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ZNF189 Gene

protein-coding   GIFtS: 52
GCID: GC09P104161

Zinc Finger Protein 189

  Search for ZNF189
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 1891 2

External Ids:    HGNC: 129801   Entrez Gene: 77432   Ensembl: ENSG000001368707   OMIM: 6031325   UniProtKB: O758203   

Export aliases for ZNF189 gene to outside databases

Previous GC identifers: GC09P094961 GC09P095904 GC09P097618 GC09P099541 GC09P101240 GC09P103200 GC09P073760


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF189 Gene:
Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a
variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al.,
1998 (PubMed 9653648)). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal
Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be
subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression,
and a B box, which is not always present.(supplied by OMIM, May 2010)

GeneCards Summary for ZNF189 Gene:
ZNF189 (zinc finger protein 189) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF334.

UniProtKB/Swiss-Prot: ZN189_HUMAN, O75820
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF189 gene promoter:
         CREB   POU2F1   CP2   POU2F1a   POU3F1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF189 promoter sequence
   Search Chromatin IP Primers for ZNF189

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF189


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22-q31   Ensembl cytogenetic band:  9q31.1   HGNC cytogenetic band: 9q22-q31

ZNF189 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF189 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P104161:  view genomic region     (about GC identifiers)

Start:
104,161,155 bp from pter      End:
104,172,942 bp from pter
Size:
11,788 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN189_HUMAN, O75820 (See protein sequence)
Recommended Name: Zinc finger protein 189  
Size: 626 amino acids; 72976 Da
Secondary accessions: O75802 Q5T7D7 Q5T7D8 Q5T7D9 Q9UBL4 Q9UPE9 Q9UPF0 Q9UPF1
Alternative splicing: 4 isoforms:  O75820-1   O75820-2   O75820-3   O75820-4   

Explore the universe of human proteins at neXtProt for ZNF189: NX_O75820

Explore proteomics data for ZNF189 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF189 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001265160.1  NP_001265161.1  NP_001265169.1  NP_003443.2  NP_932094.1  

    ENSEMBL proteins: 
     ENSP00000363995   ENSP00000342019   ENSP00000259395  
    Reactome Protein details: O75820

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O75820

    ProtoNet protein and cluster: O75820

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN189_HUMAN, O75820
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 16 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF189           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN189_HUMAN, O75820
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF189:
    zinc finger protein 189,Kruppel-like,KRAB group,ubiquitously expressed,with tissue or cell type restricted
    expression pattern for the splice variants four

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF189           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF189:
     Decreased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF189
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    SwitchGear 3'UTR luciferase reporter plasmidZNF189 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN189_HUMAN, O75820: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF189           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF189 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF189           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF189
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF189
    Interactions:

        Search GeneGlobe Interaction Network for ZNF189

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS9653648
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    Find genes that share ontologies with ZNF189           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF189 (ZN189)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF189 gene (5 alternative transcripts): 
    NM_001278231.1  NM_001278232.1  NM_001278240.1  NM_003452.3  NM_197977.2  

    Unigene Cluster for ZNF189:

    Zinc finger protein 189
    Hs.50123  [show with all ESTs]
    Unigene Representative Sequence: NM_197977
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374861(uc022bld.1 uc004bbg.1 uc004bbh.1 uc004bbi.1 uc011lvk.1)
    ENST00000339664 ENST00000259395
    miRNA
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    hsa-miR-34c-3p hsa-miR-548d-3p hsa-miR-124 hsa-miR-186* hsa-miR-508-5p hsa-miR-506 hsa-miR-150
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF189
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    Additional mRNA sequence: 

    AF025770.1 AK290163.1 AK308935.1 AK313655.1 BC065718.1 BC092425.1 BC126120.1 BC143876.1 
    BC143877.1 U75454.1 U95991.1 U95992.1 

    7 DOTS entries:

    DT.100785787  DT.121163638  DT.95163073  DT.100785785  DT.411998  DT.100731001  DT.91723091 

    Selected AceView cDNA sequences (see all 100):

    CD518756 AW292639 AI215891 BC065718 AI868043 BQ424456 AI681591 AA253069 
    AW264169 AL046790 BM820380 BM811224 NM_003452 BP342603 BQ010030 NM_197977 
    BM543076 CB162392 AI342941 AW612584 AF025770 AI816892 AA235376 CB957563 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF189 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f
    SP1:                                -     -     -     -           -                                                   
    SP2:                                -     -     -     -           -     -                                             
    SP3:                                                  -           -     -     -                                       
    SP4:                                -     -     -     -           -     -     -                                       
    SP5:                                -     -     -     -           -     -     -                                       


