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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF157 Gene

protein-coding GIFtS: 51
GCID: GC0XP047230

zinc finger protein 157

(Previous name: zinc finger protein 157 (HZF22) )

Search for ZNF157
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 157¹ ²
HZF22¹ ²
Zinc Finger Protein HZF22² ³
Zinc Finger Protein 157 (HZF22)¹
Zinc Finger Protein 22²

External Ids:	HGNC: 12942¹	Entrez Gene: 7712²	Ensembl: ENSG00000147117⁷	OMIM: 300024⁵	UniProtKB: P51786³

Export aliases for ZNF157 gene to outside databases

Previous GC identifers: GC0XP046032 GC0XP045490 GC0XP046275 GC0XP046986 GC0XP047114 GC0XP044943

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF157:

This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act

as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking

regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ZN157_HUMAN, P51786

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_079573.4

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF157 gene promoter:
E2F-3a E2F-4 Elk-1 E2F-5 FOXF2 LUN-1 E2F-2 YY1 E2F-1 E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF157 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF157

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF157

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.2 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.2

ZNF157 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF157 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP047230: view genomic region (about GC identifiers)

Start:	47,229,982 bp from pter	End:	47,273,704 bp from pter
Size:	43,723 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN157_HUMAN, P51786 (See protein sequence)

Recommended Name: Zinc finger protein 157

Size: 506 amino acids; 58291 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: Q96LE9

Explore the universe of human proteins at neXtProt for ZNF157: NX_P51786

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P51786

ZNF157 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003437.2

ENSEMBL proteins:

ENSP00000366273

Reactome Protein details: P51786
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	Uscn Proteins for ZNF157

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZNF157 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF157 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry P51786

ProtoNet protein and cluster: P51786

2 Blocks protein families:

IPB001909 KRAB box

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN157_HUMAN, P51786

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 12 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN157_HUMAN, P51786

Function: May be involved in transcriptional regulation

Genatlas biochemistry entry for ZNF157:

zinc finger 157 (C2H2 type,Kruppel-like)

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	8586441
GO:0008270	zinc ion binding	IEA	--

ZNF157 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ZNF157:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF157

	Generic Transcription Pathway
	Gene Expression

ZNF157 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF157

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS	8586441
GO:0006351	transcription, DNA-dependent	IEA	--

ZNF157 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF157
Search CenterWatch for drugs/clinical trials and news about ZNF157 / ZN157

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for ZNF157 gene:

NM_003446.3

Unigene Cluster for ZNF157:

Zinc finger protein 157

Hs.89897 [show with all ESTs]

Unigene Representative Sequence: U28687

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000377073(uc004dhr.1)

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Additional cDNA sequence:

BC075003.2 U28687.1

1 DOTS entry:

DT.454973

13 AceView cDNA sequences:

BC075003 CO245598 BG911227 U28687 CO245594 CO245585 NM_003446 CO250117

T10258 CO245744 CO247685 CO250200 T10259

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF157 About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5a	·	5b
SP1:
SP2:									-
SP3:					-				-

ECgene alternative splicing isoforms for ZNF157

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF157 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ZNF157 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZNF157 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF157

SOURCE GeneReport for Unigene cluster: Hs.89897

SABiosciences Custom PCR Arrays for ZNF157

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF157 gene from 1/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	-- -- (see all 8)	--	40(a) 34(a) (see all 8)	many ↔ many many ↔ many (see all 8)	Un(41687425-41690654) Un(18847108-18852277)

ENSEMBL Gene Tree for ZNF157 (if available)
TreeFam Gene Tree for ZNF157 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF157 gene

ZNF684² ZNF25²

18/466 SIMAP similar genes for ZNF157 using alignment to 1 protein entry: ZN157_HUMAN(see all similar genes):

HZF36 ZNF530 ZFP2 ZNF391 ZSCAN16 HZF30

ZNF347 ZNF501 ZNF544 ZNF665 ZNF696 zf30

ZNF135 DKFZp434G1930 DKFZp666M039 DKFZp686B16128 ZNF146 ZNF160

ZNF157 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188816895^1,2		--	47228116(+)	`CCTCAA/GGTGAT`	1	--	us2k¹		0	--	--	--	--
rs199730633^1,2		--	47228279(+)	`GTGTT-/TTTG TTTGT`	1	--	us2k¹		0	--	--	--	--
rs112491869^1,2	C,	--	47228399(+)	`AAAGCC/TGTGAG`	1	--	us2k¹		1		WA	2
rs192738271^1,2		--	47228464(+)	`CCTCCC/TTCCTT`	1	--	us2k¹		0	--	--	--	--
rs76488786^1,2	F,	--	47228484(+)	`CTTCCT/ATCCTT`	1	--	us2k¹		1		NA	4
rs74710555^1,2	F	--	47228497(+)	`TTCCTC/TTCTTT`	1	--	us2k¹		1		NA	4
rs189187962^1,2		--	47228516(+)	`CTTTCG/TTTCTT`	1	--	us2k¹		0	--	--	--	--
rs180713497^1,2		--	47228521(+)	`TTTCTC/TTCTTT`	1	--	us2k¹		0	--	--	--	--
rs186422271^1,2		--	47228536(+)	`CTTTCG/TTTCTT`	1	--	us2k¹		0	--	--	--	--
rs189305342^1,2		--	47228540(+)	`CTTTCG/TTTCTT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF157 (47229982 - 47273704 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF157: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF157 for disorders About MalaCards

ZNF157 for disorders About GeneDecksing

OMIM gene information: 300024 OMIM disorders: --

Export disorders for ZNF157 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF157 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF157)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and characterization of a novel zinc finger gene in Xp11.2. (PubMed id 8586441)^{1, 2, 3, 9} Derry J.M.J.... Francke U. (1995)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genome-wide association identifies ATOH7 as a major g ene determining human optic disc size. (PubMed id 20395239)¹ Macgregor S....Mackey D.A. (2010)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. (PubMed id 11944989)¹ Thiselton D.L.... Meindl A. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7712	HGNC: 12942	AceView: ZNF157	Ensembl:ENSG00000147117	euGenes: HUgn7712
ECgene: ZNF157	H-InvDB: ZNF157

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF157	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF157 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF157 gene:
Search GeneIP for patents involving ZNF157

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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ZNF157 Gene

zinc finger protein 157

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ZNF157 Gene

zinc finger protein 157

Aliasesfor ZNF157 gene

Summariesfor ZNF157 gene

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Protein Domains /Familiesfor ZNF157 gene

Functionfor ZNF157 gene

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for ZNF157 gene

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for ZNF157 gene

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