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Aliases for ZNF180 Gene

Aliases for ZNF180 Gene

  • Zinc Finger Protein 180 2 3
  • HHZ168 3 4
  • Zinc Finger Protein 180 (HHZ168) 2

External Ids for ZNF180 Gene

Previous GeneCards Identifiers for ZNF180 Gene

  • GC19M045625
  • GC19M045371
  • GC19M049655
  • GC19M049671
  • GC19M044979
  • GC19M041412

Summaries for ZNF180 Gene

Entrez Gene Summary for ZNF180 Gene

  • Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2002]

GeneCards Summary for ZNF180 Gene

ZNF180 (Zinc Finger Protein 180) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF10.

UniProtKB/Swiss-Prot for ZNF180 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF180 Gene

Genomics for ZNF180 Gene

Regulatory Elements for ZNF180 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF180 Gene

44,474,428 bp from pter
44,500,524 bp from pter
26,097 bases
Minus strand

Genomic View for ZNF180 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF180 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF180 Gene

Proteins for ZNF180 Gene

  • Protein details for ZNF180 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 180
    Protein Accession:
    Secondary Accessions:
    • B2RCN6
    • B3KV56
    • K7EQX9
    • Q58F03
    • Q9P1U2

    Protein attributes for ZNF180 Gene

    692 amino acids
    Molecular mass:
    79111 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF180 Gene


neXtProt entry for ZNF180 Gene

Proteomics data for ZNF180 Gene at MOPED

Post-translational modifications for ZNF180 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF180 Gene

Domains for ZNF180 Gene

Gene Families for ZNF180 Gene

  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF180 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9UJW8
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF180: view

Function for ZNF180 Gene

Molecular function for ZNF180 Gene

GENATLAS Biochemistry:
zinc finger 180,human heart 168,C2H2 type,involved in DNA repair deficiencies and cellular malignancies
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF180: view

Animal Model Products

CRISPR Products

miRNA for ZNF180 Gene

miRTarBase miRNAs that target ZNF180

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF180

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF180 Gene

Localization for ZNF180 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF180 Gene

Subcellular locations from

Jensen Localization Image for ZNF180 Gene COMPARTMENTS Subcellular localization image for ZNF180 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF180: view

Pathways for ZNF180 Gene

SuperPathways for ZNF180 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF180: view

Pathways by source for ZNF180 Gene

2 Reactome pathways for ZNF180 Gene

Gene Ontology (GO) - Biological Process for ZNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF180: view

Transcripts for ZNF180 Gene

Unigene Clusters for ZNF180 Gene

Zinc finger protein 180:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF180

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF180 Gene

No ASD Table

Relevant External Links for ZNF180 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF180 Gene

mRNA expression in normal human tissues for ZNF180 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF180 Gene

SOURCE GeneReport for Unigene cluster for ZNF180 Gene Hs.22305

genes like me logo Genes that share expressions with ZNF180: view

Expression partners for ZNF180 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF180 Gene

Orthologs for ZNF180 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF180 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF180 35
  • 88.29 (n)
  • 84.31 (a)
ZNF180 36
  • 84 (a)
(Canis familiaris)
Mammalia ZNF180 35
  • 88.56 (n)
  • 85.52 (a)
ZNF180 36
  • 85 (a)
(Mus musculus)
Mammalia Zfp180 35
  • 74.14 (n)
  • 69.43 (a)
Zfp180 16
Zfp180 36
  • 60 (a)
(Pan troglodytes)
Mammalia ZNF180 35
  • 98.14 (n)
  • 97.44 (a)
ZNF180 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Zfp180 35
  • 74.81 (n)
  • 71.3 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2202 37
  • 54 (a)
Kr-h1 37
  • 38 (a)
Meics 37
  • 39 (a)
Neu2 37
  • 37 (a)
Species with no ortholog for ZNF180:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF180 Gene

Gene Tree for ZNF180 (if available)
Gene Tree for ZNF180 (if available)

Paralogs for ZNF180 Gene

Selected SIMAP similar genes for ZNF180 Gene using alignment to 8 proteins: Pseudogenes for ZNF180 Gene

genes like me logo Genes that share paralogs with ZNF180: view

Variants for ZNF180 Gene

Sequence variations from dbSNP and Humsavar for ZNF180 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs9389 -- 44,475,795(-) TAAAA(C/G)CATTA utr-variant-3-prime
rs517503 -- 44,498,331(+) CCCCA(A/C)CCTCT intron-variant
rs589512 -- 44,498,165(-) GCCTT(C/G)TTGTA intron-variant
rs892596 -- 44,499,215(+) AGCTC(A/C)ATGGG intron-variant
rs926020 -- 44,484,819(+) AGCAT(A/G)ACCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF180 Gene

Variant ID Type Subtype PubMed ID
dgv3944n71 CNV Loss 21882294
nsv912115 CNV Loss 21882294
esv270884 CNV Insertion 20981092
nsv521513 CNV Loss 19592680

Relevant External Links for ZNF180 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF180 Gene

Disorders for ZNF180 Gene

Relevant External Links for ZNF180

Genetic Association Database (GAD)

No disorders were found for ZNF180 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZNF180 Gene

Publications for ZNF180 Gene

  1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M. … Stubbs L. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  4. Genome-wide association scan for five major dimensions of personality. (PMID: 18957941) Terracciano A. … Costa P.T. (Mol. Psychiatry 2010) 3 48
  5. Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling. (PMID: 25391492) Lamoliatte F. … Thibault P. (Nat Commun 2014) 3

Products for ZNF180 Gene

Sources for ZNF180 Gene

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