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Aliases for ZNF181 Gene

Aliases for ZNF181 Gene

  • Zinc Finger Protein 181 2 3
  • HHZ181 3 4
  • Zinc Finger Protein 181 (HHZ181) 2

External Ids for ZNF181 Gene

Previous GeneCards Identifiers for ZNF181 Gene

  • GC00U990426
  • GC19P039901
  • GC19P039916
  • GC19P039914
  • GC19P035225
  • GC19P031732

Summaries for ZNF181 Gene

Entrez Gene Summary for ZNF181 Gene

  • Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2003]

GeneCards Summary for ZNF181 Gene

ZNF181 (Zinc Finger Protein 181) is a Protein Coding gene. An important paralog of this gene is ZNF529.

UniProtKB/Swiss-Prot for ZNF181 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF181 Gene

Genomics for ZNF181 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF181 Gene

34,733,314 bp from pter
34,745,378 bp from pter
12,065 bases
Plus strand

Genomic View for ZNF181 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF181 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF181 Gene

No data available for Regulatory Elements for ZNF181 Gene

Proteins for ZNF181 Gene

  • Protein details for ZNF181 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 181
    Protein Accession:
    Secondary Accessions:
    • B7ZKX3
    • Q49A75

    Protein attributes for ZNF181 Gene

    571 amino acids
    Molecular mass:
    65842 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF181 Gene


neXtProt entry for ZNF181 Gene

Proteomics data for ZNF181 Gene at MOPED

Post-translational modifications for ZNF181 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF181 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF181 Gene

Domains for ZNF181 Gene

Gene Families for ZNF181 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF181 Gene

Suggested Antigen Peptide Sequences for ZNF181 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q2M3W8
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF181: view

Function for ZNF181 Gene

Molecular function for ZNF181 Gene

GENATLAS Biochemistry:
zinc finger 181,human heart 181,C2H2 type,involved in DNA repair deficiencies and cellular malignancies
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF181: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF181 Gene

Localization for ZNF181 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF181 Gene

Subcellular locations from

Jensen Localization Image for ZNF181 Gene COMPARTMENTS Subcellular localization image for ZNF181 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF181: view

Pathways for ZNF181 Gene

SuperPathways for ZNF181 Gene

No Data Available

Interacting Proteins for ZNF181 Gene

Gene Ontology (GO) - Biological Process for ZNF181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF181: view

No data available for Pathways by source for ZNF181 Gene

Transcripts for ZNF181 Gene

mRNA/cDNA for ZNF181 Gene

Unigene Clusters for ZNF181 Gene

Zinc finger protein 181:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF181

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF181 Gene

No ASD Table

Relevant External Links for ZNF181 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF181 Gene

mRNA expression in normal human tissues for ZNF181 Gene

Protein differential expression in normal tissues for ZNF181 Gene

This gene is overexpressed in Urinary Bladder (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF181 Gene

SOURCE GeneReport for Unigene cluster for ZNF181 Gene Hs.720472

genes like me logo Genes that share expressions with ZNF181: view

Expression partners for ZNF181 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF181 Gene

Orthologs for ZNF181 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF181 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF181 35
  • 88.3 (n)
  • 82.98 (a)
ZNF181 36
  • 72 (a)
(Canis familiaris)
Mammalia ZNF181 35
  • 89.03 (n)
  • 85.74 (a)
ZNF181 36
  • 86 (a)
(Pan troglodytes)
Mammalia ZNF181 35
  • 99.36 (n)
  • 98.77 (a)
ZNF181 36
  • 92 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6654 36
  • 23 (a)
Species with no ortholog for ZNF181:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF181 Gene

Gene Tree for ZNF181 (if available)
Gene Tree for ZNF181 (if available)

Paralogs for ZNF181 Gene

Selected SIMAP similar genes for ZNF181 Gene using alignment to 5 proteins: Pseudogenes for ZNF181 Gene

genes like me logo Genes that share paralogs with ZNF181: view

Variants for ZNF181 Gene

Sequence variations from dbSNP and Humsavar for ZNF181 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7624 -- 34,733,565(+) AGGGG(A/G)CGTAA upstream-variant-2KB, utr-variant-5-prime
rs715945 -- 34,734,547(-) CACGC(G/T)cccac upstream-variant-2KB, intron-variant, utr-variant-5-prime
rs2607243 -- 34,741,413(+) CATAC(G/T)CAAGA synonymous-codon, reference
rs2607244 -- 34,741,467(+) AGGTC(A/G)TCTCT reference, synonymous-codon
rs2862789 -- 34,734,627(-) CATTT(A/G)TTCAA utr-variant-5-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF181 Gene

Variant ID Type Subtype PubMed ID
dgv1074e1 CNV Complex 17122850
esv2718487 CNV Deletion 23290073

Relevant External Links for ZNF181 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF181 Gene

Disorders for ZNF181 Gene

(1) University of Copenhagen DISEASES for ZNF181 Gene

genes like me logo Genes that share disorders with ZNF181: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for ZNF181 Gene

Publications for ZNF181 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  4. Identification of a locus of zinc finger genes in human chromosome 19q13.1-q13.3 region by fluorescence in situ hybridization. (PMID: 8914611) Wang R. … Liew C.C. (Somat. Cell Mol. Genet. 1996) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF181 Gene

Sources for ZNF181 Gene

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