ZNF181 Gene
protein-coding GIFtS: 43
GCID: GC19P035225
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zinc finger protein 181(Previous name: zinc finger protein 181 (HHZ181) )
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Aliases
for ZNF181 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 1811 2 | | HHZ1811 2 3 | | MGC443161 | | Zinc Finger Protein 181 (HHZ181)1 |
Export aliases for ZNF181 gene to outside databasesPrevious GC identifers: GC00U990426 GC19P039901 GC19P039916 GC19P039914 GC19P031732 |
Summaries
for ZNF181 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF181:
Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc fingerdomain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines thatare involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 foradditional information on zinc finger proteins.(supplied by OMIM, Jul 2003)
UniProtKB/Swiss-Prot: ZN181_HUMAN, Q2M3W8Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF181 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZNF181
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF181
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF181 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.11 Ensembl cytogenetic band: 19q13.11 HGNC cytogenetic band: 19q13.13ZNF181 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P035225: view genomic region
(about GC identifiers)
Start:
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35,225,061 bp from pter |
End:
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35,233,777 bp from pter |
Size:
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8,717 bases |
Orientation:
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plus strand |
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Proteins
for ZNF181 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN181_HUMAN, Q2M3W8 (See
protein sequence)Recommended Name: Zinc finger protein 181 Size: 571 amino acids; 65842 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B7ZKX3 Q49A75Alternative splicing: 3 isoforms: Q2M3W8-1 Q2M3W8-2 Q2M3W8-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF181: NX_Q2M3W8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2M3W8
ZNF181 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001025168.2 NP_001139137.1
ENSEMBL proteins: ENSP00000376065 ENSP00000420727 ENSP00000419435
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF181 for ontologies About GeneDecksing
ZNF181 Antibody Products:
Assay Products for ZNF181: |
Protein
Domains /
Families
for ZNF181 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF181 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q2M3W8ProtoNet protein and cluster: Q2M3W8 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN181_HUMAN, Q2M3W8Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 11 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF181 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN181_HUMAN, Q2M3W8Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF181:zinc finger 181,human heart 181,C2H2 type,involved in DNA repair deficiencies and cellular malignancies
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF181 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF181 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF181 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF181 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF181
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF181 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF181 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF181
Search CenterWatch for drugs/clinical trials and news about ZNF181 / ZN181
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Transcripts
for ZNF181 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF181 gene (2 alternative transcripts): NM_001029997.3 NM_001145665.1 Unigene Cluster for ZNF181: Zinc finger protein 181 Hs.720472 [show with all ESTs]Unigene Representative Sequence: NM_0010299974 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000392232 ENST00000448715(uc010xsb.1 uc002nvu.3 uc010xsc.1)
ENST00000492450 ENST00000459757
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF181 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF181 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF181 (NM_001029997) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF181 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF181 |
Additional cDNA sequence: AK295492.1 AK297316.1 BC104759.1 BC143441.1 BC143442.1 9 DOTS entries: DT.95268209 DT.100816621 DT.40227434 DT.121500830 DT.80101891 DT.100816624 DT.102832035 DT.86849768 DT.92438326 12 AceView cDNA sequences: CR624408 N28632 BQ228633 BC043228 N22826 BF857495 AI566117 BX415480 BG471438 N87549 N83317 BG541663
GeneLoc Exon Structure
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Expression
for ZNF181 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF181 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF181 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.720472
SABiosciences Custom PCR Arrays for ZNF181
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF181
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF181 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF181 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF181 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF181 |
Orthologs
for ZNF181 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF181 (if available)
TreeFam Gene Tree for ZNF181 (if available) |
Paralogs
for ZNF181 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF181 gene
- ZNF5702 ZNF2872 ZFP282 ZNF4712 ZNF72 ZNF2502 ZNF8792 ZNF3022
- ZNF354C2 ZNF742 ZNF5832 ZFP902 ZNF1892 ZNF354A2 ZNF354B2 ZNF1352
- ZNF5682 ZNF342 ZNF5272 ZNF82 ZNF5692 ZNF4702
18/507 SIMAP similar genes for ZNF181 using alignment to 5 protein entries: ZN181_HUMAN (see all proteins)
(see all similar genes):HZF17 MST154 kr-znf3 ZFS-5 ZNF302 ZNF66
ZNF826P ZNF738 ZNF818P ZNF146 ZNF78L1 FLJ00301
DKFZp313M0722 POM121C ZNF55 ZNF56 ZNF781 ZNF789
ZNF181 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF181
PGOHUM00000234286
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Genomic Variants
for ZNF181 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF181 (35225061 - 35233777 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF181
1 CNV: 4077 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF181 |
|
Disorders
/ Diseases
for ZNF181 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF181 for disorders About GeneDecksing
OMIM gene information: 606741
OMIM disorders: --
1  disease for ZNF181: About MalaCardshypospadias
1 disease from the University of Copenhagen DISEASES database for ZNF181:Hypospadias Export disorders for ZNF181 gene to outside databases
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Publications
for ZNF181 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF181 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF181) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Identification of a locus of zinc finger genes in human chromosome 19q13.1-q13.3 region by fluorescence in situ hybridization. (PubMed id 8914611)1 Wang R....Liew C.C. (1996)
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External Searches for ZNF181 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF181 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF181 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF181 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF181 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZNF181 gene:
Search GeneIP for patents involving ZNF181
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF181 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | ZNF181 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF181 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF181 |
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