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Aliases for ZNF169 Gene

Aliases for ZNF169 Gene

  • Zinc Finger Protein 169 2 3 5
  • EC 2.1.1.43 61

External Ids for ZNF169 Gene

Previous GeneCards Identifiers for ZNF169 Gene

  • GC09U990077
  • GC09M088768
  • GC09P090320
  • GC09P092363
  • GC09P092382
  • GC09P094101
  • GC09P096061
  • GC09P097021
  • GC09P066701

Summaries for ZNF169 Gene

GeneCards Summary for ZNF169 Gene

ZNF169 (Zinc Finger Protein 169) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF133.

UniProtKB/Swiss-Prot for ZNF169 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF169 Gene

Genomics for ZNF169 Gene

Regulatory Elements for ZNF169 Gene

Enhancers for ZNF169 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F094277 0.9 Ensembl ENCODE 7.3 +19.6 19635 1.9 PKNOX1 ATF1 GATA2 FOS JUNB NCOA1 REST MBD2 MEF2D SMARCA4 MFSD14B LOC100132077 ZNF169 GC09P094279 PIR44325 PIR48739
GH09F094899 1.1 Ensembl ENCODE 5.9 +643.1 643087 5.7 TBP ZNF133 RAD21 RARA YY1 RCOR1 FOS CREM MIXL1 CEBPB MIR2278 FBP1 ZNF169 ENSG00000236095 LOC101928119
GH09F094911 1.4 FANTOM5 Ensembl ENCODE 5.9 +661.5 661536 19.6 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF548 FOS DEK ZHX2 MIR2278 ENSG00000271155 LOC100132077 FBP1 ZNF169 FANCC C9orf3 LOC101928119 ENSG00000236095
GH09F094949 1.5 FANTOM5 Ensembl ENCODE 5.6 +692.5 692544 5.0 ELF3 PKNOX1 SIN3A THRB RAD21 RARA RFX5 YY1 RCOR1 MIXL1 ZNF169 FBP1 C9orf3 LOC101928119 MIR6081
GH09F094781 1 Ensembl ENCODE 5.5 +524.9 524925 4.7 HDGF PKNOX1 SIN3A BRCA1 FOS DEK MIER2 REST ZNF623 ZNF592 ZNF169 MIR2278 MIR24-1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF169 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF169 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001308798 334 1601 HDGF ATF1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF2

Genomic Location for ZNF169 Gene

Chromosome:
9
Start:
94,259,266 bp from pter
End:
94,303,008 bp from pter
Size:
43,743 bases
Orientation:
Plus strand

Genomic View for ZNF169 Gene

Genes around ZNF169 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF169 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF169 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF169 Gene

Proteins for ZNF169 Gene

  • Protein details for ZNF169 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14929-ZN169_HUMAN
    Recommended name:
    Zinc finger protein 169
    Protein Accession:
    Q14929
    Secondary Accessions:
    • A2AGP5
    • A8K127
    • Q6PI28

    Protein attributes for ZNF169 Gene

    Size:
    603 amino acids
    Molecular mass:
    68488 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47702.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF82431.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF169 Gene

Selected DME Specific Peptides for ZNF169 Gene

Post-translational modifications for ZNF169 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ZNF169 Gene

Gene Families for ZNF169 Gene

Graphical View of Domain Structure for InterPro Entry

Q14929

UniProtKB/Swiss-Prot:

ZN169_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF169: view

Function for ZNF169 Gene

Molecular function for ZNF169 Gene

GENATLAS Biochemistry:
zinc finger protein 169 (C2H2,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Enzyme Numbers (IUBMB) for ZNF169 Gene

Gene Ontology (GO) - Molecular Function for ZNF169 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF169: view

Phenotypes for ZNF169 Gene

genes like me logo Genes that share phenotypes with ZNF169: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF169 Gene

Localization for ZNF169 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF169 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF169 Gene COMPARTMENTS Subcellular localization image for ZNF169 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF169 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF169: view

Pathways & Interactions for ZNF169 Gene

SuperPathways for ZNF169 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF169: view

Pathways by source for ZNF169 Gene

2 Reactome pathways for ZNF169 Gene

Gene Ontology (GO) - Biological Process for ZNF169 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF169: view

