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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF197 Gene

protein-coding   GIFtS: 53
GCID: GC03P044688

zinc finger protein 197

(Previous name: zinc finger protein 166 )
(Previous symbol: ZNF166)
 Explore 7 diseases affiliated with
ZNF197 via our new
 Human Malady Compendium 
Biological research products
for ZNF197
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 1971 2     Zinc Finger Protein With KRAB And SCAN Domains 92 3
ZKSCAN91 2 3     PVHL-Associated KRAB Domain-Containing Protein2 3
ZNF1661 2 3     VHLaK2
D3S1363E1 2     ZNF202
P181 2     VHL-Associated KRAB-A Domain-Containing Protein2
ZSCAN411 2     Zinc Finger Protein 202
Zinc Finger Protein 1661 2     ZnF203

External Ids:    HGNC: 129881   Entrez Gene: 101682   Ensembl: ENSG000001864487   UniProtKB: O147093   

Export aliases for ZNF197 gene to outside databases

Previous GC identifers: GC03P044135 GC03P043850 GC03P044416 GC03P044631 GC03P044558 GC03P044645 GC03P044674


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF197:
This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins
characterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-type
zinc fingers, a Kruppel-associated box (KRAB) domain, and a SCAN box. This transcript turns over rapidly and contains
3' UTR AUUUA motifs, which are often a hallmark of rapid turnover. It is overexpressed in some thyroid papillary
carcinomas. This gene is located in a cluster of zinc finger genes at 3p21. Two alternatively spliced transcripts
encoding different isoforms have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ZN197_HUMAN, O14709
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF197 gene promoter:
         ZID   MIF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF197 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF197

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF197


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

ZNF197 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF197 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P044688:  view genomic region     (about GC identifiers)

Start:
44,626,380 bp from pter      End:
44,689,963 bp from pter
Size:
63,584 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN197_HUMAN, O14709 (See protein sequence)
Recommended Name: Zinc finger protein 197  
Size: 1029 amino acids; 118847 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B2RAH8 Q86VG0
Alternative splicing: 2 isoforms:  O14709-1   O14709-2   (Negative regulator of HIF1A transactivation)

Explore the universe of human proteins at neXtProt for ZNF197: NX_O14709

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14709

  • ZNF197 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001020026.1  NP_008922.1  

    ENSEMBL proteins: 
     ENSP00000394713   ENSP00000373250   ENSP00000345809   ENSP00000373251   ENSP00000334616  
     ENSP00000379370  
    Reactome Protein details: O14709
    Human Recombinant Protein Products: 
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    Uscn Proteins for ZNF197

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    ZNF197 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF197 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR008916 Retrov_capsid_C
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O14709

    ProtoNet protein and cluster: O14709

    3 Blocks protein families:
    IPB001909 KRAB box
    IPB003309 Transcriptional regulator SCAN
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN197_HUMAN, O14709
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 22 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain
    Similarity: Contains 1 SCAN box domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN197_HUMAN, O14709
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF197:
    zinc finger protein 197

    miRNA
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF197 (see all 25):
    hsa-miR-30c hsa-miR-549 hsa-miR-676 hsa-let-7d hsa-miR-30d hsa-let-7c hsa-miR-138-2* hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidZNF197 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF197
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--


    ZNF197 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for ZNF197:
     Decreased POU5F1-GFP protein e  Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF197
        Generic Transcription Pathway
    Gene Expression



    ZNF197 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF197

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for ZNF197 (O147093 ENSP000003458094) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DISC1Q9NRI53, ENSP000003555964I2D: score=2 STRING: ENSP00000355596
    NDEL1Q9GZM83, ENSP000003339824I2D: score=2 STRING: ENSP00000333982
    TRIM28Q132633, ENSP000002530244I2D: score=2 STRING: ENSP00000253024
    HIF1AQ166653, ENSP000003380184I2D: score=1 STRING: ENSP00000338018
    VHLP403373, ENSP000002564744I2D: score=2 STRING: ENSP00000256474
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0016032viral reproduction IEA--


    ZNF197 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF197
    Search CenterWatch for drugs/clinical trials and news about ZNF197 / ZN197 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF197 gene (2 alternative transcripts): 
    NM_001024855.1  NM_006991.3  

    Unigene Cluster for ZNF197:

    Zinc finger protein 197
    Hs.157035  [show with all ESTs]
    Unigene Representative Sequence: NM_006991
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412641 ENST00000383744 ENST00000344387 ENST00000383745(uc003cnn.3 uc003cno.3 uc003cnp.3)
    ENST00000334075 ENST00000396058(uc003cnm.3)

