ZNF197 Gene
protein-coding GIFtS: 53
GCID: GC03P044688
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zinc finger protein 197(Previous name: zinc finger protein 166 ) (Previous symbol: ZNF166)
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Aliases for ZNF197 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 1971 2 | | Zinc Finger Protein With KRAB And SCAN Domains 92 3 | | ZKSCAN91 2 3 | | PVHL-Associated KRAB Domain-Containing Protein2 3 | | ZNF1661 2 3 | | VHLaK2 | | D3S1363E1 2 | | ZNF202 | | P181 2 | | VHL-Associated KRAB-A Domain-Containing Protein2 | | ZSCAN411 2 | | Zinc Finger Protein 202 | | Zinc Finger Protein 1661 2 | | ZnF203 |
Export aliases for ZNF197 gene to outside databasesPrevious GC identifers: GC03P044135 GC03P043850 GC03P044416 GC03P044631 GC03P044558 GC03P044645 GC03P044674 |
Summaries for ZNF197 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for ZNF197: This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteinscharacterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-typezinc fingers, a Kruppel-associated box (KRAB) domain, and a SCAN box. This transcript turns over rapidly and contains3' UTR AUUUA motifs, which are often a hallmark of rapid turnover. It is overexpressed in some thyroid papillarycarcinomas. This gene is located in a cluster of zinc finger genes at 3p21. Two alternatively spliced transcriptsencoding different isoforms have been described. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: ZN197_HUMAN, O14709Function: May be involved in transcriptional regulation
|
Genomic Views for ZNF197 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF197 gene promoter: ZID MIF-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF197
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF197 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21ZNF197 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P044688: view genomic region
(about GC identifiers)
Start:
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44,626,380 bp from pter |
End:
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44,689,963 bp from pter |
Size:
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63,584 bases |
Orientation:
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plus strand |
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Proteins for ZNF197 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZN197_HUMAN, O14709 (See
protein sequence)Recommended Name: Zinc finger protein 197 Size: 1029 amino acids; 118847 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B2RAH8 Q86VG0Alternative splicing: 2 isoforms: O14709-1 O14709-2 (Negative regulator of HIF1A transactivation)Explore the universe of human proteins at neXtProt for ZNF197: NX_O14709
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14709 ZNF197 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001020026.1 NP_008922.1 ENSEMBL proteins: ENSP00000394713 ENSP00000373250 ENSP00000345809 ENSP00000373251 ENSP00000334616 ENSP00000379370 Reactome Protein details: O14709 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF197 for ontologies About GeneDecksing
ZNF197 Antibody Products: Assay Products for ZNF197: |
Protein
Domains / Families for ZNF197 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF197 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry O14709ProtoNet protein and cluster: O14709 3 Blocks protein families: IPB001909 KRAB box IPB003309 Transcriptional regulator SCAN IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN197_HUMAN, O14709Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 22 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domainSimilarity: Contains 1 SCAN box domain |
Function for ZNF197 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ZN197_HUMAN, O14709Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF197:zinc finger protein 197
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF197 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF197 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF197 (NM_001024855) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF197 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF197  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF197 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
-- | -- | | GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZNF197 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for ZNF197:
|
Pathways & Interactions for ZNF197 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
2
Reactome Pathways for ZNF197
ZNF197 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF197
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
 5/7 Interacting proteins for ZNF197 (O147093 ENSP000003458094) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0016032 | viral reproduction |
IEA | -- |
ZNF197 for ontologies About GeneDecksing
|
Drugs & Compounds for ZNF197 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ZNF197 Search CenterWatch for drugs/clinical trials and news about ZNF197 / ZN197 
|