No data available for SIGNOR curated interactions for ZNF169 Gene

Transcripts for ZNF169 Gene

Unigene Clusters for ZNF169 Gene

Zinc finger protein 169:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF169 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: -
SP3: - -
SP4: -
SP5:

Relevant External Links for ZNF169 Gene

GeneLoc Exon Structure for
ZNF169
ECgene alternative splicing isoforms for
ZNF169

Expression for ZNF169 Gene

mRNA expression in normal human tissues for ZNF169 Gene

Protein differential expression in normal tissues from HIPED for ZNF169 Gene

This gene is overexpressed in Platelet (43.5), Plasma (11.8), and Lung (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF169 Gene



Protein tissue co-expression partners for ZNF169 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF169 Gene:

ZNF169

SOURCE GeneReport for Unigene cluster for ZNF169 Gene:

Hs.387623

mRNA Expression by UniProt/SwissProt for ZNF169 Gene:

Q14929-ZN169_HUMAN
Tissue specificity: Highly expressed in kidney, weakly expressed in heart, liver, spleen, and small intestine. Not expressed in adult brain or spinal cord.
genes like me logo Genes that share expression patterns with ZNF169: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF169 Gene

Orthologs for ZNF169 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF169 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF169 34 35
  • 99.23 (n)
cow
(Bos Taurus)
Mammalia ZNF169 34 35
  • 81.38 (n)
dog
(Canis familiaris)
Mammalia ZNF169 34
  • 81.1 (n)
rat
(Rattus norvegicus)
Mammalia Zfp169 34
  • 72.28 (n)
mouse
(Mus musculus)
Mammalia Zfp169 34 16 35
  • 72.26 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSF2 37
Species where no ortholog for ZNF169 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF169 Gene

ENSEMBL:
Gene Tree for ZNF169 (if available)
TreeFam:
Gene Tree for ZNF169 (if available)

Paralogs for ZNF169 Gene

Paralogs for ZNF169 Gene

(533) SIMAP similar genes for ZNF169 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF169: view

Variants for ZNF169 Gene

Sequence variations from dbSNP and Humsavar for ZNF169 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10114209 -- 94,257,638(+) TTGCA(A/G)AGACT upstream-variant-2KB
rs10122555 -- 94,272,448(+) tttcc(C/T)cttcc intron-variant, upstream-variant-2KB
rs10217472 -- 94,279,146(+) cagta(C/T)tttgg intron-variant
rs10435913 -- 94,281,405(+) GGGAG(C/G)TGGTA intron-variant
rs10435925 -- 94,279,581(+) GTTGC(A/G)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF169 Gene

Variant ID Type Subtype PubMed ID
dgv1491e214 CNV gain 21293372
esv1152524 CNV insertion 17803354
esv2761545 CNV gain 21179565
esv3621113 CNV gain 21293372
esv3621119 CNV gain 21293372
nsv1046906 CNV gain 25217958
nsv1112196 CNV deletion 24896259
nsv1135294 CNV deletion 24896259
nsv831655 CNV gain 17160897
nsv968732 CNV duplication 23825009

Variation tolerance for ZNF169 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.47; 88.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF169 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF169

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF169 Gene

Disorders for ZNF169 Gene

Relevant External Links for ZNF169

Genetic Association Database (GAD)
ZNF169
Human Genome Epidemiology (HuGE) Navigator
ZNF169
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF169

No disorders were found for ZNF169 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF169 Gene

Publications for ZNF169 Gene

  1. Characterization of a YAC contig containing the NBCCS locus and a novel Kruppel-type zinc finger sequence on chromosome segment 9q22.3. (PMID: 9071574) Chidambaram A. … Dean M. (Genes Chromosomes Cancer 1997) 2 3 4 64
  2. Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. (PMID: 22344221) Okada Y. … Tanaka T. (Nat. Genet. 2012) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Pulsed-field gel electrophoresis and FISH mapping of chromosome 9q22: placement of a novel zinc finger gene within the NBCCS and ESS1 region. (PMID: 9186526) Levanat S. … Bale A.E. (Cytogenet. Cell Genet. 1997) 2 3 64
  5. HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP. (PMID: 25925205) Bhattacharya S. … Ghosh M.K. (Cell Oncol (Dordr) 2015) 3 64

Products for ZNF169 Gene

Sources for ZNF169 Gene

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