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Aliases for ZNF165 Gene

Aliases for ZNF165 Gene

  • Zinc Finger Protein 165 2 3 5
  • Cancer/Testis Antigen 53 2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 7 3 4
  • ZSCAN7 3 4
  • CT53 3 4
  • LD65 3 4
  • ZPF165 4

External Ids for ZNF165 Gene

Previous GeneCards Identifiers for ZNF165 Gene

  • GC06P028106
  • GC06P028155
  • GC06P028159
  • GC06P028164
  • GC06P028165
  • GC06P028046
  • GC06P027856

Summaries for ZNF165 Gene

Entrez Gene Summary for ZNF165 Gene

  • This gene encodes a member of the Kruppel family of zinc finger proteins. Members of this DNA-binding protein family act as transcriptional regulators. This gene is located within a cluster of zinc finger family members. The encoded protein may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF165 Gene

ZNF165 (Zinc Finger Protein 165) is a Protein Coding gene. Diseases associated with ZNF165 include Suppurative Thyroiditis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZSCAN16.

UniProtKB/Swiss-Prot for ZNF165 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF165 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF165 Gene

Genomics for ZNF165 Gene

Regulatory Elements for ZNF165 Gene

Enhancers for ZNF165 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF165 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF165 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF165 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF165 Gene

28,080,704 bp from pter
28,089,563 bp from pter
8,860 bases
Plus strand

Genomic View for ZNF165 Gene

Genes around ZNF165 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF165 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF165 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF165 Gene

Proteins for ZNF165 Gene

  • Protein details for ZNF165 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 165
    Protein Accession:

    Protein attributes for ZNF165 Gene

    485 amino acids
    Molecular mass:
    55771 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF165 Gene

Proteomics data for ZNF165 Gene at MOPED

Post-translational modifications for ZNF165 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF165 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF165 Gene

Domains & Families for ZNF165 Gene

Gene Families for ZNF165 Gene

Suggested Antigen Peptide Sequences for ZNF165 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 6 C2H2-type zinc fingers.
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF165: view

Function for ZNF165 Gene

Molecular function for ZNF165 Gene

GENATLAS Biochemistry:
zinc finger protein 165,C2H2 type,Kruppel-like,specifically expressed in testis
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF165 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with ZNF165: view
genes like me logo Genes that share phenotypes with ZNF165: view

Animal Model Products

CRISPR Products

miRNA for ZNF165 Gene

miRTarBase miRNAs that target ZNF165
Targeted motifs for ZNF165 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF165
  • Consensus sequence: AAGGKGRCGCAGGCA Submotif: canonical Cell Type: WHIM12 GEO ID: GSE65937

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF165 Gene

Localization for ZNF165 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF165 Gene

Subcellular locations from

Jensen Localization Image for ZNF165 Gene COMPARTMENTS Subcellular localization image for ZNF165 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF165 Gene

Pathways & Interactions for ZNF165 Gene

SuperPathways for ZNF165 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF165 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF165 Gene

Drugs & Compounds for ZNF165 Gene

No Compound Related Data Available

Transcripts for ZNF165 Gene

mRNA/cDNA for ZNF165 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF165 Gene

Zinc finger protein 165:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF165 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5
SP2: - -
SP3: -
SP4: - - - -

Relevant External Links for ZNF165 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF165 Gene

mRNA expression in normal human tissues for ZNF165 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF165 Gene

This gene is overexpressed in Testis (x11.7).

SOURCE GeneReport for Unigene cluster for ZNF165 Gene Hs.55481

mRNA Expression by UniProt/SwissProt for ZNF165 Gene

Tissue specificity: Expressed specifically in testis.
genes like me logo Genes that share expression patterns with ZNF165: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZNF165 Gene

Orthologs for ZNF165 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF165 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF165 35
  • 86.19 (n)
  • 80.41 (a)
ZNF165 36
  • 80 (a)
(Canis familiaris)
Mammalia ZNF165 35
  • 84.24 (n)
  • 75.79 (a)
(Pan troglodytes)
Mammalia ZNF165 35
  • 99.59 (n)
  • 99.38 (a)
ZNF165 36
  • 99 (a)
Species with no ortholog for ZNF165:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF165 Gene

Gene Tree for ZNF165 (if available)
Gene Tree for ZNF165 (if available)

Paralogs for ZNF165 Gene

(390) SIMAP similar genes for ZNF165 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF165: view

Variants for ZNF165 Gene

Sequence variations from dbSNP and Humsavar for ZNF165 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1321504 -- 28,084,991(+) ATTTC(C/G)TATTT intron-variant
rs1321505 -- 28,085,045(+) ATTTC(A/C)TGTTT intron-variant
rs10484404 -- 28,087,717(+) AAGGG(C/T)GGTTC intron-variant
rs10946951 -- 28,085,919(+) AAGAC(A/C)TCCAT intron-variant
rs203866 -- 28,083,572(-) CTGCA(C/T)AGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF165 Gene

Variant ID Type Subtype PubMed ID
nsv830619 CNV Loss 17160897
esv33436 CNV Gain 17666407
dgv1005n67 CNV Gain 20364138

Variation tolerance for ZNF165 Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF165 Gene

Disorders for ZNF165 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF165 Gene - From: DISEASES

Disorder Aliases PubMed IDs
suppurative thyroiditis
  • acute suppurative thyroiditis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF165

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZNF165: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF165 Gene

Publications for ZNF165 Gene

  1. Characterization of a novel zinc finger gene (ZNF165) mapping to 6p21 that is expressed specifically in testis. (PMID: 7490084) Tirosvoutis K.N. … Affara N.A. (Genomics 1995) 2 3 4 67
  2. Frequent expression of zinc-finger protein ZNF165 in human urinary bladder transitional cell carcinoma. (PMID: 25214475) Singh P.K. … Bhatt M.L. (Immunobiology 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for ZNF165 Gene

Sources for ZNF165 Gene