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Aliases & Descriptions for ZMYM2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases FIM 1 , 2 , 3 MYM 1 , 2 RAMP 1 , 2 , 3 SCLL 2 ZNF198 2 , 3
Descriptions Fused in myeloproliferative disorders protein 3 Rearranged in atypical myeloproliferative disorder protein 3 Zinc finger protein 198 1 , 2 , 3 fused in myeloproliferative disorder 2 rearranged in an atypical myeloproliferative disorder 2 zinc finger, MYM-type 2 2
Search outside databases for aliases for ZMYM2 gene
Summaries for ZMYM2 (According to Entrez Gene ,
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UniProtKB/Swiss-Prot ,
and/or
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UniProtKB/Swiss-Prot: ZMYM2_HUMAN, Q9UBW7 Function : May function as a transcription factor
Gene Wiki entry for ZMYM2
Genomic Location for ZMYM2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ZMYM2 gene Entrez Gene cytogenetic band: 13q11-q12 Ensembl cytogenetic band: 13q12.11 HGNC cytogenetic band: 13q11-q12 ZMYM2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure
GeneLoc location for GC13P019431:
(about GC identifiers )
Start:
19,430,810 bp from pter
End:
19,561,253 bp from pter
Size:
130,444 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000013.9 NT_024524.13 Proteins for ZMYM2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ZMYM2_HUMAN, Q9UBW7 (See
protein sequence )Recommended Name: Zinc finger MYM-type protein 2 Size : 1377 amino acids; 154911 Da
Subunit : May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2,HMG20B/BRAF35, AOF2/LSD1, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I
Subcellular location : Nucleus (Potential)
Sequence caution : Sequence=AAB88464.1; Type=Frameshift; Positions=330, 966, 1009, 1017;Sequence=AAC23591.1; Type=Frameshift; Positions=330;
Secondary accessions : A6NDG0 A6NI02 O43212 O43434 O60898 Q5W0Q4 Q63HP0 Q8NE39 Q9H538 Q9UEU2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_003444.1 NP_932072.1 ENSEMBL proteins: ENSP00000372323 ENSP00000372334 ENSP00000372324 ENSP00000372327 ENSP00000372336 ENSP00000372322 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for ZMYM2: Assays for ZMYM2:
Protein
Domains/ Families for ZMYM2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UBW7 ProtoNet protein and cluster: Q9UBW7
2 Blocks protein families : IPB010507 MYM-type zinc finger IPB011017 TRASH UniProtKB/Swiss-Prot: ZMYM2_HUMAN, Q9UBW7 Similarity : Contains 9 MYM-type zinc fingers
Gene Function for ZMYM2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_197968 Applied Biosystems Silencer ® siRNAs for ZMYM2 Sigma-Aldrich siRNA and siRNA Panels for ZMYM2 Sigma-Aldrich shRNA for ZMYM2 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_003453                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_003453                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_003453  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_197968 UniProtKB/Swiss-Prot: ZMYM2_HUMAN, Q9UBW7 Function : May function as a transcription factor
3 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for ZMYM2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for ZMYM2 5/23 Interacting proteins for ZMYM2 (ENSP00000372336 3 Q9UBW7 2 ) via UniProtKB, MINT, and/or STRING (see all 23
)About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006350 transcription
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0008150 biological_process
ND --
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Drugs & Compounds for ZMYM2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for ZMYM2 2 Novoseek chemical compound relationships for ZMYM2 gene
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Transcripts for ZMYM2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_197968 Sigma-Aldrich siRNA and siRNA Panels for ZMYM2 Sigma-Aldrich shRNA for ZMYM2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_003453 NM_197968
REFSEQ mRNAs for ZMYM2 gene (2 alternative transcripts): NM_003453.2 NM_197968.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003453 NM_197968
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_003453                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_003453                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_003453  
Additional cDNA sequence: AF012126.1 AF035374.1 AF060181.1 AJ224901.1 AK226118.1 AK289741.1 AK302917.1 AK310505.1 AL136621.1 BC036372.1 BX647944.1 BX648905.1 Y13472.1
24/27 DOTS entries (see all 27
