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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF189 Gene

protein-coding   GIFtS: 50
GCID: GC09P104161

zinc finger protein 189

 Explore 4 diseases affiliated with
ZNF189 via our new
 Human Malady Compendium 
Biological research products
for ZNF189
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 1891 2

External Ids:    HGNC: 129801   Entrez Gene: 77432   Ensembl: ENSG000001368707   OMIM: 6031325   UniProtKB: O758203   

Export aliases for ZNF189 gene to outside databases

Previous GC identifers: GC09P094961 GC09P095904 GC09P097618 GC09P099541 GC09P101240 GC09P103200 GC09P073760


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF189:
Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable
number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 (PubMed
9653648)). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box
(KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is
present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always
present.(supplied by OMIM, May 2010)

UniProtKB/Swiss-Prot: ZN189_HUMAN, O75820
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF189 gene promoter:
         CREB   POU2F1   CP2   POU2F1a   POU3F1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF189 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF189

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF189


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22-q31   Ensembl cytogenetic band:  9q31.1   HGNC cytogenetic band: 9q22-q31

ZNF189 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF189 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P104161:  view genomic region     (about GC identifiers)

Start:
104,161,155 bp from pter      End:
104,172,942 bp from pter
Size:
11,788 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN189_HUMAN, O75820 (See protein sequence)
Recommended Name: Zinc finger protein 189  
Size: 626 amino acids; 72976 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: O75802 Q5T7D7 Q5T7D8 Q5T7D9 Q9UBL4 Q9UPE9 Q9UPF0 Q9UPF1
Alternative splicing: 4 isoforms:  O75820-1   O75820-2   O75820-3   O75820-4   

Explore the universe of human proteins at neXtProt for ZNF189: NX_O75820

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75820

  • ZNF189 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_003443.2  NP_932094.1  

    ENSEMBL proteins: 
     ENSP00000363995   ENSP00000342019   ENSP00000259395  
    Reactome Protein details: O75820
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF189

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    ZNF189 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF189 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O75820

    ProtoNet protein and cluster: O75820

    2 Blocks protein families:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN189_HUMAN, O75820
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 16 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN189_HUMAN, O75820
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF189:
    zinc finger protein 189,Kruppel-like,KRAB group,ubiquitously expressed,with tissue or cell type restricted expression
    pattern for the splice variants four

    miRNA
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    hsa-miR-34c-3p hsa-miR-548d-3p hsa-miR-124 hsa-miR-186* hsa-miR-508-5p hsa-miR-506 hsa-miR-150
    SwitchGear 3'UTR luciferase reporter plasmidZNF189 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9653648
    GO:0008270zinc ion binding IEA--


    ZNF189 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZNF189:
     Decreased homologous recombina 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF189
        Generic Transcription Pathway
    Gene Expression



    ZNF189 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF189

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS9653648
    GO:0006351transcription, DNA-dependent IEA--


    ZNF189 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF189
    Search CenterWatch for drugs/clinical trials and news about ZNF189 / ZN189 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF189 gene (2 alternative transcripts): 
    NM_003452.2  NM_197977.1  

    Unigene Cluster for ZNF189:

    Zinc finger protein 189
    Hs.50123  [show with all ESTs]
    Unigene Representative Sequence: NM_197977
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374861(uc022bld.1 uc004bbg.1 uc004bbh.1 uc004bbi.1 uc011lvk.1)
    ENST00000339664 ENST00000259395

    miRNA
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    hsa-miR-34c-3p hsa-miR-548d-3p hsa-miR-124 hsa-miR-186* hsa-miR-508-5p hsa-miR-506 hsa-miR-150
    SwitchGear 3'UTR luciferase reporter plasmidZNF189 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF025770.1 AK290163.1 AK308935.1 AK313655.1 BC065718.1 BC092425.1 BC126120.1 BC143876.1 
    BC143877.1 U75454.1 U95991.1 U95992.1 

    7 DOTS entries:

    DT.100785787  DT.121163638  DT.95163073  DT.100785785  DT.411998  DT.100731001  DT.91723091 

    24/100 AceView cDNA sequences (see all 100):

    AI868043 AI342941 BQ010030 NM_003452 BM543076 AW292639 BC065718 AA253069 
    AW264169 BM811224 AI215891 BM820380 CB162392 AI681591 BP342603 NM_197977 
    AL046790 BQ424456 CD518756 AW192671 AA604790 U95992 AI816892 AW591504 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF189 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f
    SP1:                                -     -     -     -           -                                                   
    SP2:                                -     -     -     -           -     -                                             
    SP3:                                                  -           -     -     -                                       
    SP4:                                -     -     -     -           -     -     -                                       
    SP5:                                -     -     -     -           -     -     -                                       


