Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF195 Gene

Aliases for ZNF195 Gene

  • Zinc Finger Protein 195 2 3 5
  • ZNFP104 3 4
  • Krueppel Family Zinc Finger Protein (Znfp104) 3
  • Hypoxia-Regulated Factor-1 3
  • HRF1 3

External Ids for ZNF195 Gene

Previous GeneCards Identifiers for ZNF195 Gene

  • GC11M003444
  • GC11M003643
  • GC11M003339
  • GC11M003344
  • GC11M003118

Summaries for ZNF195 Gene

Entrez Gene Summary for ZNF195 Gene

  • This gene encodes a protein belonging to the Krueppel C2H2-type zinc-finger protein family. These family members are transcription factors that are implicated in a variety of cellular processes. This gene is located near the centromeric border of chromosome 11p15.5, next to an imprinted domain that is associated with maternal-specific loss of heterozygosity in Wilms' tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

GeneCards Summary for ZNF195 Gene

ZNF195 (Zinc Finger Protein 195) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF732.

UniProtKB/Swiss-Prot for ZNF195 Gene

  • May be involved in transcriptional regulation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF195 Gene

Genomics for ZNF195 Gene

Regulatory Elements for ZNF195 Gene

Enhancers for ZNF195 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G003377 1.4 Ensembl ENCODE 33.4 -0.6 -605 4.6 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 TSSC2 ZNF195
GH11G003339 0.8 ENCODE 12.2 +39.0 39030 1.6 HDAC1 CBX3 ATF1 NFRKB GATA2 FOS CREM PAF1 JUNB ZEB2 ZNF195 TSSC2 ENSG00000224513 MRGPRG MRGPRG-AS1 RNU1-91P NAP1L4 SNORA54 ART1 ART5
GH11G003341 0.6 ENCODE 12.2 +37.8 37807 0.0 CTCF ZNF654 ARNT TRIM22 REST RAD21 SMC3 DEK ZNF195 TSSC2 ENSG00000224513 MRGPRG MRGPRG-AS1 RNU1-91P NAP1L4 SNORA54 ART1 ART5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF195 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF195 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036071 422 1601 PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for ZNF195 Gene

Chromosome:
11
Start:
3,339,261 bp from pter
End:
3,379,222 bp from pter
Size:
39,962 bases
Orientation:
Minus strand

Genomic View for ZNF195 Gene

Genes around ZNF195 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF195 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF195 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF195 Gene

Proteins for ZNF195 Gene

  • Protein details for ZNF195 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14628-ZN195_HUMAN
    Recommended name:
    Zinc finger protein 195
    Protein Accession:
    O14628
    Secondary Accessions:
    • A8K234
    • B3KTK2
    • B4DEL0
    • C9JLY9
    • L7MNK2
    • Q0VAJ6
    • Q658N8
    • Q6ZNA9

    Protein attributes for ZNF195 Gene

    Size:
    629 amino acids
    Molecular mass:
    72332 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG57121.1; Type=Frameshift; Positions=118; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF195 Gene

neXtProt entry for ZNF195 Gene

Post-translational modifications for ZNF195 Gene

  • Ubiquitination at posLast=220220 and isoforms=4, 5, 6, 7223
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF195 Gene

Domains & Families for ZNF195 Gene

Gene Families for ZNF195 Gene

Suggested Antigen Peptide Sequences for ZNF195 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14628

UniProtKB/Swiss-Prot:

ZN195_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF195: view

Function for ZNF195 Gene

Molecular function for ZNF195 Gene

GENATLAS Biochemistry:
zinc finger protein 195,C2H2 type,Kruppel-like,KRAB subfamily,with two alternatively spliced forms,expressed in heart,brain,placenta,skeletal muscle
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF195 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS 9344677
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF195: view
genes like me logo Genes that share phenotypes with ZNF195: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF195 Gene

Localization for ZNF195 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF195 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF195 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF195 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF195: view

Pathways & Interactions for ZNF195 Gene

SuperPathways for ZNF195 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF195: view

Pathways by source for ZNF195 Gene

2 Reactome pathways for ZNF195 Gene

Gene Ontology (GO) - Biological Process for ZNF195 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF195: view

No data available for SIGNOR curated interactions for ZNF195 Gene

Drugs & Compounds for ZNF195 Gene

No Compound Related Data Available

Transcripts for ZNF195 Gene

Unigene Clusters for ZNF195 Gene

Zinc finger protein 195:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF195 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - - - -
SP15: - - - -
SP16: - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - - - - - - - - - - - - - -
SP20: - - -
SP21: - - - - - - - - - - -
SP22: - - - - -
SP23: - - - - - - -
SP24: - - - - - - - - - -
SP25: -
SP26:
SP27: - - - - - - - - -
SP28: - -

