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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF165 Gene

protein-coding   GIFtS: 51
GCID: GC06P028046

zinc finger protein 165
 Explore 2 diseases affiliated with
ZNF165 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZNF165    

Aliases
for ZNF165 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zinc Finger Protein 1651 2     Cancer/Testis Antigen 532 3
CT531 2 3     Zinc Finger And SCAN Domain-Containing Protein 72 3
ZSCAN71 2 3     ZPF1653
LD652 3 5     

External Ids:    HGNC: 129531   Entrez Gene: 77182   Ensembl: ENSG000001972797   OMIM: 6008345   UniProtKB: P499103   

Export aliases for ZNF165 gene to outside databases

Previous GC identifers: GC06P028106 GC06P028155 GC06P028159 GC06P028164 GC06P028165 GC06P027856


Summaries
for ZNF165 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ZNF165:
This gene encodes a member of the Kruppel family of zinc finger proteins. Members of this DNA-binding protein family
act as transcriptional regulators. This gene is located within a cluster of zinc finger family members. The encoded
protein may play a role in spermatogenesis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ZN165_HUMAN, P49910
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF165 (Zinc finger protein 165)


Genomic Views
for ZNF165 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF165 gene promoter:
         TBP   Sox5   AML1a   p53   HSF1 (long)   MyoD   TFIID   HSF1short   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF165 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF165

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF165


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21

ZNF165 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF165 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P028046:  view genomic region     (about GC identifiers)

Start:
 28,048,482 bp from pter      End:
 28,057,341 bp from pter
Size:
 8,860 bases      Orientation:
 plus strand

Proteins
for ZNF165 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZN165_HUMAN, P49910 (See protein sequence)
Recommended Name: Zinc finger protein 165  
Size: 485 amino acids; 55771 Da
Subcellular location: Nucleus (Potential)

Explore the universe of human proteins at neXtProt for ZNF165: NX_P49910

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49910

    • ZNF165 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003438.1  
    ENSEMBL proteins: 
     ENSP00000366542  

    Human Recombinant Protein Products: 
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    Uscn Proteins for ZNF165

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--


    ZNF165 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ZNF165 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZNF165 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR008916 Retrov_capsid_C
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2
     IPR003309 Tscrpt_reg_SCAN

    Graphical View of Domain Structure for InterPro Entry P49910

    ProtoNet protein and cluster: P49910

    2 Blocks protein families:
    IPB003309 Transcriptional regulator SCAN
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN165_HUMAN, P49910
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 6 C2H2-type zinc fingers
    Similarity: Contains 1 SCAN box domain


    Function
    for ZNF165 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZN165_HUMAN, P49910
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF165:
    zinc finger protein 165,C2H2 type,Kruppel-like,specifically expressed in testis

    miRNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--
    GO:0005515protein binding IPI16189514
    GO:0008270zinc ion binding IEA--


    ZNF165 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ZNF165 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF165

    5/17 Interacting proteins for ZNF165 (P499101, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC130P139941, 3EBI-741694,EBI-716093 I2D: score=5 
    DVL2O146411, 3EBI-741694,EBI-740850 I2D: score=5 
    EWSR1Q018441, 3EBI-741694,EBI-739737 I2D: score=4 
    CCDC85BQ158343I2D: score=4 
    KAT7O952513I2D: score=4 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0016032viral reproduction IEA--


    ZNF165 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZNF165 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF165
    Search CenterWatch for drugs/clinical trials and news about ZNF165 / ZN165 

    Transcripts
    for ZNF165 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZNF165 gene: 
    NM_003447.3  

    Unigene Cluster for ZNF165:

    Zinc finger protein 165
    Hs.55481  [show with all ESTs]
    Unigene Representative Sequence: AY083664
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377325(uc021yro.1 uc003nkh.3 uc003nki.4)

    miRNA
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    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AK292371.1 AY083664.1 AY366500.1 BC026092.1 BC037779.2 U78722.1 X84801.1 

    4 DOTS entries:

    DT.308303  DT.95249015  DT.91805739  DT.40113765 

    24/26 AceView cDNA sequences (see all 26):

    AY366500 NM_003447 AY083664 BX104338 AI798474 BC026092 X84801 BF980027 
    U78722 BE613722 BC037779 BF979736 W31899 BG771463 BM829284 AI559497 
    W39262 BE614607 BE000513 AI581244 BI465337 C05700 AI792510 AI254486 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF165    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5
    SP1:                                                            
    SP2:                          -     -                           
    SP3:                                -                           
    SP4:              -     -     -     -                           


    ECgene alternative splicing isoforms for ZNF165

    Expression
    for ZNF165 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF165 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGGAAAACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZNF165 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZNF165 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF165

