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Aliases for ZNF197 Gene

Aliases for ZNF197 Gene

  • Zinc Finger Protein 197 2 3
  • Zinc Finger Protein With KRAB And SCAN Domains 9 3 4
  • PVHL-Associated KRAB Domain-Containing Protein 3 4
  • Zinc Finger Protein 166 2 3
  • ZKSCAN9 3 4
  • ZNF166 3 4
  • ZNF20 3 4
  • VHL-Associated KRAB-A Domain-Containing Protein 3
  • Zinc Finger Protein 20 3
  • D3S1363E 3
  • ZSCAN41 3
  • VHLaK 3
  • P18 3

External Ids for ZNF197 Gene

Previous HGNC Symbols for ZNF197 Gene

  • ZNF166

Previous GeneCards Identifiers for ZNF197 Gene

  • GC03P044135
  • GC03P043850
  • GC03P044416
  • GC03P044631
  • GC03P044558
  • GC03P044645
  • GC03P044674
  • GC03P044688
  • GC03P044716
  • GC03P044783

Summaries for ZNF197 Gene

Entrez Gene Summary for ZNF197 Gene

  • This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-type zinc fingers, a Kruppel-associated box (KRAB) domain, and a SCAN box. This transcript turns over rapidly and contains 3' UTR AUUUA motifs, which are often a hallmark of rapid turnover. It is overexpressed in some thyroid papillary carcinomas. This gene is located in a cluster of zinc finger genes at 3p21. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF197 Gene

ZNF197 (Zinc Finger Protein 197) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF268.

UniProtKB/Swiss-Prot for ZNF197 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF197 Gene

Genomics for ZNF197 Gene

Regulatory Elements for ZNF197 Gene

Transcription factor binding sites by QIAGEN in the ZNF197 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF197 Gene

Start:
44,584,888 bp from pter
End:
44,648,471 bp from pter
Size:
63,584 bases
Orientation:
Plus strand

Genomic View for ZNF197 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF197 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF197 Gene

Proteins for ZNF197 Gene

  • Protein details for ZNF197 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14709-ZN197_HUMAN
    Recommended name:
    Zinc finger protein 197
    Protein Accession:
    O14709
    Secondary Accessions:
    • B2RAH8
    • Q86VG0

    Protein attributes for ZNF197 Gene

    Size:
    1029 amino acids
    Molecular mass:
    118847 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF197 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF197 Gene

Proteomics data for ZNF197 Gene at MOPED

Post-translational modifications for ZNF197 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF197 Gene

No data available for DME Specific Peptides for ZNF197 Gene

Domains for ZNF197 Gene

Gene Families for ZNF197 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF197 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14709

UniProtKB/Swiss-Prot:

ZN197_HUMAN :
  • O14709
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 22 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF197: view

Function for ZNF197 Gene

Molecular function for ZNF197 Gene

GENATLAS Biochemistry: zinc finger protein 197
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF197 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF197: view
genes like me logo Genes that share phenotypes with ZNF197: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF197 Gene

Localization for ZNF197 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF197 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF197 Gene COMPARTMENTS Subcellular localization image for ZNF197 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF197 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF197: view

Pathways for ZNF197 Gene

SuperPathways for ZNF197 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF197: view

Pathways by source for ZNF197 Gene

2 Reactome pathways for ZNF197 Gene

Gene Ontology (GO) - Biological Process for ZNF197 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF197: view

Transcripts for ZNF197 Gene

Unigene Clusters for ZNF197 Gene

Zinc finger protein 197:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF197

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF197
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF197 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1:
SP2: -

Relevant External Links for ZNF197 Gene

GeneLoc Exon Structure for
ZNF197
ECgene alternative splicing isoforms for
ZNF197

Expression for ZNF197 Gene

mRNA expression in normal human tissues for ZNF197 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF197 Gene

SOURCE GeneReport for Unigene cluster for ZNF197 Gene Hs.157035

genes like me logo Genes that share expressions with ZNF197: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF197 Gene

Orthologs for ZNF197 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF197 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF197 35
  • 91.05 (n)
  • 92.22 (a)
ZNF197 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp616 36
  • 32 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4900 35
fruit fly
(Drosophila melanogaster)
Insecta CG11902 37
  • 24 (a)
CG10959 37
  • 37 (a)
zf30C 37
  • 33 (a)
CG6654 37
  • 39 (a)
CG6689 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
CSA.1668 36
  • 32 (a)
ManyToMany
Species with no ortholog for ZNF197:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF197 Gene

ENSEMBL:
Gene Tree for ZNF197 (if available)
TreeFam:
Gene Tree for ZNF197 (if available)

Paralogs for ZNF197 Gene

Selected SIMAP similar genes for ZNF197 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF197: view

Variants for ZNF197 Gene

Sequence variations from dbSNP and Humsavar for ZNF197 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs882450 -- 44,633,523(+) CATTT(A/G)TACTG intron-variant
rs1402752 -- 44,645,808(-) CTGCA(C/T)TGGCT intron-variant
rs1608006 -- 44,641,073(-) AAGTG(C/T)GAGAG intron-variant
rs2272045 -- 44,632,169(+) ATGGC(A/G)CTTAT reference, synonymous-codon
rs2372772 -- 44,626,821(+) TTCTG(A/T)TTCAA intron-variant

Relevant External Links for ZNF197 Gene

HapMap Linkage Disequilibrium report
ZNF197

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF197 Gene

Disorders for ZNF197 Gene

No disorders were found for ZNF197 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF197 Gene

Publications for ZNF197 Gene

  1. Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets. (PMID: 9380504) Gonsky R. … Fagin J.A. (Nucleic Acids Res. 1997) 2 3 4 23
  2. The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity. (PMID: 12682018) Li Z. … Wu G. (EMBO J. 2003) 3 4 23
  3. YAC-assisted cloning of transcribed sequences from the human chromosome 3p21 region. (PMID: 8353497) Pengue G. … D'Urso M. (Hum. Mol. Genet. 1993) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PMID: 17043677) Camargo L.M. … Brandon N.J. (Mol. Psychiatry 2007) 3

Products for ZNF197 Gene

Sources for ZNF197 Gene

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