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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF185 Gene

protein-coding   GIFtS: 51
GCID: GC0XP152082

zinc finger protein 185 (LIM domain)

 Explore 10 diseases affiliated with
ZNF185 via our new
 Human Malady Compendium 
Biological research products
for ZNF185
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 185 (LIM Domain)1 2
P1-A2 3
Zinc Finger Protein 1852
LIM Domain Protein ZNF1853

External Ids:    HGNC: 129761   Entrez Gene: 77392   Ensembl: ENSG000001473947   OMIM: 3003815   UniProtKB: O152313   

Export aliases for ZNF185 gene to outside databases

Previous GC identifers: GC0XP146426 GC0XP148743 GC0XP149834 GC0XP150704 GC0XP151757 GC0XP140883


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF185:
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell
proliferation, differentiation, and apoptosis. This gene encodes a LIM-domain zinc finger protein. The LIM domain is
composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. The LIM
domain mediates protein:protein interactions. Multiple alternatively spliced transcript variants encoding different
isoforms have been identified.(provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: ZN185_HUMAN, O15231
Function: May be involved in the regulation of cellular proliferation and/or differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF185 gene promoter:
         Max1   Sp1   Pax-5   p300   MyoD   Tal-1beta   SREBP-1b   E47   SREBP-1a   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF185 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF185

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF185


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

ZNF185 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF185 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP152082:  view genomic region     (about GC identifiers)

Start:
152,082,986 bp from pter      End:
152,142,025 bp from pter
Size:
59,040 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN185_HUMAN, O15231 (See protein sequence)
Recommended Name: Zinc finger protein 185  
Size: 689 amino acids; 73525 Da
Subcellular location: Cytoplasm, cytoskeleton. Cell junction, focal adhesion
Secondary accessions: A4FTV3 A6NME5 B4DLE9 B7Z771 B8K2L9 E9PFR6 F8W8V7 O00345 Q9NSD2
Alternative splicing: 5 isoforms:  O15231-1   O15231-2   O15231-3   O15231-4   O15231-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF185: NX_O15231

ZNF185 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins (8 alternative transcripts): 
NP_001171577.1  NP_001171578.1  NP_001171579.1  NP_001171580.1  NP_001171581.1  NP_001171584.1  NP_001171586.1  NP_009081.2  

ENSEMBL proteins: 
 ENSP00000359291   ENSP00000359293   ENSP00000409121   ENSP00000413924   ENSP00000401766  
 ENSP00000391272   ENSP00000392984   ENSP00000440847   ENSP00000444367   ENSP00000395228  
 ENSP00000312782   ENSP00000325307   ENSP00000313919  

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Uscn Proteins for ZNF185

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IEA--
GO:0005856cytoskeleton IEA--
GO:0005925focal adhesion IEA--


ZNF185 for ontologies           About GeneDecksing



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Uscn ELISAs and CLIAs for ZNF185


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF185 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR001781 Znf_LIM

Graphical View of Domain Structure for InterPro Entry O15231

ProtoNet protein and cluster: O15231

1 Blocks protein family: IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: ZN185_HUMAN, O15231
Similarity: Contains 1 LIM zinc-binding domain


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: ZN185_HUMAN, O15231
Function: May be involved in the regulation of cellular proliferation and/or differentiation

     Genatlas biochemistry entry for ZNF185:
zinc finger protein with a LIM domain regulating cellular proliferation and differentiation

miRNA
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7 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF185:
hsa-miR-182* hsa-miR-370 hsa-miR-4263 hsa-miR-4293 hsa-miR-664 hsa-miR-1284 hsa-miR-3616-3p
SwitchGear 3'UTR luciferase reporter plasmidZNF185 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008270zinc ion binding IEA--


ZNF185 for ontologies           About GeneDecksing



(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF185

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ZNF185 (ENSP000003592914) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
UBCENSP000003448184STRING: ENSP00000344818
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF185
Search CenterWatch for drugs/clinical trials and news about ZNF185 / ZN185 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF185 gene (9 alternative transcripts): 
NM_001178106.1  NM_001178107.1  NM_001178108.1  NM_001178109.1  NM_001178110.1  NM_001178113.1  NM_001178115.1  NM_007150.3  
NM_001178114.1  

Unigene Cluster for ZNF185:

Zinc finger protein 185 (LIM domain)
Hs.16622  [show with all ESTs]
Unigene Representative Sequence: NM_001178106
13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000370268 ENST00000370270(uc004fgu.3) ENST00000426821 ENST00000447088
ENST00000447792 ENST00000436731 ENST00000454925(uc004fgx.3) ENST00000535861(uc011myg.2)
ENST00000539731(uc011myh.2) ENST00000449285(uc011myk.2 uc010ntv.2 uc011myi.2 uc004fgv.3)
ENST00000318504(uc011myj.2) ENST00000324823 ENST00000318529(uc004fgw.4)


miRNA
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7 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF185:
hsa-miR-182* hsa-miR-370 hsa-miR-4263 hsa-miR-4293 hsa-miR-664 hsa-miR-1284 hsa-miR-3616-3p
SwitchGear 3'UTR luciferase reporter plasmidZNF185 3' UTR sequence
Inhib. RNA
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Additional cDNA sequence: 

AK056517.1 AK095258.1 AK296967.1 AK301530.1 AK304323.1 AY997296.1 BX640940.1 DQ508022.1 
DQ508023.1 DQ508024.1 DQ508025.1 DQ508026.1 Y09538.1 

