ZNF177 Gene
protein-coding GIFtS: 45
GCID: GC19P009437
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|
zinc finger protein 177
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Aliases
for ZNF177 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 1771 2 | | PIGX2 |
Export aliases for ZNF177 gene to outside databasesPrevious GC identifers: GC19P009595 GC19P009696 GC19P009097 GC19P009114 GC19P009334 GC19P009475 |
Summaries
for ZNF177 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN177_HUMAN, Q13360Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF177 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF177 gene promoter:
Nkx3-1 Nkx3-1 v4 C/EBPbeta Pbx1a Nkx3-1 v1 Evi-1 AREB6 Nkx3-1 v2 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF177
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF177 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2ZNF177 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P009437: view genomic region
(about GC identifiers)
Start:
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9,435,017 bp from pter |
End:
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9,493,293 bp from pter |
Size:
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58,277 bases |
Orientation:
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plus strand |
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Proteins
for ZNF177 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN177_HUMAN, Q13360 (See
protein sequence)Recommended Name: Zinc finger protein 177 Size: 481 amino acids; 54782 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B4DY57 E9PDG0 I3L0I4 Q96ER2Alternative splicing: 3 isoforms: Q13360-1 Q13360-2 Q13360-3 Explore the universe of human proteins at neXtProt for ZNF177: NX_Q13360
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13360
ZNF177 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001166122.1 NP_003442.2
ENSEMBL proteins: ENSP00000445323 ENSP00000413568 ENSP00000341497 ENSP00000467978 ENSP00000468531 ENSP00000465438 ENSP00000415070
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF177 for ontologies About GeneDecksing
ZNF177 Antibody Products:
Assay Products for ZNF177: |
Protein
Domains /
Families
for ZNF177 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF177 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13360ProtoNet protein and cluster: Q13360 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN177_HUMAN, Q13360Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 10 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF177 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN177_HUMAN, Q13360Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF177 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF177 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZNF177 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF177 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF177 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF177 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF177:
|
Pathways & Interactions
for ZNF177 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF177
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZNF177 (ENSP000003414974) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
-- | -- | | GO:0006351 | transcription, DNA-dependent |
-- | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- |
ZNF177 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF177 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF177
Search CenterWatch for drugs/clinical trials and news about ZNF177 / ZN177
|
Transcripts
for ZNF177 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF177 gene (2 alternative transcripts): NM_001172651.1 NM_003451.2 Unigene Cluster for ZNF177: Zinc finger protein 177 Hs.728944 [show with all ESTs]Unigene Representative Sequence: NM_0012024257 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000541595(uc002mli.3) ENST00000446085(uc002mlj.3) ENST00000343499(uc002mlk.3)
ENST00000592912 ENST00000589262 ENST00000590616 ENST00000434737(uc021uon.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF177 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF177 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF177 (NM_003451) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF177 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF177 |
Additional cDNA sequence: AK302274.1 BC012012.1 U37263.1 10 DOTS entries: DT.100751491 DT.95369832 DT.65284154 DT.100751490 DT.101957034 DT.121425585 DT.95369833 DT.100660535 DT.91785220 DT.102845093 24/150 AceView cDNA sequences (see all 150): AI784620 AI095439 Z39151 BG259372 AX747491 AA602592 BF222264 BX093009 NM_032497 AA334485 BX508392 BP380389 AA283931 BC012012 CK904313 BC006436 AA283932 BF475851 AA195740 BX114567 AA773700 BF223163 BC015058 F06238
GeneLoc Exon Structure
|
Expression
for ZNF177 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF177 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCTTCAATA
About this image
See ZNF177 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF177
SOURCE GeneReport for Unigene cluster: Hs.728944
SABiosciences Custom PCR Arrays for ZNF177
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF177
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF177 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF177 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF177 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF177 |
Orthologs
for ZNF177 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF177 (if available)
TreeFam Gene Tree for ZNF177 (if available) |
Paralogs
for ZNF177 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF177 gene
- ZNF5572 ZNF3332 ZNF8912 ZNF3172 ZNF5582
18/479 SIMAP similar genes for ZNF177 using alignment to 3 protein entries: ZN177_HUMAN (see all proteins)
(see all similar genes):ZNF721 ZNF761 ZNF66 ZNF226 ZNF573 ZNF559
ZNF229 POM121C ZNF738 ZNF78L1 ZFP90 ZNF84
ZNF230 HZF36 KRBOX4 MGC12518 ZNF826P ZNF534
ZNF177 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF177 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF177 (9435017 - 9493293 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF177: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF177 |
|
Disorders
/ Diseases
for ZNF177 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF177 for disorders About MalaCards
ZNF177 for disorders About GeneDecksing
OMIM gene information: 601276
OMIM disorders: --
Export disorders for ZNF177 gene to outside databases
|
Publications
for ZNF177 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF177 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF177) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Repetitive elements in the 5' untranslated region of a human zinc-finger gene modulate transcription and translation efficiency. (PubMed id 11549323)1, 2 Landry J.R....Mager D.L. (2001)
- Transcripts from a novel human KRAB zinc finger gene contain spliced Alu and endogenous retroviral segments. (PubMed id 8661005)1, 2 Baban S.... Mager D.L. (1996)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF177 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF177 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF177 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF177 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF177 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF177 gene:
Search GeneIP for patents involving ZNF177
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF177 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF177 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF177 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF177 | | | OriGene Protein Over-expression Lysate for ZNF177 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF177 | | OriGene 3'-UTR Clone for ZNF177 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF177 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF177 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF177 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF177 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF177 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF177 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF177 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF177 |
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 | | | ZNF177 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF177 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF177 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF177 |
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