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ZNF19 Gene

protein-coding   GIFtS: 46
GCID: GC16M071507

Zinc Finger Protein 19

(Previous name: zinc finger protein 19 (KOX 12))
  Search for ZNF19
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 191 2
KOX122 3 5
Zinc Finger Protein 19 (KOX 12)1 2
Zinc Finger Protein KOX122 3

External Ids:    HGNC: 129811   Entrez Gene: 75672   Ensembl: ENSG000001574297   OMIM: 1945255   UniProtKB: P170233   

Export aliases for ZNF19 gene to outside databases

Previous GC identifers: GC16U990061 GC16M072231 GC16M071217 GC16M071284 GC16M070065 GC16M057276


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF19 Gene:
The protein encoded by this gene contains a zinc finger, a nucleic acid-binding domain present in many
transcription factors. This gene is located in a region next to ZNF23, a gene also encoding a zinc finger
protein, on chromosome 16. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZNF19 Gene:
ZNF19 (zinc finger protein 19) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF621.

UniProtKB/Swiss-Prot: ZNF19_HUMAN, P17023
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF19 gene promoter:
         AML1a   NRSF form 1   HNF-1   NRSF form 2   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF19 promoter sequence
   Search Chromatin IP Primers for ZNF19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22   Ensembl cytogenetic band:  16q22.2   HGNC cytogenetic band: 16q22

ZNF19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF19 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M071507:  view genomic region     (about GC identifiers)

Start:
71,498,453 bp from pter      End:
71,598,992 bp from pter
Size:
100,540 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZNF19_HUMAN, P17023 (See protein sequence)
Recommended Name: Zinc finger protein 19  
Size: 458 amino acids; 52449 Da
Sequence caution: Sequence=AAA36814.1; Type=Erroneous initiation;
Secondary accessions: A8K895 Q86Y66 Q8NDE2 Q96M79 Q96NE5
Alternative splicing: 2 isoforms:  P17023-1   P17023-2   

Explore the universe of human proteins at neXtProt for ZNF19: NX_P17023

Explore proteomics data for ZNF19 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008892.2  
    ENSEMBL proteins: 
     ENSP00000462566   ENSP00000288177   ENSP00000454864   ENSP00000462810   ENSP00000456143  
     ENSP00000458105   ENSP00000454549   ENSP00000455796   ENSP00000462021   ENSP00000455575  
     ENSP00000454862   ENSP00000457992  
    Reactome Protein details: P17023

    ZNF19 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF19

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17023

    ProtoNet protein and cluster: P17023

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZNF19_HUMAN, P17023
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF19           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF19_HUMAN, P17023
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF19:
    zinc finger protein 19 (KOX12) (C2H2 type,Kruppel-like)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS7557990
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF19           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF19
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    hsa-miR-580 hsa-miR-597 hsa-miR-888* hsa-miR-592
    SwitchGear 3'UTR luciferase reporter plasmidZNF19 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNF19_HUMAN, P17023: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus NAS7557990

    Find genes that share ontologies with ZNF19           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF19 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF19           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF19
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF19
    Interactions:

        Search GeneGlobe Interaction Network for ZNF19

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated NAS7557990

    Find genes that share ontologies with ZNF19           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF19



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF19 gene: 
    NM_006961.3  

    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000567225 ENST00000288177(uc002fak.1 uc010cgc.1 uc002fal.1 uc002fam.1)
    ENST00000565637 ENST00000565100 ENST00000569717 ENST00000564230 ENST00000565541
    ENST00000568815 ENST00000561469 ENST00000562210 ENST00000564225 ENST00000566202
    ENST00000569072 ENST00000568446
    miRNA
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    Block miRNA regulation of human, mouse, rat ZNF19 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ZNF19:
    hsa-miR-580 hsa-miR-597 hsa-miR-888* hsa-miR-592
    SwitchGear 3'UTR luciferase reporter plasmidZNF19 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF19
      QuantiFast Probe-based Assays in human, mouse, rat ZNF19

    Selected AceView cDNA sequences (see all 132):

    CK429424 N45703 CR614408 X52343 BM310950 AI937864 CB265954 BX537507 
    X52347 BT007400 AL080123 BM021862 BM465669 BM310653 BC048974 H21693 
    BM271734 BE856369 BF439946 BQ000009 CF890829 AA805092 AA026601 BX098236 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF19 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
    SP1:                          -     -                             -                                       
    SP2:                                -                 -     -     -                                       
    SP3:                                                                                                      
    SP4:                          -                                                                           
    SP5:                                -                             -                                       


    ECgene alternative splicing isoforms for ZNF19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF19 Expression
    About this image

    ZNF19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF19 Protein Expression
        Custom PCR Arrays for ZNF19
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF19 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF191 zinc finger protein 19 87.82(n)
    82.71(a)
      489721  XM_005620738.1  XP_005620795.1 


    ENSEMBL Gene Tree for ZNF19 (if available)
    TreeFam Gene Tree for ZNF19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF19 gene
    ZNF6212  ZNF6202  ZNF6192  ZNF6622  ENSG000002616112  
    Selected SIMAP similar genes for ZNF19 using alignment to 10 protein entries:     ZNF19_HUMAN (see all proteins) (see all similar genes):
    ZNF23    ZNF78L1    ZNF818P    ZNF826P    kr-znf3    ZNF83
    HZF36    ZNF55    ZNF347    ZNF345    ZNF320    ZNF707
    ZNF271    ZNF808    ZNF761    ZNF28    DKFZp313M0722    DKFZp571N1833

    Find genes that share paralogs with ZNF19           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ZNF19
    PGOHUM00000262302 PGOHUM00000240627


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF19 (see all 345)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1905789271,2
    --71507478(+) TGTACA/TACCAT 1 -- ds50010--------
    rs99408301,2
    C,F,H--71507490(+) attcaT/Cggttt 1 -- ds50017Minor allele frequency- C:0.06NS EA WA 538
    rs1413868141,2
    --71507517(+) GGAATC/TTCACT 1 -- ds50010--------
    rs1835601331,2
    --71507557(+) ATCTCA/GGCTCA 1 -- ds50010--------
    rs1508204131,2
    --71507632(+) ACAGGC/TATGCA 1 -- ds50010--------
    rs1882209851,2
    --71507719(+) TTGACC/TTGATG 1 -- ds50010--------
    rs1381834521,2
    --71507777(+) CACCGC/TGCCTG 1 -- ds50010--------
    rs1132006301,2
    F--71507820(+) CTTCAA/G/TTTAAA 1 -- ds50011CSA 2
    rs1460776061,2
    --71507864(+) ATTGGA/TCAACC 1 -- ds50010--------
    rs1400814331,2
    --71507901(+) ATCTGA/CTGACA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZNF19 (71498453 - 71598992 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF19:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7285OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF19
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 194525    OMIM disorders: --


    Find genes that share disorders with ZNF19           About GenesLikeMe

    Genetic Association Database (GAD): ZNF19

    Export disorders for ZNF19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF19 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ZNF19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and mapping of human genes encoding zinc finger proteins. (PubMed id 1946370)1, 2, 3 Bray P.L.... Dawid I.B. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PubMed id 1505991)1, 3 Lichter P.... Ward D.C. (Genomics 1992)
    5. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (New Biol. 1990)
    6. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7567 HGNC: 12981 AceView: ZNF19andZNF23 Ensembl:ENSG00000157429 euGenes: HUgn7567
    ECgene: ZNF19 H-InvDB: ZNF19

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF19 gene:
    Search GeneIP for patents involving ZNF19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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