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Aliases for ZNF177 Gene

Aliases for ZNF177 Gene

  • Zinc Finger Protein 177 2 3 5
  • PIGX 3

External Ids for ZNF177 Gene

Previous GeneCards Identifiers for ZNF177 Gene

  • GC19P009595
  • GC19P009696
  • GC19P009097
  • GC19P009114
  • GC19P009334
  • GC19P009475
  • GC19P009437

Summaries for ZNF177 Gene

GeneCards Summary for ZNF177 Gene

ZNF177 (Zinc Finger Protein 177) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF559-ZNF177.

UniProtKB/Swiss-Prot for ZNF177 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF177 Gene

Genomics for ZNF177 Gene

Regulatory Elements for ZNF177 Gene

Enhancers for ZNF177 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F010100 1.5 FANTOM5 ENCODE 24.6 +741.4 741368 8.3 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A YBX1 DMAP1 FBXL12 ZNF699 ZNF561 LOC100419831 ZNF559 TIMM29 YIPF2 ZNF562 EIF3G ZNF121
GH19F008361 1.3 FANTOM5 ENCODE 24.6 -999.7 -999710 3.4 PKNOX1 ARNT ZFP64 ARID4B SIN3A ZNF48 YY1 ZNF121 FOS ZNF263 ZNF177 RAB11B RAB11B-AS1 ANGPTL4 MARCH2 MIR4999
GH19F008511 1.5 FANTOM5 ENCODE 16.5 -847.0 -846955 8.4 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 XAB2 ZNF414 MYO1F ZNF177 PRAM1 HNRNPM ENSG00000267273 ZNF558 ZNF699 MARCH2
GH19F009933 1.2 Ensembl ENCODE 16.5 +571.5 571523 1.3 ATF1 SIN3A ARID4B GLIS2 ZNF143 KLF7 SP3 NFYC REST KAT8 ZNF177 OLFM2 ZNF561 FBXL12 S1PR2 LOC100996288 ENSG00000267273 ENSG00000200237 GC19P009927
GH19F010267 1.2 ENCODE 16.5 +907.3 907318 5.6 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3 ZNF699 FBXL12 ZNF559 LOC100419831 ZNF561 ZNF426 RAVER1 TIMM29 EIF3G ZNF121
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF177 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF177 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000214772 81 999 ZBTB11 KDM4B HMGN3 ZBTB40 SPI1 GABPA

Genomic Location for ZNF177 Gene

Chromosome:
19
Start:
9,363,020 bp from pter
End:
9,382,617 bp from pter
Size:
19,598 bases
Orientation:
Plus strand

Genomic View for ZNF177 Gene

Genes around ZNF177 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF177 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF177 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF177 Gene

Proteins for ZNF177 Gene

  • Protein details for ZNF177 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13360-ZN177_HUMAN
    Recommended name:
    Zinc finger protein 177
    Protein Accession:
    Q13360
    Secondary Accessions:
    • B4DY57
    • E9PDG0
    • I3L0I4
    • Q96ER2

    Protein attributes for ZNF177 Gene

    Size:
    481 amino acids
    Molecular mass:
    54782 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF177 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF177 Gene

Post-translational modifications for ZNF177 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF177 Gene

No data available for DME Specific Peptides for ZNF177 Gene

Domains & Families for ZNF177 Gene

Gene Families for ZNF177 Gene

Suggested Antigen Peptide Sequences for ZNF177 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13360

UniProtKB/Swiss-Prot:

ZN177_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF177: view

Function for ZNF177 Gene

Molecular function for ZNF177 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF177 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF177: view
genes like me logo Genes that share phenotypes with ZNF177: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF177 Gene

Localization for ZNF177 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF177 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF177 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF177 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with ZNF177: view

Pathways & Interactions for ZNF177 Gene

SuperPathways for ZNF177 Gene

No Data Available

Interacting Proteins for ZNF177 Gene

Gene Ontology (GO) - Biological Process for ZNF177 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 8661005
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF177: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF177 Gene

Transcripts for ZNF177 Gene

Unigene Clusters for ZNF177 Gene

Zinc finger protein 177:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF177 Gene

No ASD Table

Relevant External Links for ZNF177 Gene

GeneLoc Exon Structure for
ZNF177
ECgene alternative splicing isoforms for
ZNF177

Expression for ZNF177 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF177 Gene

Protein differential expression in normal tissues from HIPED for ZNF177 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF177 Gene



Protein tissue co-expression partners for ZNF177 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF177 Gene:

ZNF177

SOURCE GeneReport for Unigene cluster for ZNF177 Gene:

Hs.728944
genes like me logo Genes that share expression patterns with ZNF177: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF177 Gene

Orthologs for ZNF177 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF177 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF177 34
  • 99.51 (n)
-- 35
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZNF177 34
  • 83.86 (n)
-- 35
  • 48 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZNF177 34
  • 83.02 (n)
-- 35
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 47 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 5730507C01Rik 35
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 27 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF557 35
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3407 36
  • 40 (a)
BG:DS02740.8 36
  • 37 (a)
Species where no ortholog for ZNF177 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF177 Gene

ENSEMBL:
Gene Tree for ZNF177 (if available)
TreeFam:
Gene Tree for ZNF177 (if available)

Paralogs for ZNF177 Gene

Paralogs for ZNF177 Gene

genes like me logo Genes that share paralogs with ZNF177: view

Variants for ZNF177 Gene

Sequence variations from dbSNP and Humsavar for ZNF177 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10164324 -- 9,365,585(+) ccaag(A/G)caggc intron-variant
rs10403714 -- 9,372,391(+) AACTG(C/T)TCACT intron-variant
rs10404549 -- 9,364,740(+) agggc(A/G)gcagt intron-variant
rs10404815 -- 9,364,909(+) ctgac(A/G)agcaa utr-variant-5-prime
rs10411115 -- 9,379,752(+) CAATC(A/G)TTCAT intron-variant

Variation tolerance for ZNF177 Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF177 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF177

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF177 Gene

Disorders for ZNF177 Gene

Relevant External Links for ZNF177

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF177

No disorders were found for ZNF177 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF177 Gene

Publications for ZNF177 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Repetitive elements in the 5' untranslated region of a human zinc- finger gene modulate transcription and translation efficiency. (PMID: 11549323) Landry J.R. … Mager D.L. (Genomics 2001) 3 4 64
  3. Transcripts from a novel human KRAB zinc finger gene contain spliced Alu and endogenous retroviral segments. (PMID: 8661005) Baban S. … Mager D.L. (Genomics 1996) 3 4 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart A.E. … Wells C.M. (J. Cell Biol. 2015) 3 64

Products for ZNF177 Gene

Sources for ZNF177 Gene

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