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Aliases for ZNF17 Gene

Aliases for ZNF17 Gene

  • Zinc Finger Protein 17 2 3 5
  • Zinc Finger Protein 17 (HPF3, KOX 10) 2 3
  • Zinc Finger Protein KOX10 3 4
  • Zinc Finger Protein HPF3 3 4
  • KOX10 3 4
  • KIAA1947 4
  • HPF3 3

External Ids for ZNF17 Gene

Previous GeneCards Identifiers for ZNF17 Gene

  • GC19P058829
  • GC19P058376
  • GC19P062539
  • GC19P062615
  • GC19P062616
  • GC19P062617
  • GC19P057922
  • GC19P054235

Summaries for ZNF17 Gene

GeneCards Summary for ZNF17 Gene

ZNF17 (Zinc Finger Protein 17) is a Protein Coding gene. Diseases associated with ZNF17 include Parainfluenza Virus Type 3 and Croup. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF749.

UniProtKB/Swiss-Prot for ZNF17 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF17 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF17 Gene

Genomics for ZNF17 Gene

GeneHancer (GH) Regulatory Elements for ZNF17 Gene

Promoters and enhancers for ZNF17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I057410 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.2 236 1.8 PKNOX1 ATF1 FOXA2 ARID4B SIN3A DMAP1 YY1 ETS1 SLC30A9 POLR2B ZNF17 ZNF548 ZNF805 ZNF264 ZNF543 ZNF304 ZNF134 GC19P057420 ENSG00000268533 ENSG00000269533
GH19I058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 89.6 +772.1 772075 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF550 ZNF773 LOC105372483 ZNF264
GH19I056594 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 88.7 -815.7 -815721 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 ZNF48 YY1 ZNF71 U2AF2 ZNF17 ZNF543 ZNF549 ZNF264 ZNF773 ENSG00000269696 ZNF550 ZFP28
GH19I058325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 75.1 +915.7 915710 3.6 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZSCAN22 LOC105372480 PIR44424 ZNF134 ZNF606 ZNF417 ZNF549 ZNF135 ZNF17 ZNF446
GH19I057599 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 49.3 +188.9 188876 1.5 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 E2F8 ZNF207 ZNF143 KLF13 ZNF530 ZNF606 ZNF549 ZNF135 ZNF417 ZNF132 ZNF418 ZNF446 ZNF17 LOC105372482
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF17 gene promoter:

Genomic Locations for ZNF17 Gene

Genomic Locations for ZNF17 Gene
chr19:57,411,161-57,421,953
(GRCh38/hg38)
Size:
10,793 bases
Orientation:
Plus strand
chr19:57,922,529-57,933,307
(GRCh37/hg19)

Genomic View for ZNF17 Gene

Genes around ZNF17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF17 Gene

Proteins for ZNF17 Gene

  • Protein details for ZNF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17021-ZNF17_HUMAN
    Recommended name:
    Zinc finger protein 17
    Protein Accession:
    P17021
    Secondary Accessions:
    • B3KXU2
    • B3KY20
    • Q8N7M1
    • Q8N893
    • Q8TF54

    Protein attributes for ZNF17 Gene

    Size:
    662 amino acids
    Molecular mass:
    77204 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04956.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05252.1; Type=Erroneous termination; Positions=461; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF17 Gene

Post-translational modifications for ZNF17 Gene

No Post-translational modifications

Other Protein References for ZNF17 Gene

No data available for DME Specific Peptides for ZNF17 Gene

Domains & Families for ZNF17 Gene

Gene Families for ZNF17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF17 Gene

Suggested Antigen Peptide Sequences for ZNF17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17021

UniProtKB/Swiss-Prot:

ZNF17_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF17: view

Function for ZNF17 Gene

Molecular function for ZNF17 Gene

GENATLAS Biochemistry:
zinc finger protein 17 (KOX10) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF17 Gene

Gene Ontology (GO) - Molecular Function for ZNF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF17: view
genes like me logo Genes that share phenotypes with ZNF17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF17 Gene

Localization for ZNF17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF17 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF17 Gene

Pathways & Interactions for ZNF17 Gene

SuperPathways for ZNF17 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF17: view

Pathways by source for ZNF17 Gene

2 Reactome pathways for ZNF17 Gene

Gene Ontology (GO) - Biological Process for ZNF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF17: view

No data available for SIGNOR curated interactions for ZNF17 Gene

Drugs & Compounds for ZNF17 Gene

(1) Drugs for ZNF17 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ZNF17 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZNF17: view

Transcripts for ZNF17 Gene

Unigene Clusters for ZNF17 Gene

Zinc finger protein 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF17 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1:
SP2: -
SP3: -
SP4: - -

Relevant External Links for ZNF17 Gene

GeneLoc Exon Structure for
ZNF17
ECgene alternative splicing isoforms for
ZNF17

Expression for ZNF17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF17 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF17 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF17 Gene:

ZNF17

SOURCE GeneReport for Unigene cluster for ZNF17 Gene:

Hs.729403

Evidence on tissue expression from TISSUES for ZNF17 Gene

  • Spleen(4.2)
  • Nervous system(4.2)
  • Liver(4)
genes like me logo Genes that share expression patterns with ZNF17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF17 Gene

Orthologs for ZNF17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF17 33
  • 99.3 (n)
cow
(Bos Taurus)
Mammalia ZNF17 33
  • 71.81 (n)
-- 34
  • 49 (a)
ManyToMany
Species where no ortholog for ZNF17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF17 Gene

ENSEMBL:
Gene Tree for ZNF17 (if available)
TreeFam:
Gene Tree for ZNF17 (if available)

Paralogs for ZNF17 Gene

(494) SIMAP similar genes for ZNF17 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF17: view

Variants for ZNF17 Gene

Sequence variations from dbSNP and Humsavar for ZNF17 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000195050 -- 57,408,405(+) C/T upstream_transcript_variant
rs1000371523 -- 57,408,108(+) C/A/T upstream_transcript_variant
rs1000400318 -- 57,414,190(+) T/C intron_variant
rs1000755043 -- 57,412,443(+) AAAA/AA intron_variant
rs1000774038 -- 57,419,703(+) G/A coding_sequence_variant, missense_variant

Variation tolerance for ZNF17 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF17 Gene

Human Gene Mutation Database (HGMD)
ZNF17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF17 Gene

Disorders for ZNF17 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF17 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
parainfluenza virus type 3
  • human parainfluenza virus type 3
croup
  • acute laryngotracheobronchitis
- elite association - COSMIC cancer census association via MalaCards
Search ZNF17 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZNF17

genes like me logo Genes that share disorders with ZNF17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF17 Gene

Publications for ZNF17 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 58
  4. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (PMID: 2014798) Huebner K … Thiesen HJ (American journal of human genetics 1991) 2 3 58
  5. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4 58

Products for ZNF17 Gene

Sources for ZNF17 Gene

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