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Aliases for ZNF160 Gene

Aliases for ZNF160 Gene

  • Zinc Finger Protein 160 2 3 5
  • Zinc Finger Protein HZF5 3 4
  • Zinc Finger Protein Kr18 3 4
  • HKr18 3 4
  • KRAB Zinc Finger Protein KR18 3
  • Zinc Finger Protein 5 3
  • KIAA1611 4
  • HZF5 3
  • KR18 3
  • F11 3

External Ids for ZNF160 Gene

Previous GeneCards Identifiers for ZNF160 Gene

  • GC19U990141
  • GC19M058102
  • GC19M058260
  • GC19M053569
  • GC19M049897

Summaries for ZNF160 Gene

Entrez Gene Summary for ZNF160 Gene

  • The protein encoded by this gene is a Kruppel-related zinc finger protein which is characterized by the presence of an N-terminal repressor domain, the Kruppel-associated box (KRAB). The KRAB domain is a potent repressor of transcription; thus this protein may function in transcription regulation. Multiple transcript variants have been found for this gene. [provided by RefSeq, Apr 2016]

GeneCards Summary for ZNF160 Gene

ZNF160 (Zinc Finger Protein 160) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF607.

UniProtKB/Swiss-Prot for ZNF160 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF160 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF160 Gene

Genomics for ZNF160 Gene

Regulatory Elements for ZNF160 Gene

Enhancers for ZNF160 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF160 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF160 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF160 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF160 gene promoter:

Genomic Location for ZNF160 Gene

Chromosome:
19
Start:
53,064,882 bp from pter
End:
53,103,471 bp from pter
Size:
38,590 bases
Orientation:
Minus strand

Genomic View for ZNF160 Gene

Genes around ZNF160 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF160 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF160 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF160 Gene

Proteins for ZNF160 Gene

  • Protein details for ZNF160 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCG1-ZN160_HUMAN
    Recommended name:
    Zinc finger protein 160
    Protein Accession:
    Q9HCG1
    Secondary Accessions:
    • Q14589
    • Q504Q8
    • Q96JC5
    • Q9BVY9
    • Q9H7N6

    Protein attributes for ZNF160 Gene

    Size:
    818 amino acids
    Molecular mass:
    94112 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA55528.1; Type=Miscellaneous discrepancy; Note=Dubious alternative splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF160 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF160 Gene

Proteomics data for ZNF160 Gene at MOPED

Post-translational modifications for ZNF160 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF160 Gene

Domains & Families for ZNF160 Gene

Gene Families for ZNF160 Gene

Protein Domains for ZNF160 Gene

Suggested Antigen Peptide Sequences for ZNF160 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCG1

UniProtKB/Swiss-Prot:

ZN160_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 20 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 20 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF160: view

Function for ZNF160 Gene

Molecular function for ZNF160 Gene

GENATLAS Biochemistry:
zinc finger protein 160 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF160: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF160 Gene

Localization for ZNF160 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF160 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF160 Gene COMPARTMENTS Subcellular localization image for ZNF160 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF160 Gene

Pathways & Interactions for ZNF160 Gene

SuperPathways for ZNF160 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF160: view

Pathways by source for ZNF160 Gene

2 Reactome pathways for ZNF160 Gene

Interacting Proteins for ZNF160 Gene

Gene Ontology (GO) - Biological Process for ZNF160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF160: view

No data available for SIGNOR curated interactions for ZNF160 Gene

Drugs & Compounds for ZNF160 Gene

No Compound Related Data Available

Transcripts for ZNF160 Gene

Unigene Clusters for ZNF160 Gene

Zinc finger protein 160:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF160 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - -
SP4: - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - - - -
SP8:
SP9:
SP10: - -

Relevant External Links for ZNF160 Gene

GeneLoc Exon Structure for
ZNF160
ECgene alternative splicing isoforms for
ZNF160

Expression for ZNF160 Gene

mRNA expression in normal human tissues for ZNF160 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF160 Gene

This gene is overexpressed in Plasma (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF160 Gene



SOURCE GeneReport for Unigene cluster for ZNF160 Gene Hs.655967

mRNA Expression by UniProt/SwissProt for ZNF160 Gene

Q9HCG1-ZN160_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ZNF160: view

Protein tissue co-expression partners for ZNF160 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZNF160 Gene

Orthologs for ZNF160 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF160 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF160 35
  • 99.43 (n)
  • 99.27 (a)
-- 36
  • 51 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 49 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp52 36
  • 40 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
CSA.1668 36
  • 32 (a)
ManyToMany
Species with no ortholog for ZNF160:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF160 Gene

ENSEMBL:
Gene Tree for ZNF160 (if available)
TreeFam:
Gene Tree for ZNF160 (if available)

Paralogs for ZNF160 Gene

(548) SIMAP similar genes for ZNF160 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZNF160 Gene

genes like me logo Genes that share paralogs with ZNF160: view

Variants for ZNF160 Gene

Sequence variations from dbSNP and Humsavar for ZNF160 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs329709 - 53,075,179(-) GGTAC(A/G)GTTGA reference, missense, utr-variant-5-prime
rs8105668 - 53,074,166(+) ATTCC(A/C/G/T)GCGTT reference, missense
rs7256694 -- 53,092,765(+) GTGGA(A/G)GATTT intron-variant, upstream-variant-2KB
rs7257177 -- 53,083,927(+) TCTTA(C/T)TTTCT intron-variant
rs7258975 -- 53,089,787(+) TCTGT(A/G)CATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF160 Gene

Variant ID Type Subtype PubMed ID
esv2718787 CNV Deletion 23290073
dgv1116e1 CNV Complex 17122850
nsv428370 CNV Loss 18775914
nsv912342 CNV Gain 21882294
nsv912343 CNV Loss 21882294
nsv9748 CNV Gain 18304495
dgv3991n71 CNV Gain+Loss 21882294
nsv435700 CNV Deletion 17901297
esv2488809 CNV Deletion 19546169
nsv527053 CNV Gain 19592680
nsv912345 CNV Loss 21882294
nsv470153 CNV Loss 18288195
dgv429n27 CNV Gain 19166990
esv2718810 CNV Deletion 23290073
esv8151 CNV Loss 19470904
nsv515862 CNV Gain+Loss 19592680
dgv3992n71 CNV Gain 21882294

Variation tolerance for ZNF160 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF160 Gene

HapMap Linkage Disequilibrium report
ZNF160

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF160 Gene

Disorders for ZNF160 Gene

Relevant External Links for ZNF160

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF160

No disorders were found for ZNF160 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF160 Gene

Publications for ZNF160 Gene

  1. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M. … Hellman L. (DNA Cell Biol. 1995) 2 3 4 67
  2. A novel C2H2 zinc-finger protein gene (ZNF160) maps to human chromosome 19q13.3-q13.4. (PMID: 7774943) Halford S. … Scambler P.J. (Genomics 1995) 2 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. Epigenetic regulation of TLR4 gene expression in intestinal epithelial cells for the maintenance of intestinal homeostasis. (PMID: 19846881) Takahashi K. … Kaminogawa S. (J. Immunol. 2009) 3
  5. Two-dimensional differential in-gel electrophoresis for identification of gastric cancer-specific protein markers. (PMID: 19424620) Wu C. … Zhu L. (Oncol. Rep. 2009) 23

Products for ZNF160 Gene

Sources for ZNF160 Gene

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