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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF180 Gene

protein-coding   GIFtS: 50
GCID: GC19M044979

Zinc Finger Protein 180

(Previous name: zinc finger protein 180 (HHZ168))
  Search for ZNF180
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 1801 2
HHZ1682 3
Zinc Finger Protein 180 (HHZ168)1

External Ids:    HGNC: 129701   Entrez Gene: 77332   Ensembl: ENSG000001673847   OMIM: 6067405   UniProtKB: Q9UJW83   

Export aliases for ZNF180 gene to outside databases

Previous GC identifers: GC19M045625 GC19M045371 GC19M049655 GC19M049671 GC19M041412


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF180 Gene:
Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger
domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines
that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM
604749 for additional information on zinc finger proteins.(supplied by OMIM, Jul 2002)

GeneCards Summary for ZNF180 Gene: 
ZNF180 (zinc finger protein 180) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF436.

UniProtKB/Swiss-Prot: ZN180_HUMAN, Q9UJW8
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF180 gene promoter:
         Max1   STAT5A   LCR-F1   AREB6   PPAR-gamma1   FOXC1   ARP-1   PPAR-gamma2   MRF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF180 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF180

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF180


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

ZNF180 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF180 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M044979:  view genomic region     (about GC identifiers)

Start:
44,979,854 bp from pter      End:
45,004,576 bp from pter
Size:
24,723 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN180_HUMAN, Q9UJW8 (See protein sequence)
Recommended Name: Zinc finger protein 180  
Size: 692 amino acids; 79111 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B2RCN6 Q9P1U2

Explore the universe of human proteins at neXtProt for ZNF180: NX_Q9UJW8

Explore proteomics data for ZNF180 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UJW8

  • ZNF180 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF180 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001265437.1  NP_001265438.1  NP_037388.2  

    ENSEMBL proteins: 
     ENSP00000375818   ENSP00000221327   ENSP00000466516   ENSP00000468523   ENSP00000468021  
     ENSP00000466726   ENSP00000467916   ENSP00000465426  
    Reactome Protein details: Q9UJW8
    Human Recombinant Protein Products for ZNF180: 
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    Novus Biologicals ZNF180 Proteins
    Novus Biologicals ZNF180 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF180 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF180 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UJW8

    ProtoNet protein and cluster: Q9UJW8

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN180_HUMAN, Q9UJW8
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF180 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN180_HUMAN, Q9UJW8
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF180:
    zinc finger 180,human heart 168,C2H2 type,involved in DNA repair deficiencies and cellular malignancies

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF180 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZNF180 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF180 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF180
        Generic Transcription Pathway
    Gene Expression



    ZNF180 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF180

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF180 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF180 (ZN180)

    Search CenterWatch for drugs/clinical trials and news about ZNF180 / ZN180

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF180 gene (3 alternative transcripts): 
    NM_001278508.1  NM_001278509.1  NM_013256.4  

    Unigene Cluster for ZNF180:

    Zinc finger protein 180
    Hs.22305  [show with all ESTs]
    Unigene Representative Sequence: BC051903
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391956 ENST00000221327(uc002ozh.4 uc002ozi.4 uc002ozf.4 uc002ozg.4 uc010ejm.3)
    ENST00000592095 ENST00000590088 ENST00000592529 ENST00000586637 ENST00000591064
    ENST00000587047 ENST00000585514 ENST00000592140 ENST00000590366
    miRNA
    Products:
         
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF180 (see all 15):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-302a hsa-miR-302e hsa-miR-373 hsa-miR-188-3p hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF180 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF180

    Additional mRNA sequence: 

    AF192913.1 AK024047.1 AK122688.1 AK315193.1 BC033642.1 BC051903.2 BC113015.1 

    6 DOTS entries:

    DT.107750  DT.97782427  DT.99942890  DT.101962066  DT.121430293  DT.121430313 

    24/66 AceView cDNA sequences (see all 66):

    AI457108 CA413071 AA905103 AA814415 AU143397 AA835661 CA392191 CB143307 
    AI800267 BC033642 AW514580 AI472318 AI378392 AA809495 CB123987 BC051903 
    BF431495 BF002910 BX119638 BG403453 AF192913 AI824326 AI984830 AI803238 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF180 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGTTGGAAG
    ZNF180 Expression
    About this image


