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ZNF157 Gene

protein-coding   GIFtS: 51
GCID: GC0XP047230

Zinc Finger Protein 157

(Previous name: zinc finger protein 157 (HZF22))
  Search for ZNF157
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 1571 2
Zinc Finger Protein HZF222 3
Zinc Finger Protein 157 (HZF22)1
HZF222
Zinc Finger Protein 222

External Ids:    HGNC: 129421   Entrez Gene: 77122   Ensembl: ENSG000001471177   OMIM: 3000245   UniProtKB: P517863   

Export aliases for ZNF157 gene to outside databases

Previous GC identifers: GC0XP046032 GC0XP045490 GC0XP046275 GC0XP046986 GC0XP047114 GC0XP044943


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF157 Gene:
This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that
act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger
linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ZNF157 Gene:
ZNF157 (zinc finger protein 157) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF175.

UniProtKB/Swiss-Prot: ZN157_HUMAN, P51786
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF157 gene promoter:
         E2F-3a   E2F-4   Elk-1   E2F-5   FOXF2   LUN-1   E2F-2   YY1   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF157 promoter sequence
   Search Chromatin IP Primers for ZNF157

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF157


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.2   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.2

ZNF157 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF157 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP047230:  view genomic region     (about GC identifiers)

Start:
47,229,982 bp from pter      End:
47,273,704 bp from pter
Size:
43,723 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN157_HUMAN, P51786 (See protein sequence)
Recommended Name: Zinc finger protein 157  
Size: 506 amino acids; 58291 Da
Secondary accessions: Q96LE9

Explore the universe of human proteins at neXtProt for ZNF157: NX_P51786

Explore proteomics data for ZNF157 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF157 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003437.2  
    ENSEMBL proteins: 
     ENSP00000366273  
    Reactome Protein details: P51786

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P51786

    ProtoNet protein and cluster: P51786

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN157_HUMAN, P51786
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF157 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN157_HUMAN, P51786
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF157:
    zinc finger 157 (C2H2 type,Kruppel-like)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    ZNF157 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF157:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    hsa-mir-335-5p (MIRT017547)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN157_HUMAN, P51786: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF157 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF157 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF157
        Generic Transcription Pathway



    ZNF157 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF157
    Interactions:

        Search GeneGlobe Interaction Network for ZNF157

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS8586441
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    ZNF157 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF157 (ZN157)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF157 gene: 
    NM_003446.3  

    Unigene Cluster for ZNF157:

    Zinc finger protein 157
    Hs.89897  [show with all ESTs]
    Unigene Representative Sequence: U28687
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377073(uc004dhr.1)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF157

    Additional mRNA sequence: 

    BC075003.2 U28687.1 

    1 DOTS entry:

    DT.454973 

    13 AceView cDNA sequences:

    BC075003 U28687 NM_003446 CO245585 CO245594 CO245598 BG911227 CO245744 
    CO250117 T10258 CO250200 CO247685 T10259 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF157    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:                          -               
    SP3:              -           -               


    ECgene alternative splicing isoforms for ZNF157

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF157 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF157 Expression
    About this image

    ZNF157 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF157 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.89897
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF157 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp8105 zinc finger protein 810   --   9 (8.79 cM) 22276748 


    ENSEMBL Gene Tree for ZNF157 (if available)
    TreeFam Gene Tree for ZNF157 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF157 gene
    ZNF1752  ZNF6742  ZNF4872  ZNF5102  ZIM32  ZNF6142  ZNF262  ZNF6132  
    ZNF812  ZNF6492  ENSG000002673602  ZNF7822  ZNF7932  ZNF252  ZNF5682  ENSG000002365752  
    ENSG000002296312  ZNF5672  ZNF1822  ZNF37A2  ZNF2482  ZNF3002  ZNF3822  RBAK-RBAKDN2  
    Selected SIMAP similar genes for ZNF157 using alignment to 1 protein entry:     ZN157_HUMAN(see all similar genes):
    HZF36    ZNF323    ZNF135    ZNF530    ZFP2    ZNF391
    ZSCAN16    HZF30    ZNF347    ZNF501    ZNF544    ZNF665
    ZNF696    zf30    DKFZp434G1930    DKFZp666M039    DKFZp686B16128    ZNF146

    ZNF157 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF157 (see all 686)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1888168951,2
    --47228116(+) CCTCAA/GGTGAT 1 -- us2k10--------
    rs1997306331,2
    --47228279(+) GTGTT-/TTTG  
            
    TTTGT
    1 -- us2k10--------
    rs1124918691,2
    C,F--47228399(+) AAAGCC/TGTGAG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1927382711,2
    --47228464(+) CCTCCC/TTCCTT 1 -- us2k10--------
    rs764887861,2
    F--47228484(+) CTTCCT/ATCCTT 1 -- us2k11Minor allele frequency- A:0.50NA 4
    rs747105551,2
    F--47228497(+) TTCCTC/TTCTTT 1 -- us2k11Minor allele frequency- T:0.50NA 4
    rs1891879621,2
    --47228516(+) CTTTCG/TTTCTT 1 -- us2k10--------
    rs1807134971,2
    --47228521(+) TTTCTC/TTCTTT 1 -- us2k10--------
    rs1864222711,2
    --47228536(+) CTTTCG/TTTCTT 1 -- us2k10--------
    rs1893053421,2
    --47228540(+) CTTTCG/TTTCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF157 (47229982 - 47273704 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZNF157: --
    Human Gene Mutation Database (HGMD): ZNF157
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF157
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF157

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300024    OMIM disorders: --


    ZNF157 for disorders           About GeneDecksing


    Export disorders for ZNF157 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF157 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF157)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel zinc finger gene in Xp11.2. (PubMed id 8586441)1, 2, 3, 9 Derry J.M.J.... Francke U. (Genomics 1995)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. (PubMed id 20395239)1 Macgregor S....Mackey D.A. (Hum. Mol. Genet. 2010)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    6. An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. (PubMed id 11944989)1 Thiselton D.L.... Meindl A. (Genomics 2002)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7712 HGNC: 12942 AceView: ZNF157 Ensembl:ENSG00000147117 euGenes: HUgn7712
    ECgene: ZNF157 H-InvDB: ZNF157

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZNF157 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF157 gene:
    Search GeneIP for patents involving ZNF157

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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