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Aliases for ZNF185 Gene

Aliases for ZNF185 Gene

  • Zinc Finger Protein 185 (LIM Domain) 2 3 5
  • Sciellin Like 2 3
  • P1-A 3 4
  • LIM Domain Protein ZNF185 4
  • SCELL 3

External Ids for ZNF185 Gene

Previous GeneCards Identifiers for ZNF185 Gene

  • GC0XP146426
  • GC0XP148743
  • GC0XP149834
  • GC0XP150704
  • GC0XP151757
  • GC0XP152082
  • GC0XP140883

Summaries for ZNF185 Gene

Entrez Gene Summary for ZNF185 Gene

  • Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a LIM-domain zinc finger protein. The LIM domain is composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. The LIM domain mediates protein:protein interactions. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]

GeneCards Summary for ZNF185 Gene

ZNF185 (Zinc Finger Protein 185 (LIM Domain)) is a Protein Coding gene. An important paralog of this gene is SCEL.

UniProtKB/Swiss-Prot for ZNF185 Gene

  • May be involved in the regulation of cellular proliferation and/or differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF185 Gene

Genomics for ZNF185 Gene

Regulatory Elements for ZNF185 Gene

Genomic Location for ZNF185 Gene

Chromosome:
X
Start:
152,898,132 bp from pter
End:
152,973,481 bp from pter
Size:
75,350 bases
Orientation:
Plus strand

Genomic View for ZNF185 Gene

Genes around ZNF185 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF185 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF185 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF185 Gene

Proteins for ZNF185 Gene

  • Protein details for ZNF185 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15231-ZN185_HUMAN
    Recommended name:
    Zinc finger protein 185
    Protein Accession:
    O15231
    Secondary Accessions:
    • A4FTV3
    • A6NME5
    • B4DLE9
    • B7Z771
    • B8K2L9
    • B8K2M0
    • B8K2M1
    • B8K2M2
    • E9PFR6
    • F5GXF7
    • F5GZL4
    • F8W8V7
    • H0Y4M8
    • O00345
    • Q8N1R8
    • Q9NSD2

    Protein attributes for ZNF185 Gene

    Size:
    689 amino acids
    Molecular mass:
    73525 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF185 Gene

neXtProt entry for ZNF185 Gene

Proteomics data for ZNF185 Gene at MOPED

Post-translational modifications for ZNF185 Gene

  • Ubiquitination at Lys 591
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF185 Gene

Domains & Families for ZNF185 Gene

Gene Families for ZNF185 Gene

Protein Domains for ZNF185 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O15231

UniProtKB/Swiss-Prot:

ZN185_HUMAN :
  • Contains 1 LIM zinc-binding domain.
Domain:
  • Contains 1 LIM zinc-binding domain.
genes like me logo Genes that share domains with ZNF185: view

Function for ZNF185 Gene

Molecular function for ZNF185 Gene

GENATLAS Biochemistry:
zinc finger protein with a LIM domain regulating cellular proliferation and differentiation
UniProtKB/Swiss-Prot Function:
May be involved in the regulation of cellular proliferation and/or differentiation.

Phenotypes for ZNF185 Gene

genes like me logo Genes that share phenotypes with ZNF185: view

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF185 Gene

Localization for ZNF185 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF185 Gene

Cytoplasm, cytoskeleton. Cell junction, focal adhesion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF185 Gene COMPARTMENTS Subcellular localization image for ZNF185 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF185 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0005925 focal adhesion IDA --
genes like me logo Genes that share ontologies with ZNF185: view

Pathways & Interactions for ZNF185 Gene

SuperPathways for ZNF185 Gene

No Data Available

Interacting Proteins for ZNF185 Gene

Gene Ontology (GO) - Biological Process for ZNF185 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF185 Gene

Drugs & Compounds for ZNF185 Gene

No Compound Related Data Available

Transcripts for ZNF185 Gene

Unigene Clusters for ZNF185 Gene

Zinc finger protein 185 (LIM domain):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF185 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19
SP1: - - - - -
SP2: - - - - - - -
SP3:
SP4:
SP5: - - - -
SP6: - - -
SP7: -
SP8: -
SP9: - - - -

