Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF181 Gene

Aliases for ZNF181 Gene

  • Zinc Finger Protein 181 2 3 5
  • HHZ181 3 4
  • Zinc Finger Protein 181 (HHZ181) 2

External Ids for ZNF181 Gene

Previous GeneCards Identifiers for ZNF181 Gene

  • GC00U990426
  • GC19P039901
  • GC19P039916
  • GC19P039914
  • GC19P035225
  • GC19P031732

Summaries for ZNF181 Gene

Entrez Gene Summary for ZNF181 Gene

  • Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2003]

GeneCards Summary for ZNF181 Gene

ZNF181 (Zinc Finger Protein 181) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF345.

UniProtKB/Swiss-Prot for ZNF181 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF181 Gene

Genomics for ZNF181 Gene

Regulatory Elements for ZNF181 Gene

Enhancers for ZNF181 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF181 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF181 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF181 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF181 Gene

34,733,316 bp from pter
34,745,378 bp from pter
12,063 bases
Plus strand

Genomic View for ZNF181 Gene

Genes around ZNF181 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF181 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF181 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF181 Gene

Proteins for ZNF181 Gene

  • Protein details for ZNF181 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 181
    Protein Accession:
    Secondary Accessions:
    • B7ZKX3
    • Q49A75

    Protein attributes for ZNF181 Gene

    571 amino acids
    Molecular mass:
    65842 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF181 Gene


neXtProt entry for ZNF181 Gene

Proteomics data for ZNF181 Gene at MOPED

Post-translational modifications for ZNF181 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF181 Gene

No data available for DME Specific Peptides for ZNF181 Gene

Domains & Families for ZNF181 Gene

Gene Families for ZNF181 Gene

Protein Domains for ZNF181 Gene

Suggested Antigen Peptide Sequences for ZNF181 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF181: view

Function for ZNF181 Gene

Molecular function for ZNF181 Gene

GENATLAS Biochemistry:
zinc finger 181,human heart 181,C2H2 type,involved in DNA repair deficiencies and cellular malignancies
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF181: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF181 Gene

Localization for ZNF181 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF181 Gene

Subcellular locations from

Jensen Localization Image for ZNF181 Gene COMPARTMENTS Subcellular localization image for ZNF181 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF181 Gene

Pathways & Interactions for ZNF181 Gene

SuperPathways for ZNF181 Gene

No Data Available

Interacting Proteins for ZNF181 Gene

Gene Ontology (GO) - Biological Process for ZNF181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF181: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF181 Gene

Drugs & Compounds for ZNF181 Gene

No Compound Related Data Available

Transcripts for ZNF181 Gene

mRNA/cDNA for ZNF181 Gene

Unigene Clusters for ZNF181 Gene

Zinc finger protein 181:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF181 Gene

No ASD Table

Relevant External Links for ZNF181 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF181 Gene

mRNA expression in normal human tissues for ZNF181 Gene

Protein differential expression in normal tissues from HIPED for ZNF181 Gene

This gene is overexpressed in Urinary Bladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF181 Gene

SOURCE GeneReport for Unigene cluster for ZNF181 Gene Hs.720472

genes like me logo Genes that share expression patterns with ZNF181: view

Protein tissue co-expression partners for ZNF181 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF181 Gene

Orthologs for ZNF181 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF181 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF181 35
  • 88.3 (n)
  • 82.98 (a)
ZNF181 36
  • 72 (a)
(Canis familiaris)
Mammalia ZNF181 35
  • 89.03 (n)
  • 85.74 (a)
ZNF181 36
  • 86 (a)
(Pan troglodytes)
Mammalia ZNF181 35
  • 99.36 (n)
  • 98.77 (a)
ZNF181 36
  • 92 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6654 36
  • 23 (a)
Species with no ortholog for ZNF181:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF181 Gene

Gene Tree for ZNF181 (if available)
Gene Tree for ZNF181 (if available)

Paralogs for ZNF181 Gene

(516) SIMAP similar genes for ZNF181 Gene using alignment to 5 proteins: Pseudogenes for ZNF181 Gene

genes like me logo Genes that share paralogs with ZNF181: view

Variants for ZNF181 Gene

Sequence variations from dbSNP and Humsavar for ZNF181 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7257915 -- 34,738,850(+) TTTTT(A/T)AAAAT intron-variant
rs12976434 -- 34,734,619(+) GTGTA(A/C)CCTTG intron-variant, utr-variant-5-prime
rs12978557 -- 34,732,923(+) GGAAG(C/G)CTCCT upstream-variant-2KB
rs8102963 -- 34,739,997(+) TGAGC(A/G)TTGTA intron-variant
rs8106730 -- 34,737,179(+) TAGTG(A/C)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF181 Gene

Variant ID Type Subtype PubMed ID
dgv1074e1 CNV Complex 17122850
esv2718487 CNV Deletion 23290073

Variation tolerance for ZNF181 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF181 Gene

Disorders for ZNF181 Gene

Relevant External Links for ZNF181

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF181 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF181 Gene

Publications for ZNF181 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. (PMID: 24104479) Vizeacoumar F.J. … Moffat J. (Mol. Syst. Biol. 2013) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Identification of a locus of zinc finger genes in human chromosome 19q13.1-q13.3 region by fluorescence in situ hybridization. (PMID: 8914611) Wang R. … Liew C.C. (Somat. Cell Mol. Genet. 1996) 3

Products for ZNF181 Gene

Sources for ZNF181 Gene