Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF174 Gene

Aliases for ZNF174 Gene

  • Zinc Finger Protein 174 2 3
  • Zinc Finger And SCAN Domain-Containing Protein 8 3 4
  • ZSCAN8 3 4
  • AW-1 3 4

External Ids for ZNF174 Gene

Summaries for ZNF174 Gene

GeneCards Summary for ZNF174 Gene

ZNF174 (Zinc Finger Protein 174) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is ZNF396.

UniProtKB/Swiss-Prot for ZNF174 Gene

  • Transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF174 Gene

Genomics for ZNF174 Gene

Genomic Location for ZNF174 Gene

Start:
3,401,190 bp from pter
End:
3,409,370 bp from pter
Size:
8,181 bases
Orientation:
Plus strand

Genomic View for ZNF174 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF174 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF174 Gene

Regulatory Elements for ZNF174 Gene

Proteins for ZNF174 Gene

  • Protein details for ZNF174 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15697-ZN174_HUMAN
    Recommended name:
    Zinc finger protein 174
    Protein Accession:
    Q15697
    Secondary Accessions:
    • Q53Y68
    • Q9BQ34

    Protein attributes for ZNF174 Gene

    Size:
    407 amino acids
    Molecular mass:
    46455 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for ZNF174 Gene

    Alternative splice isoforms for ZNF174 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF174 Gene

Proteomics data for ZNF174 Gene at MOPED

Post-translational modifications for ZNF174 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF174 Gene

No data available for DME Specific Peptides for ZNF174 Gene

Domains for ZNF174 Gene

Gene Families for ZNF174 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

UniProtKB/Swiss-Prot:

ZN174_HUMAN
Domain:
  • Contains 1 SCAN box domain.:
    • Q15697
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q15697
Similarity:
  • Contains 3 C2H2-type zinc fingers.:
    • Q15697
genes like me logo Genes that share domains with ZNF174: view

Function for ZNF174 Gene

Molecular function for ZNF174 Gene

GENATLAS Biochemistry: zinc finger 174 (C2H2 type,Kruppel-like),most strongly expressed in adult testis and ovary,potential transcriptional repressor
UniProtKB/Swiss-Prot Function: Transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZNF174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 7673192
GO:0042803 protein homodimerization activity IPI 15629724
GO:0044212 transcription regulatory region DNA binding IDA 7673192
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF174: view

miRNA for ZNF174 Gene

miRTarBase miRNAs that target ZNF174

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF174 Gene

Localization for ZNF174 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF174 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF174 Gene COMPARTMENTS Subcellular localization image for ZNF174 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 7673192
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with ZNF174: view

Pathways for ZNF174 Gene

SuperPathways for ZNF174 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 7673192
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 7673192
genes like me logo Genes that share ontologies with ZNF174: view

No data available for Pathways by source for ZNF174 Gene

Transcripts for ZNF174 Gene

Unigene Clusters for ZNF174 Gene

Zinc finger protein 174:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF174 Gene

No ASD Table

Relevant External Links for ZNF174 Gene

GeneLoc Exon Structure for
ZNF174
ECgene alternative splicing isoforms for
ZNF174

Expression for ZNF174 Gene

mRNA expression in normal human tissues for ZNF174 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF174 Gene

SOURCE GeneReport for Unigene cluster for ZNF174 Gene Hs.155204

mRNA Expression by UniProt/SwissProt for ZNF174 Gene

Q15697-ZN174_HUMAN
Tissue specificity: Expressed in a variety of organs, but most strongly in adult testis and ovary followed by small intestine, colon, prostate, thymus, spleen, pancreas, skeletal muscle, heart, brain and kidney. Also expressed in umbilical vein endothelial cells, foreskin fibroblast and Hep-G2 cells
genes like me logo Genes that share expressions with ZNF174: view

Orthologs for ZNF174 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF174 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF174 36
  • 99.26 (n)
  • 99.02 (a)
ZNF174 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF174 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF174 36
  • 87.55 (n)
  • 88.21 (a)
ZNF174 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp174 36
  • 80.41 (n)
  • 75.31 (a)
Zfp174 16
Zfp174 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 28 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 28 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC102551846 36
  • 80.58 (n)
  • 76.05 (a)
chicken
(Gallus gallus)
Aves ZFP92 37
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZNF174 37
  • 28 (a)
OneToOne
Species with no ortholog for ZNF174:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF174 Gene

ENSEMBL:
Gene Tree for ZNF174 (if available)
TreeFam:
Gene Tree for ZNF174 (if available)

Paralogs for ZNF174 Gene

genes like me logo Genes that share paralogs with ZNF174: view

Variants for ZNF174 Gene

Sequence variations from dbSNP and Humsavar for ZNF174 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs12323 -- 3,409,138(+) ACTGG(A/G)GCAAA utr-variant-3-prime
rs37812 -- 3,403,882(+) TCAGG(A/G)CCTAG intron-variant
rs37813 -- 3,405,079(+) TACTT(C/T)AGATC downstream-variant-500B, intron-variant
rs37814 -- 3,405,247(+) CAAGA(C/T)GACAA downstream-variant-500B, intron-variant
rs37815 -- 3,405,912(+) ctgag(A/G)cagga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF174 Gene

Variant ID Type Subtype PubMed ID
nsv905212 CNV Gain 21882294

Relevant External Links for ZNF174 Gene

HapMap Linkage Disequilibrium report
ZNF174

Disorders for ZNF174 Gene

No disorders were found for ZNF174 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF174 Gene

Publications for ZNF174 Gene

  1. Isolation and characterization of a novel zinc-finger protein with transcription repressor activity. (PMID: 7673192) Williams A.J. … Collins T. (J. Biol. Chem. 1995) 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain. (PMID: 15629724) Ivanov D. … Wagner G. (Mol. Cell 2005) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. (PMID: 17000644) Vertegaal A.C. … Lamond A.I. (Mol. Cell Proteomics 2006) 3

Products for ZNF174 Gene

Sources for ZNF174 Gene

Back to Top

Content