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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF160 Gene

protein-coding   GIFtS: 54
GCID: GC19M053569

zinc finger protein 160

 Explore 1 disease affiliated with
ZNF160 via our new
 Human Malady Compendium 
Biological research products
for ZNF160
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 1601 2     Zinc Finger Protein HZF52 3
HKr181 2 3     Zinc Finger Protein Kr182 3
F111 2     FLJ000321
HZF51 2     KRAB Zinc Finger Protein KR182
KR181 2     Zinc Finger Protein 52
KIAA16111 3     

External Ids:    HGNC: 129481   Entrez Gene: 903382   Ensembl: ENSG000001709497   OMIM: 6003985   UniProtKB: Q9HCG13   

Export aliases for ZNF160 gene to outside databases

Previous GC identifers: GC19U990141 GC19M058102 GC19M058260 GC19M049897


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF160:
The protein encoded by this gene is a Kruppel-related zinc finger protein which is characterized by the presence of an
N-terminal repressor domain, the Kruppel-associated box (KRAB). The KRAB domain is a potent repressor of
transcription; thus this protein may function in transcription regulation. Three alternative transcripts encoding the
same protein have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ZN160_HUMAN, Q9HCG1
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF160


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF160 gene promoter:
         HTF   Ik-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF160 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF160

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF160


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

ZNF160 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF160 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M053569:  view genomic region     (about GC identifiers)

Start:
53,569,867 bp from pter      End:
53,606,687 bp from pter
Size:
36,821 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN160_HUMAN, Q9HCG1 (See protein sequence)
Recommended Name: Zinc finger protein 160  
Size: 818 amino acids; 94112 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=CAA55528.1; Type=Miscellaneous discrepancy; Note=Dubious alternative splicing;
Secondary accessions: Q14589 Q504Q8 Q96JC5 Q9H7N6

Explore the universe of human proteins at neXtProt for ZNF160: NX_Q9HCG1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HCG1

  • ZNF160 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001096073.1  NP_150630.2  NP_942596.1  

    ENSEMBL proteins: 
     ENSP00000406201   ENSP00000409597   ENSP00000347273  
    Reactome Protein details: Q9HCG1
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    Uscn Proteins for ZNF160

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus NAS--


    ZNF160 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF160 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9HCG1

    ProtoNet protein and cluster: Q9HCG1

    2 Blocks protein families:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN160_HUMAN, Q9HCG1
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 20 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN160_HUMAN, Q9HCG1
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF160:
    zinc finger protein 160 (C2H2 type,Kruppel-like)

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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    ZNF160 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for ZNF160:
     Decreased number of cells in m  Decreased viability  Lamellipodia and high actin ra 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF160
        Generic Transcription Pathway
    Gene Expression



    ZNF160 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF160

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0030097hemopoiesis NAS11410164


    ZNF160 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF160
    Search CenterWatch for drugs/clinical trials and news about ZNF160 / ZN160 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF160 gene (3 alternative transcripts): 
    NM_001102603.1  NM_033288.3  NM_198893.2  

    Unigene Cluster for ZNF160:

    Zinc finger protein 160
    Hs.655967  [show with all ESTs]
    Unigene Representative Sequence: NM_001102603
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429604(uc010eqk.3 uc002qaq.4) ENST00000418871(uc002qar.4)
    ENST00000355147(uc002qas.4)

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    Additional cDNA sequence: 

    AF027144.1 AF277623.1 AK024442.1 AK024789.1 BC000807.1 BC012054.1 BC094880.1 CR749613.1 
    X77744.1 X78928.1 

    14 DOTS entries:

    DT.100049108  DT.70104669  DT.121462036  DT.100035462  DT.205688  DT.95267506  DT.121462325  DT.100655228 
    DT.91896755  DT.75187941  DT.121461946  DT.95316252  DT.99963014  DT.96085328 

    24/98 AceView cDNA sequences (see all 98):

    CB998561 CD634977 NM_033288 NM_198893 BQ061855 BQ028772 AL603285 BM741934 
    BM703742 BC000807 AW089035 BM668494 BP368213 BE734288 BM741462 BM722404 
    BQ007175 BC012054 BM724824 AI964015 AF027144 BE734756 BU741456 CK001584 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF160 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
    SP1:                          -     -           -     -           -     -     -     -     -     -     -     -                           
    SP2:                          -     -                 -           -     -     -     -     -     -     -     -                           
    SP3:                          -                       -                                                                                 
    SP4:                          -     -                 -           -                                                                     
    SP5:                          -     -           -     -           -                                   -                                 


    ECgene alternative splicing isoforms for ZNF160

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF160 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTGTAAATC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF160 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF160

