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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF169 Gene

protein-coding   GIFtS: 53
GCID: GC09P097021

Zinc Finger Protein 169

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 1691 2
EC 2.1.1.438

External Ids:    HGNC: 129571   Entrez Gene: 1698412   Ensembl: ENSG000001757877   OMIM: 6034045   UniProtKB: Q149293   

Export aliases for ZNF169 gene to outside databases

Previous GC identifers: GC09U990077 GC09M088768 GC09P090320 GC09P092363 GC09P092382 GC09P094101 GC09P096061 GC09P066701


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF169 Gene: 
ZNF169 (zinc finger protein 169) is a protein-coding gene. Diseases associated with ZNF169 include multiple self healing squamous epithelioma, and hereditary sensory neuropathy, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF589.

UniProtKB/Swiss-Prot: ZN169_HUMAN, Q14929
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF169 gene promoter:
         Elk-1   MAZR   RREB-1   LUN-1   Cdc5   HNF-3beta   NF-kappaB   MZF-1   CP2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF169 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF169

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF169


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.32   Ensembl cytogenetic band:  9q22.32   HGNC cytogenetic band: 9q22.32

ZNF169 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF169 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P097021:  view genomic region     (about GC identifiers)

Start:
97,021,578 bp from pter      End:
97,065,291 bp from pter
Size:
43,714 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN169_HUMAN, Q14929 (See protein sequence)
Recommended Name: Zinc finger protein 169  
Size: 603 amino acids; 68488 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH47702.1; Type=Erroneous initiation; Sequence=BAF82431.1; Type=Erroneous initiation;
Secondary accessions: A2AGP5 A8K127 Q6PI28

Explore the universe of human proteins at neXtProt for ZNF169: NX_Q14929

Explore proteomics data for ZNF169 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14929

  • 2 DME Specific Peptides for ZNF169 (Q14929)
     CRECGRGF  HQRTHTGEKPY 

    ZNF169 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF169 Protein Expression
    REFSEQ proteins: NP_919301.2  
    ENSEMBL proteins: 
     ENSP00000378792   ENSP00000340711   ENSP00000474608   ENSP00000475038   ENSP00000364503  
    Reactome Protein details: Q14929
    Human Recombinant Protein Products for ZNF169: 
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    Cloud-Clone Corp. Proteins for ZNF169 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus NAS--

    ZNF169 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q14929

    ProtoNet protein and cluster: Q14929

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN169_HUMAN, Q14929
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF169 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN169_HUMAN, Q14929
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF169:
    zinc finger protein 169 (C2H2,Kruppel-like)

         Enzyme Number (IUBMB): EC 2.1.1.432

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF169 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF169 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF169
        Generic Transcription Pathway
    Gene Expression



    ZNF169 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF169

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--

    ZNF169 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF169 (ZN169)

    Search CenterWatch for drugs/clinical trials and news about ZNF169 / ZN169

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF169 gene: 
    NM_194320.2  

    Unigene Cluster for ZNF169:

    Zinc finger protein 169
    Hs.387623  [show with all ESTs]
    Unigene Representative Sequence: AK122832
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395395(uc004aum.1) ENST00000492115 ENST00000340911(uc022bki.1)
    ENST00000481550(uc004aun.3) ENST00000480716(uc004auo.3) ENST00000375354

    miRNA
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    hsa-miR-513a-5p
    SwitchGear 3'UTR luciferase reporter plasmidZNF169 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK093956.1 AK122832.1 AK289742.1 BC011947.2 BC019228.3 BC035060.2 BC047702.2 

    9 DOTS entries:

    DT.101982918  DT.308788  DT.101966447  DT.95084953  DT.208216  DT.91935611  DT.75140696  DT.92003625 
    DT.95162694 

    24/39 AceView cDNA sequences (see all 39):

    CR608109 AA398957 BX279717 AK122832 BP873364 BC035060 AI095009 AK093956 
    BC047702 T70255 BC011947 AA770358 AI379532 BX338539 AA399540 AW137410 
    NM_194320 AA805446 AA255753 R48755 T88890 BX111198 BC019228 CF136819 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF169    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:              -                 -                 -               
    SP2:                                -                                 
    SP3:                                -                 -               
    SP4:                                -                                 
    SP5:                                                                  


