ZNF175 Gene
protein-coding GIFtS: 56
GCID: GC19P052074
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|
zinc finger protein 175
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Aliases
for ZNF175 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 1751 2 | | OTK181 2 5 | | Zinc Finger Protein OTK182 3 |
Export aliases for ZNF175 gene to outside databasesPrevious GC identifers: GC19P052705 GC19P052435 GC19P056750 GC19P056766 GC19P048406 |
Summaries
for ZNF175 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN175_HUMAN, Q9Y473Function: Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication bysuppressing Tat-induced viral LTR promoter activity
|
Genomic Views
for ZNF175 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF175 gene promoter:
AP-2rep ISGF-3 Spz1 IRF-1 GATA-1 AREB6 CP2 Msx-1 ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF175
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF175 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.4ZNF175 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P052074: view genomic region
(about GC identifiers)
Start:
|
52,074,531 bp from pter |
End:
|
52,092,991 bp from pter |
Size:
|
18,461 bases |
Orientation:
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plus strand |
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Proteins
for ZNF175 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN175_HUMAN, Q9Y473 (See
protein sequence)Recommended Name: Zinc finger protein 175 Size: 711 amino acids; 81609 Da
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: A8K9H2Explore the universe of human proteins at neXtProt for ZNF175: NX_Q9Y473
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y473
ZNF175 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009078.1
ENSEMBL proteins: ENSP00000444424 ENSP00000262259 ENSP00000440578 Reactome Protein details: Q9Y473
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
ZNF175 for ontologies About GeneDecksing
ZNF175 Antibody Products:
Assay Products for ZNF175: |
Protein
Domains /
Families
for ZNF175 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF175 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y473ProtoNet protein and cluster: Q9Y473 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN175_HUMAN, Q9Y473Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 15 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF175 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN175_HUMAN, Q9Y473Function: Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication bysuppressing Tat-induced viral LTR promoter activityInduction: By HIV-1 infection Genatlas biochemistry entry for ZNF175:zinc finger protein 175,C2H2 type,ubiquitously expressed
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF175 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZNF175 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF175 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF175 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZNF175 for ontologies About GeneDecksing
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Zfp719):
ZNF175 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ZNF175 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF175
ZNF175 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF175
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for ZNF175 (Q9Y4733 ENSP000002622594) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0009615 | response to virus |
-- | -- | | GO:0051607 | defense response to virus |
IEA | -- |
ZNF175 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF175 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ZNF175 for compounds About GeneDecksing
 Browse Tocris compounds for ZNF175
1 Novoseek chemical compound relationship for ZNF175 gene About this table
Search CenterWatch for drugs/clinical trials and news about ZNF175 / ZN175
|
Transcripts
for ZNF175 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF175 gene: NM_007147.2 Unigene Cluster for ZNF175: Zinc finger protein 175 Hs.119014 [show with all ESTs]Unigene Representative Sequence: BC0529973 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000545217 ENST00000262259(uc002pxb.3) ENST00000436511
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF175 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF175 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF175 (NM_007147) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF175 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF175 |
Additional cDNA sequence: AK292687.1 BC007778.2 BC052997.1 D50419.1 5 DOTS entries: DT.211792 DT.70100059 DT.75101994 DT.40125572 DT.91933270 24/54 AceView cDNA sequences (see all 54): AI373900 NM_007147 F12094 BC052997 BQ669671 BU156607 D50419 BU166343 BU192641 BC007778 BU190214 AL043887 AI221738 BX955441 AA838730 AL702907 BX117819 AI799380 AI223386 AI453754 AL119279 AI080395 AL119380 BF685446
GeneLoc Exon Structure
|
Expression
for ZNF175 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF175 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGTTTGGCC
About this image
See ZNF175 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF175
SOURCE GeneReport for Unigene cluster: Hs.119014
UniProtKB/Swiss-Prot: ZN175_HUMAN, Q9Y473Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for ZNF175
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF175
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF175 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF175 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF175 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF175 |
Orthologs
for ZNF175 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF175 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for ZNF175 (if available)
TreeFam Gene Tree for ZNF175 (if available) |
Paralogs
for ZNF175 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF175 gene
- ZNF6742 LOC1002875152 ZNF6142 ZNF4322 ZNF6132 ZNF262 ZNF3502 ZNF812
- ZNF6492 ZNF6052 ZNF5772 ZNF842 ZNF6302 ZFP372 ZNF4842 ENSG000002296312
- ZNF1822 ZNF412 ZNF2682 LOC1009964642 ZNF6152 ZNF3002
18/436 SIMAP similar genes for ZNF175 using alignment to 6 protein entries: ZN175_HUMAN (see all proteins)
(see all similar genes):ZNF3 POM121C ZNF101 ZNF300P1 ZNF323 ZNF705F
ZSCAN16 ZNF586 ZNF721 HZF36 ZNF655 ZNF670
ZNF705A ZNF705G ZFP1 ZNF81 ZNF84 GLI4
ZNF175 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF175 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF175 (52074531 - 52092991 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF175
1 CNV: 4085 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF175 |
|
Disorders
/ Diseases
for ZNF175 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF175 for disorders About GeneDecksing
OMIM gene information: 601139
OMIM disorders: --
3  diseases for ZNF175: About MalaCardsencephalitis rubella endocarditis
1 disease from the University of Copenhagen DISEASES database for ZNF175:Encephalitis Human Genome Epidemiology (HuGE) Navigator: ZNF175 (1 document)
Export disorders for ZNF175 gene to outside databases
|
Publications
for ZNF175 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF175 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with ZNF175) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and mapping of a novel human gene encoding a protein containing zinc-finger structures. (PubMed id 8838321)1, 2, 3 Saito H.... Nakamura Y. (1996)
- Molecular characterization of a putative antiretroviral transcriptional factor, OTK18. (PubMed id 14688346)1, 2, 9 Carlson K.A.... Ikezu T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis. (PubMed id 15081264)1, 9 Carlson K.A....Gendelman H.E. (2004)
- OTK18, a zinc-finger protein, regulates human immunod eficiency virus type 1 long terminal repeat through two distinct regulatory reg ions. (PubMed id 17170456)1, 9 Horiba M....Ikezu T. (2007)
- YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1 infection. (PubMed id 19034670)1, 9 Buescher J.L....Ikezu T. (2009)
- Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET. (PubMed id 19034669)1, 9 Martinez L.B....Ikezu T. (2009)
- Genome-wide association analysis implicates the involv ement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PubMed id 22491018)1 Wang J....Platt A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
|
External Searches for ZNF175 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF175 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF175 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF175 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF175 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF175 gene:
Search GeneIP for patents involving ZNF175
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF175 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF175 | | OriGene Custom Protein Services for ZNF175 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF175 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF175 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF175 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF175 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF175 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF175 |
| |
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| |  |  |  |  | | | | |
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 | | | ZNF175 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF175 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF175 |
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