ExUns: 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d · 14e · 14f · 14g · 14h · 14i · 14j · 14k · 14l
SP1: - - -
SP2: - - - - - - -
SP3: - - - -
SP4:
SP5: - - - - - - -
SP6: - - - -
SP7:
SP8: - - - -
SP9: - - - - -
SP10: - - - - - - -
SP11:
SP12: - - - -
SP13: - - - - -
SP14: - - - -
SP15:
SP16: - - - - - - -
SP17: - - - - - - -
SP18: - - - - -
SP19: - - - - - - -
SP20:
SP21:
SP22:
SP23:
SP24: -
SP25: - - - - -
SP26: -
SP27: - - - - -
SP28: - - - - - - -

Relevant External Links for ZNF195 Gene

GeneLoc Exon Structure for
ZNF195
ECgene alternative splicing isoforms for
ZNF195

Expression for ZNF195 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF195 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF195 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF195 Gene



Protein tissue co-expression partners for ZNF195 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF195 Gene:

ZNF195

SOURCE GeneReport for Unigene cluster for ZNF195 Gene:

Hs.386294

mRNA Expression by UniProt/SwissProt for ZNF195 Gene:

O14628-ZN195_HUMAN
Tissue specificity: Expressed in adult heart, brain, placenta, skeletal muscle and pancreas, and in fetal lung, kidney and brain. There is little expression in adult lung, liver and kidney.

Evidence on tissue expression from TISSUES for ZNF195 Gene

  • Nervous system(4.7)
  • Stomach(4.2)
genes like me logo Genes that share expression patterns with ZNF195: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF195 Gene

Orthologs for ZNF195 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF195 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF195 34 35
  • 99.26 (n)
mouse
(Mus musculus)
Mammalia Zfp493 35
  • 52 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 48 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 47 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 47 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14655 36
  • 48 (a)
CG9793 36
  • 43 (a)
Species where no ortholog for ZNF195 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF195 Gene

ENSEMBL:
Gene Tree for ZNF195 (if available)
TreeFam:
Gene Tree for ZNF195 (if available)

Paralogs for ZNF195 Gene

Paralogs for ZNF195 Gene

Pseudogenes.org Pseudogenes for ZNF195 Gene

genes like me logo Genes that share paralogs with ZNF195: view

Variants for ZNF195 Gene

Sequence variations from dbSNP and Humsavar for ZNF195 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000085505 -- 3,370,288(+) ATACT(A/G)AAAAA intron-variant
rs1000116895 -- 3,370,029(+) ATATG(A/C/T)CCACA intron-variant
rs1000129116 -- 3,363,384(+) TAGGA(C/T)AGGCC intron-variant
rs1000148922 -- 3,358,218(+) AGGGG(A/G)GTTTG nc-transcript-variant, utr-variant-3-prime
rs1000420362 -- 3,364,664(+) TATAC(A/G)AGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF195 Gene

Variant ID Type Subtype PubMed ID
esv1009338 CNV insertion 20482838
esv1119865 CNV insertion 17803354
esv2759796 CNV gain+loss 17122850
esv27813 CNV loss 19812545
esv3579246 CNV loss 25503493
esv3625139 CNV loss 21293372
esv3891908 CNV loss 25118596
nsv428245 CNV gain 18775914
nsv7649 CNV deletion 18451855
nsv7650 CNV insertion 18451855
nsv8771 CNV loss 18304495
nsv951297 CNV deletion 24416366

Variation tolerance for ZNF195 Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.33; 81.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF195 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF195

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF195 Gene

Disorders for ZNF195 Gene

Relevant External Links for ZNF195

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF195

No disorders were found for ZNF195 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF195 Gene

Publications for ZNF195 Gene

  1. Characterization of a KRAB family zinc finger gene, ZNF195, mapping to chromosome band 11p15.5. (PMID: 9344677) Hussey D.J. … Dobrovic A. (Genomics 1997) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. DNA microarray reveals ZNF195 and SBF1 are potential biomarkers for gemcitabine sensitivity in head and neck squamous cell carcinoma cell lines. (PMID: 24817947) Zhu M.H. … Zheng H.L. (Int J Clin Exp Pathol 2014) 3 64
  5. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 4 64

Products for ZNF195 Gene

Sources for ZNF195 Gene

Content
Loading form....