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Aliases for ZNF195 Gene

Aliases for ZNF195 Gene

  • Zinc Finger Protein 195 2 3
  • ZNFP104 3 4
  • Krueppel Family Zinc Finger Protein (Znfp104) 3
  • Hypoxia-Regulated Factor-1 3
  • HRF1 3

External Ids for ZNF195 Gene

Summaries for ZNF195 Gene

Entrez Gene Summary for ZNF195 Gene

  • This gene encodes a protein belonging to the Krueppel C2H2-type zinc-finger protein family. These family members are transcription factors that are implicated in a variety of cellular processes. This gene is located near the centromeric border of chromosome 11p15.5, next to an imprinted domain that is associated with maternal-specific loss of heterozygosity in Wilms' tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

GeneCards Summary for ZNF195 Gene

ZNF195 (Zinc Finger Protein 195) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF195 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF195 Gene

Genomics for ZNF195 Gene

Genomic Location for ZNF195 Gene

Start:
3,339,261 bp from pter
End:
3,379,222 bp from pter
Size:
39,962 bases
Orientation:
Minus strand

Genomic View for ZNF195 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF195 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF195 Gene

Regulatory Elements for ZNF195 Gene

Proteins for ZNF195 Gene

  • Protein details for ZNF195 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14628-ZN195_HUMAN
    Recommended name:
    Zinc finger protein 195
    Protein Accession:
    O14628
    Secondary Accessions:
    • A8K234
    • B3KTK2
    • B4DEL0
    • C9JLY9
    • L7MNK2
    • Q0VAJ6
    • Q658N8
    • Q6ZNA9

    Protein attributes for ZNF195 Gene

    Size:
    629 amino acids
    Molecular mass:
    72332 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG57121.1; Type=Frameshift; Positions=118; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF195 Gene

neXtProt entry for ZNF195 Gene

Proteomics data for ZNF195 Gene at MOPED

Post-translational modifications for ZNF195 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys220 and Lys223

No data available for DME Specific Peptides for ZNF195 Gene

Domains for ZNF195 Gene

Gene Families for ZNF195 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

UniProtKB/Swiss-Prot:

ZN195_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • O14628
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • O14628
Similarity:
  • Contains 10 C2H2-type zinc fingers.:
    • O14628
genes like me logo Genes that share domains with ZNF195: view

Function for ZNF195 Gene

Molecular function for ZNF195 Gene

GENATLAS Biochemistry: zinc finger protein 195,C2H2 type,Kruppel-like,KRAB subfamily,with two alternatively spliced forms,expressed in heart,brain,placenta,skeletal muscle
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF195 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS 9344677
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF195: view

miRNA for ZNF195 Gene

miRTarBase miRNAs that target ZNF195

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF195 Gene

Localization for ZNF195 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF195 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF195 Gene COMPARTMENTS Subcellular localization image for ZNF195 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF195 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF195: view

Pathways for ZNF195 Gene

SuperPathways for ZNF195 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF195: view

Pathways by source for ZNF195 Gene

2 Reactome pathways for ZNF195 Gene

Gene Ontology (GO) - Biological Process for ZNF195 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF195: view

Transcripts for ZNF195 Gene

Unigene Clusters for ZNF195 Gene

Zinc finger protein 195:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF195 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - - - -
SP15: - - - -
SP16: - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - - - - - - - - - - - - - -
SP20: - - -
SP21: - - - - - - - - - - -
SP22: - - - - -
SP23: - - - - - - -
SP24: - - - - - - - - - -
SP25: -
SP26:
SP27: - - - - - - - - -
SP28: - -

ExUns: 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d · 14e · 14f · 14g · 14h · 14i · 14j · 14k · 14l
SP1: - - -
SP2: - - - - - - -
SP3: - - - -
SP4:
SP5: - - - - - - -
SP6: - - - -
SP7:
SP8: - - - -
SP9: - - - - -
SP10: - - - - - - -
SP11:
SP12: - - - -
SP13: - - - - -
SP14: - - - -
SP15:
SP16: - - - - - - -
SP17: - - - - - - -
SP18: - - - - -
SP19: - - - - - - -
SP20:
SP21:
SP22:
SP23:
SP24: -
SP25: - - - - -
SP26: -
SP27: - - - - -
SP28: - - - - - - -

Relevant External Links for ZNF195 Gene

GeneLoc Exon Structure for
ZNF195
ECgene alternative splicing isoforms for
ZNF195

Expression for ZNF195 Gene

mRNA expression in normal human tissues for ZNF195 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF195 Gene

SOURCE GeneReport for Unigene cluster for ZNF195 Gene Hs.386294

mRNA Expression by UniProt/SwissProt for ZNF195 Gene

O14628-ZN195_HUMAN
Tissue specificity: Expressed in adult heart, brain, placenta, skeletal muscle and pancreas, and in fetal lung, kidney and brain. There is little expression in adult lung, liver and kidney
genes like me logo Genes that share expressions with ZNF195: view

Orthologs for ZNF195 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF195 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF195 36
  • 99.26 (n)
  • 98.8 (a)
ZNF195 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 48 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 33 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp493 37
  • 52 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 35 (a)
ManyToMany
-- 37
  • 47 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 47 (a)
ManyToMany
-- 37
  • 31 (a)
ManyToMany
-- 37
  • 38 (a)
ManyToMany
-- 37
  • 36 (a)
ManyToMany
-- 37
  • 29 (a)
ManyToMany
-- 37
  • 30 (a)
ManyToMany
-- 37
  • 29 (a)
ManyToMany
-- 37
  • 27 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9793 38
  • 43 (a)
CG14655 38
  • 48 (a)
Species with no ortholog for ZNF195:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF195 Gene

ENSEMBL:
Gene Tree for ZNF195 (if available)
TreeFam:
Gene Tree for ZNF195 (if available)

Paralogs for ZNF195 Gene

Pseudogenes.org Pseudogenes for ZNF195 Gene

genes like me logo Genes that share paralogs with ZNF195: view

Variants for ZNF195 Gene

Sequence variations from dbSNP and Humsavar for ZNF195 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs739393 -- 3,378,510(-) GATTT(C/G)AGCTA intron-variant
rs1011282 -- 3,365,776(-) TTTGT(C/T)TCATC intron-variant
rs1011283 -- 3,365,630(-) tttag(C/G)attaa intron-variant
rs1989783 -- 3,369,186(-) aaggc(A/C)aaaac intron-variant
rs1989784 -- 3,369,026(-) ACTTT(A/T)GGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF195 Gene

Variant ID Type Subtype PubMed ID
nsv7649 CNV Loss 18451855
dgv335e1 CNV Complex 17122850
nsv428245 CNV Gain 18775914
dgv336e1 CNV Complex 17122850
esv27813 CNV Loss 19812545
esv1009338 CNV Insertion 20482838
esv1119865 CNV Insertion 17803354
nsv8771 CNV Loss 18304495
nsv7650 CNV Insertion 18451855

Relevant External Links for ZNF195 Gene

HapMap Linkage Disequilibrium report
ZNF195

Disorders for ZNF195 Gene

No disorders were found for ZNF195 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF195 Gene

Publications for ZNF195 Gene

  1. Characterization of a KRAB family zinc finger gene, ZNF195, mapping to chromosome band 11p15.5. (PMID: 9344677) Hussey D.J. … Dobrovic A. (Genomics 1997) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  5. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3

Products for ZNF195 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF195
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF195
    • Block miRNA regulation of ZNF195 using miScript Target Protectors

    Sources for ZNF195 Gene

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