    SOURCE GeneReport for Unigene cluster: Hs.655967

    UniProtKB/Swiss-Prot: ZN160_HUMAN, Q9HCG1
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF160 gene from 3/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01028403.26
    BX572103.56
    (see all 96)
    --
    50(a)
    50(a)
    (see all 96)
    possible ortholog
    possible ortholog
    (see all 96)
    4(29566845-29568897)
    Zv9_scaffold3530(784950-801038)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79876
    CG312246
    (see all 10)
    --
    9(a)
    6(a)
    (see all 10)
    possible ortholog
    possible ortholog
    (see all 10)
    3R(10396194-10401570)
    3R(14475843-14484963)
    worm
    (Caenorhabditis elegans)
    Secernentea Y55F3AM.146
    Y48G8AL.106
    (see all 3)
    --
    16(a)
    13(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    IV(1058845-1063187)
    I(1142033-1154389)


    ENSEMBL Gene Tree for ZNF160 (if available)
    TreeFam Gene Tree for ZNF160 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF160 gene
    ZNF6162  ZNF8502  ZNF992  ZNF5462  ZNF6652  ZNF8362  ZNF7212  ZNF8412  
    ZNF912  ZNF432  ZNF780B2  ZNF1972  ZNF585A2  ZNF3472  ZNF8082  ZNF7292  
    ZNF8452  ZNF1842  ZNF585B2  ZNF6582  ZNF6242  ZNF2082  
    18/501 SIMAP similar genes for ZNF160 using alignment to 6 protein entries:     ZN160_HUMAN (see all proteins) (see all similar genes):
    DKFZp686B16128    ZNF665    ZNF420    ZNF702P    ZNF78L1    kr-znf3
    HZF30    ZFS-1    ZNF347    DKFZp686M04222    HZF36    ZFS-4
    ZNF146    ZNF283    ZNF558    ZNF818P    ZNF28    ZNF616

    ZNF160 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZNF160
    PGOHUM00000262842 PGOHUM00000248805


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/834 NCBI SNPs in ZNF160 are shown (see all 834    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1430200861,2
    --53569428(+) CCTCCC/TAAAGT 3 -- ds50010--------
    rs1482047451,2
    --53569458(+) GCCACC/TGTGCC 3 -- ds50010--------
    rs1427510421,2
    --53569484(+) TTCTCA/GCATTC 3 -- ds50010--------
    rs795831831,2
    --53569523(+) CAAGAT/GGCAAA 3 -- ds50013Minor allele frequency- G:0.13CSA WA NA 240
    rs3297371,2
    C,H,--53569527(-) ATGCTA/TTGCAT 3 -- ds500120Minor allele frequency- T:0.00MN NS EA NA WA CSA 877
    rs1124651021,2
    --53569712(+) AAATGC/TGGTTA 3 -- ds50012Minor allele frequency- T:0.02CSA WA 120
    rs1929645211,2
    --53569787(+) CCTAGC/TGGTGT 3 -- ds50010--------
    rs1473794751,2
    --53569806(+) TGTGTC/TATGGA 3 -- ds50010--------
    rs1384450441,2
    --53569922(+) ATTCTA/GAATAA 3 -- ut310--------
    rs779383941,2
    C,--53569968(+) AGTTCT/CACTAA 3 -- ut312Minor allele frequency- C:0.09CSA WA 120

    HapMap Linkage Disequilibrium report for ZNF160 (53569867 - 53606687 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for ZNF160
         5 CNVs: 23221 4087 53219 30918 102870

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF160
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF160

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF160 for disorders           About GeneDecksing

    OMIM gene information: 600398    OMIM disorders: --

    1 disease for ZNF160:    About MalaCards
    gastric cancer


    Export disorders for ZNF160 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF160 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ZNF160)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 2, 3 Abrink M.... Hellman L. (1995)
    2. Molecular cloning and preliminary functional analysis of two novel human KRAB zinc finger proteins, HKr18 and HKr19. (PubMed id 11410164)1, 2 Mark C.... Hellman L. (2001)
    3. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (2000)
    4. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
    5. A novel C2H2 zinc-finger protein gene (ZNF160) maps to human chromosome 19q13.3-q13.4. (PubMed id 7774943)1, 3 Halford S....Scambler P.J. (1995)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Epigenetic regulation of TLR4 gene expression in inte stinal epithelial cells for the maintenance of intestinal homeostasis. (PubMed id 19846881)1 Takahashi K....Kaminogawa S. (2009)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90338 HGNC: 12948 AceView: ZNF160 Ensembl:ENSG00000170949 euGenes: HUgn90338
    ECgene: ZNF160 H-InvDB: ZNF160

    (According to HUGE)
    About This Section
    HUGE: KIAA1611

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF160 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF160 gene:
    Search GeneIP for patents involving ZNF160

    GeneCards and IP:
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