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Aliases for ZNF16 Gene

Aliases for ZNF16 Gene

  • Zinc Finger Protein 16 2 3 5
  • Zinc Finger Protein KOX9 3 4
  • HZF1 3 4
  • KOX9 3 4
  • Zinc Finger Protein Kruppel Type 9 3
  • Zinc Finger Protein 16 (KOX 9) 2

External Ids for ZNF16 Gene

Previous GeneCards Identifiers for ZNF16 Gene

  • GC08M143762
  • GC08M146192
  • GC08M145603
  • GC08M146004
  • GC08M146006
  • GC08M146126
  • GC08M141271
  • GC08M146155

Summaries for ZNF16 Gene

Entrez Gene Summary for ZNF16 Gene

  • The protein encoded by this gene contains multiple tandem zinc finger motifs. The encoded protein is involved in the differentiation of erythroid and megakaryocytic cells. This gene is located in a cluster of related genes on chromosome 8 encoding zinc finger proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

GeneCards Summary for ZNF16 Gene

ZNF16 (Zinc Finger Protein 16) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF607.

UniProtKB/Swiss-Prot for ZNF16 Gene

  • Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis.

Gene Wiki entry for ZNF16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF16 Gene

Genomics for ZNF16 Gene

Regulatory Elements for ZNF16 Gene

Enhancers for ZNF16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF16 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF16 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF16 Gene

Chromosome:
8
Start:
144,930,358 bp from pter
End:
144,950,888 bp from pter
Size:
20,531 bases
Orientation:
Minus strand

Genomic View for ZNF16 Gene

Genes around ZNF16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF16 Gene

Proteins for ZNF16 Gene

  • Protein details for ZNF16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17020-ZNF16_HUMAN
    Recommended name:
    Zinc finger protein 16
    Protein Accession:
    P17020
    Secondary Accessions:
    • B3KXM4
    • D3DWP2
    • Q45SH7
    • Q96FG0
    • Q9NRA4

    Protein attributes for ZNF16 Gene

    Size:
    682 amino acids
    Molecular mass:
    76472 Da
    Quaternary structure:
    • Interacts with INCA1; the interaction inhibits INCA1 activity and induces the cell cycle process.
    SequenceCaution:
    • Sequence=AAF75235.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAZ20773.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF16 Gene

Proteomics data for ZNF16 Gene at MOPED

Post-translational modifications for ZNF16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF16 Gene

No data available for DME Specific Peptides for ZNF16 Gene

Domains & Families for ZNF16 Gene

Gene Families for ZNF16 Gene

Protein Domains for ZNF16 Gene

Suggested Antigen Peptide Sequences for ZNF16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17020

UniProtKB/Swiss-Prot:

ZNF16_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 17 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 17 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF16: view

Function for ZNF16 Gene

Molecular function for ZNF16 Gene

GENATLAS Biochemistry:
zinc finger protein 16 (KOX9) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis.
UniProtKB/Swiss-Prot Induction:
Up-regulated by hemin during erythroid differentiation. Up-regulated by phorbol myristate acetate (PMA) during megakaryocytic differentiation. Up-regulated by the transcriptional activator MEF2A.

Gene Ontology (GO) - Molecular Function for ZNF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21874239
genes like me logo Genes that share ontologies with ZNF16: view
genes like me logo Genes that share phenotypes with ZNF16: view

Animal Model Products

CRISPR Products

Targeted motifs for ZNF16 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF16
  • Consensus sequence: MACCTTCYATGGCTCCCTAKTGCCY Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA and Transcription Factor Targets for ZNF16 Gene

Localization for ZNF16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF16 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF16 Gene COMPARTMENTS Subcellular localization image for ZNF16 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF16 Gene

Pathways & Interactions for ZNF16 Gene

SuperPathways for ZNF16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 21874239
GO:0033674 positive regulation of kinase activity IDA 21874239
GO:0043066 negative regulation of apoptotic process IDA 21874239
GO:0045648 positive regulation of erythrocyte differentiation IMP 16628192
GO:0045654 positive regulation of megakaryocyte differentiation IMP 16628192
genes like me logo Genes that share ontologies with ZNF16: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF16 Gene

