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Aliases for ZNF180 Gene

Aliases for ZNF180 Gene

  • Zinc Finger Protein 180 2 3 5
  • HHZ168 3 4
  • Zinc Finger Protein 180 (HHZ168) 2

External Ids for ZNF180 Gene

Previous GeneCards Identifiers for ZNF180 Gene

  • GC19M045625
  • GC19M045371
  • GC19M049655
  • GC19M049671
  • GC19M044979
  • GC19M041412

Summaries for ZNF180 Gene

Entrez Gene Summary for ZNF180 Gene

  • Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2002]

GeneCards Summary for ZNF180 Gene

ZNF180 (Zinc Finger Protein 180) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF606.

UniProtKB/Swiss-Prot for ZNF180 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF180 Gene

Genomics for ZNF180 Gene

Regulatory Elements for ZNF180 Gene

Enhancers for ZNF180 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZNF180 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF180 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZNF180 Gene

Chromosome:
19
Start:
44,474,428 bp from pter
End:
44,501,750 bp from pter
Size:
27,323 bases
Orientation:
Minus strand

Genomic View for ZNF180 Gene

Genes around ZNF180 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF180 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF180 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF180 Gene

Proteins for ZNF180 Gene

  • Protein details for ZNF180 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJW8-ZN180_HUMAN
    Recommended name:
    Zinc finger protein 180
    Protein Accession:
    Q9UJW8
    Secondary Accessions:
    • B2RCN6
    • B3KV56
    • K7EQX9
    • Q58F03
    • Q9P1U2

    Protein attributes for ZNF180 Gene

    Size:
    692 amino acids
    Molecular mass:
    79111 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF180 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF180 Gene

Post-translational modifications for ZNF180 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF180 Gene

Domains & Families for ZNF180 Gene

Gene Families for ZNF180 Gene

Protein Domains for ZNF180 Gene

Suggested Antigen Peptide Sequences for ZNF180 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJW8

UniProtKB/Swiss-Prot:

ZN180_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF180: view

Function for ZNF180 Gene

Molecular function for ZNF180 Gene

GENATLAS Biochemistry:
zinc finger 180,human heart 168,C2H2 type,involved in DNA repair deficiencies and cellular malignancies
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF180: view

Phenotypes for ZNF180 Gene

genes like me logo Genes that share phenotypes with ZNF180: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF180 Gene

Localization for ZNF180 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF180 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF180 Gene COMPARTMENTS Subcellular localization image for ZNF180 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF180: view

Pathways & Interactions for ZNF180 Gene

SuperPathways for ZNF180 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF180: view

Pathways by source for ZNF180 Gene

2 Reactome pathways for ZNF180 Gene

Gene Ontology (GO) - Biological Process for ZNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF180: view

No data available for SIGNOR curated interactions for ZNF180 Gene

Drugs & Compounds for ZNF180 Gene

No Compound Related Data Available

Transcripts for ZNF180 Gene

Unigene Clusters for ZNF180 Gene

Zinc finger protein 180:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF180 Gene

No ASD Table

Relevant External Links for ZNF180 Gene

GeneLoc Exon Structure for
ZNF180
ECgene alternative splicing isoforms for
ZNF180

Expression for ZNF180 Gene

mRNA expression in normal human tissues for ZNF180 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF180 Gene



Protein tissue co-expression partners for ZNF180 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF180 Gene:

ZNF180

SOURCE GeneReport for Unigene cluster for ZNF180 Gene:

Hs.22305
genes like me logo Genes that share expression patterns with ZNF180: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF180 Gene

Orthologs for ZNF180 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF180 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF180 34
  • 88.29 (n)
  • 84.31 (a)
ZNF180 35
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF180 34
  • 88.56 (n)
  • 85.52 (a)
ZNF180 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp180 34
  • 74.14 (n)
  • 69.43 (a)
Zfp180 16
Zfp180 35
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF180 34
  • 98.14 (n)
  • 97.44 (a)
ZNF180 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp180 34
  • 74.81 (n)
  • 71.3 (a)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG2202 36
  • 54 (a)
Kr-h1 36
  • 38 (a)
Meics 36
  • 39 (a)
Neu2 36
  • 37 (a)
Species where no ortholog for ZNF180 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF180 Gene

ENSEMBL:
Gene Tree for ZNF180 (if available)
TreeFam:
Gene Tree for ZNF180 (if available)

Paralogs for ZNF180 Gene

(559) SIMAP similar genes for ZNF180 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF180 Gene

genes like me logo Genes that share paralogs with ZNF180: view

Variants for ZNF180 Gene

Sequence variations from dbSNP and Humsavar for ZNF180 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2571108 - 44,497,294(-) GAAGG(C/T)CTGTG reference, missense, utr-variant-5-prime
rs2253563 - 44,479,350(+) GGGTT(C/G)CAAGT intron-variant, reference, missense, utr-variant-5-prime
rs1897820 - 44,477,666(-) TAAAT(C/G)CTATG reference, missense, utr-variant-5-prime
rs3745146 -- 44,484,693(-) TTAGC(G/T)GCAAT intron-variant, utr-variant-5-prime
rs3745147 -- 44,484,680(-) GCTGG(C/T)CCAGA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF180 Gene

Variant ID Type Subtype PubMed ID
esv3306608 CNV mobile element insertion 20981092
esv3412314 CNV insertion 20981092
nsv1061350 CNV loss 25217958
nsv1125674 CNV tandem duplication 24896259
nsv521513 CNV loss 19592680
nsv960853 CNV duplication 23825009

Variation tolerance for ZNF180 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.74; 97.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF180 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF180

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF180 Gene

Disorders for ZNF180 Gene

Relevant External Links for ZNF180

Genetic Association Database (GAD)
ZNF180
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF180

No disorders were found for ZNF180 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF180 Gene

Publications for ZNF180 Gene

  1. Genome-wide association scan for five major dimensions of personality. (PMID: 18957941) Terracciano A. … Costa P.T. (Mol. Psychiatry 2010) 3 46 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 65
  4. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M. … Stubbs L. (Genome Res. 2003) 3 4 65
  5. SUMO-2 orchestrates chromatin modifiers in response to DNA damage. (PMID: 25772364) Hendriks I.A. … Vertegaal A.C. (Cell Rep. 2015) 4 65

Products for ZNF180 Gene

Sources for ZNF180 Gene

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