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Aliases for ZNF175 Gene

Aliases for ZNF175 Gene

  • Zinc Finger Protein 175 2 3 5
  • Zinc Finger Protein OTK18 3 4
  • OTK18 3

External Ids for ZNF175 Gene

Previous GeneCards Identifiers for ZNF175 Gene

  • GC19P052705
  • GC19P052435
  • GC19P056750
  • GC19P056766
  • GC19P052074
  • GC19P048406

Summaries for ZNF175 Gene

GeneCards Summary for ZNF175 Gene

ZNF175 (Zinc Finger Protein 175) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF81.

UniProtKB/Swiss-Prot for ZNF175 Gene

  • Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.

Additional gene information for ZNF175 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF175 Gene

Genomics for ZNF175 Gene

Regulatory Elements for ZNF175 Gene

Enhancers for ZNF175 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H050678 1.3 Ensembl ENCODE 126.2 -891.8 -891802 1 HDGF PKNOX1 ATF1 ZNF133 SIN3A YBX1 GLI4 BRCA1 TCF12 GLIS2 ZNF175 NUP62 POLD1 ENSG00000267808 CPT1C ADM5 ENSG00000268047 PTOV1-AS2 ZNF473 PTOV1
GH19H051687 1.8 FANTOM5 ENCODE dbSUPER 80.6 +119.2 119213 6 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B ZNF207 ZNF143 SP3 ZNF137P ZNF808 ZNF841 ZNF616 ZNF766 ZNF577 ZNF175 ENSG00000269825 ZNF836 ENSG00000268970
GH19H050649 1.3 Ensembl ENCODE 100.2 -921.4 -921441 0 HDGF ATF1 ARNT YBX1 GLI4 ETS1 ZNF766 ZNF416 ZNF143 ATF7 ZNF175 POLD1 IRF3 SIGLEC17P BCL2L12 NUP62 PTOV1 ENSG00000267808 PRMT1 CPT1C
GH19H051393 1.5 FANTOM5 ENCODE 58.7 -176.2 -176231 2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A YY1 ZNF143 FOS SP3 ZNF577 ZNF766 ZNF841 ZNF616 ZNF175 ZNF432 ZNF836 ZNF613 ZNF614 SPACA6P-AS
GH19H051360 1.7 Ensembl ENCODE dbSUPER 45.9 -206.3 -206335 8 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A MEF2D ZNF175 ZNF577 ZNF766 ZNF836 ZNF841 ZNF616 LOC100419835 ZNF614 ZNF350 ZNF649
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF175 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF175 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111212 -77 1200 HDGF PKNOX1 ARNT SIN3A ARID4B FEZF1 ZNF2 YY1 ZNF766 ZNF143

Genomic Location for ZNF175 Gene

Chromosome:
19
Start:
51,571,278 bp from pter
End:
51,592,510 bp from pter
Size:
21,233 bases
Orientation:
Plus strand

Genomic View for ZNF175 Gene

Genes around ZNF175 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF175 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF175 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF175 Gene

Proteins for ZNF175 Gene

  • Protein details for ZNF175 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y473-ZN175_HUMAN
    Recommended name:
    Zinc finger protein 175
    Protein Accession:
    Q9Y473
    Secondary Accessions:
    • A8K9H2

    Protein attributes for ZNF175 Gene

    Size:
    711 amino acids
    Molecular mass:
    81609 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF175 Gene

Post-translational modifications for ZNF175 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF175 Gene

Antibody Products

  • Abcam antibodies for ZNF175

No data available for DME Specific Peptides for ZNF175 Gene

Domains & Families for ZNF175 Gene

Gene Families for ZNF175 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF175 Gene

Suggested Antigen Peptide Sequences for ZNF175 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y473

UniProtKB/Swiss-Prot:

ZN175_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF175: view

Function for ZNF175 Gene

Molecular function for ZNF175 Gene

GENATLAS Biochemistry:
zinc finger protein 175,C2H2 type,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.
UniProtKB/Swiss-Prot Induction:
By HIV-1 infection.

