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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF180 Gene

protein-coding GIFtS: 48
GCID: GC19M044979

zinc finger protein 180

(Previous name: zinc finger protein 180 (HHZ168) )

Search for ZNF180
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 180¹ ²
HHZ168¹ ² ³
Zinc Finger Protein 180 (HHZ168)¹

External Ids:	HGNC: 12970¹	Entrez Gene: 7733²	Ensembl: ENSG00000167384⁷	OMIM: 606740⁵	UniProtKB: Q9UJW8³

Export aliases for ZNF180 gene to outside databases

Previous GC identifers: GC19M045625 GC19M045371 GC19M049655 GC19M049671 GC19M041412

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF180:

Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger

domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that

are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for

additional information on zinc finger proteins.(supplied by OMIM, Jul 2002)

UniProtKB/Swiss-Prot: ZN180_HUMAN, Q9UJW8

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF180 gene promoter:
Max1 STAT5A LCR-F1 AREB6 PPAR-gamma1 FOXC1 ARP-1 PPAR-gamma2 MRF-2 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF180 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF180

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF180

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.31 HGNC cytogenetic band: 19q13.2

ZNF180 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF180 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M044979: view genomic region (about GC identifiers)

Start:	44,979,854 bp from pter	End:	45,004,576 bp from pter
Size:	24,723 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN180_HUMAN, Q9UJW8 (See protein sequence)

Recommended Name: Zinc finger protein 180

Size: 692 amino acids; 79111 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: B2RCN6 Q9P1U2

Explore the universe of human proteins at neXtProt for ZNF180: NX_Q9UJW8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UJW8

ZNF180 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_037388.2

ENSEMBL proteins:

ENSP00000375818 ENSP00000221327 ENSP00000466516 ENSP00000468523 ENSP00000468021

ENSP00000466726 ENSP00000467916 ENSP00000465426

Reactome Protein details: Q9UJW8
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF180 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF180 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9UJW8

ProtoNet protein and cluster: Q9UJW8

2 Blocks protein families:

IPB001909 KRAB box

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN180_HUMAN, Q9UJW8

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 12 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN180_HUMAN, Q9UJW8

Function: May be involved in transcriptional regulation

Genatlas biochemistry entry for ZNF180:

zinc finger 180,human heart 168,C2H2 type,involved in DNA repair deficiencies and cellular malignancies

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF180 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF180

	Generic Transcription Pathway
	Gene Expression

ZNF180 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF180

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF180 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF180
Search CenterWatch for drugs/clinical trials and news about ZNF180 / ZN180

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF180 gene:

NM_013256.3

Unigene Cluster for ZNF180:

Zinc finger protein 180

Hs.22305 [show with all ESTs]

Unigene Representative Sequence: BC051903

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000391956 ENST00000221327(uc002ozh.4 uc002ozi.4 uc002ozf.4 uc002ozg.4 uc010ejm.3)

ENST00000592095 ENST00000590088 ENST00000592529 ENST00000586637 ENST00000591064

ENST00000587047 ENST00000585514 ENST00000592140 ENST00000590366

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		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF180 (see all 15):
		hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-302a hsa-miR-302e hsa-miR-373 hsa-miR-188-3p hsa-miR-520a-3p

		SwitchGear 3'UTR luciferase reporter plasmid: ZNF180 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF180

Additional cDNA sequence:

AF192913.1 AK024047.1 AK122688.1 AK315193.1 BC033642.1 BC051903.2 BC113015.1

6 DOTS entries:

DT.107750 DT.97782427 DT.99942890 DT.101962066 DT.121430293 DT.121430313

24/66 AceView cDNA sequences (see all 66):

AU143397 AI378392 AA809495 AI472318 AI457108 BF002910 AW514580 AA814415

BC033642 AI800267 CB123987 BC051903 BX119638 AA905103 AA835661 BF431495

CB143307 CA392191 CA413071 AW292345 AA890711 N45120 AU132370 BM718830

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF180 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGTTGGAAG

