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ZNF174 Gene

protein-coding   GIFtS: 50
GCID: GC16P003451

Zinc Finger Protein 174

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 1741 2
Zinc Finger And SCAN Domain-Containing Protein 82 3
AW-12 3
ZSCAN82 3

External Ids:    HGNC: 129631   Entrez Gene: 77272   Ensembl: ENSG000001033437   OMIM: 6039005   UniProtKB: Q156973   

Export aliases for ZNF174 gene to outside databases

Previous GC identifers: GC16P003480 GC16P003391 GC16P003420


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF174 Gene:
ZNF174 (zinc finger protein 174) is a protein-coding gene. GO annotations related to this gene include transcription regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF446.

UniProtKB/Swiss-Prot: ZN174_HUMAN, Q15697
Function: Transcriptional repressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF174 gene promoter:
         c-Fos   Sp1   AP-1   CUTL1   AP-4   YY1   AREB6   c-Jun   RSRFC4   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF174 promoter sequence
   Search Chromatin IP Primers for ZNF174

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF174


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13

ZNF174 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF174 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P003451:  view genomic region     (about GC identifiers)

Start:
3,451,190 bp from pter      End:
3,459,370 bp from pter
Size:
8,181 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN174_HUMAN, Q15697 (See protein sequence)
Recommended Name: Zinc finger protein 174  
Size: 407 amino acids; 46455 Da
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for ZNF174:
1Y7Q (3D)    
Secondary accessions: Q53Y68 Q9BQ34
Alternative splicing: 2 isoforms:  Q15697-1   Q15697-2   

Explore the universe of human proteins at neXtProt for ZNF174: NX_Q15697

Explore proteomics data for ZNF174 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF174 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001027463.1  NP_003441.1  

    ENSEMBL proteins: 
     ENSP00000461502   ENSP00000460397   ENSP00000339781   ENSP00000268655   ENSP00000459681  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 7):
     IPR027778 Zfp174
     IPR008916 Retrov_capsid_C
     IPR003309 Tscrpt_reg_SCAN
     IPR015880 Znf_C2H2-like
     IPR027775 C2H2_Znf_fam

    Graphical View of Domain Structure for InterPro Entry Q15697

    ProtoNet protein and cluster: Q15697

    2 Blocks protein domains:
    IPB003309 Transcriptional regulator SCAN
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN174_HUMAN, Q15697
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers
    Similarity: Contains 1 SCAN box domain


    Find genes that share domains with ZNF174           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN174_HUMAN, Q15697
    Function: Transcriptional repressor

         Genatlas biochemistry entry for ZNF174:
    zinc finger 174 (C2H2 type,Kruppel-like),most strongly expressed in adult testis and ovary,potential
    transcriptional repressor

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA7673192
    GO:0042803protein homodimerization activity IPI15629724
    GO:0044212transcription regulatory region DNA binding IDA7673192
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF174           About GenesLikeMe


    Animal Models:
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    hsa-mir-877-5p (MIRT037309), hsa-mir-92a-3p (MIRT049596)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN174_HUMAN, Q15697: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS7673192
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0015629actin cytoskeleton IDA--

    Find genes that share ontologies with ZNF174           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF174
    Interactions:

        Search GeneGlobe Interaction Network for ZNF174

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for ZNF174 (Q156973 ENSP000002686554) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZKSCAN8Q157763, ENSP000003327504I2D: score=1 STRING: ENSP00000332750
    ZSCAN32Q9NX653, ENSP000003025024I2D: score=1 STRING: ENSP00000302502
    ZNF20P170243, ENSP000003354374I2D: score=1 STRING: ENSP00000335437
    ZNF24P170283, ENSP000002613324I2D: score=2 STRING: ENSP00000261332
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA7673192
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter IBA--
    GO:0045892negative regulation of transcription, DNA-templated IDA7673192

    Find genes that share ontologies with ZNF174           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF174 (ZN174)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF174 gene (2 alternative transcripts): 
    NM_001032292.2  NM_003450.2  

    Unigene Cluster for ZNF174:

    Zinc finger protein 174
    Hs.155204  [show with all ESTs]
    Unigene Representative Sequence: NM_003450
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575752 ENST00000571936 ENST00000344823(uc002cva.2 uc002cvb.3)
    ENST00000268655(uc002cvc.3) ENST00000572544
    miRNA
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    hsa-miR-224 hsa-miR-877
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF542096.1 BC000876.1 BC001161.1 BT006923.1 U31248.1 

    4 DOTS entries:

    DT.75124294  DT.311686  DT.97811350  DT.100657791 

    Selected AceView cDNA sequences (see all 91):