Phenotypes From GWAS Catalog for ZNF175 Gene

Gene Ontology (GO) - Molecular Function for ZNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 17170456
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 17170456
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 17170456
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZNF175: view

Phenotypes for ZNF175 Gene

genes like me logo Genes that share phenotypes with ZNF175: view

Animal Models for ZNF175 Gene

MGI Knock Outs for ZNF175:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF175
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF175 Gene

Localization for ZNF175 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF175 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF175 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF175: view

Pathways & Interactions for ZNF175 Gene

SuperPathways for ZNF175 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF175: view

Pathways by source for ZNF175 Gene

2 Reactome pathways for ZNF175 Gene

Gene Ontology (GO) - Biological Process for ZNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 17170456
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 17170456
genes like me logo Genes that share ontologies with ZNF175: view

No data available for SIGNOR curated interactions for ZNF175 Gene

Drugs & Compounds for ZNF175 Gene

(1) Drugs for ZNF175 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF175: view

Transcripts for ZNF175 Gene

Unigene Clusters for ZNF175 Gene

Zinc finger protein 175:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF175
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF175 Gene

No ASD Table

Relevant External Links for ZNF175 Gene

GeneLoc Exon Structure for
ZNF175
ECgene alternative splicing isoforms for
ZNF175

Expression for ZNF175 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF175 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF175 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF175 Gene:

ZNF175

SOURCE GeneReport for Unigene cluster for ZNF175 Gene:

Hs.119014

mRNA Expression by UniProt/SwissProt for ZNF175 Gene:

Q9Y473-ZN175_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ZNF175 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF175: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF175 Gene

Orthologs for ZNF175 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF175 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF175 33 34
  • 98.83 (n)
cow
(Bos Taurus)
Mammalia ZNF175 33 34
  • 83.83 (n)
dog
(Canis familiaris)
Mammalia LOC100686614 33
  • 81.26 (n)
ZNF175 34
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp715 33 16
  • 63.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta D19A 35
  • 35 (a)
CG6792 35
  • 34 (a)
CG2129 35
  • 29 (a)
Species where no ortholog for ZNF175 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF175 Gene

ENSEMBL:
Gene Tree for ZNF175 (if available)
TreeFam:
Gene Tree for ZNF175 (if available)

Paralogs for ZNF175 Gene

Paralogs for ZNF175 Gene

(449) SIMAP similar genes for ZNF175 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF175: view

Variants for ZNF175 Gene

Sequence variations from dbSNP and Humsavar for ZNF175 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000070484 -- 51,577,836(+) TTTTT(C/T)GTATT intron-variant
rs1000087142 -- 51,583,932(+) CATTG(C/T)ATTTA intron-variant
rs1000455032 -- 51,573,443(+) CGTGA(A/G)GGCAG intron-variant, nc-transcript-variant
rs1000865976 -- 51,586,616(+) CTCTT(C/T)CTCCT intron-variant
rs1000923440 -- 51,585,737(+) TCAGG(A/G)ACTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF175 Gene

Variant ID Type Subtype PubMed ID
esv2758767 CNV gain+loss 17122850
esv3304500 CNV mobile element insertion 20981092
esv3451949 CNV insertion 20981092
esv3644673 CNV loss 21293372
nsv1140251 OTHER inversion 24896259
nsv469584 CNV loss 16826518
nsv579966 CNV loss 21841781

Variation tolerance for ZNF175 Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.35; 81.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF175 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF175

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF175 Gene

Disorders for ZNF175 Gene

Relevant External Links for ZNF175

Genetic Association Database (GAD)
ZNF175
Human Genome Epidemiology (HuGE) Navigator
ZNF175
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF175

No disorders were found for ZNF175 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF175 Gene

Publications for ZNF175 Gene

  1. Molecular characterization of a putative antiretroviral transcriptional factor, OTK18. (PMID: 14688346) Carlson KA … Ikezu T (Journal of immunology (Baltimore, Md. : 1950) 2004) 3 4 22 60
  2. Isolation and mapping of a novel human gene encoding a protein containing zinc-finger structures. (PMID: 8838321) Saito H … Nakamura Y (Genomics 1996) 2 3 4 60
  3. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PMID: 22491018) Wang J … Platt A (The pharmacogenomics journal 2013) 3 45 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1 infection. (PMID: 19034670) Buescher JL … Ikezu T (Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2009) 3 22 60

Products for ZNF175 Gene

Sources for ZNF175 Gene

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