Transcripts for ZNF197 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZNF197 gene (2 alternative transcripts): NM_001024855.1 NM_006991.3 Unigene Cluster for ZNF197: Zinc finger protein 197 Hs.157035 [show with all ESTs]Unigene Representative Sequence: NM_0069916 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000412641 ENST00000383744 ENST00000344387 ENST00000383745(uc003cnn.3 uc003cno.3 uc003cnp.3) ENST00000334075 ENST00000396058(uc003cnm.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF197 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF197 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF197 (NM_001024855) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF197 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF197  |
Additional cDNA sequence: AF011573.1 AK314196.1 AL117657.1 AY074878.1 AY261677.1 AY279353.1 BC017584.1 BC031209.1 L32163.1 Z21707.1 8 DOTS entries: DT.87015004 DT.101974543 DT.92421579 DT.95241240 DT.40223028 DT.120928274 DT.95361407 DT.92062677 24/94 AceView cDNA sequences (see all 94): BG170556 BF477932 BU184659 AI341305 NM_006991 AI091827 BX955582 CF138878 AY261677 AI693874 BQ002665 AA385151 CR610755 BQ018704 AI491958 AI333785 CR624024 AL555231 AL134897 AF011573 BI834382 AU125702 AI968863 BG035800 GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF197 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for ZNF197
|
Expression for ZNF197 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF197 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See ZNF197 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF197
SOURCE GeneReport for Unigene cluster: Hs.157035 SABiosciences Custom PCR Arrays for ZNF197
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF197 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF197 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF197 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF197 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF197 |
Orthologs for ZNF197 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF197 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
tropical clawed frog (Xenopus tropicalis) |
Amphibia |
Str.49002 |
Transcribed sequence with weak similarity to protein more |
72.56(n) |
  |
142031492 |
ENSEMBL Gene Tree for ZNF197 (if available) TreeFam Gene Tree for ZNF197 (if available)  |
Paralogs for ZNF197 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ZNF197 gene
- ZNF6162 ZNF1602 ZNF8502 ZNF992 ZNF5462 ZNF6652 ZNF7212 ZNF8362
- ZNF8412 ZNF912 ZNF432 ZNF780B2 ZNF585A2 ZNF8082 ZNF7292 ZNF3472
- ZNF8452 ZNF1842 ZNF585B2 ZNF6582 ZNF6242 ZNF2082
18/300 SIMAP similar genes for ZNF197 using alignment to 4 protein entries: ZN197_HUMAN (see all proteins)
(see all similar genes):ZSCAN29 SCAND1 ZSCAN21 ZSCAN2 ZNF396 ZNF444 ZNF500 DKFZp434K202 ZNF394 DKFZp686B16128 ZFS-1 ZSCAN32 LOC100128510 ZNF101 ZNF345 ZNF883 HZF41 ZFP2
ZNF197 for paralogs About GeneDecksing
|
Genomic Variants for ZNF197 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF197 (44626380 - 44689963 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ZNF197: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF197 |
|
Disorders
/ Diseases for ZNF197 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF197 for disorders About GeneDecksing
7 diseases for ZNF197: About MalaCardssubacute sclerosing panencephalitis papillary carcinoma thyroiditis carcinoma measles thyroid cancer schizophrenia Export disorders for ZNF197 gene to outside databases
|
Publications for ZNF197 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF197 gene integrated from 9 sources: (articles sorted by number of sources associating them with ZNF197) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets. (PubMed id 9380504)1, 2, 3, 9 Gonsky R.... Fagin J.A. (1997)
- The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity. (PubMed id 12682018)1, 2, 9 Li Z.... Wu G. (2003)
- YAC-assisted cloning of transcribed sequences from the human chromosome 3p21 region. (PubMed id 8353497)1, 3 Pengue G.... D'Urso M. (1993)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PubMed id 17043677)1 Camargo L.M....Brandon N.J. (2007)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes. (PubMed id 7814019)1 Calabro V....Lania L. (1995)
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External Searches for ZNF197 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZNF197 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF197 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF197 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for ZNF197 gene: Search GeneIP for patents involving ZNF197
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZNF197 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
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| | | Search Tocris compounds for ZNF197 |
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 | | ZNF197 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF197 |
|  |  |  | | | ThermoFisher Antibodies for ZNF197 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF197 |
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