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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF197 (see all 25):
    hsa-miR-30c hsa-miR-549 hsa-miR-676 hsa-let-7d hsa-miR-30d hsa-let-7c hsa-miR-138-2* hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidZNF197 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF011573.1 AK314196.1 AL117657.1 AY074878.1 AY261677.1 AY279353.1 BC017584.1 BC031209.1 
    L32163.1 Z21707.1 

    8 DOTS entries:

    DT.87015004  DT.101974543  DT.92421579  DT.95241240  DT.40223028  DT.120928274  DT.95361407  DT.92062677 

    24/94 AceView cDNA sequences (see all 94):

    BG170556 BF477932 BU184659 AI341305 NM_006991 AI091827 BX955582 CF138878 
    AY261677 AI693874 BQ002665 AA385151 CR610755 BQ018704 AI491958 AI333785 
    CR624024 AL555231 AL134897 AF011573 BI834382 AU125702 AI968863 BG035800 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF197    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
    SP1:                                                
    SP2:              -                                 


    ECgene alternative splicing isoforms for ZNF197

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF197 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF197 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF197

    SOURCE GeneReport for Unigene cluster: Hs.157035
        SABiosciences Custom PCR Arrays for ZNF197
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF197

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF197 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.49002 Transcribed sequence with weak similarity to protein more 72.56(n)    142031492 


    ENSEMBL Gene Tree for ZNF197 (if available)
    TreeFam Gene Tree for ZNF197 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF197 gene
    ZNF6162  ZNF1602  ZNF8502  ZNF992  ZNF5462  ZNF6652  ZNF7212  ZNF8362  
    ZNF8412  ZNF912  ZNF432  ZNF780B2  ZNF585A2  ZNF8082  ZNF7292  ZNF3472  
    ZNF8452  ZNF1842  ZNF585B2  ZNF6582  ZNF6242  ZNF2082  
    18/300 SIMAP similar genes for ZNF197 using alignment to 4 protein entries:     ZN197_HUMAN (see all proteins) (see all similar genes):
    ZSCAN29    SCAND1    ZSCAN21    ZSCAN2    ZNF396    ZNF444
    ZNF500    DKFZp434K202    ZNF394    DKFZp686B16128    ZFS-1    ZSCAN32
    LOC100128510    ZNF101    ZNF345    ZNF883    HZF41    ZFP2

    ZNF197 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/377 NCBI SNPs in ZNF197 are shown (see all 377    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857341531,2
    --44664596(+) GGTGGC/TGTGCG 2 -- us2k10--------
    rs1436545071,2
    --44664664(+) CGGAGA/GTTGCA 2 -- us2k10--------
    rs1480977711,2
    --44664714(+) AGAGTG/TAGACT 2 -- us2k10--------
    rs1902724161,2
    --44664797(+) AAACTC/TGGAGA 2 -- us2k10--------
    rs1810909411,2
    --44665084(+) CCTGGA/TGCAAT 2 -- us2k10--------
    rs1865345751,2
    --44665155(+) AAAAAC/TGACCC 2 -- us2k10--------
    rs1913439321,2
    --44665170(+) CTTATC/GATCAG 2 -- us2k10--------
    rs1822041121,2
    --44665180(+) GCTTTA/CACATT 2 -- us2k10--------
    rs1410896581,2
    --44665201(+) TACCAC/TCACCT 2 -- us2k10--------
    rs15510631,2
    C,F,A,H,--44665285(+) TTTATC/TTATGT 2 -- us2k1 tfbs318Minor allele frequency- T:0.25NS EA NA CSA WA 1973

    HapMap Linkage Disequilibrium report for ZNF197 (44626380 - 44689963 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNF197: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF197 for disorders           About GeneDecksing

    7 diseases for ZNF197:    About MalaCards
    subacute sclerosing panencephalitis    papillary carcinoma    thyroiditis    carcinoma
    measles    thyroid cancer    schizophrenia


    Export disorders for ZNF197 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF197 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF197)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets. (PubMed id 9380504)1, 2, 3, 9 Gonsky R.... Fagin J.A. (1997)
    2. The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity. (PubMed id 12682018)1, 2, 9 Li Z.... Wu G. (2003)
    3. YAC-assisted cloning of transcribed sequences from the human chromosome 3p21 region. (PubMed id 8353497)1, 3 Pengue G.... D'Urso M. (1993)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PubMed id 17043677)1 Camargo L.M....Brandon N.J. (2007)
    6. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes. (PubMed id 7814019)1 Calabro V....Lania L. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10168 HGNC: 12988 AceView: ZNF197 Ensembl:ENSG00000186448 euGenes: HUgn10168
    ECgene: ZNF197 H-InvDB: ZNF197

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF197 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZNF197 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF197 gene:
    Search GeneIP for patents involving ZNF197

    GeneCards and IP:
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