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Aliases for ZNF19 Gene

Aliases for ZNF19 Gene

  • Zinc Finger Protein 19 2 3 5
  • Zinc Finger Protein 19 (KOX 12) 2 3
  • Zinc Finger Protein KOX12 3 4
  • KOX12 3 4

External Ids for ZNF19 Gene

Previous GeneCards Identifiers for ZNF19 Gene

  • GC16U990061
  • GC16M072231
  • GC16M071217
  • GC16M071284
  • GC16M070065
  • GC16M057276

Summaries for ZNF19 Gene

Entrez Gene Summary for ZNF19 Gene

  • The protein encoded by this gene contains a zinc finger, a nucleic acid-binding domain present in many transcription factors. This gene is located in a region next to ZNF23, a gene also encoding a zinc finger protein, on chromosome 16. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF19 Gene

ZNF19 (Zinc Finger Protein 19) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF619.

UniProtKB/Swiss-Prot for ZNF19 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF19 Gene

Genomics for ZNF19 Gene

Regulatory Elements for ZNF19 Gene

Enhancers for ZNF19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F071707 1.3 FANTOM5 Ensembl ENCODE 48.1 -143.8 -143765 3.3 MAX RAD21 ZNF121 ZNF664 ZNF316 GATA3 SMC3 FOS MAFK TCF7L2 ZNF19 PMFBP1 PHLPP2 MARVELD3 RNU6-208P HPR HYDIN ENSG00000261513 SNORA70D
GH16F071426 1.1 ENCODE 11 +138.6 138557 0.5 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ZNF302 DHX38 ZNF23 ENSG00000247324 SF3B3 AP1G1 ENSG00000262120 LOC102723796 LOC105371335 LOC102723786 ENSG00000261673
GH16F071412 1.1 Ensembl ENCODE 10.6 +152.4 152428 1.0 ELF3 DRAP1 CTCF ARID4B MAX DMAP1 EBF1 ZNF48 RAD21 GLIS2 ZNF23 ENSG00000247324 ZNF19 CALB2 ENSG00000262120 LOC105371332
GH16F071387 0.5 ENCODE 10.4 +177.6 177554 0.9 MAX ZMYM3 KDM1A CALB2 ZNF19 HPR LOC105371332
GH16F071563 1.1 ENCODE 0.8 0.0 -43 3.3 HDGF PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 DHX38 ENSG00000247324 PHLPP2 ZNF23 TAT-AS1 DHODH HPR ZNF19 TAT
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF19 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001802672 -111 1601 HDGF ARNT MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 FOS

Genomic Location for ZNF19 Gene

Chromosome:
16
Start:
71,464,555 bp from pter
End:
71,565,089 bp from pter
Size:
100,535 bases
Orientation:
Minus strand

Genomic View for ZNF19 Gene

Genes around ZNF19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF19 Gene

Proteins for ZNF19 Gene

  • Protein details for ZNF19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17023-ZNF19_HUMAN
    Recommended name:
    Zinc finger protein 19
    Protein Accession:
    P17023
    Secondary Accessions:
    • A8K895
    • Q86Y66
    • Q8NDE2
    • Q96M79
    • Q96NE5

    Protein attributes for ZNF19 Gene

    Size:
    458 amino acids
    Molecular mass:
    52449 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA36814.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF19 Gene

Post-translational modifications for ZNF19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for ZNF19

No data available for DME Specific Peptides for ZNF19 Gene

Domains & Families for ZNF19 Gene

Gene Families for ZNF19 Gene

Suggested Antigen Peptide Sequences for ZNF19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17023

UniProtKB/Swiss-Prot:

ZNF19_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF19: view

Function for ZNF19 Gene

Molecular function for ZNF19 Gene

GENATLAS Biochemistry:
zinc finger protein 19 (KOX12) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 7557990
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF19: view
genes like me logo Genes that share phenotypes with ZNF19: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF19 Gene

Localization for ZNF19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF19 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF19 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus NAS 7557990
genes like me logo Genes that share ontologies with ZNF19: view

Pathways & Interactions for ZNF19 Gene

SuperPathways for ZNF19 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF19: view

Pathways by source for ZNF19 Gene

2 Reactome pathways for ZNF19 Gene

Gene Ontology (GO) - Biological Process for ZNF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 7557990
genes like me logo Genes that share ontologies with ZNF19: view

No data available for SIGNOR curated interactions for ZNF19 Gene

Transcripts for ZNF19 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF19 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - -
SP3:
SP4: -
SP5: - -
SP6: -

Relevant External Links for ZNF19 Gene

GeneLoc Exon Structure for
ZNF19
ECgene alternative splicing isoforms for
ZNF19

Expression for ZNF19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF19 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF19 Gene:

ZNF19
genes like me logo Genes that share expression patterns with ZNF19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF19 Gene

Orthologs for ZNF19 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF19 34
  • 99.34 (n)
-- 35
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZNF19 34
  • 87.82 (n)
-- 35
  • 85 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZNF19 34
  • 84.62 (n)
Species where no ortholog for ZNF19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF19 Gene

ENSEMBL:
Gene Tree for ZNF19 (if available)
TreeFam:
Gene Tree for ZNF19 (if available)

Paralogs for ZNF19 Gene

(546) SIMAP similar genes for ZNF19 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for ZNF19 Gene

genes like me logo Genes that share paralogs with ZNF19: view

Variants for ZNF19 Gene

Sequence variations from dbSNP and Humsavar for ZNF19 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10500557 -- 71,475,876(+) AGGCT(C/T)GCCCA reference, missense
rs111484292 -- 71,480,164(+) TTCTG(G/T)CATCT intron-variant
rs111687131 -- 71,483,843(+) TAAAG(C/G)AAAGA intron-variant
rs111793980 -- 71,482,203(+) CTTTA(A/G)AGCAA intron-variant
rs112162990 -- 71,476,712(+) TAAAA(A/G)CTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF19 Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER inversion 18451855

Variation tolerance for ZNF19 Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF19 Gene

Disorders for ZNF19 Gene

Relevant External Links for ZNF19

Genetic Association Database (GAD)
ZNF19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF19

No disorders were found for ZNF19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF19 Gene

Publications for ZNF19 Gene

  1. Characterization and mapping of human genes encoding zinc finger proteins. (PMID: 1946370) Bray P.L. … Dawid I.B. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P. … Ward D.C. (Genomics 1992) 2 3 64
  5. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4 64

Products for ZNF19 Gene

Sources for ZNF19 Gene

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