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Aliases for ZNF157 Gene

Aliases for ZNF157 Gene

  • Zinc Finger Protein 157 2 3 5
  • Zinc Finger Protein HZF22 3 4
  • Zinc Finger Protein 157 (HZF22) 2
  • Zinc Finger Protein 22 3
  • HZF22 3

External Ids for ZNF157 Gene

Previous GeneCards Identifiers for ZNF157 Gene

  • GC0XP046032
  • GC0XP045490
  • GC0XP046275
  • GC0XP046986
  • GC0XP047114
  • GC0XP047230
  • GC0XP044943

Summaries for ZNF157 Gene

Entrez Gene Summary for ZNF157 Gene

  • This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF157 Gene

ZNF157 (Zinc Finger Protein 157) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF248.

UniProtKB/Swiss-Prot for ZNF157 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF157 Gene

Genomics for ZNF157 Gene

Regulatory Elements for ZNF157 Gene

Genomic Location for ZNF157 Gene

47,370,583 bp from pter
47,414,305 bp from pter
43,723 bases
Plus strand

Genomic View for ZNF157 Gene

Genes around ZNF157 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF157 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF157 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF157 Gene

Proteins for ZNF157 Gene

  • Protein details for ZNF157 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 157
    Protein Accession:
    Secondary Accessions:
    • Q96LE9

    Protein attributes for ZNF157 Gene

    506 amino acids
    Molecular mass:
    58291 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF157 Gene

Proteomics data for ZNF157 Gene at MOPED

Post-translational modifications for ZNF157 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF157 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF157 Gene

Domains & Families for ZNF157 Gene

Gene Families for ZNF157 Gene

Protein Domains for ZNF157 Gene

Suggested Antigen Peptide Sequences for ZNF157 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF157: view

Function for ZNF157 Gene

Molecular function for ZNF157 Gene

GENATLAS Biochemistry:
zinc finger 157 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF157: view
genes like me logo Genes that share phenotypes with ZNF157: view

Animal Model Products

CRISPR Products

miRNA for ZNF157 Gene

miRTarBase miRNAs that target ZNF157

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF157 Gene

Localization for ZNF157 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF157 Gene

Subcellular locations from

Jensen Localization Image for ZNF157 Gene COMPARTMENTS Subcellular localization image for ZNF157 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF157 Gene

Pathways & Interactions for ZNF157 Gene

SuperPathways for ZNF157 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF157: view

Pathways by source for ZNF157 Gene

2 Reactome pathways for ZNF157 Gene

Interacting Proteins for ZNF157 Gene

Gene Ontology (GO) - Biological Process for ZNF157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 8586441
genes like me logo Genes that share ontologies with ZNF157: view

No data available for SIGNOR curated interactions for ZNF157 Gene

Drugs & Compounds for ZNF157 Gene

No Compound Related Data Available

Transcripts for ZNF157 Gene

mRNA/cDNA for ZNF157 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF157 Gene

Zinc finger protein 157:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF157 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP2: -
SP3: - -

Relevant External Links for ZNF157 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF157 Gene

mRNA expression in normal human tissues for ZNF157 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF157 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.0), Brain - Cerebellum (x4.9), and Pituitary (x4.9).

SOURCE GeneReport for Unigene cluster for ZNF157 Gene Hs.89897

genes like me logo Genes that share expression patterns with ZNF157: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF157 Gene

Orthologs for ZNF157 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF157 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF157 35
  • 89.32 (n)
  • 85.77 (a)
ZNF157 36
  • 84 (a)
(Canis familiaris)
Mammalia ZNF157 35
  • 92.33 (n)
  • 91.47 (a)
ZNF157 36
  • 73 (a)
(Pan troglodytes)
Mammalia ZNF157 35
  • 99.65 (n)
  • 99.58 (a)
ZNF157 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100911510 35
  • 83.57 (n)
  • 80.76 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
-- 36
  • 47 (a)
-- 36
  • 42 (a)
-- 36
  • 42 (a)
-- 36
  • 45 (a)
-- 36
  • 42 (a)
-- 36
  • 38 (a)
-- 36
  • 36 (a)
-- 36
  • 44 (a)
-- 36
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11696 37
  • 30 (a)
CG15436 37
  • 42 (a)
jim 37
  • 48 (a)
Species with no ortholog for ZNF157:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF157 Gene

Gene Tree for ZNF157 (if available)
Gene Tree for ZNF157 (if available)

Paralogs for ZNF157 Gene

(469) SIMAP similar genes for ZNF157 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF157: view

Variants for ZNF157 Gene

Sequence variations from dbSNP and Humsavar for ZNF157 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs4289943 -- 47,394,503(+) aggcc(A/G)cccct intron-variant
rs3810665 -- 47,370,536(-) TATCC(A/G)TATCA upstream-variant-2KB
rs3810666 -- 47,370,510(-) ATTCA(C/T)GCCAC upstream-variant-2KB
rs4538999 -- 47,377,355(+) CTCTA(C/T)TGCAG intron-variant
rs4543671 -- 47,377,748(+) ttttt(A/T)aaaaa intron-variant

Variation tolerance for ZNF157 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF157 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF157 Gene

Disorders for ZNF157 Gene

Relevant External Links for ZNF157

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF157 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF157 Gene

Publications for ZNF157 Gene

  1. Cloning and characterization of a novel zinc finger gene in Xp11.2. (PMID: 8586441) Derry J.M.J. … Francke U. (Genomics 1995) 2 3 4 23 67
  2. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. (PMID: 20395239) Macgregor S. … Mackey D.A. (Hum. Mol. Genet. 2010) 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for ZNF157 Gene

Sources for ZNF157 Gene

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