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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF16 Gene

protein-coding   GIFtS: 48
GCID: GC08M146155

zinc finger protein 16

(Previous name: zinc finger protein 16 (KOX 9) )
  Search for ZNF16
in our new
 Human Malady Compendium 
Biological research products
for ZNF16
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 161 2
KOX91 2 3 5
Zinc Finger Protein KOX92 3
Zinc Finger Protein 16 (KOX 9)1
HZF12
Zinc Finger Protein Kruppel Type 92

External Ids:    HGNC: 129471   Entrez Gene: 75642   Ensembl: ENSG000001706317   OMIM: 6012625   UniProtKB: P170203   

Export aliases for ZNF16 gene to outside databases

Previous GC identifers: GC08M143762 GC08M146192 GC08M145603 GC08M146004 GC08M146006 GC08M146126 GC08M141271


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF16:
The protein encoded by this gene contains multiple tandem zinc finger motifs. The encoded protein is involved in the
differentiation of erythroid and megakaryocytic cells. This gene is located in a cluster of related genes on
chromosome 8 encoding zinc finger proteins. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Sep 2012)

UniProtKB/Swiss-Prot: ZNF16_HUMAN, P17020
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF16


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_037704.5  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF16 gene promoter:
         PPAR-gamma1   PPAR-gamma2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF16 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24

ZNF16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF16 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M146155:  view genomic region     (about GC identifiers)

Start:
146,155,744 bp from pter      End:
146,176,274 bp from pter
Size:
20,531 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZNF16_HUMAN, P17020 (See protein sequence)
Recommended Name: Zinc finger protein 16  
Size: 682 amino acids; 76472 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: B3KXM4 D3DWP2 Q96FG0

Explore the universe of human proteins at neXtProt for ZNF16: NX_P17020

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17020

  • ZNF16 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001025147.2  NP_008889.2  

    ENSEMBL proteins: 
     ENSP00000276816   ENSP00000378369   ENSP00000434321   ENSP00000432755  

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    Uscn Proteins for ZNF16

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    ZNF16 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF16 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17020

    ProtoNet protein and cluster: P17020

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZNF16_HUMAN, P17020
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 17 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZNF16_HUMAN, P17020
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF16:
    zinc finger protein 16 (KOX9) (C2H2 type,Kruppel-like)

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    ZNF16 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ZNF16:
     Decreased influenza A virus in  Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF16

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF16 (ENSP000002768164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBX3ENSP000003366874STRING: ENSP00000336687
    GORABENSP000003567374STRING: ENSP00000356737
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    ZNF16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF16
    Search CenterWatch for drugs/clinical trials and news about ZNF16 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF16 gene (2 alternative transcripts): 
    NM_001029976.2  NM_006958.2  

    Unigene Cluster for ZNF16:

    Zinc finger protein 16
    Hs.493225  [show with all ESTs]
    Unigene Representative Sequence: DQ117529
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000276816(uc003zet.3 uc003zeu.3) ENST00000394909 ENST00000532351
    ENST00000532811 ENST00000527512 ENST00000527811 ENST00000527427 ENST00000529378


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    Additional cDNA sequence: 

    AF024700.1 AF244088.1 AK127625.1 AK226016.1 AL834451.1 BC010996.2 DQ117529.1 X52340.1 

    4 DOTS entries:

    DT.211312  DT.92327154  DT.121474754  DT.99933493 

    24/54 AceView cDNA sequences (see all 54):

    AA865317 BG746647 AK127625 AA913738 AL834451 BM470181 CK824650 AF244088 
    BC010996 BE741789 BG283656 T17349 CR623646 NM_006958 AA417034 AI803692 
    CD672680 AK096815 BG746406 BM263813 AA564305 AI377536 CA425248 BG117671 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF16 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e
    SP1:              -                       -     -                                 
    SP2:              -     -     -           -     -                                 
    SP3:              -     -     -                 -                                 
    SP4:                    -     -           -     -                                 
    SP5:                          -           -     -                                 


    ECgene alternative splicing isoforms for ZNF16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATAGAGTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF16