About this image
See ZNF180 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF180

SOURCE GeneReport for Unigene cluster: Hs.22305

SABiosciences Custom PCR Arrays for ZNF180

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF180 gene from 2/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- --	--	38(a) 37(a)	many ↔ many many ↔ many	4(91121742-91140941) GL343672.1(271909-279192)
zebrafish (Danio rerio)	Actinopterygii	CABZ01019476.1⁶ CR759907.4⁶ (see all 33)	--	59(a) 55(a) (see all 33)	many ↔ many many ↔ many (see all 33)	Zv9_NA51(35483-36223) 4(33810478-33819304)

ENSEMBL Gene Tree for ZNF180 (if available)
TreeFam Gene Tree for ZNF180 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF180 gene

ZNF329² ZNF544² ZNF10² ZNF606²

18/546 SIMAP similar genes for ZNF180 using alignment to 8 protein entries: ZN180_HUMAN (see all proteins) (see all similar genes):

ZNF78L1 DKFZp666M039 WT1 ZNF436 ADCK1 ARL6IP5

HZF36 ABI2 KIAA1651 SUV420H1 ZNF32 ZNF818P

kr-znf3 DKFZp686M04222 ZFP41 ZFS-1 ZNF383 ZNF391

ZNF180 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ZNF180
PGOHUM00000263020

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148145555^1,2		--	44979403(+)	`TCAAAC/GAGTAA`	1	--	int¹		0	--	--	--	--
rs2571051^1,2	C,F,O,A,H,	--	44979443(-)	`ATTATA/GCTTGC`	1	--	int¹		38		EA NA NS WA CSA	3493
rs190392165^1,2		--	44979454(+)	`TTAGAC/TGGTCA`	1	--	int¹		0	--	--	--	--
rs182744570^1,2		--	44979456(+)	`AGACGG/TTCAGC`	1	--	int¹		0	--	--	--	--
rs11882639^1,2	C,F,H,	--	44979597(+)	`ATATAT/CGAAAA`	1	--	int¹		8		NS EA NA WA	542
rs16979124^1,2	C,F,H,	--	44979710(+)	`TTTTCA/CATGAG`	1	--	int¹		26		NA NS EA WA	2792
rs2253210^1,2	C,F,A,H,	--	44979734(+)	`AATCTG/ATGTCC`	1	--	int¹		22		EA NS NA WA CSA	3836
rs147327729^1,2		--	44979814(+)	`TGCTTA/CGTCTT`	1	--	int¹		0	--	--	--	--
rs137857093^1,2		--	44979910(+)	`ACAGCA/GTACAT`	1	--	ut3¹		0	--	--	--	--
rs9389^1,2		--	44980012(-)	`TAAAAC/GCATTA`	1	--	ut3¹		2		MN NA	186

HapMap Linkage Disequilibrium report for ZNF180 (44979854 - 45004576 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ZNF180
4 CNVs: 78215 89265 78216 89267

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF180

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF180 for disorders About MalaCards

ZNF180 for disorders About GeneDecksing

OMIM gene information: 606740 OMIM disorders: --

Export disorders for ZNF180 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF180 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF180)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PubMed id 12743021)^{1, 2} Shannon M.... Stubbs L. (2003)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
Genome-wide association scan for five major dimensions of personality. (PubMed id 18957941)¹ Terracciano A....Costa P.T. (2008)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Identification of a locus of zinc finger genes in human chromosome 19q13.1-q13.3 region by fluorescence in situ hybridization. (PubMed id 8914611)¹ Wang R....Liew C.C. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7733	HGNC: 12970	AceView: ZNF180	Ensembl:ENSG00000167384	euGenes: HUgn7733
ECgene: ZNF180	H-InvDB: ZNF180

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF180	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF180 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF180 gene:
Search GeneIP for patents involving ZNF180

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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ThermoFisher Antibody for ZNF180

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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ZNF180 Gene

zinc finger protein 180

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ZNF180 Gene

zinc finger protein 180

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