Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF18 Gene

Aliases for ZNF18 Gene

  • Zinc Finger Protein 18 2 3
  • KOX11 3 4 6
  • Zinc Finger Protein With KRAB And SCAN Domains 6 3 4
  • Heart Development-Specific Gene 1 Protein 3 4
  • Zinc Finger Protein 18 (KOX 11) 2 3
  • Zinc Finger Protein 535 3 4
  • ZKSCAN6 3 4
  • ZNF535 3 4
  • HDSG1 3 4
  • Zinc Finger Protein KOX11 4
  • ZSCAN38 3
  • Zfp535 3

External Ids for ZNF18 Gene

Previous GeneCards Identifiers for ZNF18 Gene

  • GC17M012223
  • GC17M012995
  • GC17M011823
  • GC17M012081
  • GC17M011821
  • GC17M011884

Summaries for ZNF18 Gene

GeneCards Summary for ZNF18 Gene

ZNF18 (Zinc Finger Protein 18) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is ZNF396.

UniProtKB/Swiss-Prot for ZNF18 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF18 Gene

Genomics for ZNF18 Gene

Regulatory Elements for ZNF18 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF18 Gene

Start:
11,977,439 bp from pter
End:
11,997,510 bp from pter
Size:
20,072 bases
Orientation:
Minus strand

Genomic View for ZNF18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF18 Gene

Proteins for ZNF18 Gene

  • Protein details for ZNF18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17022-ZNF18_HUMAN
    Recommended name:
    Zinc finger protein 18
    Protein Accession:
    P17022
    Secondary Accessions:
    • Q5QHQ3
    • Q8IYC4
    • Q8NAH6

    Protein attributes for ZNF18 Gene

    Size:
    549 amino acids
    Molecular mass:
    62288 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF18 Gene

Proteomics data for ZNF18 Gene at MOPED

Post-translational modifications for ZNF18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF18 Gene

No data available for DME Specific Peptides for ZNF18 Gene

Domains for ZNF18 Gene

Gene Families for ZNF18 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17022

UniProtKB/Swiss-Prot:

ZNF18_HUMAN :
  • P17022
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF18: view

Function for ZNF18 Gene

Molecular function for ZNF18 Gene

GENATLAS Biochemistry: zinc finger protein 18 (KOX11) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with ZNF18: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF18

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF18 Gene

Localization for ZNF18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF18 Gene COMPARTMENTS Subcellular localization image for ZNF18 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZNF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF18: view

Pathways for ZNF18 Gene

SuperPathways for ZNF18 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF18: view

Pathways by source for ZNF18 Gene

2 Reactome pathways for ZNF18 Gene

Gene Ontology (GO) - Biological Process for ZNF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ZNF18: view

Transcripts for ZNF18 Gene

Unigene Clusters for ZNF18 Gene

Zinc finger protein 18:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF18

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF18

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF18 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - -
SP2: - - - - -
SP3: -
SP4:
SP5: -
SP6: - - -
SP7:

Relevant External Links for ZNF18 Gene

GeneLoc Exon Structure for
ZNF18
ECgene alternative splicing isoforms for
ZNF18

Expression for ZNF18 Gene

mRNA expression in normal human tissues for ZNF18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ZNF18 Gene Hs.370473

genes like me logo Genes that share expressions with ZNF18: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for ZNF18 Gene

Orthologs for ZNF18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF18 35
  • 99.39 (n)
  • 99.27 (a)
ZNF18 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF18 35
  • 78.37 (n)
  • 75.42 (a)
ZNF18 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF18 35
  • 85.05 (n)
  • 82.72 (a)
ZNF18 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zkscan6 35
  • 82.05 (n)
  • 78.39 (a)
Zkscan6 16
Zkscan6 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF18 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp18 35
  • 82.54 (n)
  • 80.4 (a)
Species with no ortholog for ZNF18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF18 Gene

ENSEMBL:
Gene Tree for ZNF18 (if available)
TreeFam:
Gene Tree for ZNF18 (if available)

Paralogs for ZNF18 Gene

genes like me logo Genes that share paralogs with ZNF18: view

Variants for ZNF18 Gene

Sequence variations from dbSNP and Humsavar for ZNF18 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1860089 -- 11,979,975(+) TTTTG(C/T)GACTA intron-variant
rs2079626 -- 11,980,011(+) TCTTC(A/G)TAAGT intron-variant
rs4450439 -- 11,987,148(+) TGGAA(C/T)TGGCA intron-variant
rs4791485 -- 11,997,729(+) TGCGC(A/G)CCTAT upstream-variant-2KB
rs6502173 -- 11,996,296(+) TCCAA(C/T)CTATT intron-variant

Relevant External Links for ZNF18 Gene

HapMap Linkage Disequilibrium report
ZNF18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF18 Gene

Disorders for ZNF18 Gene

No disorders were found for ZNF18 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF18 Gene

Publications for ZNF18 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification and characterization of human ZNF18 gene in silico. (PMID: 15702252) Yoshida K. (Int. J. Mol. Med. 2005) 2 3
  4. Molecular cloning and expression analysis of a novel human gene ZNF18. (PMID: 16120570) Guo L.L. … Li Y.P. (Yi Chuan 2005) 3 4
  5. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4

Products for ZNF18 Gene

Sources for ZNF18 Gene

Back to Top

Content