ZNF16 Gene
protein-coding GIFtS: 48
GCID: GC08M146155
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zinc finger protein 16(Previous name: zinc finger protein 16 (KOX 9) )
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Aliases for ZNF16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 161 2 | | KOX91 2 3 5 | | Zinc Finger Protein KOX92 3 | | Zinc Finger Protein 16 (KOX 9)1 | | HZF12 | | Zinc Finger Protein Kruppel Type 92 |
Export aliases for ZNF16 gene to outside databasesPrevious GC identifers: GC08M143762 GC08M146192 GC08M145603 GC08M146004 GC08M146006 GC08M146126 GC08M141271 |
Summaries for ZNF16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for ZNF16: The protein encoded by this gene contains multiple tandem zinc finger motifs. The encoded protein is involved in thedifferentiation of erythroid and megakaryocytic cells. This gene is located in a cluster of related genes onchromosome 8 encoding zinc finger proteins. Alternative splicing results in multiple transcript variants. (provided byRefSeq, Sep 2012) UniProtKB/Swiss-Prot: ZNF16_HUMAN, P17020Function: May be involved in transcriptional regulation Gene Wiki entry for ZNF16
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Genomic Views for ZNF16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_037704.5
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF16 gene promoter: PPAR-gamma1 PPAR-gamma2 GATA-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF16
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF16 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24ZNF16 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M146155: view genomic region
(about GC identifiers)
Start:
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146,155,744 bp from pter |
End:
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146,176,274 bp from pter |
Size:
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20,531 bases |
Orientation:
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minus strand |
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Proteins for ZNF16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZNF16_HUMAN, P17020 (See
protein sequence)Recommended Name: Zinc finger protein 16 Size: 682 amino acids; 76472 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: B3KXM4 D3DWP2 Q96FG0Explore the universe of human proteins at neXtProt for ZNF16: NX_P17020
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P17020 ZNF16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001025147.2 NP_008889.2 ENSEMBL proteins: ENSP00000276816 ENSP00000378369 ENSP00000434321 ENSP00000432755 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF16 for ontologies About GeneDecksing
ZNF16 Antibody Products: Assay Products for ZNF16: |
Protein
Domains / Families for ZNF16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF16 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P17020ProtoNet protein and cluster: P17020 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZNF16_HUMAN, P17020Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 17 C2H2-type zinc fingers |
Function for ZNF16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ZNF16_HUMAN, P17020Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF16:zinc finger protein 16 (KOX9) (C2H2 type,Kruppel-like)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF16 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF16 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZNF16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF16  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF16 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF16 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZNF16:
|
Pathways & Interactions for ZNF16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF16
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 2 Interacting proteins for ZNF16 (ENSP000002768164) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF16 for ontologies About GeneDecksing
|
Drugs & Compounds for ZNF16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ZNF16 Search CenterWatch for drugs/clinical trials and news about ZNF16 
|
Transcripts for ZNF16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZNF16 gene (2 alternative transcripts): NM_001029976.2 NM_006958.2 Unigene Cluster for ZNF16: Zinc finger protein 16 Hs.493225 [show with all ESTs]Unigene Representative Sequence: DQ1175298 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000276816(uc003zet.3 uc003zeu.3) ENST00000394909 ENST00000532351 ENST00000532811 ENST00000527512 ENST00000527811 ENST00000527427 ENST00000529378
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF16 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF16 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF16 (NM_006958) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF16  |
Additional cDNA sequence: AF024700.1 AF244088.1 AK127625.1 AK226016.1 AL834451.1 BC010996.2 DQ117529.1 X52340.1 4 DOTS entries: DT.211312 DT.92327154 DT.121474754 DT.99933493 24/54 AceView cDNA sequences (see all 54): AA865317 BG746647 AK127625 AA913738 AL834451 BM470181 CK824650 AF244088 BC010996 BE741789 BG283656 T17349 CR623646 NM_006958 AA417034 AI803692 CD672680 AK096815 BG746406 BM263813 AA564305 AI377536 CA425248 BG117671 GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF16 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | |
| SP1: | |   | |   | - |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for ZNF16
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Expression for ZNF16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF16 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AATAGAGTTT
About this image See ZNF16 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF16
SOURCE GeneReport for Unigene cluster: Hs.493225 SABiosciences Custom PCR Arrays for ZNF16
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF16 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF16 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF16 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF16 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF16 |
Orthologs for ZNF16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF16 gene from 2/10 species (see all 10) About this table
ENSEMBL Gene Tree for ZNF16 (if available) TreeFam Gene Tree for ZNF16 (if available)  |
Paralogs for ZNF16 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ZNF16 gene
- ZNF712 ZNF5862 ZNF5012 ZNF6232 ZFP22 ZNF3452 ZNF232 ZFP32
- ZNF8522 ZNF5022 ZNF352 ZNF6602 ZKSCAN72
18/497 SIMAP similar genes for ZNF16 using alignment to 4 protein entries: ZNF16_HUMAN (see all proteins)
(see all similar genes):DKFZp547L155 ZFP41 ZNF391 ZNF436 HZF36 ZNF146 ZNF331 DKFZp666C237 GLI4 ZNF696 ZNF883 DKFZp686H10254 DKFZp686L0787 ZNF662 ZNF75A ZSCAN21 ZSCAN22 HZF30
ZNF16 for paralogs About GeneDecksing
|
Genomic Variants for ZNF16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 8 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF16 (146155744 - 146176274 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for ZNF16 2 CNVs: 2779 70499 1 Indel: 47502  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF16 |
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Disorders
/ Diseases for ZNF16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF16 for disorders About MalaCards
ZNF16 for disorders About GeneDecksing
OMIM gene information: 601262
OMIM disorders: --
Export disorders for ZNF16 gene to outside databases
|
Publications for ZNF16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF16 gene, integrated from 9 sources (see all 13): (articles sorted by number of sources associating them with ZNF16) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
- Identification of HZF1 as a novel target gene of the MEF2 transcription factor. (PubMed id 21468593)1 Liu X....Li X.Q. (2011)
- Zinc finger protein HZF1 promotes K562 cell prolifera tion by interacting with and inhibiting INCA1. (PubMed id 21874239)1 Li X.B....Zhang J.W. (2011)
- Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16). (PubMed id 19763908)1 Deng M.J....Zhang J.W. (2010)
- The ancient mammalian KRAB zinc finger gene cluster on human chromosome 8q24.3 illustrates principles of C2H2 zinc finger evolution as sociated with unique expression profiles in human tissues. (PubMed id 20346131)1 Lorenz P....Thiesen H.J. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Identification and characterization of a novel zinc finger protein (HZF1) gene and its function in erythroid and megakaryocytic differentiation of K562 cells. (PubMed id 16628192)1 Peng H....Zhang J.W. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ZNF16 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZNF16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ZNF16 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF16 gene: Search GeneIP for patents involving ZNF16
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZNF16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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 | |
 | |
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 | | ZNF16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF16 |
|  |  |  | | | Search ThermoFisher Antibodies for ZNF16 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF16 |
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