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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF195 Gene

protein-coding GIFtS: 53
GCID: GC11M003336

zinc finger protein 195

Explore 3 diseases affiliated with
ZNF195 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 195¹ ²
ZNFP104² ³
HRF1²
Hypoxia-Regulated Factor-1²
Krueppel Family Zinc Finger Protein (Znfp104)²

External Ids:	HGNC: 12986¹	Entrez Gene: 7748²	Ensembl: ENSG00000005801⁷	OMIM: 602187⁵	UniProtKB: O14628³

ORGUL members:
	NONCODE:n381594 n411614

Export aliases for ZNF195 gene to outside databases

Previous GC identifers: GC11M003444 GC11M003643 GC11M003339 GC11M003344 GC11M003118

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF195:

This gene encodes a protein belonging to the Krueppel C2H2-type zinc-finger protein family. These family members are

transcription factors that are implicated in a variety of cellular processes. This gene is located near the

centromeric border of chromosome 11p15.5, next to an imprinted domain that is associated with maternal-specific loss

of heterozygosity in Wilms' tumors. Alternative splicing results in multiple transcript variants. (provided by RefSeq,

Feb 2012)

UniProtKB/Swiss-Prot: ZN195_HUMAN, O14628

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF195 gene promoter:
c-Fos TBP AP-1 Pax-5 FOXO3 AREB6 Nkx6-1 TFIID c-Myb c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF195 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF195

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF195

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.5

ZNF195 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF195 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M003336: view genomic region (about GC identifiers)

Start:	3,360,491 bp from pter	End:	3,400,448 bp from pter
Size:	39,958 bases	Orientation:	minus strand

ORGUL member locations:
Legend (see complete legend)

n381594
n411614

lncRNA
Full Legend

3379155 3389804 3400452 chr11

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN195_HUMAN, O14628 (See protein sequence)

Recommended Name: Zinc finger protein 195

Size: 629 amino acids; 72332 Da

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=BAG57121.1; Type=Frameshift; Positions=118;

Secondary accessions: A8K234 B3KTK2 B4DEL0 C9JLY9 Q0VAJ6 Q658N8 Q6ZNA9

Alternative splicing: 8 isoforms: O14628-1 O14628-2 O14628-3 O14628-4 O14628-5 O14628-6 O14628-7 O14628-8

(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF195: NX_O14628

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14628

ZNF195 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (9 alternative transcripts):

NP_001123991.1 NP_001123992.1 NP_001229770.1 NP_001229771.1 NP_001229772.1 NP_001243752.1 NP_001243753.1 NP_001243754.1

NP_009083.2

ENSEMBL proteins:

ENSP00000432720 ENSP00000346613 ENSP00000382511 ENSP00000387998 ENSP00000005082

ENSP00000435828 ENSP00000414353 ENSP00000431937 ENSP00000436384 ENSP00000435741

ENSP00000433911 ENSP00000434361 ENSP00000434715 ENSP00000390663 ENSP00000437265

ENSP00000435093 ENSP00000434006 ENSP00000432552 ENSP00000435153 ENSP00000344483

Reactome Protein details: O14628
Human Recombinant Protein Products:

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	Uscn Proteins for ZNF195

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	NAS	--

ZNF195 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ZNF195

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF195 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry O14628

ProtoNet protein and cluster: O14628

2 Blocks protein families:

IPB001909 KRAB box

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN195_HUMAN, O14628

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 10 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN195_HUMAN, O14628

Function: May be involved in transcriptional regulation

Genatlas biochemistry entry for ZNF195:

zinc finger protein 195,C2H2 type,Kruppel-like,KRAB subfamily,with two alternatively spliced forms,expressed in

heart,brain,placenta,skeletal muscle

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In Situ Assay
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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	NAS	--
GO:0008270	zinc ion binding	NAS	9344677

ZNF195 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF195

	Generic Transcription Pathway
	Gene Expression

ZNF195 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF195

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for ZNF195 (O14628³ ENSP00000005082⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PCBD1	P61457³, ENSP00000299299⁴	I2D: score=1 STRING: ENSP00000299299
CBX5	ENSP00000209875⁴	STRING: ENSP00000209875
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	NAS	--

ZNF195 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF195
Search CenterWatch for drugs/clinical trials and news about ZNF195 / ZN195

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF195 gene (9 alternative transcripts):

NM_001130519.2 NM_001130520.2 NM_001242841.1 NM_001242842.1 NM_001242843.1 NM_001256823.1 NM_001256824.1 NM_001256825.1

NM_007152.4

Unigene Cluster for ZNF195:

Zinc finger protein 195

Hs.386294 [show with all ESTs]

Unigene Representative Sequence: NR_040083

18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):

ENST00000528796 ENST00000354599(uc010qxr.2 uc001lxt.3 uc009ydz.3 uc001lxu.3 uc001lxv.3 uc021qck.1 uc001lxs.3)

ENST00000399602 ENST00000429541 ENST00000005082 ENST00000526601 ENST00000438262

ENST00000528410 ENST00000528218 ENST00000529789 ENST00000525313 ENST00000533036

ENST00000529228 ENST00000526540 ENST00000529678 ENST00000526598 ENST00000528636

ENST00000427810

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Additional cDNA sequence:

AF003540.1 AF028728.1 AK095720.1 AK131296.1 AK290099.1 AK293679.1 AK308024.1 AK308068.1

AK308209.1 AL833722.1 BC121028.1 BC121029.1 NR_040083.1 NR_046381.1 NR_046382.1

14 DOTS entries:

DT.91917593 DT.95373561 DT.120759479 DT.97861747 DT.101956862 DT.97861746 DT.95373558 DT.102828837

DT.120759454 DT.120759462 DT.120759484 DT.91751621 DT.101982394 DT.92063411

24/112 AceView cDNA sequences (see all 112):

AW241205 BQ717379 BQ427615 AK131296 AI049825 AW820304 Z41948 AI000149

BP349870 BG576135 BX115394 BX485437 AA721509 AF028728 AI281694 AK095720

CF994869 BG829602 CK005237 AW820233 BP354285 BE932284 BF976384 CD359486

GeneLoc Exon Structure

5/28 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF195 (see all 28) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b	^
SP1:													-		-		-		-		-		-						-						-		-		-		-		-		-		-		-		-
SP2:																	-		-										-						-		-		-		-		-		-		-		-		-
SP3:													-		-		-		-										-						-		-		-		-		-		-		-				-
SP4:													-		-		-		-		-		-						-								-		-		-		-		-		-				-
SP5:													-		-		-		-										-						-		-		-		-		-		-		-				-

ExUns:	11a	·	11b	·	11c	·	11d	^	12a	·	12b	^	13	^	14a	·	14b	·	14c	·	14d	·	14e	·	14f	·	14g	·	14h	·	14i	·	14j	·	14k	·	14l
SP1:	-		-										-
SP2:	-		-		-		-		-		-		-
SP3:	-		-		-		-
SP4:
SP5:	-		-		-		-		-		-		-

ECgene alternative splicing isoforms for ZNF195

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF195 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGCATTCA

About this image
See ZNF195 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF195

SOURCE GeneReport for Unigene cluster: Hs.386294

UniProtKB/Swiss-Prot: ZN195_HUMAN, O14628

Tissue specificity: Expressed in adult heart, brain, placenta, skeletal muscle and pancreas, and in fetal lung, kidney

and brain. There is little expression in adult lung, liver and kidney

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for ZNF195 (if available)
TreeFam Gene Tree for ZNF195 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF195 gene

18/529 SIMAP similar genes for ZNF195 using alignment to 12 protein entries: ZN195_HUMAN (see all proteins) (see all similar genes):

ZNF519 ZNF554 OK/SW-cl.41 ZNF28 ZNF701 ZNF283

ZNF816 ZNF763 ZNF420 ZNF726 ZNF559 ZNF124

ZNF571 ZNF586 ZNF3 ZNF624 ZNF439 ZNF529

ZNF195 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for ZNF195
PGOHUM00000258051 PGOHUM00000258268 PGOHUM00000258271

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76401009^1,2		--	3117564(+)	`GTTCAG/CCCAGG`	12	--	ds500¹		1		WA	118
rs72848286^1,2	C,F,	--	3117599(+)	`GGAGAA/GAGGGA`	12	--	ds500¹		2		WA NA	238
rs73410510^1,2	C,	--	3117857(+)	`GGTGCT/AGGTGT`	12	--	ut3¹ nc-transcript-variant		1		WA	2
rs77995808^1,2		--	3118495(+)	`CACAGA/GGATTC`	12	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs79949661^1,2		--	3120490(+)	`CACAGA/GCCCTA`	12	--	int¹		0	--	--	--	--
rs113722759^1,2		--	3120666(+)	`CAGTAC/TAGCAT`	12	--	int¹		1		CSA	2
rs200549959^1,2	C	--	3121092(+)	`GCAGGA/GGGCTT`	12	--	int¹		0	--	--	--	--
rs79025622^1,2		--	3121141(+)	`CAAAGC/TATTAG`	12	--	int¹		0	--	--	--	--
rs73410516^1,2	C,F,	--	3121548(+)	`GAGATT/GACCAG`	12	--	int¹		3		WA	122
rs12288641^1,2	H,	--	3122125(+)	`GATACG/ACATAT`	12	--	int¹		4		NS EA	392

HapMap Linkage Disequilibrium report for ZNF195 (3360491 - 3400448 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZNF195
2 CNVs: 3833 31797

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF195 for disorders           About GeneDecksing

OMIM gene information: 602187    OMIM disorders: --

3 diseases for ZNF195:    About MalaCards

wilms tumor hypoxia endocarditis

Export disorders for ZNF195 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF195 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with ZNF195)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of a KRAB family zinc finger gene, ZNF195, mapping to chromosome band 11p15.5. (PubMed id 9344677)^{1, 2, 3} Hussey D.J.... Dobrovic A. (1997)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)¹ Nozawa R.S....Obuse C. (2010)
An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (2010)
Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)² Choudhary C.... Mann M. (2009)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7748	HGNC: 12986	AceView: ZNF195	Ensembl:ENSG00000005801	euGenes: HUgn7748
ECgene: ZNF195	H-InvDB: ZNF195

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ZNF195	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF195 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ZNF195 gene:
Search GeneIP for patents involving ZNF195

GeneCards and IP:
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ZNF195 Gene

zinc finger protein 195

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ZNF195 Gene

zinc finger protein 195

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