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Aliases for ZNF174 Gene

Aliases for ZNF174 Gene

  • Zinc Finger Protein 174 2 3 5
  • Zinc Finger And SCAN Domain-Containing Protein 8 3 4
  • ZSCAN8 3 4
  • AW-1 3 4

External Ids for ZNF174 Gene

Previous GeneCards Identifiers for ZNF174 Gene

  • GC16P003480
  • GC16P003451
  • GC16P003391
  • GC16P003420

Summaries for ZNF174 Gene

Entrez Gene Summary for ZNF174 Gene

  • This gene encodes a protein with three Cys2-His2-type zinc fingers in the carboxy-terminus, a putative nuclear localization signal, and an amino-terminus SCAN box which forms homodimers. This protein is believed to function as a transcriptional repressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]

GeneCards Summary for ZNF174 Gene

ZNF174 (Zinc Finger Protein 174) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is ZSCAN25.

UniProtKB/Swiss-Prot for ZNF174 Gene

  • Transcriptional repressor.

Additional gene information for ZNF174 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF174 Gene

Genomics for ZNF174 Gene

Regulatory Elements for ZNF174 Gene

Enhancers for ZNF174 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H002903 1.9 FANTOM5 Ensembl ENCODE dbSUPER 31.4 -495.6 -495583 4 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF548 CREBBP ZNF597 ZNF263 ZNF174 ENSG00000261938 TBL3 ZNF75A TSC2 FLYWCH2 E4F1
GH16H002511 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.9 -884.7 -884738 10.7 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS ZNF75A CRAMP1 TBC1D24 IFT140 ZNF213-AS1 ZNF174 ZNF263 ERVK13-1 TSC2 SNHG19
GH16H002679 1.4 ENCODE dbSUPER 30.2 -719.7 -719701 4 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000261613 TBL3 E4F1 ZNF263 ZNF174 ENSG00000261207 ZNF597 ZNF75A ENSG00000261938 ERVK13-1
GH16H003019 1.4 ENCODE dbSUPER 29.1 -378.9 -378888 5.2 MLX DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 ZC3H11A NFYC MEF2D ENSG00000261938 ZNF263 ZNF75A E4F1 TSC2 ERVK13-1 SRRM2 CREBBP ZNF597 SNHG19
GH16H004270 1.8 FANTOM5 ENCODE dbSUPER 21.1 +871.5 871525 4.5 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF500 ZNF75A CREBBP ANKS3 ENSG00000261938 ZNF597 ZNF174 TIGD7 ENSG00000261789 LOC105371067
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF174 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF174 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082640 -90 2201 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207

Genomic Locations for ZNF174 Gene

Genomic Locations for ZNF174 Gene
29,662 bases
Plus strand

Genomic View for ZNF174 Gene

Genes around ZNF174 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF174 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF174 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF174 Gene

Proteins for ZNF174 Gene

  • Protein details for ZNF174 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 174
    Protein Accession:
    Secondary Accessions:
    • Q53Y68
    • Q9BQ34

    Protein attributes for ZNF174 Gene

    407 amino acids
    Molecular mass:
    46455 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for ZNF174 Gene

    Alternative splice isoforms for ZNF174 Gene


neXtProt entry for ZNF174 Gene

Post-translational modifications for ZNF174 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF174 Gene

Domains & Families for ZNF174 Gene

Gene Families for ZNF174 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF174 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF174: view

Function for ZNF174 Gene

Molecular function for ZNF174 Gene

GENATLAS Biochemistry:
zinc finger 174 (C2H2 type,Kruppel-like),most strongly expressed in adult testis and ovary,potential transcriptional repressor
UniProtKB/Swiss-Prot Function:
Transcriptional repressor.

Phenotypes From GWAS Catalog for ZNF174 Gene

Gene Ontology (GO) - Molecular Function for ZNF174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IC --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,IDA 7673192
genes like me logo Genes that share ontologies with ZNF174: view
genes like me logo Genes that share phenotypes with ZNF174: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF174 Gene

Localization for ZNF174 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF174 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF174 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Actin filaments (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,NAS 7673192
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with ZNF174: view

Pathways & Interactions for ZNF174 Gene

SuperPathways for ZNF174 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 7673192
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 7673192
genes like me logo Genes that share ontologies with ZNF174: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF174 Gene

Drugs & Compounds for ZNF174 Gene

No Compound Related Data Available

Transcripts for ZNF174 Gene

Unigene Clusters for ZNF174 Gene

Zinc finger protein 174:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF174 Gene

No ASD Table

Relevant External Links for ZNF174 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF174 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF174 Gene

Protein differential expression in normal tissues from HIPED for ZNF174 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (58.0) and CD8 Tcells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF174 Gene

Protein tissue co-expression partners for ZNF174 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF174 Gene:


SOURCE GeneReport for Unigene cluster for ZNF174 Gene:


mRNA Expression by UniProt/SwissProt for ZNF174 Gene:

Tissue specificity: Expressed in a variety of organs, but most strongly in adult testis and ovary followed by small intestine, colon, prostate, thymus, spleen, pancreas, skeletal muscle, heart, brain and kidney. Also expressed in umbilical vein endothelial cells, foreskin fibroblast and Hep-G2 cells.

Evidence on tissue expression from TISSUES for ZNF174 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF174: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF174 Gene

Orthologs for ZNF174 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF174 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF174 33 34
  • 99.26 (n)
(Canis familiaris)
Mammalia ZNF174 33 34
  • 87.55 (n)
(Bos Taurus)
Mammalia ZNF174 34
  • 82 (a)
(Rattus norvegicus)
Mammalia LOC102551846 33
  • 80.58 (n)
(Mus musculus)
Mammalia Zfp174 33 16 34
  • 80.41 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 28 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 28 (a)
(Gallus gallus)
Aves ZFP92 34
  • 22 (a)
(Anolis carolinensis)
Reptilia ZNF174 34
  • 28 (a)
Species where no ortholog for ZNF174 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF174 Gene

Gene Tree for ZNF174 (if available)
Gene Tree for ZNF174 (if available)

Paralogs for ZNF174 Gene

Variants for ZNF174 Gene

Sequence variations from dbSNP and Humsavar for ZNF174 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs761098156 Likely benign 3,408,899(+) ATCAC(C/T)GACTT reference, stop-gained
rs1000169149 -- 3,404,517(+) GCAGA(C/T)TCCTA reference, missense
rs1000540005 -- 3,407,024(+) TCAGG(A/C)TCTTA intron-variant
rs1000541786 -- 3,405,548(+) AGGGC(A/G)GCACC intron-variant, utr-variant-3-prime
rs1000553807 -- 3,400,130(+) TTTTT(A/G)TATTT intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF174 Gene

Variant ID Type Subtype PubMed ID
dgv2695n100 CNV gain 25217958

Variation tolerance for ZNF174 Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF174 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF174 Gene

Disorders for ZNF174 Gene

Relevant External Links for ZNF174

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF174 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF174 Gene

Publications for ZNF174 Gene

  1. Isolation and characterization of a novel zinc-finger protein with transcription repressor activity. (PMID: 7673192) Williams AJ … Collins T (The Journal of biological chemistry 1995) 3 4 22 60
  2. Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain. (PMID: 15629724) Ivanov D … Wagner G (Molecular cell 2005) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Impact of cytosine methylation on DNA binding specificities of human transcription factors. (PMID: 28473536) Yin Y … Taipale J (Science (New York, N.Y.) 2017) 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for ZNF174 Gene

Sources for ZNF174 Gene

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