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Aliases for ZNF2 Gene

Aliases for ZNF2 Gene

  • Zinc Finger Protein 2 2 3
  • Zinc Finger Protein 2.2 3 4
  • Zinc Finger Protein 661 3 4
  • ZNF661 3 4
  • Zinc Finger Protein 2 (A1-5) 2
  • Zfp661 3
  • A1-5 3

External Ids for ZNF2 Gene

Summaries for ZNF2 Gene

Entrez Gene Summary for ZNF2 Gene

  • The protein encoded by this gene belongs to the C2H2-type zinc-finger protein family. The exact function of this gene is not known, however, zinc-finger proteins are known to interact with DNA and function as transcription regulators. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

GeneCards Summary for ZNF2 Gene

ZNF2 (Zinc Finger Protein 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression.

UniProtKB/Swiss-Prot for ZNF2 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF2 Gene

Genomics for ZNF2 Gene

Genomic Location for ZNF2 Gene

Start:
95,165,417 bp from pter
End:
95,184,317 bp from pter
Size:
18,901 bases
Orientation:
Plus strand

Genomic View for ZNF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF2 Gene

Regulatory Elements for ZNF2 Gene

Proteins for ZNF2 Gene

  • Protein details for ZNF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSG1-ZNF2_HUMAN
    Recommended name:
    Zinc finger protein 2
    Protein Accession:
    Q9BSG1
    Secondary Accessions:
    • A8MWV7
    • B4DIR4
    • Q4ZFY6
    • Q96G44
    • Q9UMC5

    Protein attributes for ZNF2 Gene

    Size:
    426 amino acids
    Molecular mass:
    48863 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX88982.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF2 Gene

Proteomics data for ZNF2 Gene at MOPED

Post-translational modifications for ZNF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF2 Gene

No data available for DME Specific Peptides for ZNF2 Gene

Domains for ZNF2 Gene

Gene Families for ZNF2 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF2 Gene

UniProtKB/Swiss-Prot:

ZNF2_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q9BSG1
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q9BSG1
Similarity:
  • Contains 9 C2H2-type zinc fingers.:
    • Q9BSG1
genes like me logo Genes that share domains with ZNF2: view

Function for ZNF2 Gene

Molecular function for ZNF2 Gene

GENATLAS Biochemistry: zinc finger protein 2 (A1-5) with Kruppel type C2H2 finger motif,ubiquitously expressed
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding NAS 1945843
genes like me logo Genes that share ontologies with ZNF2: view

Phenotypes for ZNF2 Gene

GenomeRNAi human phenotypes for ZNF2:
genes like me logo Genes that share phenotypes with ZNF2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF2 Gene

Localization for ZNF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF2 Gene COMPARTMENTS Subcellular localization image for ZNF2 gene
Compartment Confidence
nucleus 5
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF2: view

Pathways for ZNF2 Gene

SuperPathways for ZNF2 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF2: view

Pathways by source for ZNF2 Gene

2 Reactome pathways for ZNF2 Gene

Interacting Proteins for ZNF2 Gene

Selected Interacting proteins: Q9BSG1-ZNF2_HUMAN for ZNF2 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for ZNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 1945843
genes like me logo Genes that share ontologies with ZNF2: view

Transcripts for ZNF2 Gene

Unigene Clusters for ZNF2 Gene

Zinc finger protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2:
SP3: -

Relevant External Links for ZNF2 Gene

GeneLoc Exon Structure for
ZNF2
ECgene alternative splicing isoforms for
ZNF2

Expression for ZNF2 Gene

mRNA expression in normal human tissues for ZNF2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ZNF2 Gene

SOURCE GeneReport for Unigene cluster for ZNF2 Gene Hs.590916

genes like me logo Genes that share expressions with ZNF2: view

Orthologs for ZNF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF2 36
  • 99.45 (n)
  • 99.53 (a)
cow
(Bos Taurus)
Mammalia ZNF2 36
  • 85.93 (n)
  • 84.91 (a)
dog
(Canis familiaris)
Mammalia LOC100856076 36
  • 85.33 (n)
  • 84 (a)
mouse
(Mus musculus)
Mammalia Zfp661 36
  • 79.97 (n)
  • 80.29 (a)
Zfp661 16
rat
(Rattus norvegicus)
Mammalia LOC100909998 36
  • 80.52 (n)
  • 81.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18555 38
  • 44 (a)
CG17803 38
  • 36 (a)
Species with no ortholog for ZNF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF2 Gene

ENSEMBL:
Gene Tree for ZNF2 (if available)
TreeFam:
Gene Tree for ZNF2 (if available)

Paralogs for ZNF2 Gene

Selected SIMAP similar genes for ZNF2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF2: view

No data available for Paralogs for ZNF2 Gene

Variants for ZNF2 Gene

Sequence variations from dbSNP and Humsavar for ZNF2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1875402 -- 95,182,606(+) CCTGC(A/G)ATGAG utr-variant-3-prime
rs3105105 -- 95,182,270(+) TGTTA(C/T)AGAAC utr-variant-3-prime
rs3112228 -- 95,169,869(+) CTTAG(C/T)ACATT intron-variant
rs3112229 -- 95,172,929(+) actgc(A/G)cctgg intron-variant
rs3112230 -- 95,180,413(+) GCTTT(C/T)ATTTT intron-variant

Relevant External Links for ZNF2 Gene

HapMap Linkage Disequilibrium report
ZNF2

No data available for Structural Variations from Database of Genomic Variants (DGV) for ZNF2 Gene

Disorders for ZNF2 Gene

No disorders were found for ZNF2 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF2 Gene

Publications for ZNF2 Gene

  1. Members of the zinc finger protein gene family sharing a conserved N- terminal module. (PMID: 1945843) Rosati M. … Grimaldi G. (Nucleic Acids Res. 1991) 2 3 4
  2. The KrA1ppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. (PMID: 8183940) Witzgall R. … Bonventre J.V. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for ZNF2 Gene

Sources for ZNF2 Gene

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