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Aliases for ZNF189 Gene

Aliases for ZNF189 Gene

  • Zinc Finger Protein 189 2 3

External Ids for ZNF189 Gene

Previous GeneCards Identifiers for ZNF189 Gene

  • GC09P094961
  • GC09P095904
  • GC09P097618
  • GC09P099541
  • GC09P101240
  • GC09P103200
  • GC09P104161
  • GC09P073760

Summaries for ZNF189 Gene

Entrez Gene Summary for ZNF189 Gene

  • Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.[supplied by OMIM, May 2010]

GeneCards Summary for ZNF189 Gene

ZNF189 (Zinc Finger Protein 189) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF630.

UniProtKB/Swiss-Prot for ZNF189 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF189 Gene

Genomics for ZNF189 Gene

Regulatory Elements for ZNF189 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF189 Gene

101,398,854 bp from pter
101,410,660 bp from pter
11,807 bases
Plus strand

Genomic View for ZNF189 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF189 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF189 Gene

Proteins for ZNF189 Gene

  • Protein details for ZNF189 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 189
    Protein Accession:
    Secondary Accessions:
    • O75802
    • Q5T7D7
    • Q5T7D8
    • Q5T7D9
    • Q9UBL4
    • Q9UPE9
    • Q9UPF0
    • Q9UPF1

    Protein attributes for ZNF189 Gene

    626 amino acids
    Molecular mass:
    72976 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF189 Gene


neXtProt entry for ZNF189 Gene

Proteomics data for ZNF189 Gene at MOPED

Post-translational modifications for ZNF189 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF189 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF189 Gene

Domains for ZNF189 Gene

Gene Families for ZNF189 Gene

Suggested Antigen Peptide Sequences for ZNF189 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF189: view

Function for ZNF189 Gene

Molecular function for ZNF189 Gene

GENATLAS Biochemistry:
zinc finger protein 189,Kruppel-like,KRAB group,ubiquitously expressed,with tissue or cell type restricted expression pattern for the splice variants four
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF189 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF189: view

Phenotypes for ZNF189 Gene

GenomeRNAi human phenotypes for ZNF189:
genes like me logo Genes that share phenotypes with ZNF189: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF189 Gene

Localization for ZNF189 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF189 Gene

Subcellular locations from

Jensen Localization Image for ZNF189 Gene COMPARTMENTS Subcellular localization image for ZNF189 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ZNF189 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF189: view

Pathways for ZNF189 Gene

SuperPathways for ZNF189 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF189: view

Pathways by source for ZNF189 Gene

2 Reactome pathways for ZNF189 Gene

Interacting Proteins for ZNF189 Gene

Gene Ontology (GO) - Biological Process for ZNF189 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 9653648
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with ZNF189: view

Transcripts for ZNF189 Gene

Unigene Clusters for ZNF189 Gene

Zinc finger protein 189:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF189

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF189 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - - - -
SP8: - - - - -

Relevant External Links for ZNF189 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF189 Gene

mRNA expression in normal human tissues for ZNF189 Gene

Protein differential expression in normal tissues for ZNF189 Gene

This gene is overexpressed in Neutrophil (68.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF189 Gene

SOURCE GeneReport for Unigene cluster for ZNF189 Gene Hs.50123

mRNA Expression by UniProt/SwissProt for ZNF189 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with ZNF189: view

Expression partners for ZNF189 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF189 Gene

Orthologs for ZNF189 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF189 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF189 35
  • 93.79 (n)
  • 97.88 (a)
ZNF189 36
  • 98 (a)
(Canis familiaris)
Mammalia ZNF189 35
  • 94.92 (n)
  • 98.68 (a)
ZNF189 36
  • 98 (a)
(Mus musculus)
Mammalia Zfp189 35
  • 88.43 (n)
  • 93.26 (a)
Zfp189 16
Zfp189 36
  • 93 (a)
(Pan troglodytes)
Mammalia ZNF189 35
  • 99.95 (n)
  • 100 (a)
ZNF189 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zfp189 35
  • 89.8 (n)
  • 93.42 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
-- 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489897 35
  • 58.58 (n)
  • 53.51 (a)
Species with no ortholog for ZNF189:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF189 Gene

Gene Tree for ZNF189 (if available)
Gene Tree for ZNF189 (if available)

Paralogs for ZNF189 Gene

(507) SIMAP similar genes for ZNF189 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF189: view

Variants for ZNF189 Gene

Sequence variations from dbSNP and Humsavar for ZNF189 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs14641 -- 101,410,568(+) CTTAT(A/T)TCTTG utr-variant-3-prime, nc-transcript-variant
rs546577 -- 101,410,654(+) TTTTT(A/C)GCTTT utr-variant-3-prime, nc-transcript-variant
rs1047968 -- 101,408,068(+) GAAAC(A/G)TTTGA reference, synonymous-codon, utr-variant-3-prime, nc-transcript-variant
rs1047969 -- 101,410,027(+) TGTGG(G/T)TCTTT utr-variant-3-prime, nc-transcript-variant
rs1047971 -- 101,410,161(+) AGCCA(G/T)TTGTT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF189 Gene

Variant ID Type Subtype PubMed ID
esv2738839 CNV Deletion 23290073
nsv893626 CNV Loss 21882294

Relevant External Links for ZNF189 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF189 Gene

Disorders for ZNF189 Gene

Relevant External Links for ZNF189

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ZNF189 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZNF189 Gene

Publications for ZNF189 Gene

  1. Cloning and characterization of ZNF189, a novel human Kruppel-like zinc finger gene localized to chromosome 9q22-q31. (PMID: 9653648) Odeberg J. … Lundeberg J. (Genomics 1998) 2 3 4
  2. Context-dependent Taq-polymerase-mediated nucleotide alterations, as revealed by direct sequencing of the ZNF189 gene: implications for mutation detection. (PMID: 10415338) Odeberg J. … Lundeberg J. (Gene 1999) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48

Products for ZNF189 Gene

Sources for ZNF189 Gene

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