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Aliases for ZNF197 Gene

Aliases for ZNF197 Gene

  • Zinc Finger Protein 197 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 9 3 4
  • PVHL-Associated KRAB Domain-Containing Protein 3 4
  • Zinc Finger Protein 166 2 3
  • ZKSCAN9 3 4
  • ZNF166 3 4
  • ZNF20 3 4
  • VHL-Associated KRAB-A Domain-Containing Protein 3
  • Zinc Finger Protein 20 3
  • D3S1363E 3
  • ZSCAN41 3
  • VHLaK 3
  • P18 3

External Ids for ZNF197 Gene

Previous HGNC Symbols for ZNF197 Gene

  • ZNF166

Previous GeneCards Identifiers for ZNF197 Gene

  • GC03P044135
  • GC03P043850
  • GC03P044416
  • GC03P044631
  • GC03P044558
  • GC03P044645
  • GC03P044674
  • GC03P044688
  • GC03P044716
  • GC03P044783
  • GC03P044676
  • GC03P044800

Summaries for ZNF197 Gene

Entrez Gene Summary for ZNF197 Gene

  • This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-type zinc fingers, a Kruppel-associated box (KRAB) domain, and a SCAN box. This transcript turns over rapidly and contains 3' UTR AUUUA motifs, which are often a hallmark of rapid turnover. It is overexpressed in some thyroid papillary carcinomas. This gene is located in a cluster of zinc finger genes at 3p21. [provided by RefSeq, Apr 2016]

GeneCards Summary for ZNF197 Gene

ZNF197 (Zinc Finger Protein 197) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ZNF197 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF197 Gene

Genomics for ZNF197 Gene

Regulatory Elements for ZNF197 Gene

Enhancers for ZNF197 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF197 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF197 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF197 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF197 gene promoter:

Genomic Location for ZNF197 Gene

44,584,888 bp from pter
44,648,471 bp from pter
63,584 bases
Plus strand

Genomic View for ZNF197 Gene

Genes around ZNF197 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF197 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF197 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF197 Gene

Proteins for ZNF197 Gene

  • Protein details for ZNF197 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 197
    Protein Accession:
    Secondary Accessions:
    • B2RAH8
    • Q86VG0

    Protein attributes for ZNF197 Gene

    1029 amino acids
    Molecular mass:
    118847 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF197 Gene


neXtProt entry for ZNF197 Gene

Proteomics data for ZNF197 Gene at MOPED

Post-translational modifications for ZNF197 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF197 Gene

No data available for DME Specific Peptides for ZNF197 Gene

Domains & Families for ZNF197 Gene

Gene Families for ZNF197 Gene

Suggested Antigen Peptide Sequences for ZNF197 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 22 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 22 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF197: view

Function for ZNF197 Gene

Molecular function for ZNF197 Gene

GENATLAS Biochemistry:
zinc finger protein 197
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF197: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF197 Gene

Localization for ZNF197 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF197 Gene

Subcellular locations from

Jensen Localization Image for ZNF197 Gene COMPARTMENTS Subcellular localization image for ZNF197 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF197 Gene

Pathways & Interactions for ZNF197 Gene

SuperPathways for ZNF197 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF197: view

Pathways by source for ZNF197 Gene

2 Reactome pathways for ZNF197 Gene

Gene Ontology (GO) - Biological Process for ZNF197 Gene


No data available for SIGNOR curated interactions for ZNF197 Gene

Drugs & Compounds for ZNF197 Gene

No Compound Related Data Available

Transcripts for ZNF197 Gene

Unigene Clusters for ZNF197 Gene

Zinc finger protein 197:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF197 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP2: -

Relevant External Links for ZNF197 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF197 Gene

mRNA expression in normal human tissues for ZNF197 Gene

Protein differential expression in normal tissues from HIPED for ZNF197 Gene

This gene is overexpressed in Breast (39.9) and Cerebrospinal fluid (29.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF197 Gene

SOURCE GeneReport for Unigene cluster for ZNF197 Gene Hs.157035

genes like me logo Genes that share expression patterns with ZNF197: view

Protein tissue co-expression partners for ZNF197 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF197 Gene

Orthologs for ZNF197 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF197 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF197 35
  • 91.05 (n)
  • 92.22 (a)
ZNF197 36
  • 91 (a)
(Mus musculus)
Mammalia Zfp616 36
  • 32 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4900 35
fruit fly
(Drosophila melanogaster)
Insecta CG10959 37
  • 37 (a)
CG11902 37
  • 24 (a)
CG6654 37
  • 39 (a)
CG6689 37
  • 33 (a)
zf30C 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
-- 36
  • 32 (a)
-- 36
  • 42 (a)
-- 36
  • 36 (a)
-- 36
  • 40 (a)
CSA.1668 36
  • 32 (a)
Species with no ortholog for ZNF197:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF197 Gene

Gene Tree for ZNF197 (if available)
Gene Tree for ZNF197 (if available)

Paralogs for ZNF197 Gene

(306) SIMAP similar genes for ZNF197 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF197: view

No data available for Paralogs for ZNF197 Gene

Variants for ZNF197 Gene

Sequence variations from dbSNP and Humsavar for ZNF197 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2272045 -- 44,632,169(+) ATGGC(A/G)CTTAT intron-variant, reference, synonymous-codon
rs2372772 -- 44,626,821(+) TTCTG(A/T)TTCAA intron-variant
rs882450 -- 44,633,523(+) CATTT(A/G)TACTG intron-variant
rs7430217 -- 44,646,203(+) aattc(C/G)tcatc intron-variant, utr-variant-3-prime
rs1402752 -- 44,645,808(-) CTGCA(C/T)TGGCT intron-variant, utr-variant-3-prime

Variation tolerance for ZNF197 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ZNF197 Gene

Disorders for ZNF197 Gene

Relevant External Links for ZNF197

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF197 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF197 Gene

Publications for ZNF197 Gene

  1. Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets. (PMID: 9380504) Gonsky R. … Fagin J.A. (Nucleic Acids Res. 1997) 2 3 4 23 67
  2. The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity. (PMID: 12682018) Li Z. … Wu G. (EMBO J. 2003) 3 23
  3. YAC-assisted cloning of transcribed sequences from the human chromosome 3p21 region. (PMID: 8353497) Pengue G. … D'Urso M. (Hum. Mol. Genet. 1993) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for ZNF197 Gene

Sources for ZNF197 Gene