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Aliases for ZNF184 Gene

Aliases for ZNF184 Gene

  • Zinc Finger Protein 184 2 3 5
  • Zinc Finger Protein 184 (Kruppel-Like) 2 3
  • Kr-ZNF3 3

External Ids for ZNF184 Gene

Previous GeneCards Identifiers for ZNF184 Gene

  • GC06M027476
  • GC06M027389
  • GC06M027435
  • GC06M027436
  • GC06M027526
  • GC06M027226

Summaries for ZNF184 Gene

Entrez Gene Summary for ZNF184 Gene

  • The protein encoded by this gene is predicted to be a Kruppel C2H2-type zinc-finger protein family member. Sequence analysis predicts that the protein contains two Kruppel associated box (KRAB) boxes in the N-terminus and highly conserved zinc finger motifs at the C-terminus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]

GeneCards Summary for ZNF184 Gene

ZNF184 (Zinc Finger Protein 184) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF624.

UniProtKB/Swiss-Prot for ZNF184 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF184 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF184 Gene

Genomics for ZNF184 Gene

Regulatory Elements for ZNF184 Gene

Enhancers for ZNF184 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F027477 1.4 Ensembl ENCODE 11.2 -5.7 -5684 3.2 PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF391 ABT1 PGBD1 ZSCAN26 ZNF603P ZKSCAN3 ENSG00000261353 ZKSCAN4 ZNF192P1 ZNF184
GH06F027502 1.4 Ensembl ENCODE 11 -30.0 -30049 2.3 HDGF PKNOX1 ARNT CREB3L1 SIN3A ARID4B ZNF2 ZNF766 FOS ZNF263 ZNF204P ZNF391 ABT1 ZKSCAN3 ZKSCAN4 POM121L2 ZKSCAN8 ZNF184 RNU6-471P HIST1H4K
GH06F027518 1.4 Ensembl ENCODE 10.5 -45.9 -45929 2.1 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF391 ABT1 ZKSCAN3 ZKSCAN4 POM121L2 ZKSCAN8 RNU6-471P ZNF184 ENSG00000270666 PIR59423
GH06F027495 1.2 ENCODE 11.7 -22.6 -22616 1.2 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 ZNF302 ZNF143 FOS ZKSCAN8 ZKSCAN3 ABT1 ZSCAN9 ZKSCAN4 HMGN4 ZNF391 GUSBP2 ZNF322 ZNF204P
GH06F027388 1.2 ENCODE 11.2 +84.3 84312 1.5 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF391 ZNF204P HMGN4 ZKSCAN8 ABT1 ZKSCAN3 ZSCAN9 ZKSCAN4 ZNF192P1 ZNF184
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF184 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF184 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001214322 417 3399 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 SIN3A ARID4B FEZF1 DMAP1

Genomic Location for ZNF184 Gene

Chromosome:
6
Start:
27,450,742 bp from pter
End:
27,473,118 bp from pter
Size:
22,377 bases
Orientation:
Minus strand

Genomic View for ZNF184 Gene

Genes around ZNF184 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF184 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF184 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF184 Gene

Proteins for ZNF184 Gene

  • Protein details for ZNF184 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99676-ZN184_HUMAN
    Recommended name:
    Zinc finger protein 184
    Protein Accession:
    Q99676
    Secondary Accessions:
    • B2R715
    • O60792
    • Q8TBA9

    Protein attributes for ZNF184 Gene

    Size:
    751 amino acids
    Molecular mass:
    86174 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF184 Gene

Post-translational modifications for ZNF184 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF184 Gene

No data available for DME Specific Peptides for ZNF184 Gene

Domains & Families for ZNF184 Gene

Gene Families for ZNF184 Gene

Protein Domains for ZNF184 Gene

Suggested Antigen Peptide Sequences for ZNF184 Gene

Graphical View of Domain Structure for InterPro Entry

Q99676

UniProtKB/Swiss-Prot:

ZN184_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 19 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 19 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF184: view

Function for ZNF184 Gene

Molecular function for ZNF184 Gene

GENATLAS Biochemistry:
zinc finger 184,C2H2 type,Kruppel-like,Krab subfamily,predominantly but not exclusively expressed in testis
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF184 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS 9073517
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF184: view
genes like me logo Genes that share phenotypes with ZNF184: view

Animal Models for ZNF184 Gene

MGI Knock Outs for ZNF184:

Animal Model Products

miRNA for ZNF184 Gene

miRTarBase miRNAs that target ZNF184

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF184 Gene

Localization for ZNF184 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF184 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF184 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF184 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF184: view

Pathways & Interactions for ZNF184 Gene

SuperPathways for ZNF184 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF184: view

Pathways by source for ZNF184 Gene

2 Reactome pathways for ZNF184 Gene

Gene Ontology (GO) - Biological Process for ZNF184 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF184: view