    ECgene alternative splicing isoforms for ZNF189

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF189 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF189 Expression
    About this image

    ZNF189 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF189 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.50123

    UniProtKB/Swiss-Prot: ZN189_HUMAN, O75820
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF189 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp1891 , 5 zinc finger protein 1891, 5 88.43(n)1
    93.26(a)1
      4 (26.55 cM)5
    2301621  NM_145547.21  NP_663522.21 
     495211765 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004898971 zinc finger protein 850-like 58.58(n)
    53.51(a)
      100489897  XM_004912522.1  XP_004912579.1 


    ENSEMBL Gene Tree for ZNF189 (if available)
    TreeFam Gene Tree for ZNF189 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF189 gene
    ZNF3342  ZNF4202  ZNF780A2  ZNF6652  ZNF72  ZNF232  ZNF33A2  RBAK2  
    ZNF7172  ZNF302  ZNF5732  ZNF33B2  ZNF5402  ZNF2512  ZNF6052  ZNF842  
    ZNF5712  ZNF6302  ZNF3372  ZNF2832  ZNF4042  ZNF1352  ZNF4842  ZNF122  
    ZNF3452  ZNF1842  ZNF6992  ZNF412  ZNF6152  ZNF4702  ZNF5692  
    Selected SIMAP similar genes for ZNF189 using alignment to 2 protein entries:     ZN189_HUMAN (see all proteins) (see all similar genes):
    kr-znf3    HZF36    ZNF78L1    ZFS-4    DKFZp666C237    ZNF283
    ZNF24    ZNF501    HZF30    ZFS-2    ZFS-5    ZNF146
    ZNF204    ZNF22    ZNF286B    ZNF345    ZNF702P    ZSCAN16

    Find genes that share paralogs with ZNF189           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF189 (see all 288)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs779621451,2
    C,F--104162938(+) TTTAAC/TTCGTG 2 -- int11Minor allele frequency- T:0.03NA 120
    rs169203051,2
    C,F,H--104163006(+) CACTTT/CTACTC 2 -- int118Minor allele frequency- C:0.07NA NS EA WA 1774
    rs755659931,2
    C,F--104163022(+) CTTACA/GTCATT 2 -- int12Minor allele frequency- G:0.02WA 120
    rs123447141,2
    C,F--104163074(+) AATACC/TCTATT 2 -- int11Minor allele frequency- T:0.09WA 118
    rs1437310851,2
    --104163226(+) TTAACC/GATGTT 2 -- int10--------
    rs1123968041,2
    C--104163227(+) TAACGT/ATGTTT 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1900527641,2
    --104163373(+) TTTGTG/TATAAA 2 -- int10--------
    rs1816216741,2
    --104163397(+) TCTTTA/CCTACC 2 -- int10--------
    rs1859924051,2
    C--104163489(+) TCTCCA/GCTGGG 2 -- int10--------
    rs1481287891,2
    --104163514(+) CAATAC/TTTTTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF189 (104161155 - 104172942 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF189:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738839CNV Deletion23290073
    nsv893626CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF189
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF189

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603132    OMIM disorders: --


    Find genes that share disorders with ZNF189           About GenesLikeMe

    Genetic Association Database (GAD): ZNF189
    Human Genome Epidemiology (HuGE) Navigator: ZNF189 (1 document)

    Export disorders for ZNF189 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF189 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ZNF189)
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    1. Cloning and characterization of ZNF189, a novel human Kruppel-like zinc finger gene localized to chromosome 9q22-q31. (PubMed id 9653648)1, 2, 3 Odeberg J....Lundeberg J. (Genomics 1998)
    2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    5. Context-dependent Taq-polymerase-mediated nucleotide alterations, as revealed by direct sequencing of the ZNF189 gene: implications for mutation detection. (PubMed id 10415338)1, 2 Odeberg J....Lundeberg J. (Gene 1999)
    6. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7743 HGNC: 12980 AceView: ZNF189 Ensembl:ENSG00000136870 euGenes: HUgn7743
    ECgene: ZNF189 H-InvDB: ZNF189

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF189 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF189 gene:
    Search GeneIP for patents involving ZNF189

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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