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Aliases for ZNF175 Gene

Aliases for ZNF175 Gene

  • Zinc Finger Protein 175 2 3 5
  • Zinc Finger Protein OTK18 3 4
  • OTK18 3

External Ids for ZNF175 Gene

Previous GeneCards Identifiers for ZNF175 Gene

  • GC19P052705
  • GC19P052435
  • GC19P056750
  • GC19P056766
  • GC19P052074
  • GC19P048406

Summaries for ZNF175 Gene

GeneCards Summary for ZNF175 Gene

ZNF175 (Zinc Finger Protein 175) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF81.

UniProtKB/Swiss-Prot for ZNF175 Gene

  • Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF175 Gene

Genomics for ZNF175 Gene

Regulatory Elements for ZNF175 Gene

Promoters for ZNF175 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF175 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF175 Gene

Chromosome:
19
Start:
51,571,278 bp from pter
End:
51,592,510 bp from pter
Size:
21,233 bases
Orientation:
Plus strand

Genomic View for ZNF175 Gene

Genes around ZNF175 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF175 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF175 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF175 Gene

Proteins for ZNF175 Gene

  • Protein details for ZNF175 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y473-ZN175_HUMAN
    Recommended name:
    Zinc finger protein 175
    Protein Accession:
    Q9Y473
    Secondary Accessions:
    • A8K9H2

    Protein attributes for ZNF175 Gene

    Size:
    711 amino acids
    Molecular mass:
    81609 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF175 Gene

Proteomics data for ZNF175 Gene at MOPED

Post-translational modifications for ZNF175 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF175 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF175 Gene

Domains & Families for ZNF175 Gene

Gene Families for ZNF175 Gene

Protein Domains for ZNF175 Gene

Suggested Antigen Peptide Sequences for ZNF175 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y473

UniProtKB/Swiss-Prot:

ZN175_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF175: view

Function for ZNF175 Gene

Molecular function for ZNF175 Gene

GENATLAS Biochemistry:
zinc finger protein 175,C2H2 type,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.
UniProtKB/Swiss-Prot Induction:
By HIV-1 infection.

Gene Ontology (GO) - Molecular Function for ZNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF175: view
genes like me logo Genes that share phenotypes with ZNF175: view

Animal Models for ZNF175 Gene

MGI Knock Outs for ZNF175:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF175 Gene

Localization for ZNF175 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF175 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF175 Gene COMPARTMENTS Subcellular localization image for ZNF175 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZNF175: view

Pathways & Interactions for ZNF175 Gene

SuperPathways for ZNF175 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF175: view

Pathways by source for ZNF175 Gene

2 Reactome pathways for ZNF175 Gene

Gene Ontology (GO) - Biological Process for ZNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with ZNF175: view

No data available for SIGNOR curated interactions for ZNF175 Gene

Drugs & Compounds for ZNF175 Gene

(1) Drugs for ZNF175 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF175: view

Transcripts for ZNF175 Gene

Unigene Clusters for ZNF175 Gene

Zinc finger protein 175:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF175 Gene

No ASD Table

Relevant External Links for ZNF175 Gene

GeneLoc Exon Structure for
ZNF175
ECgene alternative splicing isoforms for
ZNF175

Expression for ZNF175 Gene

mRNA expression in normal human tissues for ZNF175 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF175 Gene



SOURCE GeneReport for Unigene cluster for ZNF175 Gene Hs.119014

mRNA Expression by UniProt/SwissProt for ZNF175 Gene

Q9Y473-ZN175_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ZNF175: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for ZNF175 Gene

Orthologs for ZNF175 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF175 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF175 35
  • 98.83 (n)
  • 98.17 (a)
ZNF175 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF175 36
  • 78 (a)
OneToOne
ZNF175 35
  • 83.83 (n)
  • 78.06 (a)
dog
(Canis familiaris)
Mammalia LOC100686614 35
  • 81.26 (n)
  • 74.93 (a)
ZNF175 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp715 16
Zfp715 35
  • 63.19 (n)
  • 49.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2129 37
  • 29 (a)
CG6792 37
  • 34 (a)
D19A 37
  • 35 (a)
Species with no ortholog for ZNF175:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF175 Gene

ENSEMBL:
Gene Tree for ZNF175 (if available)
TreeFam:
Gene Tree for ZNF175 (if available)

Paralogs for ZNF175 Gene

Paralogs for ZNF175 Gene

(449) SIMAP similar genes for ZNF175 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF175: view

Variants for ZNF175 Gene

Sequence variations from dbSNP and Humsavar for ZNF175 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3764548 - 51,587,844(-) ACTGC(A/G)TTCAT reference, missense
rs60097262 - 51,587,418(+) AGCCC(A/T)ATAAA reference, missense
rs1530877 -- 51,588,834(+) ATGAT(A/G)ACCCT utr-variant-3-prime
rs2864108 -- 51,570,658(+) TTCCT(C/T)TAACT upstream-variant-2KB
rs2864109 -- 51,572,880(+) CAACA(C/T)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF175 Gene

Variant ID Type Subtype PubMed ID
dgv1109e1 CNV Complex 17122850
esv638 CNV CNV 17122850
nsv469584 CNV Complex 16826518
esv268778 CNV Insertion 20981092
dgv1110e1 CNV Complex 17122850

Variation tolerance for ZNF175 Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.35; 81.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF175 Gene

HapMap Linkage Disequilibrium report
ZNF175

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF175 Gene

Disorders for ZNF175 Gene

Relevant External Links for ZNF175

Genetic Association Database (GAD)
ZNF175
Human Genome Epidemiology (HuGE) Navigator
ZNF175
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF175

No disorders were found for ZNF175 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF175 Gene

Publications for ZNF175 Gene

  1. Isolation and mapping of a novel human gene encoding a protein containing zinc-finger structures. (PMID: 8838321) Saito H. … Nakamura Y. (Genomics 1996) 2 3 4 67
  2. YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1 infection. (PMID: 19034670) Buescher J.L. … Ikezu T. (J Neuroimmune Pharmacol 2009) 3 23
  3. Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET. (PMID: 19034669) Martinez L.B. … Ikezu T. (J Neuroimmune Pharmacol 2009) 3 23
  4. OTK18, a zinc-finger protein, regulates human immunodeficiency virus type 1 long terminal repeat through two distinct regulatory regions. (PMID: 17170456) Horiba M. … Ikezu T. (J. Gen. Virol. 2007) 3 23
  5. OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis. (PMID: 15081264) Carlson K.A. … Gendelman H.E. (J. Neuroimmunol. 2004) 3 23

Products for ZNF175 Gene

Sources for ZNF175 Gene

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