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Aliases for ZNF18 Gene

Aliases for ZNF18 Gene

  • Zinc Finger Protein 18 2 3
  • KOX11 3 4 6
  • Zinc Finger Protein With KRAB And SCAN Domains 6 3 4
  • Heart Development-Specific Gene 1 Protein 3 4
  • Zinc Finger Protein 18 (KOX 11) 2 3
  • Zinc Finger Protein 535 3 4
  • ZKSCAN6 3 4
  • ZNF535 3 4
  • HDSG1 3 4
  • Zinc Finger Protein KOX11 4
  • ZSCAN38 3
  • Zfp535 3

External Ids for ZNF18 Gene

Summaries for ZNF18 Gene

GeneCards Summary for ZNF18 Gene

ZNF18 (Zinc Finger Protein 18) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is ZNF396.

UniProtKB/Swiss-Prot for ZNF18 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF18 Gene

Genomics for ZNF18 Gene

Genomic Location for ZNF18 Gene

11,977,439 bp from pter
11,997,510 bp from pter
20,072 bases
Minus strand

Genomic View for ZNF18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF18 Gene

Regulatory Elements for ZNF18 Gene

Proteins for ZNF18 Gene

  • Protein details for ZNF18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 18
    Protein Accession:
    Secondary Accessions:
    • Q5QHQ3
    • Q8IYC4
    • Q8NAH6

    Protein attributes for ZNF18 Gene

    549 amino acids
    Molecular mass:
    62288 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF18 Gene


neXtProt entry for ZNF18 Gene

Proteomics data for ZNF18 Gene at MOPED

Post-translational modifications for ZNF18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF18 Gene

No data available for DME Specific Peptides for ZNF18 Gene

Domains for ZNF18 Gene

Gene Families for ZNF18 Gene

  • ZNF :Zinc fingers, C2H2-type


  • Contains 1 KRAB domain.:
    • P17022
  • Contains 1 SCAN box domain.:
    • P17022
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • P17022
  • Contains 5 C2H2-type zinc fingers.:
    • P17022
genes like me logo Genes that share domains with ZNF18: view

Function for ZNF18 Gene

Molecular function for ZNF18 Gene

GENATLAS Biochemistry: zinc finger protein 18 (KOX11) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with ZNF18: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF18 Gene

Localization for ZNF18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF18 Gene

Subcellular locations from

Jensen Localization Image for ZNF18 Gene COMPARTMENTS Subcellular localization image for ZNF18 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZNF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF18: view

Pathways for ZNF18 Gene

SuperPathways for ZNF18 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF18: view

Pathways by source for ZNF18 Gene

2 Reactome pathways for ZNF18 Gene

Gene Ontology (GO) - Biological Process for ZNF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ZNF18: view

Transcripts for ZNF18 Gene

Unigene Clusters for ZNF18 Gene

Zinc finger protein 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF18 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - -
SP2: - - - - -
SP3: -
SP5: -
SP6: - - -

Relevant External Links for ZNF18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF18 Gene

mRNA expression in normal human tissues for ZNF18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ZNF18 Gene Hs.370473

genes like me logo Genes that share expressions with ZNF18: view

Orthologs for ZNF18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF18 36
  • 99.39 (n)
  • 99.27 (a)
ZNF18 37
  • 99 (a)
(Bos Taurus)
Mammalia ZNF18 36
  • 78.37 (n)
  • 75.42 (a)
ZNF18 37
  • 76 (a)
(Canis familiaris)
Mammalia ZNF18 36
  • 85.05 (n)
  • 82.72 (a)
ZNF18 37
  • 82 (a)
(Mus musculus)
Mammalia Zkscan6 36
  • 82.05 (n)
  • 78.39 (a)
Zkscan6 16
Zkscan6 37
  • 77 (a)
(Monodelphis domestica)
Mammalia ZNF18 37
  • 51 (a)
(Rattus norvegicus)
Mammalia Zfp18 36
  • 82.54 (n)
  • 80.4 (a)
Species with no ortholog for ZNF18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF18 Gene

Gene Tree for ZNF18 (if available)
Gene Tree for ZNF18 (if available)

Paralogs for ZNF18 Gene

genes like me logo Genes that share paralogs with ZNF18: view

Variants for ZNF18 Gene

Sequence variations from dbSNP and Humsavar for ZNF18 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1860089 -- 11,979,975(+) TTTTG(C/T)GACTA intron-variant
rs2079626 -- 11,980,011(+) TCTTC(A/G)TAAGT intron-variant
rs4450439 -- 11,987,148(+) TGGAA(C/T)TGGCA intron-variant
rs4791485 -- 11,997,729(+) TGCGC(A/G)CCTAT upstream-variant-2KB
rs6502173 -- 11,996,296(+) TCCAA(C/T)CTATT intron-variant

Relevant External Links for ZNF18 Gene

HapMap Linkage Disequilibrium report

No data available for Structural Variations from Database of Genomic Variants (DGV) for ZNF18 Gene

Disorders for ZNF18 Gene

No disorders were found for ZNF18 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF18 Gene

Publications for ZNF18 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification and characterization of human ZNF18 gene in silico. (PMID: 15702252) Yoshida K. (Int. J. Mol. Med. 2005) 2 3
  4. Molecular cloning and expression analysis of a novel human gene ZNF18. (PMID: 16120570) Guo L.L. … Li Y.P. (Yi Chuan 2005) 3 4
  5. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4

Products for ZNF18 Gene

Sources for ZNF18 Gene

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