    ECgene alternative splicing isoforms for ZNF169

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF169 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF169 Expression
    About this image


    See ZNF169 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF169

    SOURCE GeneReport for Unigene cluster: Hs.387623

    UniProtKB/Swiss-Prot: ZN169_HUMAN, Q14929
    Tissue specificity: Highly expressed in kidney, weakly expressed in heart, liver, spleen, and small intestine. Not
    expressed in adult brain or spinal cord

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF169 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp1691 , 5 zinc finger protein 1691, 5 72.26(n)1
    63.56(a)1
      13 (24.81 cM)5
    679111  NM_001164575.11  NP_001158047.11 
     484876475 


    ENSEMBL Gene Tree for ZNF169 (if available)
    TreeFam Gene Tree for ZNF169 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF169 gene
    ZNF5892  ZNF1332  ENSG000002565662  ZNF3432  HKR12  
    18/540 SIMAP similar genes for ZNF169 using alignment to 6 protein entries:     ZN169_HUMAN (see all proteins) (see all similar genes):
    FAM175A    C16orf89    TMEM44    ZNF324B    FLJ00301    ZNF300P1
    ZNF577    ZNF225    ZNF420    ZNF350    ZNF229    ZFP57
    ZNF320    ZNF677    ZNF419    ZFS-4    ZNF669    ZNF155

    ZNF169 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1029 SNPs in ZNF169 are shown (see all 1029)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1840513861,2
    --97019678(+) TATGAC/TTTGGA 1 -- us2k10--------
    rs1885882901,2
    --97019756(+) TGTCAA/GATGTC 1 -- us2k10--------
    rs788508421,2
    C--97019782(+) TATTTT/CGTCCT 1 -- us2k12Minor allele frequency- C:0.09NA 122
    rs1809964801,2
    --97019832(+) TGTTAC/TTTCAT 1 -- us2k10--------
    rs101142091,2
    C,F,H--97019920(+) TTGCAA/GAGACT 1 -- us2k18Minor allele frequency- G:0.22NS EA WA CSA 534
    rs563408131,2
    C--97020082(+) AATCTC/TCTTCT 1 -- us2k10--------
    rs800598091,2
    F--97020144(+) CATACA/GCACTG 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1160016091,2
    F--97020277(+) ACCAAA/GAATCA 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs1852774551,2
    C--97020324(+) GACTGA/CAAGAG 1 -- us2k10--------
    rs1442081401,2
    --97020329(+) AAAGAA/GGCACT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF169 (97021578 - 97065291 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF169:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1152524CNV Insertion17803354
    nsv831655CNV Gain17160897
    nsv893592CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603404    OMIM disorders: --

    3 diseases for ZNF169:    About MalaCards
    multiple self healing squamous epithelioma    hereditary sensory neuropathy    neuropathy


    ZNF169 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF169
    Human Genome Epidemiology (HuGE) Navigator: ZNF169 (1 document)

    Export disorders for ZNF169 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF169 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF169)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a YAC contig containing the NBCCS locus and a novel Kruppel-type zinc finger sequence on chromosome segment 9q22.3. (PubMed id 9071574)1, 2, 3 Chidambaram A.... Dean M. (1997)
    2. Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. (PubMed id 22344221)1, 4 Okada Y....Tanaka T. (2012)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Pulsed-field gel electrophoresis and FISH mapping of chromosome 9q22: placement of a novel zinc finger gene within the NBCCS and ESS1 region. (PubMed id 9186526)1, 3 Levanat S....Bale A.E. (1997)
    5. A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome. (PubMed id 21121903)4 Rasi S....Rossi D. (2011)
    6. Distinct class of putative 'non-conserved' promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PubMed id 17567985)1 Tsuritani K....Suzuki Y. (2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 169841 HGNC: 12957 AceView: ZNF169 Ensembl:ENSG00000175787 euGenes: HUgn169841
    ECgene: ZNF169 H-InvDB: ZNF169

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF169 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF169 gene:
    Search GeneIP for patents involving ZNF169

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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