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ZNF184 Gene

protein-coding   GIFtS: 59
GCID: GC06M027436

Zinc Finger Protein 184

(Previous name: zinc finger protein 184 (Kruppel-like))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 1841 2
Zinc Finger Protein 184 (Kruppel-Like)1 2

External Ids:    HGNC: 129751   Entrez Gene: 77382   Ensembl: ENSG000000966547   OMIM: 6022775   UniProtKB: Q996763   

Export aliases for ZNF184 gene to outside databases

Previous GC identifers: GC06M027476 GC06M027389 GC06M027435 GC06M027526 GC06M027226


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF184 Gene:
ZNF184 (zinc finger protein 184) is a protein-coding gene. Diseases associated with ZNF184 include choriocarcinoma, and schizophrenia. An important paralog of this gene is ZNF334.

UniProtKB/Swiss-Prot: ZN184_HUMAN, Q99676
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF184 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF184 gene promoter:
         p300   CREB   Pax-3   E2F-1   E2F   POU2F1   POU2F1a   deltaCREB   Sox9   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF184 promoter sequence
   Search Chromatin IP Primers for ZNF184

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF184


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.3

ZNF184 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF184 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M027436:  view genomic region     (about GC identifiers)

Start:
27,418,521 bp from pter      End:
27,440,897 bp from pter
Size:
22,377 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN184_HUMAN, Q99676 (See protein sequence)
Recommended Name: Zinc finger protein 184  
Size: 751 amino acids; 86174 Da
Secondary accessions: B2R715 O60792 Q8TBA9

Explore the universe of human proteins at neXtProt for ZNF184: NX_Q99676

Explore proteomics data for ZNF184 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys416
  • Modification sites at PhosphoSitePlus

  • See ZNF184 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009080.2  
    ENSEMBL proteins: 
     ENSP00000366636   ENSP00000211936  
    Reactome Protein details: Q99676

    ZNF184 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q99676

    ProtoNet protein and cluster: Q99676

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN184_HUMAN, Q99676
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 19 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF184 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN184_HUMAN, Q99676
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF184:
    zinc finger 184,C2H2 type,Kruppel-like,Krab subfamily,predominantly but not exclusively expressed in testis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding NAS9073517
    GO:0046872metal ion binding ----
         
    ZNF184 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF184:
     Increased cell number in G1, s 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF184
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    miRNA
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    miRTarBase miRNAs that target ZNF184:
    hsa-mir-192-5p (MIRT026409), hsa-mir-215-5p (MIRT024548)

    Block miRNA regulation of human, mouse, rat ZNF184 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate ZNF184:
    hsa-miR-3163 hsa-miR-3171
    SwitchGear 3'UTR luciferase reporter plasmidZNF184 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN184_HUMAN, Q99676: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF184 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF184 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF184
        Generic Transcription Pathway



    ZNF184 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF184
    Interactions:

        Search GeneGlobe Interaction Network for ZNF184

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ZNF184 (Q996763 ENSP000002119364) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EWSR1Q018443, ENSP000003810314I2D: score=1 STRING: ENSP00000381031
    ENSG00000230685ENSP000004080944STRING: ENSP00000408094
    UBP1ENSP000002836284STRING: ENSP00000283628
    --ENSP000003369464STRING: ENSP00000336946
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF184 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF184 (ZN184)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF184 gene: 
    NM_007149.2  

    Unigene Cluster for ZNF184:

    Zinc finger protein 184
    Hs.158174  [show with all ESTs]
    Unigene Representative Sequence: AK123011
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377419 ENST00000211936(uc003njj.3 uc010jqv.3 uc003nji.3)

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ZNF184:
    hsa-miR-3163 hsa-miR-3171
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    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF184
      QuantiFast Probe-based Assays in human, mouse, rat ZNF184

    Additional mRNA sequence: 

    AK123011.1 AK131264.1 AK312804.1 BC022992.1 U52098.1 U66561.1 

    5 DOTS entries:

    DT.414041  DT.100764366  DT.102821767  DT.100764367  DT.121328165 

    Selected AceView cDNA sequences (see all 78):

