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Aliases for ZNF174 Gene

Aliases for ZNF174 Gene

  • Zinc Finger Protein 174 2 3
  • Zinc Finger And SCAN Domain-Containing Protein 8 3 4
  • ZSCAN8 3 4
  • AW-1 3 4

External Ids for ZNF174 Gene

Previous GeneCards Identifiers for ZNF174 Gene

  • GC16P003480
  • GC16P003451
  • GC16P003391
  • GC16P003420

Summaries for ZNF174 Gene

GeneCards Summary for ZNF174 Gene

ZNF174 (Zinc Finger Protein 174) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is ZNF396.

UniProtKB/Swiss-Prot for ZNF174 Gene

  • Transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF174 Gene

Genomics for ZNF174 Gene

Regulatory Elements for ZNF174 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF174 Gene

Chromosome:
16
Start:
3,401,190 bp from pter
End:
3,430,851 bp from pter
Size:
29,662 bases
Orientation:
Plus strand

Genomic View for ZNF174 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF174 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF174 Gene

Proteins for ZNF174 Gene

  • Protein details for ZNF174 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15697-ZN174_HUMAN
    Recommended name:
    Zinc finger protein 174
    Protein Accession:
    Q15697
    Secondary Accessions:
    • Q53Y68
    • Q9BQ34

    Protein attributes for ZNF174 Gene

    Size:
    407 amino acids
    Molecular mass:
    46455 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for ZNF174 Gene

    Alternative splice isoforms for ZNF174 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF174 Gene

Proteomics data for ZNF174 Gene at MOPED

Post-translational modifications for ZNF174 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF174 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF174 Gene

Domains & Families for ZNF174 Gene

Gene Families for ZNF174 Gene

Suggested Antigen Peptide Sequences for ZNF174 Gene

Graphical View of Domain Structure for InterPro Entry

Q15697

UniProtKB/Swiss-Prot:

ZN174_HUMAN :
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Domain:
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF174: view

Function for ZNF174 Gene

Molecular function for ZNF174 Gene

GENATLAS Biochemistry:
zinc finger 174 (C2H2 type,Kruppel-like),most strongly expressed in adult testis and ovary,potential transcriptional repressor
UniProtKB/Swiss-Prot Function:
Transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZNF174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 7673192
GO:0042803 protein homodimerization activity IPI 15629724
GO:0044212 transcription regulatory region DNA binding IDA 7673192
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF174: view
genes like me logo Genes that share phenotypes with ZNF174: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF174

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF174 Gene

Localization for ZNF174 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF174 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF174 Gene COMPARTMENTS Subcellular localization image for ZNF174 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 7673192
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with ZNF174: view

Pathways & Interactions for ZNF174 Gene

SuperPathways for ZNF174 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 7673192
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0045892 negative regulation of transcription, DNA-templated IDA 7673192
genes like me logo Genes that share ontologies with ZNF174: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF174 Gene

Drugs & Compounds for ZNF174 Gene

No Compound Related Data Available

Transcripts for ZNF174 Gene

Unigene Clusters for ZNF174 Gene

Zinc finger protein 174:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF174

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF174 Gene

No ASD Table

Relevant External Links for ZNF174 Gene

GeneLoc Exon Structure for
ZNF174
ECgene alternative splicing isoforms for
ZNF174

Expression for ZNF174 Gene

mRNA expression in normal human tissues for ZNF174 Gene

Protein differential expression in normal tissues from HIPED for ZNF174 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (58.0) and CD8 Tcells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF174 Gene



SOURCE GeneReport for Unigene cluster for ZNF174 Gene Hs.155204

mRNA Expression by UniProt/SwissProt for ZNF174 Gene

Q15697-ZN174_HUMAN
Tissue specificity: Expressed in a variety of organs, but most strongly in adult testis and ovary followed by small intestine, colon, prostate, thymus, spleen, pancreas, skeletal muscle, heart, brain and kidney. Also expressed in umbilical vein endothelial cells, foreskin fibroblast and Hep-G2 cells
genes like me logo Genes that share expression patterns with ZNF174: view

Protein tissue co-expression partners for ZNF174 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF174 Gene

Orthologs for ZNF174 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF174 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ZNF174 35
  • 87.55 (n)
  • 88.21 (a)
ZNF174 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp174 35
  • 80.41 (n)
  • 75.31 (a)
Zfp174 16
Zfp174 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF174 35
  • 99.26 (n)
  • 99.02 (a)
ZNF174 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102551846 35
  • 80.58 (n)
  • 76.05 (a)
cow
(Bos Taurus)
Mammalia ZNF174 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 28 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZFP92 36
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZNF174 36
  • 28 (a)
OneToOne
Species with no ortholog for ZNF174:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF174 Gene

ENSEMBL:
Gene Tree for ZNF174 (if available)
TreeFam:
Gene Tree for ZNF174 (if available)

Paralogs for ZNF174 Gene

genes like me logo Genes that share paralogs with ZNF174: view

Variants for ZNF174 Gene

Sequence variations from dbSNP and Humsavar for ZNF174 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs12323 -- 3,409,138(+) ACTGG(A/G)GCAAA utr-variant-3-prime, intron-variant
rs37812 -- 3,403,882(+) TCAGG(A/G)CCTAG intron-variant
rs37813 -- 3,405,079(+) TACTT(C/T)AGATC downstream-variant-500B, intron-variant
rs37814 -- 3,405,247(+) CAAGA(C/T)GACAA downstream-variant-500B, intron-variant
rs37815 -- 3,405,912(+) ctgag(A/G)cagga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF174 Gene

Variant ID Type Subtype PubMed ID
nsv905212 CNV Gain 21882294

Variation tolerance for ZNF174 Gene

Residual Variation Intolerance Score: 52.06% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF174 Gene

HapMap Linkage Disequilibrium report
ZNF174

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF174 Gene

Disorders for ZNF174 Gene

Relevant External Links for ZNF174

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF174
genes like me logo Genes that share disorders with ZNF174: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF174 Gene

Publications for ZNF174 Gene

  1. [Proteomic identification of necrozoospermia-related proteins]. (PMID: 18572863) Luo K.L. … Lu G.X. (Zhonghua Nan Ke Xue 2008) 23 67
  2. Isolation and characterization of a novel zinc-finger protein with transcription repressor activity. (PMID: 7673192) Williams A.J. … Collins T. (J. Biol. Chem. 1995) 23 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67
  5. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. (PMID: 22094256) Anders L. … Sicinski P. (Cancer Cell 2011) 67

Products for ZNF174 Gene

Sources for ZNF174 Gene

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