Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF181 Gene

Aliases for ZNF181 Gene

  • Zinc Finger Protein 181 2 3 5
  • HHZ181 3 4
  • Zinc Finger Protein 181 (HHZ181) 2

External Ids for ZNF181 Gene

Previous GeneCards Identifiers for ZNF181 Gene

  • GC00U990426
  • GC19P039901
  • GC19P039916
  • GC19P039914
  • GC19P035225
  • GC19P031732

Summaries for ZNF181 Gene

Entrez Gene Summary for ZNF181 Gene

  • Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2003]

GeneCards Summary for ZNF181 Gene

ZNF181 (Zinc Finger Protein 181) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF302.

UniProtKB/Swiss-Prot for ZNF181 Gene

  • May be involved in transcriptional regulation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF181 Gene

Genomics for ZNF181 Gene

Regulatory Elements for ZNF181 Gene

Enhancers for ZNF181 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G034732 1.2 ENCODE 31.1 +0.7 695 2.8 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF610 GLIS1 TMEM147-AS1 ZNF181 HAUS5 LSM14A LINC01801 ENSG00000271049 LOC102723540 RBM42 ZNF302 KIAA0355
GH19G034676 1.1 ENCODE 17.1 -55.6 -55628 2.5 PKNOX1 SIN3A FEZF1 ZNF2 ZBTB7B YY1 ZNF766 ZNF302 ZNF416 ZNF207 TMEM147-AS1 ZNF302 LSM14A RBM42 HAUS5 ZNF792 ZNF181 KIAA0355 ENSG00000271032 ENSG00000269086
GH19G034666 1.1 Ensembl ENCODE 16 -65.9 -65862 1.2 KLF17 ZNF2 GLIS2 SP3 ZEB2 ZNF645 ZNF518A ZFP69B ZSCAN16 ZNF341 ZNF302 ZNF181 ENSG00000268947 TMEM147-AS1 ZNF599 SCGB2B2 SCGB2B3P
GH19G034771 1.1 ENCODE 15.6 +39.6 39595 1.9 PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 LSM14A ZNF181 TMEM147-AS1 RBM42 KIAA0355 KMT2B HAUS5 ZNF599 LOC105372375
GH19G034645 0.9 ENCODE 16.1 -87.5 -87503 1.2 ZSCAN4 RAD21 YY1 RARA TCF12 RELB CREM IKZF2 GATAD2B REST ZNF181 ZNF302 SCGB2B3P SCGB2B2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF181 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF181 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108916 684 2001 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF610 GLIS1

Genomic Location for ZNF181 Gene

Chromosome:
19
Start:
34,733,316 bp from pter
End:
34,745,378 bp from pter
Size:
12,063 bases
Orientation:
Plus strand

Genomic View for ZNF181 Gene

Genes around ZNF181 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF181 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF181 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF181 Gene

Proteins for ZNF181 Gene

  • Protein details for ZNF181 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M3W8-ZN181_HUMAN
    Recommended name:
    Zinc finger protein 181
    Protein Accession:
    Q2M3W8
    Secondary Accessions:
    • B7ZKX3
    • Q49A75

    Protein attributes for ZNF181 Gene

    Size:
    571 amino acids
    Molecular mass:
    65842 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF181 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF181 Gene

Post-translational modifications for ZNF181 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF181 Gene

Domains & Families for ZNF181 Gene

Gene Families for ZNF181 Gene

Protein Domains for ZNF181 Gene

Suggested Antigen Peptide Sequences for ZNF181 Gene

Graphical View of Domain Structure for InterPro Entry

Q2M3W8

UniProtKB/Swiss-Prot:

ZN181_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF181: view

Function for ZNF181 Gene

Molecular function for ZNF181 Gene

GENATLAS Biochemistry:
zinc finger 181,human heart 181,C2H2 type,involved in DNA repair deficiencies and cellular malignancies
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF181: view
genes like me logo Genes that share phenotypes with ZNF181: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF181 Gene

Localization for ZNF181 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF181 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF181 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF181: view

Pathways & Interactions for ZNF181 Gene

SuperPathways for ZNF181 Gene

No Data Available

Interacting Proteins for ZNF181 Gene

Gene Ontology (GO) - Biological Process for ZNF181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF181: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF181 Gene

Drugs & Compounds for ZNF181 Gene

No Compound Related Data Available

Transcripts for ZNF181 Gene

mRNA/cDNA for ZNF181 Gene

Unigene Clusters for ZNF181 Gene

Zinc finger protein 181:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF181 Gene

No ASD Table

Relevant External Links for ZNF181 Gene

GeneLoc Exon Structure for
ZNF181
ECgene alternative splicing isoforms for
ZNF181

Expression for ZNF181 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF181 Gene

Protein differential expression in normal tissues from HIPED for ZNF181 Gene

This gene is overexpressed in Urinary Bladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF181 Gene



Protein tissue co-expression partners for ZNF181 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF181 Gene:

ZNF181

SOURCE GeneReport for Unigene cluster for ZNF181 Gene:

Hs.720472

Evidence on tissue expression from TISSUES for ZNF181 Gene

  • Lung(4.2)
  • Nervous system(2.6)
  • Kidney(2)
genes like me logo Genes that share expression patterns with ZNF181: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF181 Gene

Orthologs for ZNF181 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF181 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF181 34 35
  • 99.36 (n)
dog
(Canis familiaris)
Mammalia ZNF181 34 35
  • 89.03 (n)
cow
(Bos Taurus)
Mammalia ZNF181 34 35
  • 88.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6654 35
  • 23 (a)
OneToMany
Species where no ortholog for ZNF181 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF181 Gene

ENSEMBL:
Gene Tree for ZNF181 (if available)
TreeFam:
Gene Tree for ZNF181 (if available)

Paralogs for ZNF181 Gene

(516) SIMAP similar genes for ZNF181 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNF181 Gene

genes like me logo Genes that share paralogs with ZNF181: view

Variants for ZNF181 Gene

Sequence variations from dbSNP and Humsavar for ZNF181 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1001169493 -- 34,743,707(+) GTTAC(A/G)GGAGT utr-variant-3-prime
rs1001219030 -- 34,732,930(+) CCTGG(-/CCCT)CCCTC upstream-variant-2KB
rs1001326344 -- 34,743,471(+) CACTA(A/G)TTATG utr-variant-3-prime
rs1001470769 -- 34,732,124(+) GCCCT(C/G)GACCT upstream-variant-2KB
rs1001542785 -- 34,731,967(+) ACAAC(C/T)CCAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF181 Gene

Variant ID Type Subtype PubMed ID
esv2718487 CNV deletion 23290073
esv2758756 CNV gain 17122850
esv3329051 OTHER inversion 20981092
nsv963039 CNV duplication 23825009

Variation tolerance for ZNF181 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF181 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF181

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF181 Gene

Disorders for ZNF181 Gene

Relevant External Links for ZNF181

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF181

No disorders were found for ZNF181 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF181 Gene

Publications for ZNF181 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 4 64
  3. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. (PMID: 24104479) Vizeacoumar F.J. … Moffat J. (Mol. Syst. Biol. 2013) 3 64
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZNF181 Gene

Sources for ZNF181 Gene

Content
Loading form....