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Aliases for ZNF169 Gene

Aliases for ZNF169 Gene

  • Zinc Finger Protein 169 2 3 5
  • EC 63

External Ids for ZNF169 Gene

Previous GeneCards Identifiers for ZNF169 Gene

  • GC09U990077
  • GC09M088768
  • GC09P090320
  • GC09P092363
  • GC09P092382
  • GC09P094101
  • GC09P096061
  • GC09P097021
  • GC09P066701

Summaries for ZNF169 Gene

GeneCards Summary for ZNF169 Gene

ZNF169 (Zinc Finger Protein 169) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is HKR1.

UniProtKB/Swiss-Prot for ZNF169 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF169 Gene

Genomics for ZNF169 Gene

Regulatory Elements for ZNF169 Gene

Enhancers for ZNF169 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF169 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF169 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF169 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF169 Gene

94,259,266 bp from pter
94,303,008 bp from pter
43,743 bases
Plus strand

Genomic View for ZNF169 Gene

Genes around ZNF169 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF169 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF169 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF169 Gene

Proteins for ZNF169 Gene

  • Protein details for ZNF169 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 169
    Protein Accession:
    Secondary Accessions:
    • A2AGP5
    • A8K127
    • Q6PI28

    Protein attributes for ZNF169 Gene

    603 amino acids
    Molecular mass:
    68488 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH47702.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF82431.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF169 Gene

Proteomics data for ZNF169 Gene at MOPED

Selected DME Specific Peptides for ZNF169 Gene

Post-translational modifications for ZNF169 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF169 Gene

Domains & Families for ZNF169 Gene

Gene Families for ZNF169 Gene

Protein Domains for ZNF169 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF169: view

Function for ZNF169 Gene

Molecular function for ZNF169 Gene

GENATLAS Biochemistry:
zinc finger protein 169 (C2H2,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Enzyme Numbers (IUBMB) for ZNF169 Gene

Phenotypes for ZNF169 Gene

GenomeRNAi human phenotypes for ZNF169:
genes like me logo Genes that share phenotypes with ZNF169: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF169 Gene

Localization for ZNF169 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF169 Gene

Subcellular locations from

Jensen Localization Image for ZNF169 Gene COMPARTMENTS Subcellular localization image for ZNF169 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF169 Gene

Pathways & Interactions for ZNF169 Gene

SuperPathways for ZNF169 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF169: view

Pathways by source for ZNF169 Gene

2 Reactome pathways for ZNF169 Gene

Gene Ontology (GO) - Biological Process for ZNF169 Gene


No data available for SIGNOR curated interactions for ZNF169 Gene

Drugs & Compounds for ZNF169 Gene

No Compound Related Data Available

Transcripts for ZNF169 Gene

Unigene Clusters for ZNF169 Gene

Zinc finger protein 169:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF169 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for ZNF169 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF169 Gene

mRNA expression in normal human tissues for ZNF169 Gene

Protein differential expression in normal tissues from HIPED for ZNF169 Gene

This gene is overexpressed in Platelet (43.5), Plasma (11.8), and Lung (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF169 Gene

SOURCE GeneReport for Unigene cluster for ZNF169 Gene Hs.387623

mRNA Expression by UniProt/SwissProt for ZNF169 Gene

Tissue specificity: Highly expressed in kidney, weakly expressed in heart, liver, spleen, and small intestine. Not expressed in adult brain or spinal cord.
genes like me logo Genes that share expression patterns with ZNF169: view

Protein tissue co-expression partners for ZNF169 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF169 Gene

Orthologs for ZNF169 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF169 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF169 35
  • 81.38 (n)
  • 78.76 (a)
ZNF169 36
  • 78 (a)
(Canis familiaris)
Mammalia ZNF169 35
  • 81.1 (n)
  • 80.11 (a)
(Mus musculus)
Mammalia Zfp169 35
  • 72.26 (n)
  • 63.56 (a)
Zfp169 16
Zfp169 36
  • 43 (a)
(Pan troglodytes)
Mammalia ZNF169 35
  • 99.23 (n)
  • 98.34 (a)
ZNF169 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Zfp169 35
  • 72.28 (n)
  • 63.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSF2 38
Species with no ortholog for ZNF169:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF169 Gene

Gene Tree for ZNF169 (if available)
Gene Tree for ZNF169 (if available)

Paralogs for ZNF169 Gene

Paralogs for ZNF169 Gene

(533) SIMAP similar genes for ZNF169 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF169: view

Variants for ZNF169 Gene

Sequence variations from dbSNP and Humsavar for ZNF169 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1536690 - 94,293,028(-) TCCAA(A/C/G)GTTCG reference, missense, utr-variant-5-prime
rs12236219 - 94,300,699(+) GTGGG(C/T)GTAGC reference, missense
rs35177967 - 94,293,045(+) AGAAC(A/G)AACAT reference, missense, utr-variant-5-prime
rs34433105 - 94,300,013(+) CAGCT(C/T)ATTAA reference, missense, utr-variant-5-prime
rs12350212 - 94,301,346(+) CATCA(C/G)CTCCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF169 Gene

Variant ID Type Subtype PubMed ID
nsv831655 CNV Gain 17160897
nsv893592 CNV Gain 21882294
esv1152524 CNV Insertion 17803354

Variation tolerance for ZNF169 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.47; 88.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF169 Gene

Disorders for ZNF169 Gene

Relevant External Links for ZNF169

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF169 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF169 Gene

Publications for ZNF169 Gene

  1. Characterization of a YAC contig containing the NBCCS locus and a novel Kruppel-type zinc finger sequence on chromosome segment 9q22.3. (PMID: 9071574) Chidambaram A. … Dean M. (Genes Chromosomes Cancer 1997) 2 3 4 67
  2. Pulsed-field gel electrophoresis and FISH mapping of chromosome 9q22: placement of a novel zinc finger gene within the NBCCS and ESS1 region. (PMID: 9186526) Levanat S. … Bale A.E. (Cytogenet. Cell Genet. 1997) 2 3
  3. HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP. (PMID: 25925205) Bhattacharya S. … Ghosh M.K. (Cell Oncol (Dordr) 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. (PMID: 22344221) Okada Y. … Tanaka T. (Nat. Genet. 2012) 3

Products for ZNF169 Gene

Sources for ZNF169 Gene