): DT.100736070 DT.97802656 DT.456352 DT.92437651 DT.75124863 DT.95288110 DT.99981451 DT.445966 DT.75100191 DT.407362 DT.95288106 DT.109402 DT.433282 DT.75125302 DT.86993005 DT.91922218 DT.92437649 DT.95288111 DT.120780943 DT.120780960 DT.120780965 DT.120780977 DT.91734342 DT.92437643
24/255 AceView cDNA sequences (see all 255
):AA250925 AW204488 BX111992 BX647944 BU683335 AA234314 BU687017 AJ224901 AA452383 AL708263 BM699510 BX112568 AI472479 BM724534 AA553492 AA383517 AA281848 AI457500 CA313916 AA599563 NM_003453 AA336998 AW026945 BM471877
highest scoring ESTs for ZMYM2 :AA406293 AI702958 AJ224901 AA034499 AA115537 AA135989 AA247959 AA251580 AA251581 AA282776
Unigene Cluster for ZMYM2: Zinc finger, MYM-type 2 Hs.644041 [show with all ESTs ] Unigene Representative Sequence: BX648905 GeneLoc Exon Structure 5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ZMYM2 (see all 14
) ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a · SP1 :                     -   -   -   -       -                     SP2 :                     -   -   -   -       -   -                   SP3 :                     -   -   -   -       -                     SP4 :     -   -   -   -   -   -   -   -   -   -   -   -       -                     SP5 :                         -   -       -                    
ExUns: 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 SP1 :               SP2 :               SP3 :               SP4 :               SP5 :              
About this scheme ECgene alternative splicing isoforms for ZMYM2 6 Ensembl transcripts including schematic representations : ENST00000382870
ENST00000382881
ENST00000382871
ENST00000382874
ENST00000382883
ENST00000382869
Expression for ZMYM2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ZMYM2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ZMYM2 1 / 2 / 3
13 probe-sets matching ZMYM2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TATAATTTTTSOURCE GeneReport for Unigene cluster: Hs.644041
Orthologs for ZMYM2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ZMYM2 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for ZMYM2 ENSEMBL Gene Tree for ZMYM2 Paralogs for ZMYM2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for ZMYM2 gene ZMYM5 2 ZMYM3 2
SNPs/Variants for ZMYM2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ZMYM2 (up to first 250kb)
Disorders & Mutations for ZMYM2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 602221 UniProtKB/Swiss-Prot: ZMYM2_HUMAN, Q9UBW7
A chromosomal aberration involving ZMYM2 may be a cause of stem cell leukemia lymphomasyndrome (SCLL). Translocation t(8;13)(p11;q12) with FGFR1. SCLL usually presents as lymphoblasticlymphoma in association with a myeloproliferative disorder, often accompanied by pronouncedperipheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow
7 Novoseek disease relationships for ZMYM2 gene
About this table
Medical News for ZMYM2 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for ZMYM2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/45 PubMed articles for ZMYM2 gene (see all 45
): The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP. (PubMed id 9499416) 1, 2, 3, 4 Smedley D.... Shipley J. (1998) FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome. (PubMed id 9425908) 1, 2, 3, 4 Xiao S....Fletcher J.A. (1998) The genomic structure of ZNF198 and location of breakpoints in the t(8;13) myeloproliferative syndrome. (PubMed id 9889006) 1, 3, 4 Kulkarni S.... Cross N.C.P. (1999) Consistent fusion of ZNF198 to the fibroblast growth factor receptor- 1 in the t(8;13)(p11;q12) myeloproliferative syndrome. (PubMed id 9716603) 1, 3, 4 Reiter A.... Cross N.C.P. (1998) Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)(p12;q12). (PubMed id 9576949) 1, 3, 4 Popovici C.... Pebusque M.-J. (1998) The t(8;13) atypical myeloproliferative disorder: further analysis of the ZNF198 gene and lack of evidence for multiple genes disrupted on chromosome 13. (PubMed id 9694738) 1, 3, 4 Still I.H. and Cowell J.K. (1998) A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243) 3, 4 Beausoleil S.A.... Gygi S.P. (2006) The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823) 3, 4 Dunham A.... Ross M.T. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935) 3, 4 Beausoleil S.A....Gygi S.P. (2004)
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Genome Databases showing ZMYM2
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ZMYM2
(According to HUGE )
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Specialized Databases showing ZMYM2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for ZMYM2 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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