ZNF18 Gene
protein-coding GIFtS: 47
GCID: GC17M011884
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|
zinc finger protein 18(Previous name: zinc finger protein 18 (KOX 11) )
| |
Aliases
for ZNF18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 181 2 | | Zinc Finger Protein 18 (KOX 11)1 2 | | KOX111 2 3 5 | | Heart Development-Specific Gene 1 Protein2 3 | | HDSG11 2 3 | | Zinc Finger Protein 5352 3 | | ZKSCAN61 2 3 | | Zinc Finger Protein KOX112 3 | | ZNF5351 2 3 | | Zinc Finger Protein With KRAB And SCAN Domains 62 3 | | ZSCAN381 2 | | Heart Development-Specific Protein2 | | Zfp5351 2 | | |
Export aliases for ZNF18 gene to outside databasesPrevious GC identifers: GC17M012223 GC17M012995 GC17M011823 GC17M012081 GC17M011821 |
Summaries
for ZNF18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZNF18_HUMAN, P17022Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF18 gene promoter:
GR p53 AML1a AP-1 ATF-2 CUTL1 POU3F2 c-Jun GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p12 HGNC cytogenetic band: 17p12ZNF18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M011884: view genomic region
(about GC identifiers)
Start:
|
11,880,762 bp from pter |
End:
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11,900,827 bp from pter |
Size:
|
20,066 bases |
Orientation:
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minus strand |
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Proteins
for ZNF18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNF18_HUMAN, P17022 (See
protein sequence)Recommended Name: Zinc finger protein 18 Size: 549 amino acids; 62288 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q5QHQ3 Q8IYC4 Q8NAH6Alternative splicing: 2 isoforms: P17022-1 P17022-2 Explore the universe of human proteins at neXtProt for ZNF18: NX_P17022
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P17022
ZNF18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653281.2
ENSEMBL proteins: ENSP00000315664 ENSP00000463471 ENSP00000462296 ENSP00000391376 ENSP00000462383 ENSP00000462877 ENSP00000462416 Reactome Protein details: P17022
Human Recombinant Protein Products for ZNF18:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF18 for ontologies About GeneDecksing
ZNF18 Antibody Products:
Assay Products for ZNF18: |
Protein
Domains /
Families
for ZNF18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF18 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P17022ProtoNet protein and cluster: P17022 2 Blocks protein families: IPB001909 KRAB box IPB003309 Transcriptional regulator SCAN
UniProtKB/Swiss-Prot: ZNF18_HUMAN, P17022Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 5 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domainSimilarity: Contains 1 SCAN box domain |
Function
for ZNF18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZNF18_HUMAN, P17022Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF18:zinc finger protein 18 (KOX11) (C2H2 type,Kruppel-like)
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZNF18 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF18 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF18
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF18 (NM_144680) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF18 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF18 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF18 |
|
Pathways & Interactions
for ZNF18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF18
ZNF18 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF18
2 Interacting proteins for ZNF18 (P170223) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0016032 | viral reproduction |
IEA | -- |
ZNF18 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF18
Search CenterWatch for drugs/clinical trials and news about ZNF18
|
Transcripts
for ZNF18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF18 gene: NM_144680.2 Unigene Cluster for ZNF18: Zinc finger protein 18 Hs.370473 [show with all ESTs]Unigene Representative Sequence: NM_1446807 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000322748(uc002gng.1) ENST00000580306(uc002gnh.1 uc002gni.1)
ENST00000580613 ENST00000454073 ENST00000577671 ENST00000582607 ENST00000580903
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF18 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF18
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF18 (NM_144680) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF18 |
Additional cDNA sequence: AK057783.1 AK092656.1 AK127908.1 AY491053.1 BC036096.2 X52342.1 7 DOTS entries: DT.101954954 DT.95250735 DT.100729554 DT.95372493 DT.40293608 DT.120996589 DT.91983120 24/69 AceView cDNA sequences (see all 69): AW630806 BI522838 BI518695 AI168308 BM703582 BM194145 W32070 BF939894 CR591820 BX279546 BX114000 X52342 BU568338 C21014 AK127908 AW769629 BM553078 AI361394 AL526338 BC036096 BQ183054 AA206862 AW005028 BI601129
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF18 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF18
|
Expression
for ZNF18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCCACTCA
About this image
See ZNF18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF18
SOURCE GeneReport for Unigene cluster: Hs.370473
SABiosciences Custom PCR Arrays for ZNF18
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF18
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF18 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF18 |
Orthologs
for ZNF18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF18 gene from 1/8 species (see all 8) About this table
ENSEMBL Gene Tree for ZNF18 (if available)
TreeFam Gene Tree for ZNF18 (if available) |
Paralogs
for ZNF18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF18 gene
- ZNF4962 ZNF4492 ZNF4462 ZSCAN92 ZKSCAN12 ZNF3972 ZNF5002 ZNF2132
- ZSCAN302 ZNF2322 ZNF2632 ZNF2022 ZKSCAN42 ZNF1742 ZSCAN252 ZNF3962
- ZSCAN122 ZNF3942 ZSCAN212 ZSCAN232 ZNF1652 ZSCAN162 ZKSCAN82 ZSCAN312
- ZSCAN222 ZKSCAN32 ZNF242
18/79 SIMAP similar genes for ZNF18 using alignment to 5 protein entries: ZNF18_HUMAN (see all proteins)
(see all similar genes):ZSCAN10 ZSCAN31 ZNF444 ZKSCAN8 ZSCAN29 DKFZp434K202
ZNF24 ZNF396 ZNF585B ZNF625 ZNF78L1 ZSCAN23
KLF13 ZNF32 ZNF664 ZNF697 ZNF720 SCAND1
ZNF18 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF18 (11880762 - 11900827 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF18: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF18 |
|
Disorders
/ Diseases
for ZNF18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF18 for disorders About MalaCards
ZNF18 for disorders About GeneDecksing
OMIM gene information: 194524
OMIM disorders: --
Export disorders for ZNF18 gene to outside databases
|
Publications
for ZNF18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF18 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of human ZNF18 gene in silico. (PubMed id 15702252)1, 3 Yoshida K. (2005)
- Molecular cloning and expression analysis of a novel human gene ZNF18. (PubMed id 16120570)1, 2 Guo L.L.... Li Y.P. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Twenty-seven nonoverlapping zinc finger cDNAs from hu man T cells map to nine different chromosomes with apparent clustering. (PubMed id 2014798)1 Huebner K....Thiesen H.J. (1991)
|
External Searches for ZNF18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF18 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF18 gene:
Search GeneIP for patents involving ZNF18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF18 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF18 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF18 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF18 |
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 | | | ZNF18 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF18 |
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