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ZNF185 Gene

protein-coding   GIFtS: 52
GCID: GC0XP152082

Zinc Finger Protein 185 (LIM Domain)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 185 (LIM Domain)1 2
P1-A2 3
Zinc Finger Protein 1852
LIM Domain Protein ZNF1853

External Ids:    HGNC: 129761   Entrez Gene: 77392   Ensembl: ENSG000001473947   OMIM: 3003815   UniProtKB: O152313   

Export aliases for ZNF185 gene to outside databases

Previous GC identifers: GC0XP146426 GC0XP148743 GC0XP149834 GC0XP150704 GC0XP151757 GC0XP140883


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF185 Gene:
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell
proliferation, differentiation, and apoptosis. This gene encodes a LIM-domain zinc finger protein. The LIM domain
is composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. The
LIM domain mediates protein:protein interactions. Multiple alternatively spliced transcript variants encoding
different isoforms have been identified.(provided by RefSeq, May 2010)

GeneCards Summary for ZNF185 Gene:
ZNF185 (zinc finger protein 185 (LIM domain)) is a protein-coding gene. Diseases associated with ZNF185 include mast cell neoplasm, and intussusception. An important paralog of this gene is SCEL.

UniProtKB/Swiss-Prot: ZN185_HUMAN, O15231
Function: May be involved in the regulation of cellular proliferation and/or differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011681.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF185 gene promoter:
         Max1   Sp1   Pax-5   p300   MyoD   Tal-1beta   SREBP-1b   E47   SREBP-1a   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF185 promoter sequence
   Search Chromatin IP Primers for ZNF185

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF185


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

ZNF185 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF185 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP152082:  view genomic region     (about GC identifiers)

Start:
152,082,986 bp from pter      End:
152,142,025 bp from pter
Size:
59,040 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN185_HUMAN, O15231 (See protein sequence)
Recommended Name: Zinc finger protein 185  
Size: 689 amino acids; 73525 Da
Secondary accessions: A4FTV3 A6NME5 B4DLE9 B7Z771 B8K2L9 B8K2M0 B8K2M1 B8K2M2 E9PFR6 F5GXF7
F5GZL4 F8W8V7 O00345 Q9NSD2
Alternative splicing: 8 isoforms:  O15231-1   O15231-2   O15231-3   O15231-4   O15231-5   O15231-6   O15231-7   O15231-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF185: NX_O15231

Explore proteomics data for ZNF185 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys591
  • Modification sites at PhosphoSitePlus

  • See ZNF185 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001171577.1  NP_001171578.1  NP_001171579.1  NP_001171580.1  NP_001171581.1  NP_001171584.1  NP_001171586.1  NP_009081.2  

    ENSEMBL proteins: 
     ENSP00000359291   ENSP00000391272   ENSP00000359293   ENSP00000409121   ENSP00000401766  
     ENSP00000392984   ENSP00000440847   ENSP00000444367   ENSP00000395228   ENSP00000312782  
     ENSP00000325307   ENSP00000313919  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry O15231

    ProtoNet protein and cluster: O15231

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: ZN185_HUMAN, O15231
    Similarity: Contains 1 LIM zinc-binding domain


    ZNF185 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN185_HUMAN, O15231
    Function: May be involved in the regulation of cellular proliferation and/or differentiation

         Genatlas biochemistry entry for ZNF185:
    zinc finger protein with a LIM domain regulating cellular proliferation and differentiation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
         
    ZNF185 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF185
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF185
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    7 qRT-PCR Assays for microRNAs that regulate ZNF185:
    hsa-miR-182* hsa-miR-370 hsa-miR-4263 hsa-miR-4293 hsa-miR-664 hsa-miR-1284 hsa-miR-3616-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF185 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF185

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF185


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN185_HUMAN, O15231: Cytoplasm, cytoskeleton. Cell junction, focal adhesion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    plasma membrane3
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005856cytoskeleton ----
    GO:0005886plasma membrane IDA--
    GO:0005925focal adhesion IDA--
    GO:0015629actin cytoskeleton IDA--

