q9BSG1
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 9 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF2_HUMAN, Q9BSG1
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF2:
    zinc finger protein 2 (A1-5) with Kruppel type C2H2 finger motif,ubiquitously expressed

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding NAS1945843
    GO:0046872metal ion binding ----
         
    ZNF2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF2:
     Synthetic lethal with Ras 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF2
        Generic Transcription Pathway
    Gene Expression



    ZNF2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF2

    1 Interacting protein for ZNF2 (Q9BSG13) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM28Q132633I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS1945843

    ZNF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF2

    Search CenterWatch for drugs/clinical trials and news about ZNF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF2 gene (3 alternative transcripts): 
    NM_001017396.2  NM_001282398.1  NM_021088.3  

    Unigene Cluster for ZNF2:

    Zinc finger protein 2
    Hs.590916  [show with all ESTs]
    Unigene Representative Sequence: NM_021088
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398107(uc002suf.3 uc002sug.3 uc010yue.2 uc010fhs.3)
    ENST00000340539 ENST00000425369 ENST00000295210 ENST00000453539
    miRNA
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    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF2 (see all 38):
    hsa-miR-520f hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-519a hsa-miR-124 hsa-miR-372 hsa-miR-93
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK055072.1 AK290798.1 AK295739.1 AK299058.1 AK315762.1 AK315829.1 BC005068.1 BC009976.2 
    CR749650.1 X60152.1 X60154.1 

    6 DOTS entries:

    DT.40120485  DT.100744776  DT.100731706  DT.120994857  DT.95157287  DT.120994866 

    24/40 AceView cDNA sequences (see all 40):

    AL518577 BE257067 CR622702 BM796685 AW192150 AI631860 AI871251 BX348612 
    AK055072 BX348611 BM563361 AI871483 BX400884 X60154 BE258288 BX393207 
    BX114408 BE743895 NM_021088 CR749650 BC009976 BE257919 AI871473 AW593275 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:        -     -                                       
    SP2:                                                      
    SP3:                    -                                 


    ECgene alternative splicing isoforms for ZNF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATGACTC
    ZNF2 Expression
    About this image


    See ZNF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF2

    SOURCE GeneReport for Unigene cluster: Hs.590916
        SABiosciences Custom PCR Arrays for ZNF2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF2 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6611 , 5 zinc finger protein 6611, 5 79.97(n)1
    80.29(a)1
      2 (62.05 cM)5
    721801  NM_028141.31  NP_082417.31 
     1275746625 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    30(a)
    1 → many
    GL343417.1(237294-242292)


    ENSEMBL Gene Tree for ZNF2 (if available)
    TreeFam Gene Tree for ZNF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF2 gene
    ZNF7072  ZFP922  ZNF3022  ZNF1402  ZNF8292  ZNF5662  
    18/527 SIMAP similar genes for ZNF2 using alignment to 5 protein entries:     ZNF2_HUMAN (see all proteins) (see all similar genes):
    DKFZp686D2168    kr-znf3    ZNF78L1    ZFS-6    ZNF55    ZFS-1
    ZNF502    ZNF345    ZFS-4    ZNF808    DKFZp686M04222    HZF16
    ZNF702P    ZNF826P    ZNF852    DKFZp666C237    GLI4    HZF36

    ZNF2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF2
    PGOHUM00000240785


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/370 SNPs in ZNF2 are shown (see all 370)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860384051,2
    --95829469(+) ATTGCC/TTGAGC 2 -- us2k10--------
    rs1897958981,2
    --95829583(+) CTTGAA/GGCTGA 2 -- us2k10--------
    rs1814061991,2
    --95829599(+) GAGGAC/GTACGT 2 -- us2k10--------
    rs1859868671,2
    --95829877(+) CCACCC/TTCAGT 2 -- us2k10--------
    rs760384741,2
    C--95830119(+) GACTAT/CGCCTT 2 -- us2k11Minor allele frequency- C:0.01EA 120
    rs2018064491,2
    --95830154(+) CACAC-/TTTTTT 2 -- us2k10--------
    rs1908748581,2
    --95830170(+) TTAAGA/TATTTA 2 -- us2k10--------
    rs1396204791,2
    --95830255(+) GTATGC/TTGAAT 2 -- us2k10--------
    rs1497729041,2
    C--95830286(+) ACTGCC/TTCTAT 2 -- us2k10--------
    rs1456865521,2
    --95830433(+) GAGAGG/TAGAAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF2 (95831177 - 95850065 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZNF2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF2
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 194500    OMIM disorders: --

    2 diseases for ZNF2:    About MalaCards
    cryptococcosis    hypoparathyroidism


    ZNF2 for disorders           About GeneDecksing


    Export disorders for ZNF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF2 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Members of the zinc finger protein gene family sharing a conserved N- terminal module. (PubMed id 1945843)1, 2, 3 Rosati M.... Grimaldi G. (1991)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The Kruppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. (PubMed id 8183940)1, 3 Witzgall R....Bonventre J.V. (1994)
    5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. The human KRAB/FPB containing zinc finger gene ZNF2 maps to chromosome 2q11.2. (PubMed id 10575230)1 Rocchi M....Grimaldi G. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7549 HGNC: 12991 AceView: ZNF2 Ensembl:ENSG00000163067 euGenes: HUgn7549
    ECgene: ZNF2 H-InvDB: ZNF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF2 gene:
    Search GeneIP for patents involving ZNF2

    GeneCards and IP:
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