    AW192958 BQ014894 BU509083 CA487438 BM553908 Z42206 BU153439 AI689979 
    BE301456 Z38457 BM924063 BM969505 BM929972 CR590935 BM873376 BC001161 
    AU132320 AI796897 BF437990 AW772330 AA910691 AF542096 BQ003068 BE670279 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF174 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCACACTTC
    ZNF174 Expression
    About this image

    ZNF174 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF174 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.155204

    UniProtKB/Swiss-Prot: ZN174_HUMAN, Q15697
    Tissue specificity: Expressed in a variety of organs, but most strongly in adult testis and ovary followed by
    small intestine, colon, prostate, thymus, spleen, pancreas, skeletal muscle, heart, brain and kidney. Also
    expressed in umbilical vein endothelial cells, foreskin fibroblast and Hep-G2 cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF174 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp1741 , 5 zinc finger protein 1741, 5 80.41(n)1
    75.31(a)1
      16 (2.26 cM)5
    3856741  NM_001081217.11  NP_001074686.11 
     38472685 
    chicken
    (Gallus gallus)
    Aves ZFP926
    Gallus gallus zinc finger protein 92 homolog (mous...
    22(a)
    1 → many
    1(91248215-91253003)
    lizard
    (Anolis carolinensis)
    Reptilia ZNF1746
    zinc finger protein 174
    28(a)
    1 ↔ 1
    GL343253.1(1511803-1517102)


    ENSEMBL Gene Tree for ZNF174 (if available)
    TreeFam Gene Tree for ZNF174 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF174 gene
    ZNF4462  ZSCAN92  ZKSCAN12  ZNF3972  ZNF5002  ZNF2132  ZNF2322  ZSCAN302  
    ZNF32  ZKSCAN42  ZNF3962  ZSCAN122  ZNF3942  ZSCAN212  ZSCAN232  ZNF1652  
    ZSCAN162  ZKSCAN82  ZSCAN222  ZSCAN312  ZNF242  ZKSCAN32  ZNF182  
    Selected SIMAP similar genes for ZNF174 using alignment to 3 protein entries:     ZN174_HUMAN (see all proteins) (see all similar genes):
    ZNF202    ZNF444    ZSCAN31    LOC100128510    ZKSCAN8    ZNF263
    SCAND1    SCAND3    FLJ00320    ZNF394    ZSCAN10    ZSCAN18
    ZKSCAN1    ZNF500    ZSCAN21    ZNF24    ZSCAN30    ZNF397

    Find genes that share paralogs with ZNF174           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF174 (see all 191)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs397281,2
    C,F,A,H--3453076(+) TGGGTA/TGCAGT 2 -- int121Minor allele frequency- T:0.35NS EA NA WA CSA 2348
    rs1468838151,2
    C--3453140(+) TGTTT-/AGCT  
     TATAGTC
    TTTTT
    2 -- int10--------
    rs1173115731,2
    C,F--3453203(+) CTTGCT/AGTGTT 2 -- int12Minor allele frequency- A:0.03NA EA 240
    rs1908521471,2
    --3453252(+) GCAACC/GTCTGC 2 -- int10--------
    rs1469236821,2
    --3453321(+) CCTGCC/TACCAC 2 -- int10--------
    rs1840383321,2
    C--3453358(+) TAGAGA/GGGGGG 2 -- int10--------
    rs116466161,2
    C,H--3453451(+) caggcA/Gtgagc 2 -- int10--------
    rs1885626181,2
    --3453538(+) CTGGAA/GGGCAG 2 -- int10--------
    rs1176952111,2
    F--3453560(+) CAGCTC/TGCTGC 2 -- int11Minor allele frequency- T:0.02NA 120
    rs116477021,2
    C,H--3453615(+) aagtaG/Actggg 2 -- int11Minor allele frequency- A:0.25NA 4

    HapMap Linkage Disequilibrium report for ZNF174 (3451190 - 3459370 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF174:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv905212CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603900    OMIM disorders: --


    Find genes that share disorders with ZNF174           About GenesLikeMe


    Export disorders for ZNF174 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF174 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with ZNF174)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a novel zinc-finger protein with transcription repressor activity. (PubMed id 7673192)1, 2, 9 Williams A.J.... Collins T. (J. Biol. Chem. 1995)
    2. Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain. (PubMed id 15629724)1, 2 Ivanov D.... Wagner G. (Mol. Cell 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. (PubMed id 22094256)1 Anders L....Sicinski P. (Cancer Cell 2011)
    6. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    7. Heterodimer formation of the myeloid zinc finger 1 SCAN domain and association with promyelocytic leukemia nuclear bodies. (PubMed id 18472161)1 Noll L....Sander T. (Leuk. Res. 2008)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7727 HGNC: 12963 AceView: ZNF174 Ensembl:ENSG00000103343 euGenes: HUgn7727
    ECgene: ZNF174 H-InvDB: ZNF174

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF174 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF174 gene:
    Search GeneIP for patents involving ZNF174

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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