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Aliases for ZNF175 Gene

Aliases for ZNF175 Gene

  • Zinc Finger Protein 175 2 3
  • Zinc Finger Protein OTK18 3 4
  • OTK18 3 6

External Ids for ZNF175 Gene

Summaries for ZNF175 Gene

GeneCards Summary for ZNF175 Gene

ZNF175 (Zinc Finger Protein 175) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF182.

UniProtKB/Swiss-Prot for ZNF175 Gene

  • Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF175 Gene

Genomics for ZNF175 Gene

Genomic Location for ZNF175 Gene

51,571,278 bp from pter
51,592,508 bp from pter
21,231 bases
Plus strand

Genomic View for ZNF175 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF175 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF175 Gene

Regulatory Elements for ZNF175 Gene

Proteins for ZNF175 Gene

  • Protein details for ZNF175 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 175
    Protein Accession:
    Secondary Accessions:
    • A8K9H2

    Protein attributes for ZNF175 Gene

    711 amino acids
    Molecular mass:
    81609 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF175 Gene

Proteomics data for ZNF175 Gene at MOPED

Post-translational modifications for ZNF175 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF175 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF175 Gene

Domains for ZNF175 Gene

Gene Families for ZNF175 Gene

  • ZNF :Zinc fingers, C2H2-type


  • Contains 1 KRAB domain.:
    • Q9Y473
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q9Y473
  • Contains 15 C2H2-type zinc fingers.:
    • Q9Y473
genes like me logo Genes that share domains with ZNF175: view

Function for ZNF175 Gene

Molecular function for ZNF175 Gene

GENATLAS Biochemistry: zinc finger protein 175,C2H2 type,ubiquitously expressed
UniProtKB/Swiss-Prot Function: Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.
UniProtKB/Swiss-Prot Induction: By HIV-1 infection

Gene Ontology (GO) - Molecular Function for ZNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF175: view

miRNA for ZNF175 Gene

miRTarBase miRNAs that target ZNF175

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF175 Gene

Localization for ZNF175 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF175 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for ZNF175 Gene COMPARTMENTS Subcellular localization image for ZNF175 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with ZNF175: view

Pathways for ZNF175 Gene

SuperPathways for ZNF175 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF175: view

Pathways by source for ZNF175 Gene

2 Reactome pathways for ZNF175 Gene

Gene Ontology (GO) - Biological Process for ZNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with ZNF175: view

Compounds for ZNF175 Gene

(1) Novoseek inferred chemical compound relationships for ZNF175 Gene

Compound -log(P) Hits PubMed IDs
zinc 49.9 5
genes like me logo Genes that share compounds with ZNF175: view

Transcripts for ZNF175 Gene

Unigene Clusters for ZNF175 Gene

Zinc finger protein 175:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF175 Gene

No ASD Table

Relevant External Links for ZNF175 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF175 Gene

mRNA expression in normal human tissues for ZNF175 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF175 Gene

SOURCE GeneReport for Unigene cluster for ZNF175 Gene Hs.119014

mRNA Expression by UniProt/SwissProt for ZNF175 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with ZNF175: view

Orthologs for ZNF175 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF175 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF175 36
  • 98.83 (n)
  • 98.17 (a)
ZNF175 37
  • 98 (a)
(Bos Taurus)
Mammalia ZNF175 36
  • 83.83 (n)
  • 78.06 (a)
ZNF175 37
  • 78 (a)
(Canis familiaris)
Mammalia LOC100686614 36
  • 81.26 (n)
  • 74.93 (a)
ZNF175 37
  • 73 (a)
(Mus musculus)
Mammalia Zfp715 36
  • 63.19 (n)
  • 49.14 (a)
Zfp719 16
fruit fly
(Drosophila melanogaster)
Insecta D19A 38
  • 35 (a)
CG2129 38
  • 29 (a)
CG6792 38
  • 34 (a)
Species with no ortholog for ZNF175:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF175 Gene

Gene Tree for ZNF175 (if available)
Gene Tree for ZNF175 (if available)

Paralogs for ZNF175 Gene

Selected SIMAP similar genes for ZNF175 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF175: view

Variants for ZNF175 Gene

Sequence variations from dbSNP and Humsavar for ZNF175 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3752 -- 51,585,187(+) TGAAT(C/G)TTATC intron-variant
rs1054328 -- 51,589,568(+) CCCCC(C/G)CTTTC utr-variant-3-prime
rs1063973 -- 51,588,529(+) GAGAA(A/C)ATCTT utr-variant-3-prime
rs1133254 -- 51,589,720(+) ggaac(A/C)cagcc utr-variant-3-prime
rs1530877 -- 51,588,834(+) ATGAT(A/G)ACCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF175 Gene

Variant ID Type Subtype PubMed ID
dgv1109e1 CNV Complex 17122850
esv638 CNV CNV 17122850
nsv469584 CNV Complex 16826518
esv268778 CNV Insertion 20981092
dgv1110e1 CNV Complex 17122850

Relevant External Links for ZNF175 Gene

HapMap Linkage Disequilibrium report

Disorders for ZNF175 Gene

(1) University of Copenhagen DISEASES for ZNF175 Gene

Relevant External Links for ZNF175

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ZNF175: view

No data available for UniProtKB/Swiss-Prot for ZNF175 Gene

Publications for ZNF175 Gene

  1. Molecular characterization of a putative antiretroviral transcriptional factor, OTK18. (PMID: 14688346) Carlson K.A. … Ikezu T. (J. Immunol. 2004) 3 4 23
  2. Isolation and mapping of a novel human gene encoding a protein containing zinc-finger structures. (PMID: 8838321) Saito H. … Nakamura Y. (Genomics 1996) 2 3 4
  3. Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET. (PMID: 19034669) Martinez L.B. … Ikezu T. (J Neuroimmune Pharmacol 2009) 3 23
  4. YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1 infection. (PMID: 19034670) Buescher J.L. … Ikezu T. (J Neuroimmune Pharmacol 2009) 3 23
  5. OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis. (PMID: 15081264) Carlson K.A. … Gendelman H.E. (J. Neuroimmunol. 2004) 3 23

Products for ZNF175 Gene

Sources for ZNF175 Gene

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