    ZNF185 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including ZNF185: 
              Prostate Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ZNF185

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ZNF185 (ENSP000003592914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    ARHGAP27ENSP000003661214STRING: ENSP00000366121
    PAK7ENSP000003229574STRING: ENSP00000322957
    --ENSP000004085804STRING: ENSP00000408580
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF185 (ZN185)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF185 gene (9 alternative transcripts): 
    NM_001178106.1  NM_001178107.1  NM_001178108.1  NM_001178109.1  NM_001178110.1  NM_001178113.1  NM_001178115.1  NM_007150.3  
    NM_001178114.1  

    Unigene Cluster for ZNF185:

    Zinc finger protein 185 (LIM domain)
    Hs.16622  [show with all ESTs]
    Unigene Representative Sequence: NM_001178106
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370268 ENST00000436731 ENST00000370270(uc004fgu.3) ENST00000426821
    ENST00000447792 ENST00000454925(uc004fgx.3) ENST00000535861(uc011myg.2)
    ENST00000539731(uc011myh.2) ENST00000449285(uc011myk.2 uc010ntv.2 uc011myi.2 uc004fgv.3)
    ENST00000318504(uc011myj.2) ENST00000324823 ENST00000318529(uc004fgw.4)

    miRNA
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    Block miRNA regulation of human, mouse, rat ZNF185 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate ZNF185:
    hsa-miR-182* hsa-miR-370 hsa-miR-4263 hsa-miR-4293 hsa-miR-664 hsa-miR-1284 hsa-miR-3616-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF185 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF185
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    GenScript: all cDNA clones in your preferred vector (see all 8): ZNF185 (NM_001178115)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF185
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF185
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF185
      QuantiFast Probe-based Assays in human, mouse, rat ZNF185

    Additional mRNA sequence: 

    AK056517.1 AK095258.1 AK296967.1 AK301530.1 AK304323.1 AY997296.1 BX640940.1 DQ508022.1 
    DQ508023.1 DQ508024.1 DQ508025.1 DQ508026.1 Y09538.1 

    10 DOTS entries:

    DT.92425591  DT.453003  DT.92425593  DT.100786318  DT.100734013  DT.92425590  DT.102835777  DT.121318574 
    DT.95374138  DT.100695949 

    Selected AceView cDNA sequences (see all 149):

    AI351792 BX094505 BQ948969 X96622 AW135622 CB127359 AW955818 T93849 
    AI377437 AI633931 BX476942 BQ933727 BX640940 AA630138 T85942 AI825619 
    AA372722 R62979 BE242940 AA442162 BE242196 CB156362 AK056517 AW134714 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF185 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19
    SP1:                                            -                       -           -     -     -                                                         
    SP2:                                            -           -     -     -           -     -     -                                                         
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                    -           -     -     -                                                         


    ECgene alternative splicing isoforms for ZNF185

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF185 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTAAAAAGG
    ZNF185 Expression
    About this image


    ZNF185 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Cartilage (Muscoskeletal System)
             Intervertebral disc (IVD) annulus fibrosus (AF) cells
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Heart (Cardiovascular System)
             Cardiac Crescent Cells Cardiac Crescent
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
    ZNF185 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF185 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.16622

    UniProtKB/Swiss-Prot: ZN185_HUMAN, O15231
    Tissue specificity: Expressed in placenta, pancreas and kidney. Also expressed in prostate, testis, ovary and
    blood

        Pathway & Disease-focused RT2 Profiler PCR Array including ZNF185: 
              Prostate Cancer in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF185

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF185 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp1855 zinc finger protein 185   --   X (37.29 cM) 72987360 
    chicken
    (Gallus gallus)
    Aves ZNF1856
    zinc finger protein 185 (LIM domain)
    33(a)
    1 ↔ 1
    4(11178097-11207186)
    lizard
    (Anolis carolinensis)
    Reptilia ZNF1856
    zinc finger protein 185 (LIM domain)
    38(a)
    1 ↔ 1
    GL343202.1(1745141-1781805)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.26902 Xenopus laevis transcribed sequence with moderate similarity more 72.08(n)    BJ031947.1 
    zebrafish
    (Danio rerio)
    Actinopterygii znf1856
    zinc finger protein 185 (LIM domain)
    13(a)
    1 ↔ 1
    14(18522903-18543174) ENSDARG00000057726