Relevant External Links for ZNF185 Gene

GeneLoc Exon Structure for
ZNF185
ECgene alternative splicing isoforms for
ZNF185

Expression for ZNF185 Gene

mRNA expression in normal human tissues for ZNF185 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF185 Gene

This gene is overexpressed in Esophagus - Mucosa (x18.3), Vagina (x6.1), and Cervix - Ectocervix (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF185 Gene

This gene is overexpressed in Cervix (20.0), Skin (11.7), Nasal epithelium (9.2), and Urine (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF185 Gene



SOURCE GeneReport for Unigene cluster for ZNF185 Gene Hs.16622

mRNA Expression by UniProt/SwissProt for ZNF185 Gene

O15231-ZN185_HUMAN
Tissue specificity: Expressed in placenta, pancreas and kidney. Also expressed in prostate, testis, ovary and blood.
genes like me logo Genes that share expression patterns with ZNF185: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ZNF185 Gene

Orthologs for ZNF185 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF185 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF185 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF185 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF185 36
  • 71 (a)
OneToOne
ZNF185 35
  • 73.66 (n)
  • 65.78 (a)
mouse
(Mus musculus)
Mammalia Zfp185 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF185 36
  • 26 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF185 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp185 35
  • 72.99 (n)
  • 61.74 (a)
chicken
(Gallus gallus)
Aves ZNF185 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF185 36
  • 38 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2690 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13506 35
zebrafish
(Danio rerio)
Actinopterygii znf185 36
  • 13 (a)
OneToOne
Species with no ortholog for ZNF185:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF185 Gene

ENSEMBL:
Gene Tree for ZNF185 (if available)
TreeFam:
Gene Tree for ZNF185 (if available)

Paralogs for ZNF185 Gene

Paralogs for ZNF185 Gene

(2) SIMAP similar genes for ZNF185 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF185: view

Variants for ZNF185 Gene

Sequence variations from dbSNP and Humsavar for ZNF185 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs580 -- 152,946,598(+) GGAGG(A/C)GGCGA intron-variant
rs11582 -- 152,972,995(-) ATCCA(A/C)TACAA utr-variant-3-prime
rs874517 -- 152,944,436(+) TGAAA(C/T)GCTGG intron-variant
rs762728 -- 152,941,497(+) CCACA(C/G)CCCTC intron-variant, upstream-variant-2KB
rs762729 -- 152,942,018(+) GGGAG(C/G)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF185 Gene

Variant ID Type Subtype PubMed ID
nsv470373 CNV Gain 18288195
nsv517284 CNV Gain+Loss 19592680
nsv520008 CNV Gain 19592680
esv2740624 CNV Deletion 23290073
esv24602 CNV Loss 19812545
esv2659838 CNV Deletion 23128226
esv2657083 CNV Deletion 23128226
esv2678287 CNV Deletion 23128226
esv2740625 CNV Deletion 23290073

Variation tolerance for ZNF185 Gene

Residual Variation Intolerance Score: 80.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.97; 79.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF185 Gene

HapMap Linkage Disequilibrium report
ZNF185

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF185 Gene

Disorders for ZNF185 Gene

Relevant External Links for ZNF185

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF185

No disorders were found for ZNF185 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF185 Gene

Publications for ZNF185 Gene

  1. Genomic structure of a novel LIM domain gene (ZNF185) in Xq28 and comparisons with the orthologous murine transcript. (PMID: 9268636) Heiss N.S. … Poustka A. (Genomics 1997) 2 3 4 67
  2. Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression. (PMID: 12873976) Vanaja D.K. … Young C.Y. (Cancer Res. 2003) 3 23
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. ZNF185, an actin-cytoskeleton-associated growth inhibitory LIM protein in prostate cancer. (PMID: 16799630) Zhang J.S. … Young C.Y. (Oncogene 2007) 3

Products for ZNF185 Gene

Sources for ZNF185 Gene

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