No data available for SIGNOR curated interactions for ZNF184 Gene

Transcripts for ZNF184 Gene

Unigene Clusters for ZNF184 Gene

Zinc finger protein 184:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF184 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for ZNF184 Gene

GeneLoc Exon Structure for
ZNF184
ECgene alternative splicing isoforms for
ZNF184

Expression for ZNF184 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF184 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF184 Gene

This gene is overexpressed in Plasma (65.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF184 Gene



Protein tissue co-expression partners for ZNF184 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF184 Gene:

ZNF184

SOURCE GeneReport for Unigene cluster for ZNF184 Gene:

Hs.158174

mRNA Expression by UniProt/SwissProt for ZNF184 Gene:

Q99676-ZN184_HUMAN
Tissue specificity: Predominant expression in testis.
genes like me logo Genes that share expression patterns with ZNF184: view

Primer Products

No data available for mRNA differential expression in normal tissues for ZNF184 Gene

Orthologs for ZNF184 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF184 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF184 34 35
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia ZNF184 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC515674 34
  • 91.43 (n)
ZNF184 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp184 34
  • 85.19 (n)
mouse
(Mus musculus)
Mammalia Zfp184 34 16 35
  • 84.94 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 58 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
-- 35
  • 48 (a)
OneToMany
-- 35
  • 48 (a)
OneToMany
-- 35
  • 48 (a)
OneToMany
-- 35
  • 48 (a)
OneToMany
-- 35
  • 47 (a)
OneToMany
-- 35
  • 47 (a)
OneToMany
-- 35
  • 47 (a)
OneToMany
-- 35
  • 47 (a)
OneToMany
-- 35
  • 47 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
-- 35
  • 44 (a)
OneToMany
-- 35
  • 44 (a)
OneToMany
-- 35
  • 44 (a)
OneToMany
-- 35
  • 44 (a)
OneToMany
-- 35
  • 44 (a)
OneToMany
-- 35
  • 43 (a)
OneToMany
-- 35
  • 43 (a)
OneToMany
-- 35
  • 43 (a)
OneToMany
-- 35
  • 43 (a)
OneToMany
-- 35
  • 43 (a)
OneToMany
-- 35
  • 42 (a)
OneToMany
-- 35
  • 42 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
-- 35
  • 38 (a)
OneToMany
-- 35
  • 35 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Kr 36
  • 44 (a)
Meics 36
  • 40 (a)
crol 36
  • 39 (a)
wdn 36
  • 39 (a)
CG6254 36
  • 36 (a)
CG6689 36
  • 34 (a)
Neu2 36
  • 34 (a)
CG7987 36
  • 33 (a)
CG4707 36
  • 31 (a)
CG9609 36
  • 31 (a)
zf30C 36
  • 30 (a)
CG4282 36
  • 29 (a)
CG8484 36
  • 27 (a)
CG11902 36
  • 26 (a)
CG18476 36
  • 26 (a)
Species where no ortholog for ZNF184 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF184 Gene

ENSEMBL:
Gene Tree for ZNF184 (if available)
TreeFam:
Gene Tree for ZNF184 (if available)

Paralogs for ZNF184 Gene

(461) SIMAP similar genes for ZNF184 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF184 Gene

genes like me logo Genes that share paralogs with ZNF184: view

Variants for ZNF184 Gene

Sequence variations from dbSNP and Humsavar for ZNF184 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs193921063 Uncertain significance 27,457,372(-) CTTTA(A/C)CCAGG reference, missense, utr-variant-5-prime
rs10484398 -- 27,457,181(+) ATTTA(C/G)AAATG intron-variant
rs10807024 -- 27,460,926(+) ACAAG(C/T)TCTGA intron-variant
rs10807025 -- 27,464,049(+) tcact(C/G)gtctc intron-variant
rs10946920 -- 27,461,212(+) ACATT(C/T)TTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF184 Gene

Variant ID Type Subtype PubMed ID
esv3570827 CNV loss 25503493
nsv1131951 CNV deletion 24896259
nsv830617 CNV loss 17160897

Variation tolerance for ZNF184 Gene

Residual Variation Intolerance Score: 8.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF184 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF184

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF184 Gene

Disorders for ZNF184 Gene

Relevant External Links for ZNF184

Genetic Association Database (GAD)
ZNF184
Human Genome Epidemiology (HuGE) Navigator
ZNF184
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF184

No disorders were found for ZNF184 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF184 Gene

Publications for ZNF184 Gene

  1. Common variants on chromosome 6p22.1 are associated with schizophrenia. (PMID: 19571809) Shi J. … Gejman P.V. (Nature 2009) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Identification of a novel Krueppel-related zinc finger gene (ZNF184) mapping to 6p21.3. (PMID: 9073517) Goldwurm S. … Jazwinska E.C. (Genomics 1997) 3 4 64
  4. GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. (PMID: 24871463) Armstrong D.L. … Jacob C.O. (Genes Immun. 2014) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for ZNF184 Gene

Sources for ZNF184 Gene

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