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Aliases for ZNF2 Gene

Aliases for ZNF2 Gene

  • Zinc Finger Protein 2 2 3 5
  • Zinc Finger Protein 2.2 3 4
  • Zinc Finger Protein 661 3 4
  • ZNF661 3 4
  • Zinc Finger Protein 2 (A1-5) 2
  • Zfp661 3
  • A1-5 3

External Ids for ZNF2 Gene

Previous GeneCards Identifiers for ZNF2 Gene

  • GC02P093728
  • GC02P094264
  • GC02P095299
  • GC02P095315
  • GC02P095162
  • GC02P095253
  • GC02P095194
  • GC02P095831
  • GC02P089859

Summaries for ZNF2 Gene

Entrez Gene Summary for ZNF2 Gene

  • The protein encoded by this gene belongs to the C2H2-type zinc-finger protein family. The exact function of this gene is not known, however, zinc-finger proteins are known to interact with DNA and function as transcription regulators. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

GeneCards Summary for ZNF2 Gene

ZNF2 (Zinc Finger Protein 2) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF34.

UniProtKB/Swiss-Prot for ZNF2 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF2 Gene

Genomics for ZNF2 Gene

Regulatory Elements for ZNF2 Gene

Enhancers for ZNF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF2 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF2 Gene

Chromosome:
2
Start:
95,165,417 bp from pter
End:
95,184,317 bp from pter
Size:
18,901 bases
Orientation:
Plus strand

Genomic View for ZNF2 Gene

Genes around ZNF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF2 Gene

Proteins for ZNF2 Gene

  • Protein details for ZNF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSG1-ZNF2_HUMAN
    Recommended name:
    Zinc finger protein 2
    Protein Accession:
    Q9BSG1
    Secondary Accessions:
    • A8MWV7
    • B4DIR4
    • Q4ZFY6
    • Q96G44
    • Q9UMC5

    Protein attributes for ZNF2 Gene

    Size:
    426 amino acids
    Molecular mass:
    48863 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX88982.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF2 Gene

Proteomics data for ZNF2 Gene at MOPED

Post-translational modifications for ZNF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for ZNF2

No data available for DME Specific Peptides for ZNF2 Gene

Domains & Families for ZNF2 Gene

Gene Families for ZNF2 Gene

Protein Domains for ZNF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BSG1

UniProtKB/Swiss-Prot:

ZNF2_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF2: view

Function for ZNF2 Gene

Molecular function for ZNF2 Gene

GENATLAS Biochemistry:
zinc finger protein 2 (A1-5) with Kruppel type C2H2 finger motif,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF2: view

Phenotypes for ZNF2 Gene

genes like me logo Genes that share phenotypes with ZNF2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF2 Gene

Localization for ZNF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF2 Gene COMPARTMENTS Subcellular localization image for ZNF2 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF2 Gene

Pathways & Interactions for ZNF2 Gene

SuperPathways for ZNF2 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF2: view

Pathways by source for ZNF2 Gene

2 Reactome pathways for ZNF2 Gene

Interacting Proteins for ZNF2 Gene

Selected Interacting proteins: Q9BSG1-ZNF2_HUMAN for ZNF2 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for ZNF2 Gene

None

No data available for SIGNOR curated interactions for ZNF2 Gene

Drugs & Compounds for ZNF2 Gene

No Compound Related Data Available

Transcripts for ZNF2 Gene

Unigene Clusters for ZNF2 Gene

Zinc finger protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF2 Gene

No ASD Table

Relevant External Links for ZNF2 Gene

GeneLoc Exon Structure for
ZNF2
ECgene alternative splicing isoforms for
ZNF2

Expression for ZNF2 Gene

mRNA expression in normal human tissues for ZNF2 Gene

Protein differential expression in normal tissues from HIPED for ZNF2 Gene

This gene is overexpressed in Heart (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ZNF2 Gene



SOURCE GeneReport for Unigene cluster for ZNF2 Gene Hs.590916

genes like me logo Genes that share expression patterns with ZNF2: view

Protein tissue co-expression partners for ZNF2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF2 Gene

Orthologs for ZNF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF2 35
  • 85.93 (n)
  • 84.91 (a)
dog
(Canis familiaris)
Mammalia LOC100856076 35
  • 85.33 (n)
  • 84 (a)
mouse
(Mus musculus)
Mammalia Zfp661 35
  • 79.97 (n)
  • 80.29 (a)
Zfp661 16
chimpanzee
(Pan troglodytes)
Mammalia ZNF2 35
  • 99.45 (n)
  • 99.53 (a)
rat
(Rattus norvegicus)
Mammalia LOC100909998 35
  • 80.52 (n)
  • 81.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17803 37
  • 36 (a)
CG18555 37
  • 44 (a)
Species with no ortholog for ZNF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF2 Gene

ENSEMBL:
Gene Tree for ZNF2 (if available)
TreeFam:
Gene Tree for ZNF2 (if available)

Paralogs for ZNF2 Gene

(527) SIMAP similar genes for ZNF2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF2: view

Variants for ZNF2 Gene

Sequence variations from dbSNP and Humsavar for ZNF2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1875402 -- 95,182,606(+) CCTGC(A/G)ATGAG utr-variant-3-prime
rs4854210 -- 95,181,350(+) CAGGA(A/G)TGCAG reference, synonymous-codon
rs4854246 -- 95,171,674(+) CCGCA(C/G)CCAGC intron-variant
rs3105105 -- 95,182,270(+) TGTTA(C/T)AGAAC utr-variant-3-prime
rs3112228 -- 95,169,869(+) CTTAG(C/T)ACATT intron-variant

Variation tolerance for ZNF2 Gene

Residual Variation Intolerance Score: 47.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ZNF2 Gene

Disorders for ZNF2 Gene

Relevant External Links for ZNF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF2

No disorders were found for ZNF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF2 Gene

Publications for ZNF2 Gene

  1. Members of the zinc finger protein gene family sharing a conserved N- terminal module. (PMID: 1945843) Rosati M. … Grimaldi G. (Nucleic Acids Res. 1991) 2 3 4 67
  2. The KrA1ppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. (PMID: 8183940) Witzgall R. … Bonventre J.V. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3

Products for ZNF2 Gene

Sources for ZNF2 Gene

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