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ZNF16 Gene

protein-coding   GIFtS: 50
GCID: GC08M146155

Zinc Finger Protein 16

(Previous name: zinc finger protein 16 (KOX 9))
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 161 2
KOX92 3 5
Zinc Finger Protein KOX92 3
HZF12 3
Zinc Finger Protein 16 (KOX 9)1
Zinc Finger Protein Kruppel Type 92

External Ids:    HGNC: 129471   Entrez Gene: 75642   Ensembl: ENSG000001706317   OMIM: 6012625   UniProtKB: P170203   

Export aliases for ZNF16 gene to outside databases

Previous GC identifers: GC08M143762 GC08M146192 GC08M145603 GC08M146004 GC08M146006 GC08M146126 GC08M141271


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF16 Gene:
The protein encoded by this gene contains multiple tandem zinc finger motifs. The encoded protein is involved in
the differentiation of erythroid and megakaryocytic cells. This gene is located in a cluster of related genes on
chromosome 8 encoding zinc finger proteins. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Sep 2012)

GeneCards Summary for ZNF16 Gene:
ZNF16 (zinc finger protein 16) is a protein-coding gene. Diseases associated with ZNF16 include malaria. An important paralog of this gene is ZNF623.

UniProtKB/Swiss-Prot: ZNF16_HUMAN, P17020
Function: Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase
transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced
erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis

Gene Wiki entry for ZNF16 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF16 gene promoter:
         PPAR-gamma1   PPAR-gamma2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF16 promoter sequence
   Search Chromatin IP Primers for ZNF16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24

ZNF16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF16 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M146155:  view genomic region     (about GC identifiers)

Start:
146,155,744 bp from pter      End:
146,176,274 bp from pter
Size:
20,531 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZNF16_HUMAN, P17020 (See protein sequence)
Recommended Name: Zinc finger protein 16  
Size: 682 amino acids; 76472 Da
Subunit: Interacts with INCA1; the interaction inhibits INCA1 activity and induces the cell cycle process
Sequence caution: Sequence=AAF75235.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAZ20773.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KXM4 D3DWP2 Q45SH7 Q96FG0 Q9NRA4

Explore the universe of human proteins at neXtProt for ZNF16: NX_P17020

Explore proteomics data for ZNF16 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001025147.2  NP_008889.2  

    ENSEMBL proteins: 
     ENSP00000276816   ENSP00000378369   ENSP00000434321   ENSP00000432755  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17020

    ProtoNet protein and cluster: P17020

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZNF16_HUMAN, P17020
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 17 C2H2-type zinc fingers


    ZNF16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF16_HUMAN, P17020
    Function: Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase
    transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced
    erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis
    Induction: Up-regulated by hemin during erythroid differentiation. Up-regulated by phorbol myristate acetate (PMA)
    during megakaryocytic differentiation. Up-regulated by the transcriptional activator MEF2A

         Genatlas biochemistry entry for ZNF16:
    zinc finger protein 16 (KOX9) (C2H2 type,Kruppel-like)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--
         
    ZNF16 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF16:
     Decreased influenza A virus in  Increased gamma-H2AX phosphory 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNF16_HUMAN, P17020: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16628192

    ZNF16 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF16
    Interactions:

        Search GeneGlobe Interaction Network for ZNF16

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for ZNF16 (P170201 ENSP000002768164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INCA1Q0VD861EBI-3921553,EBI-6509505
    CBX3ENSP000003366874STRING: ENSP00000336687
    GORABENSP000003567374STRING: ENSP00000356737
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--
    GO:0007049cell cycle IEA--
    GO:0008284positive regulation of cell proliferation IDA--
    GO:0033674positive regulation of kinase activity IDA--

    ZNF16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF16



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF16 gene (2 alternative transcripts): 
    NM_001029976.2  NM_006958.2  

    Unigene Cluster for ZNF16:

    Zinc finger protein 16
    Hs.493225  [show with all ESTs]
    Unigene Representative Sequence: DQ117529
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000276816(uc003zet.3 uc003zeu.3) ENST00000394909 ENST00000532351
    ENST00000532811 ENST00000527512 ENST00000527811 ENST00000527427 ENST00000529378

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      QuantiFast Probe-based Assays in human, mouse, rat ZNF16

    Additional mRNA sequence: 

    AF024700.1 AF244088.1 AK127625.1 AK226016.1 AL834451.1 BC010996.2 DQ117529.1 X52340.1 

    4 DOTS entries:

    DT.211312  DT.92327154  DT.121474754  DT.99933493 

    Selected AceView cDNA sequences (see all 54):