    SOURCE GeneReport for Unigene cluster: Hs.493225
        SABiosciences Custom PCR Arrays for ZNF16
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF16 gene from 2/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    ZNF7746
    (see all 6)
    --
    57(a)
    57(a)
    (see all 6)
    1 ↔ many
    possible ortholog
    (see all 6)
    GL343220.1(2330463-2336819)
    2(199167583-199168815)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG147113   -- 47(a)
    (best of 9)
      86E16   --


    ENSEMBL Gene Tree for ZNF16 (if available)
    TreeFam Gene Tree for ZNF16 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF16 gene
    ZNF712  ZNF5862  ZNF5012  ZNF6232  ZFP22  ZNF3452  ZNF232  ZFP32  
    ZNF8522  ZNF5022  ZNF352  ZNF6602  ZKSCAN72  
    18/497 SIMAP similar genes for ZNF16 using alignment to 4 protein entries:     ZNF16_HUMAN (see all proteins) (see all similar genes):
    DKFZp547L155    ZFP41    ZNF391    ZNF436    HZF36    ZNF146
    ZNF331    DKFZp666C237    GLI4    ZNF696    ZNF883    DKFZp686H10254
    DKFZp686L0787    ZNF662    ZNF75A    ZSCAN21    ZSCAN22    HZF30

    ZNF16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/575 NCBI SNPs in ZNF16 are shown (see all 575    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs100871421,2
    C,H,--141285881(+) ttttgC/Taaaga 1 -- int15Minor allele frequency- T:0.00NS EA WA 530
    rs1135276051,2
    F,--141286793(+) CCTGGT/CTGTTG 1 -- int13Minor allele frequency- C:0.13CSA WA 122
    rs1114047141,2
    --141286964(+) CAGAGT/CACCCC 1 -- int12Minor allele frequency- C:0.03CSA NA 122
    rs743712861,2
    --141286986(+) TACCTG/ATGATG 1 -- int11Minor allele frequency- A:0.01WA 118
    rs126814291,2
    H--146155492(+) GGGGCC/TTAAGT 2 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs24719251,2
    C,H--146155589(-) TTCCAG/AAATTT 2 -- ds50015Minor allele frequency- A:0.00NS EA NA 528
    rs1408737791,2
    --146155723(+) ACAAAA/GAATTC 2 -- ds50010--------
    rs1172382661,2
    C,F,--146155731(+) TTCACG/ACCACA 2 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1910500301,2
    --146155747(+) CATTAA/CCAATC 2 -- ut310--------
    rs32071,2
    C,F,--146155874(+) ACAAAT/CGTGCA 2 -- ut31 ese32Minor allele frequency- C:0.39MN NA 304

    HapMap Linkage Disequilibrium report for ZNF16 (146155744 - 146176274 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for ZNF16
         2 CNVs: 2779 70499
         1 Indel: 47502

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF16 for disorders           About MalaCards

    ZNF16 for disorders           About GeneDecksing

    OMIM gene information: 601262    OMIM disorders: --


    Export disorders for ZNF16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF16 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ZNF16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
    4. Identification of HZF1 as a novel target gene of the MEF2 transcription factor. (PubMed id 21468593)1 Liu X....Li X.Q. (2011)
    5. Zinc finger protein HZF1 promotes K562 cell prolifera tion by interacting with and inhibiting INCA1. (PubMed id 21874239)1 Li X.B....Zhang J.W. (2011)
    6. Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16). (PubMed id 19763908)1 Deng M.J....Zhang J.W. (2010)
    7. The ancient mammalian KRAB zinc finger gene cluster on human chromosome 8q24.3 illustrates principles of C2H2 zinc finger evolution as sociated with unique expression profiles in human tissues. (PubMed id 20346131)1 Lorenz P....Thiesen H.J. (2010)
    8. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    9. Identification and characterization of a novel zinc finger protein (HZF1) gene and its function in erythroid and megakaryocytic differentiation of K562 cells. (PubMed id 16628192)1 Peng H....Zhang J.W. (2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7564 HGNC: 12947 AceView: ZNF16 Ensembl:ENSG00000170631 euGenes: HUgn7564
    ECgene: ZNF16 H-InvDB: ZNF16

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF16 gene:
    Search GeneIP for patents involving ZNF16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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