    ECgene alternative splicing isoforms for ZNF189

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF189 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    ZNF189 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZNF189 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF189

    SOURCE GeneReport for Unigene cluster: Hs.50123

    UniProtKB/Swiss-Prot: ZN189_HUMAN, O75820
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF189

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF189 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp1891 , 5 zinc finger protein 1891, 5 88.71(n)1
    93.42(a)1
      4 (26.55 cM)5
    2301621  NM_145547.21  NP_663522.21 
     495211765 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF4366
    --
    53(a)
    1 → many
    AAWZ02041558(3671-4483)
    zebrafish
    (Danio rerio)
    Actinopterygii CR382372.26
    --
    51(a)
    1 → many
    4(28587019-28588287)


    ENSEMBL Gene Tree for ZNF189 (if available)
    TreeFam Gene Tree for ZNF189 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF189 gene
    ZNF5702  ZNF2872  ZNF1812  ZFP282  ZNF4712  ZNF72  ZNF2502  ZNF8792  
    ZNF3022  ZNF354C2  ZNF742  ZNF5832  ZFP902  ZNF354A2  ZNF354B2  ZNF1352  
    ZNF5682  ZNF342  ZNF5272  ZNF82  ZNF5692  ZNF4702  
    18/502 SIMAP similar genes for ZNF189 using alignment to 2 protein entries:     ZN189_HUMAN (see all proteins) (see all similar genes):
    kr-znf3    HZF36    ZNF78L1    ZFS-4    DKFZp666C237    ZNF283
    ZNF24    ZNF501    HZF30    ZFS-2    ZFS-5    ZNF146
    ZNF204    ZNF22    ZNF286B    ZNF345    ZNF702P    ZSCAN16

    ZNF189 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/314 NCBI SNPs in ZNF189 are shown (see all 314    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs561299421,2
    --104159177(+) CAAGAC/TAGCGC 3 -- int1 us2k10--------
    rs107607941,2
    C,F,A,H,--104159217(+) GACTCC/TATCTC 3 -- us2k1 int17Minor allele frequency- T:0.33NA WA 248
    rs1496374851,2
    --104159303(+) AGAGAC/TGTTGG 3 -- us2k1 int10--------
    rs734949391,2
    C,--104159449(+) ACACAA/CAAATT 3 -- int1 us2k12Minor allele frequency- C:0.06WA 120
    rs1473277701,2
    --104159462(+) AACTGA/GCCAGG 3 -- int1 us2k10--------
    rs1144018071,2
    F,--104159471(+) GGTGTG/TGTGGC 3 -- us2k1 int11Minor allele frequency- T:0.04WA 118
    rs561379741,2
    --104159477(+) GTGGCC/TCACCC 3 -- int1 us2k10--------
    rs134401711,2
    C,--104159523(+) aaattA/Ccttga 3 -- us2k1 int10--------
    rs2009260311,2
    --104159595(+) AAAAC-/AGAAAGT 3 -- int1 us2k10--------
    rs1385987421,2
    --104159651(+) ATCAAA/GTTGTA 3 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for ZNF189 (104161155 - 104172942 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNF189: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF189
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF189

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF189 for disorders           About GeneDecksing

    OMIM gene information: 603132    OMIM disorders: --

    4 diseases for ZNF189:    About MalaCards
    basal cell carcinoma    intrahepatic cholangiocarcinoma    cholangiocarcinoma    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: ZNF189 (1 document)

    Export disorders for ZNF189 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF189 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF189)
        Utopia: connect your pdf to the dynamic
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    1. Cloning and characterization of ZNF189, a novel human Kruppel-like zinc finger gene localized to chromosome 9q22-q31. (PubMed id 9653648)1, 2, 3 Odeberg J....Lundeberg J. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. Context-dependent Taq-polymerase-mediated nucleotide alterations, as revealed by direct sequencing of the ZNF189 gene: implications for mutation detection. (PubMed id 10415338)1, 2 Odeberg J....Lundeberg J. (1999)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
    7. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
    8. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7743 HGNC: 12980 AceView: ZNF189 Ensembl:ENSG00000136870 euGenes: HUgn7743
    ECgene: ZNF189 H-InvDB: ZNF189

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF189 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF189 gene:
    Search GeneIP for patents involving ZNF189

    GeneCards and IP:
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