    See ZNF180 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF180

    SOURCE GeneReport for Unigene cluster: Hs.22305
        SABiosciences Custom PCR Arrays for ZNF180
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF180

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF180 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp1801 , 5 zinc finger protein 1801, 5 74.14(n)1
    69.43(a)1
      7 (10.27 cM)5
    2101351  NM_001045486.11  NP_001038951.11 
     240819445 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-47k16.36
    --
    (see all 18)
    --
    57(a)
    53(a)
    (see all 18)
    many ↔ many
    many ↔ many
    (see all 18)
    4(46607562-46614982)
    Zv9_scaffold3470(343883-357518)


    ENSEMBL Gene Tree for ZNF180 (if available)
    TreeFam Gene Tree for ZNF180 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF180 gene
    ZNF4362  ZNF3222  ZNF712  ZNF5722  ZFP22  ZNF6972  ZKSCAN72  ZNF6782  
    ZNF7742  ZNF102  ZFP372  ZSCAN22  ZNF8522  ZNF3292  ZNF5442  ZFP32  
    ZNF6062  ZNF8352  ZNF5022  
    18/561 SIMAP similar genes for ZNF180 using alignment to 8 protein entries:     ZN180_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    DKFZp666M039    WT1    ZNF436    ADCK1    ARL6IP5
    HZF36    ABI2    KIAA1651    SUV420H1    ZNF32    ZNF818P
    kr-znf3    DKFZp686M04222    ZFP41    ZFS-1    ZKSCAN7    ZNF383

    ZNF180 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF180
    PGOHUM00000263020


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/720 SNPs in ZNF180 are shown (see all 720)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1481455551,2
    --44979403(+) TCAAAC/GAGTAA 1 -- int10--------
    rs25710511,2
    C,F,O,A,H--44979443(-) ATTATA/GCTTGC 1 -- int138Minor allele frequency- N:0.00EA NA NS WA CSA 3493
    rs1903921651,2
    --44979454(+) TTAGAC/TGGTCA 1 -- int10--------
    rs1827445701,2
    --44979456(+) AGACGG/TTCAGC 1 -- int10--------
    rs118826391,2
    C,F,H--44979597(+) ATATAT/CGAAAA 1 -- int18Minor allele frequency- C:0.05NS EA NA WA 542
    rs169791241,2
    C,F,H--44979710(+) TTTTCA/CATGAG 1 -- int126Minor allele frequency- C:0.14NA NS EA WA 2792
    rs22532101,2
    C,F,A,H--44979734(+) AATCTG/ATGTCC 1 -- int122Minor allele frequency- A:0.46EA NS NA WA CSA 3836
    rs1473277291,2
    C--44979814(+) TGCTTA/CGTCTT 1 -- int10--------
    rs1378570931,2
    C--44979910(+) ACAGCA/GTACAT 1 -- ut310--------
    rs93891,2
    C,F--44980012(-) TAAAAC/GCATTA 1 -- ut312Minor allele frequency- G:0.00MN NA 186

    HapMap Linkage Disequilibrium report for ZNF180 (44979854 - 45004576 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZNF180:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv270884CNV Insertion20981092
    nsv521513CNV Loss19592680
    dgv3944n71CNV Loss21882294
    nsv912115CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF180 for disorders           About MalaCards
    OMIM gene information: 606740    OMIM disorders: --


    ZNF180 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF180

    Export disorders for ZNF180 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF180 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF180)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association scan for five major dimensions of personality. (PubMed id 18957941)1, 4 Terracciano A....Costa P.T. (2008)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PubMed id 12743021)1, 2 Shannon M.... Stubbs L. (2003)
    5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Identification of a locus of zinc finger genes in human chromosome 19q13.1-q13.3 region by fluorescence in situ hybridization. (PubMed id 8914611)1 Wang R....Liew C.C. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7733 HGNC: 12970 AceView: ZNF180 Ensembl:ENSG00000167384 euGenes: HUgn7733
    ECgene: ZNF180 H-InvDB: ZNF180

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF180 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF180 gene:
    Search GeneIP for patents involving ZNF180

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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