    AK131264 BC022992 CA445774 CB266491 BF000131 AI139471 AA723097 AU130244 
    BM675205 NM_007149 AI139121 N80080 BQ015962 CA438372 AK123011 N39140 
    N59184 N74667 AI275409 BQ230882 BQ959486 U66561 AW978495 BF196013 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF184    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:        -     -                                                   
    SP2:              -                                                   
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for ZNF184

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF184 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGCCAAT
    ZNF184 Expression
    About this image

    ZNF184 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF184 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.158174

    UniProtKB/Swiss-Prot: ZN184_HUMAN, Q99676
    Tissue specificity: Predominant expression in testis

        Custom PCR Arrays for ZNF184
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF184 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp1841 , 5 zinc finger protein 184 (Kruppel-like)1, 5 84.94(n)1
    84.75(a)1
      13 (8.08 cM)5
    1934521  NM_183014.11  NP_898835.11 
     219450945 


    ENSEMBL Gene Tree for ZNF184 (if available)
    TreeFam Gene Tree for ZNF184 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF184 gene
    ZNF3342  ZNF4202  ZNF780A2  ZNF6652  ZNF72  ZNF232  ZNF33A2  RBAK2  
    ZNF7172  ZNF302  ZNF5732  ZNF33B2  ZNF5402  ZNF2512  ZNF6052  ZNF842  
    ZNF1892  ZNF5712  ZNF6302  ZNF3372  ZNF2832  ZNF4042  ZNF1352  ZNF4842  
    ZNF122  ZNF3452  ZNF6992  ZNF412  ZNF6152  ZNF4702  ZNF5692  
    Selected SIMAP similar genes for ZNF184 using alignment to 1 protein entry:     ZN184_HUMAN(see all similar genes):
    ZNF78L1    ZNF345    HZF36    ZFS-1    DKFZp434G1930    HZF30
    ZNF738    HZF41    ZFP41    ZNF323    ZNF781    ZSCAN31
    ZNF    DKFZp762K012    ZNF146    ZNF883    DKFZp666M039    DKFZp686B16128

    ZNF184 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZNF184
    PGOHUM00000240786 PGOHUM00000243092


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF184 (see all 575)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs616027781,2
    C--27353503(+) AAAAAAA/-TAGAG 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1852092141,2
    --27418032(+) TAGGGC/TCTTGG 1 -- int10--------
    rs1497941141,2
    --27418121(+) TGCAAC/TGTGAT 1 -- int10--------
    rs558085441,2
    C,F--27418144(+) GGGGCC/ATTTGG 1 -- int13Minor allele frequency- A:0.06WA CSA 122
    rs1437915251,2
    C--27418192(+) GGGAT-/TAGTAGTC 1 -- int10--------
    rs581459231,2
    C--27418193(+) TTAGT-/AGTCTTAT 1 -- int10--------
    rs2018672451,2
    C--27418197(-) TAAGAA/CTACTA 1 -- int10--------
    rs585757781,2
    C,F--27418254(+) GAACAC/TAAGAA 1 -- int11Minor allele frequency- T:0.02WA 118
    rs566538001,2
    F--27418260(+) AAGAAG/AAAGAG 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1468062481,2
    --27418341(+) AGCCTC/TTTCCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF184 (27418521 - 27440897 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF184:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv883508CNV Loss21882294
    nsv830617CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF184
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602277    OMIM disorders: --

    3 diseases for ZNF184:    
    About MalaCards
    choriocarcinoma    schizophrenia    neuroblastoma


    ZNF184 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF184
    Human Genome Epidemiology (HuGE) Navigator: ZNF184 (1 document)

    Export disorders for ZNF184 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF184 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ZNF184)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common variants on chromosome 6p22.1 are associated with schizophrenia. (PubMed id 19571809)1, 4 Shi J....Gejman P.V. (Nature 2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Identification of a novel Krueppel-related zinc finger gene (ZNF184) mapping to 6p21.3. (PubMed id 9073517)1, 2 Goldwurm S.... Jazwinska E.C. (Genomics 1997)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    6. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    8. Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. (PubMed id 18463370)4 Maris J.M....Hakonarson H. (N. Engl. J. Med. 2008)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7738 HGNC: 12975 AceView: ZNF184 Ensembl:ENSG00000096654 euGenes: HUgn7738
    ECgene: ZNF184 H-InvDB: ZNF184

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF184 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF184 gene:
    Search GeneIP for patents involving ZNF184

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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