    CK824650 AL834451 AF244088 AA865317 T17349 BE741789 BM470181 BG746647 
    NM_006958 AK127625 BG283656 CR623646 AA913738 BC010996 AI338277 AI803692 
    BI222242 BI460932 CD623490 BX370603 CA425248 AK096815 BP344973 AI972589 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF16 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e
    SP1:              -                       -     -                                 
    SP2:              -     -     -           -     -                                 
    SP3:              -     -     -                 -                                 
    SP4:                    -     -           -     -                                 
    SP5:                          -           -     -                                 


    ECgene alternative splicing isoforms for ZNF16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAGAGTTT
    ZNF16 Expression
    About this image

    ZNF16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.493225

    UniProtKB/Swiss-Prot: ZNF16_HUMAN, P17020
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF16 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF161 zinc finger protein 16 85.69(n)
    83.82(a)
      100686789  XM_003431800.2  XP_003431848.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    46(a)
    1 → many
    GL344166.1(40912-42558)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004895331 zinc finger protein 850-like 56.55(n)
    48.83(a)
      100489533  XM_004914303.1  XP_004914360.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BX927130.16
    Uncharacterized protein
    38(a)
    1 → many
    1(37484564-37485703) ENSDARG00000087963


    ENSEMBL Gene Tree for ZNF16 (if available)
    TreeFam Gene Tree for ZNF16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF16 gene
    ZNF6232  ZNF6552  
    Selected SIMAP similar genes for ZNF16 using alignment to 4 protein entries:     ZNF16_HUMAN (see all proteins) (see all similar genes):
    DKFZp547L155    ZFP41    ZNF391    ZNF436    HZF36    ZNF146
    ZNF852    ZNF331    DKFZp666C237    GLI4    ZNF696    ZNF883
    DKFZp686H10254    DKFZp686L0787    ZNF662    ZNF75A    ZSCAN21    ZSCAN22

    ZNF16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF16 (see all 683)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs126814291,2
    H--146155492(+) GGGGCC/TTAAGT 2 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs24719251,2
    C,H--146155589(-) TTCCAG/AAATTT 2 -- ds50015Minor allele frequency- A:0.00NS EA NA 528
    rs1408737791,2
    --146155723(+) ACAAAA/GAATTC 2 -- ds50010--------
    rs1172382661,2
    C,F--146155731(+) TTCACG/ACCACA 2 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1910500301,2
    --146155747(+) CATTAA/CCAATC 2 -- ut310--------
    rs32071,2
    C,F--146155874(+) ACAAAT/CGTGCA 2 -- ut31 ese32Minor allele frequency- C:0.39MN NA 304
    rs1448341521,2
    --146155875(+) CAAACA/GTGCAG 2 -- ut310--------
    rs32081,2
    C,F--146155978(+) CAAAGA/GAGGGT 2 -- ut31 ese30--------
    rs1115580601,2
    C--146155996(+) TATGTA/GGCCAC 2 -- ut310--------
    rs1998425321,2
    --146156081(+) AGTTGA/GAGAGG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF16 (146155744 - 146176274 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF16 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2080072CNV Deletion18987734
    esv2669134CNV Deletion23128226
    esv2664252CNV Deletion23128226
    esv990431CNV Insertion20482838
    esv1592346CNV Insertion17803354
    esv1336384CNV Insertion17803354
    esv1750274CNV Insertion17803354
    nsv469809CNV Loss16826518
    nsv519737CNV Loss19592680
    dgv7986n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601262    OMIM disorders: --

    1 disease for ZNF16:    
    About MalaCards
    malaria


    ZNF16 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF16

    Export disorders for ZNF16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF16 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ZNF16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of HZF1 as a novel target gene of the MEF2 transcription factor. (PubMed id 21468593)1, 2 Liu X....Li X.Q. (Mol Med Rep 2011)
    2. Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1. (PubMed id 21874239)1, 2 Li X.B....Zhang J.W. (Mol Med Rep 2011)
    3. Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16). (PubMed id 19763908)1, 2 Deng M.J....Zhang J.W. (Mol. Biotechnol. 2010)
    4. Identification and characterization of a novel zinc finger protein (HZF1) gene and its function in erythroid and megakaryocytic differentiation of K562 cells. (PubMed id 16628192)1, 2 Peng H....Zhang J.W. (Leukemia 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (New Biol. 1990)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. The ancient mammalian KRAB zinc finger gene cluster on human chromosome 8q24.3 illustrates principles of C2H2 zinc finger evolution associated with unique expression profiles in human tissues. (PubMed id 20346131)1 Lorenz P....Thiesen H.J. (BMC Genomics 2010)
    10. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7564 HGNC: 12947 AceView: ZNF16 Ensembl:ENSG00000170631 euGenes: HUgn7564
    ECgene: ZNF16 H-InvDB: ZNF16

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF16 gene:
    Search GeneIP for patents involving ZNF16

    GeneCards and IP:
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