    ENSEMBL Gene Tree for ZNF185 (if available)
    TreeFam Gene Tree for ZNF185 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF185 gene
    SCEL2  
    2 SIMAP similar genes for ZNF185 using alignment to 7 protein entries:     ZN185_HUMAN (see all proteins):
    DKFZp686B22130    DKFZp686O1389

    ZNF185 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF185 (see all 1027)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59252531,2
    C,F,A,H--151947541(+) AAGGGA/GTAACT 6 -- us2k125Minor allele frequency- G:0.37NS EA NA WA CSA 2827
    rs1809732451,2
    --151947577(+) GCCTGA/GGATGG 6 -- us2k10--------
    rs1862453341,2
    C--151947609(+) ATGACC/TGTCAC 6 -- us2k10--------
    rs1914291951,2
    --151947676(+) AGGAGA/TACGTC 6 -- us2k10--------
    rs1832552661,2
    --151947685(+) TCTTTC/GAGGTG 6 -- us2k10--------
    rs1862501821,2
    C--151947876(+) ATGGGA/GCCACT 6 -- us2k10--------
    rs1910233861,2
    --151947887(+) CCACAC/GGTTGC 6 -- us2k10--------
    rs59252541,2
    C,A,H--151947946(+) TGAGCT/GCCACT 6 -- us2k12Minor allele frequency- G:0.00WA CSA 3
    rs1834870141,2
    --151948071(+) GTTCAA/GTGCAG 6 -- us2k10--------
    rs59252551,2
    C,F,A,H--151948125(+) GCTCTT/CGTCCC 6 -- us2k12Minor allele frequency- C:0.40NA CSA 5

    HapMap Linkage Disequilibrium report for ZNF185 (152082986 - 152142025 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZNF185:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740624CNV Deletion23290073
    esv2678287CNV Deletion23128226
    esv2657083CNV Deletion23128226
    esv2659838CNV Deletion23128226
    esv2740625CNV Deletion23290073
    esv24602CNV Loss19812545
    nsv470373CNV Gain18288195
    nsv520008CNV Gain19592680
    nsv517284CNV Gain+Loss19592680

    Locus Specific Mutation Databases (LSDB): ZNF185

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300381    OMIM disorders: --

    9 diseases for ZNF185:    
    About MalaCards
    mast cell neoplasm    intussusception    gastroenteritis    mastocytosis
    diarrhea    leiomyoma    prostate cancer    prostatitis
    lung cancer

    4 diseases from the University of Copenhagen DISEASES database for ZNF185:
    Mastocytosis     Gastroenteritis     Intussusception     Diarrhea

    ZNF185 for disorders           About GeneDecksing


    Export disorders for ZNF185 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF185 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ZNF185)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure of a novel LIM domain gene (ZNF185) in Xq28 and comparisons with the orthologous murine transcript. (PubMed id 9268636)1, 2, 3 Heiss N.S.... Poustka A. (Genomics 1997)
    2. ZNF185, an actin-cytoskeleton-associated growth inhibitory LIM protein in prostate cancer. (PubMed id 16799630)1, 2 Zhang J.S.... Young C.Y. (Oncogene 2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Comparative genome sequence analysis of the Bpa/Str region in mouse and man. (PubMed id 10854409)1, 2 Mallon A.-M....Brown S.D.M. (Genome Res. 2000)
    5. Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression. (PubMed id 12873976)1, 9 Vanaja D.K....Young C.Y. (Cancer Res. 2003)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7739 HGNC: 12976 AceView: ZNF185 Ensembl:ENSG00000147394 euGenes: HUgn7739
    ECgene: ZNF185 H-InvDB: ZNF185

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF185 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF185 gene:
    Search GeneIP for patents involving ZNF185

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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