10 DOTS entries:

DT.92425591  DT.453003  DT.92425593  DT.100786318  DT.100734013  DT.92425590  DT.102835777  DT.121318574 
DT.95374138  DT.100695949 

24/149 AceView cDNA sequences (see all 149):

AI377437 BE465488 BX480053 T93849 AW243136 AA630138 AI351792 AI633931 
AW103001 AI825619 T85942 AA372722 CB127359 AW134714 X96622 T93799 
CB156362 BE242196 AA442162 BE242940 R62979 AW955818 BX094505 BP377484 

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF185 (see all 9)    About this scheme

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19
SP1:                                            -                       -           -     -     -                                                         
SP2:                                            -           -     -     -           -     -     -                                                         
SP3:                                                                                                                                                      
SP4:                                                                                                                                                      
SP5:                                                                    -           -     -     -                                                         


ECgene alternative splicing isoforms for ZNF185

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF185 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTAAAAAGG

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image

ZNF185 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
Stem Cell Differentiation: 2 LifeMap Cells 
NameCategory
Definitive endoderm-like cells (A scalable, suspensi...)
Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)Cartilage
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See ZNF185 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF185

SOURCE GeneReport for Unigene cluster: Hs.16622

UniProtKB/Swiss-Prot: ZN185_HUMAN, O15231
Tissue specificity: Expressed in placenta, pancreas and kidney. Also expressed in prostate, testis, ovary and blood

    SABiosciences Expression via Pathway-Focused PCR Array including ZNF185: 
          Prostate Cancer in human mouse rat

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF185 gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Zfp1851 , 5 zinc finger protein 1851, 5 76.07(n)1
68.88(a)1
  X (37.29 cM)5
226731  NM_009549.31  NP_033575.31 
 729873605 
chicken
(Gallus gallus)
Aves ZNF1856
Uncharacterized protein
40(a)
1 ↔ 1
4(11312405-11338388)
lizard
(Anolis carolinensis)
Reptilia ZNF1856
--
40(a)
1 ↔ 1
GL343202.1(1745141-1778635)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26902 Xenopus laevis transcribed sequence with moderate similarity more 72.08(n)    BJ031947.1 


ENSEMBL Gene Tree for ZNF185 (if available)
TreeFam Gene Tree for ZNF185 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ZNF185 gene
SCEL2  
2 SIMAP similar genes for ZNF185 using alignment to 13 protein entries:     ZN185_HUMAN (see all proteins):
DKFZp686B22130    DKFZp686O1389

ZNF185 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/820 NCBI SNPs in ZNF185 are shown (see all 820    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs59252531,2
C,F,A,H,--152081027(+) AAGGGA/GTAACT 6 -- us2k125Minor allele frequency- G:0.37NS EA NA WA CSA 2827
rs1809732451,2
--152081063(+) GCCTGA/GGATGG 6 -- us2k10--------
rs1862453341,2
--152081095(+) ATGACC/TGTCAC 6 -- us2k10--------
rs1914291951,2
--152081162(+) AGGAGA/TACGTC 6 -- us2k10--------
rs1832552661,2
--152081171(+) TCTTTC/GAGGTG 6 -- us2k10--------
rs1862501821,2
--152081362(+) ATGGGA/GCCACT 6 -- us2k10--------
rs1910233861,2
--152081373(+) CCACAC/GGTTGC 6 -- us2k10--------
rs59252541,2
C,A,H,--152081432(+) TGAGCT/GCCACT 6 -- us2k12Minor allele frequency- G:0.00WA CSA 3
rs1834870141,2
--152081557(+) GTTCAA/GTGCAG 6 -- us2k10--------
rs59252551,2
C,F,A,H,--152081611(+) GCTCTT/CGTCCC 6 -- us2k12Minor allele frequency- C:0.40NA CSA 5

HapMap Linkage Disequilibrium report for ZNF185 (152082986 - 152142025 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZNF185
     2 CNVs: 52963 74081
Locus Specific Mutation Databases (LSDB): ZNF185

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF185 for disorders           About GeneDecksing

OMIM gene information: 300381    OMIM disorders: --

10 diseases for ZNF185:    About MalaCards
mast cell neoplasm    intussusception    gastroenteritis    mastocytosis
prostate cancer, progression of    diarrhea    prostate cancer    leiomyoma
lung cancer    prostatitis

4 diseases from the University of Copenhagen DISEASES database for ZNF185:
Mastocytosis     Gastroenteritis     Intussusception     Diarrhea

Export disorders for ZNF185 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ZNF185 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with ZNF185)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genomic structure of a novel LIM domain gene (ZNF185) in Xq28 and comparisons with the orthologous murine transcript. (PubMed id 9268636)1, 2, 3 Heiss N.S.... Poustka A. (1997)
  2. ZNF185, an actin-cytoskeleton-associated growth inhibitory LIM protein in prostate cancer. (PubMed id 16799630)1, 2 Zhang J.S.... Young C.Y. (2007)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. Comparative genome sequence analysis of the Bpa/Str region in mouse and man. (PubMed id 10854409)1, 2 Mallon A.-M....Brown S.D.M. (2000)
  5. Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression. (PubMed id 12873976)1, 9 Vanaja D.K....Young C.Y. (2003)
  6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
  7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
  8. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
  9. Phosphoproteome of resting human platelets. (PubMed id 18088087)2 Zahedi R.P.... Sickmann A. (2008)
  10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7739 HGNC: 12976 AceView: ZNF185 Ensembl:ENSG00000147394 euGenes: HUgn7739
ECgene: ZNF185 H-InvDB: ZNF185

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF185 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
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IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF185 gene:
Search GeneIP for patents involving ZNF185

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