Drugs & Compounds for ZNF16 Gene

No Compound Related Data Available

Transcripts for ZNF16 Gene

Unigene Clusters for ZNF16 Gene

Zinc finger protein 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF16 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - - -

Relevant External Links for ZNF16 Gene

GeneLoc Exon Structure for
ZNF16
ECgene alternative splicing isoforms for
ZNF16

Expression for ZNF16 Gene

mRNA expression in normal human tissues for ZNF16 Gene

Protein differential expression in normal tissues from HIPED for ZNF16 Gene

This gene is overexpressed in Lung (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF16 Gene



SOURCE GeneReport for Unigene cluster for ZNF16 Gene Hs.493225

mRNA Expression by UniProt/SwissProt for ZNF16 Gene

P17020-ZNF16_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ZNF16: view

Protein tissue co-expression partners for ZNF16 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF16 Gene

Orthologs for ZNF16 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF16 35
  • 78.24 (n)
  • 75.73 (a)
ZNF16 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF16 35
  • 85.69 (n)
  • 83.82 (a)
chimpanzee
(Pan troglodytes)
Mammalia ZNF16 35
  • 99.07 (n)
  • 98.97 (a)
ZNF16 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF16 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489533 35
  • 56.55 (n)
  • 48.83 (a)
zebrafish
(Danio rerio)
Actinopterygii BX927130.1 36
  • 38 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta BG:DS02740.8 37
  • 37 (a)
CG14711 37
  • 47 (a)
CG17385 37
  • 41 (a)
CG2052 37
  • 29 (a)
CG2129 37
  • 29 (a)
CG4936 37
  • 41 (a)
CG7987 37
  • 31 (a)
CG8301 37
  • 29 (a)
dwg 37
  • 43 (a)
Species with no ortholog for ZNF16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF16 Gene

ENSEMBL:
Gene Tree for ZNF16 (if available)
TreeFam:
Gene Tree for ZNF16 (if available)

Paralogs for ZNF16 Gene

(505) SIMAP similar genes for ZNF16 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF16: view

Variants for ZNF16 Gene

Sequence variations from dbSNP and Humsavar for ZNF16 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs3735784 - 144,932,474(-) TACCC(A/G)AGCTT reference, missense, utr-variant-5-prime
rs3735786 - 144,932,107(-) TCAGC(A/G)TCAAA reference, missense
rs2467655 -- 144,930,951(+) GAGCT(C/T)TGGCT reference, synonymous-codon
rs2467656 -- 144,934,030(+) CCACT(C/T)TGCTC intron-variant
rs2467657 -- 144,934,259(+) GTGCA(A/G)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF16 Gene

Variant ID Type Subtype PubMed ID
nsv469809 CNV Loss 16826518
nsv519737 CNV Loss 19592680
dgv7986n71 CNV Gain 21882294
dgv2265e1 CNV Complex 17122850
esv2669134 CNV Deletion 23128226
esv28548 CNV Gain+Loss 19812545
esv2664252 CNV Deletion 23128226
esv1336384 CNV Insertion 17803354
esv1592346 CNV Insertion 17803354
esv990431 CNV Insertion 20482838
esv1750274 CNV Insertion 17803354
esv2080072 CNV Deletion 18987734
nsv524560 CNV Gain 19592680

Variation tolerance for ZNF16 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.27; 52.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF16 Gene

HapMap Linkage Disequilibrium report
ZNF16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF16 Gene

Disorders for ZNF16 Gene

Relevant External Links for ZNF16

Genetic Association Database (GAD)
ZNF16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF16

No disorders were found for ZNF16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF16 Gene

Publications for ZNF16 Gene

  1. Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1. (PMID: 21874239) Li X.B. … Zhang J.W. (Mol Med Rep 2011) 3 4 67
  2. ZNF16 (HZF1) promotes erythropoiesis and megakaryocytopoiesis via regulation of the c-KIT gene. (PMID: 24180487) Chen J. … Zhang J.W. (Biochem. J. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Identification of HZF1 as a novel target gene of the MEF2 transcription factor. (PMID: 21468593) Liu X. … Li X.Q. (Mol Med Rep 2011) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for ZNF16 Gene

Sources for ZNF16 Gene

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