    SOURCE GeneReport for Unigene cluster: Hs.55481

    UniProtKB/Swiss-Prot: ZN165_HUMAN, P49910
    Tissue specificity: Expressed specifically in testis

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    In Situ
    Assay Products:     
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    Orthologs
    for ZNF165 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for ZNF165 (if available)
    TreeFam Gene Tree for ZNF165 (if available) 

    Paralogs
    for ZNF165 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF165 gene
    ZNF4962  ZNF4492  ZNF4462  ZSCAN92  ZKSCAN12  ZNF3972  ZNF5002  ZNF2132  
    ZSCAN302  ZNF2322  ZNF2632  ZNF2022  ZKSCAN42  ZNF1742  ZSCAN252  ZNF3962  
    ZSCAN122  ZNF3942  ZSCAN212  ZSCAN232  ZSCAN162  ZKSCAN82  ZSCAN312  ZSCAN222  
    ZKSCAN32  ZNF242  ZNF182  
    18/386 SIMAP similar genes for ZNF165 using alignment to 3 protein entries:     ZN165_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    HZF36    ZFP41    ZNF211    ZNF70    ZNF829
    ZNF22    ZNF781    ZNF780B    ZSCAN18    ZIK1    DKFZp666C237
    ZNF818P    ZNF324    ZNF92    ZNF324B    zf30    DKFZp686K03205

    ZNF165 for paralogs           About GeneDecksing



    Genomic Variants
    for ZNF165 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/170 NCBI SNPs in ZNF165 are shown (see all 170)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1821382561,2
    		--28046659(+) GGCCTC/TAGAAG 1 -- us2k10--------
    rs2038761,2
    		C,F,O,A,H,--28046673(+) AGTTGT/CCTGGG 1 -- us2k1 ese325Minor allele frequency- C:0.34MN NS EA NA WA CSA 2844
    rs93938841,2
    		C,F,A,--28046789(+) CTAGAA/GTGCAG 1 -- us2k18Minor allele frequency- G:0.28NA WA CSA EA 368
    rs779549141,2
    		--28046811(+) CAGCTC/TACTAT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1868099121,2
    		--28046936(+) AGAGAC/GGAGGT 1 -- us2k10--------
    rs767885041,2
    		C,--28047014(+) AAAGCG/AGGGAA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs748932381,2
    		F,--28047044(+) CGCCCG/AGCCCA 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs122111991,2
    		C--28047070(+) AAAAAA/CAAAAG 1 -- us2k10--------
    rs349943311,2
    		C,--28047088(+) CTGACAGAT/-  
                AGAGC     		1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs611287121,2
    		C--28047091(+) ACAGA-/TAGA  
                GCCAG     		1 -- us2k11Minor allele frequency- TAGA:0.00NA 2

    HapMap Linkage Disequilibrium report for ZNF165 (28048482 - 28057341 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZNF165
         1 CNV: 7557

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    Disorders / Diseases
    for ZNF165 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZNF165 for disorders           About GeneDecksing

    OMIM gene information: 600834    OMIM disorders: --

    2 diseases for ZNF165:    About MalaCards
    hemochromatosis    colon cancer


    Export disorders for ZNF165 gene to outside databases

    Publications
    for ZNF165 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF165 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF165)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a novel zinc finger gene (ZNF165) mapping to 6p21 that is expressed specifically in testis. (PubMed id 7490084)1, 2, 3 Tirosvoutis K.N.... Affara N.A. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain. (PubMed id 9244436)1, 2 Lee P.L.... Beutler E. (1997)
    5. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Familial t(6;21)(p21.1;p13) translocation associated with male-only sterility. (PubMed id 11076058)1 Paoloni-Giacobino A....Dahoun S.P. (2000)
    8. The zinc finger-associated SCAN box is a conserved oligomerization domain. (PubMed id 10567577)1 Williams A.J....Collins T. (1999)
    9. A strategy for cloning the hereditary hemochromatosis gene. (PubMed id 8673473)1 Beutler E.... Lee P. (1995)
    10. [Development of a K562 multidrug-resistant cell line and study on proteins with altered expression] (PubMed id 14724945)9 Wang Y....Zeng S. (2003)

    External Searches for ZNF165 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing ZNF165 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7718 HGNC: 12953 AceView: ZNF165 Ensembl:ENSG00000197279 euGenes: HUgn7718
    ECgene: ZNF165 H-InvDB: ZNF165

    Other Databases showing ZNF165 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZNF165 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF165 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZNF165 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZNF165 gene:
    Search GeneIP for patents involving ZNF165

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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