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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF154 Gene

protein-coding GIFtS: 47
GCID: GC19M058208

zinc finger protein 154

(Previous name: zinc finger protein 154 (pHZ-92) )

Search for ZNF154
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 154¹ ²
PHZ-92¹
Zinc Finger Protein 154 (PHZ-92)¹
KIAA2003³

External Ids:	HGNC: 12939¹	Entrez Gene: 7710²	Ensembl: ENSG00000179909⁷	OMIM: 604085⁵	UniProtKB: Q13106³

Export aliases for ZNF154 gene to outside databases

Previous GC identifers: GC19M059111 GC19M058662 GC19M062888 GC19M062900 GC19M054524

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN154_HUMAN, Q13106

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for ZNF154
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ZNF154

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF154

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.4

ZNF154 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF154 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M058208: view genomic region (about GC identifiers)

Start:	58,208,735 bp from pter	End:	58,220,579 bp from pter
Size:	11,845 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN154_HUMAN, Q13106 (See protein sequence)

Recommended Name: Zinc finger protein 154

Size: 437 amino acids; 49865 Da

Subcellular location: Nucleus (Potential)

Sequence caution: Sequence=BAC23100.1; Type=Erroneous initiation;

Secondary accessions: A7MCY3 Q8IVG7 Q8NAR0

Explore the universe of human proteins at neXtProt for ZNF154: NX_Q13106

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13106

ZNF154 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_001078853.1

ENSEMBL proteins:

ENSP00000421258 ENSP00000442370

Reactome Protein details: Q13106
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	7557990

ZNF154 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF154 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q13106

ProtoNet protein and cluster: Q13106

2 Blocks protein families:

IPB001909 KRAB box

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN154_HUMAN, Q13106

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 12 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN154_HUMAN, Q13106

Function: May be involved in transcriptional regulation

Genatlas biochemistry entry for ZNF154:

zinc finger protein 154 (C2H2 type,Kruppel-like)

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	NAS	7557990
GO:0008270	zinc ion binding	IEA	--

ZNF154 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ZNF154:

Decreased influenza A virus in

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF154

	Generic Transcription Pathway
	Gene Expression

ZNF154 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF154

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	NAS	7557990

ZNF154 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Search CenterWatch for drugs/clinical trials and news about ZNF154 / ZN154

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF154 gene (2 alternative transcripts):

NM_003444.1 NM_001085384.1

Unigene Cluster for ZNF154:

Zinc finger protein 154

Hs.646378 [show with all ESTs]

Unigene Representative Sequence: BC152561

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000512439 ENST00000426889(uc010euf.3)

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Additional cDNA sequence:

BC152404.1 BC152426.1 BC152561.1 U20648.1

9 DOTS entries:

DT.65285344 DT.40106249 DT.95110994 DT.102843467 DT.109378 DT.100016989 DT.102834402 DT.121503655

DT.86851471

24/38 AceView cDNA sequences (see all 38):

AA504346 BF000129 AA521248 U20648 BI962590 BI789123 BV204735 CB045750

AK092261 AI948601 AB095924 AA789092 AI028391 AI150627 AA287738 NM_003444

AA286838 AX747437 AI949650 BG717304 BQ432718 AA346157 BE069191 AW935938

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF154 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTACTAGTG

About this image
Genevestigator expression for ZNF154

SOURCE GeneReport for Unigene cluster: Hs.646378

SABiosciences Custom PCR Arrays for ZNF154

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for ZNF154 (if available)
TreeFam Gene Tree for ZNF154 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF154 gene

ZNF549² ZNF211² ZNF417² ZNF792² ZNF749² ZNF551² ZNF776² ZNF547²

ZNF17² ZNF416² ZNF548² ZNF304² ZNF587B² ZNF773² ZNF132² ZIK1²

ZNF671² ZNF134² ZNF418² ZNF256² ZNF552² ZNF772² ZNF530² ZNF419²

18/492 SIMAP similar genes for ZNF154 using alignment to 2 protein entries: ZN154_HUMAN (see all proteins) (see all similar genes):

HZF36 ZNF232 ZNF660 ZNF79 ZSCAN16 HZF30

DKFZp686H10254 ZNF204 ZNF286B ZNF358 ZNF853 ZSCAN21

DKFZp666C237 ZNF146 ZNF300 ZNF696 zf30 ZNF329

ZNF154 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114080879^1,2	F,	--	58211350(+)	`AAAAAT/AAAAAA`	1	--	ds500¹		1		WA	118
rs199826553^1,2		--	58211350(+)	`AAAAA-/TAAAAA`	1	--	ds500¹		0	--	--	--	--
rs150057408^1,2		--	58211440(+)	`TTCCTA/GTTGTT`	1	--	ds500¹		0	--	--	--	--
rs183576776^1,2		--	58211529(+)	`GTGATC/TACAAA`	1	--	ds500¹		0	--	--	--	--
rs10419113^1,2	C,F,A,H,	--	58211530(+)	`TGATCG/ACAAAT`	1	--	ds500¹		23		NS EA NA WA CSA	2331
rs80289942^1,2		--	58211668(+)	`GAGGTG/AAAAAT`	1	--	ds500¹		1		NA	120
rs144404911^1,2		--	58211943(+)	`GGATAG/TCAAGG`	1	--	ut3¹		0	--	--	--	--
rs2240025^1,2	C,F,A,H,	--	58212044(+)	`CAGAAA/GCATCA`	1	--	ut3¹		28		EA NA NS CSA WA	4457
rs111772653^1,2		--	58212172(+)	`TCAAAT/CTAGAG`	1	--	ut3¹		1		CSA	1
rs138155935^1,2	C,	--	58212219(+)	`CTGTC-/CCTGTT GAGCT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF154 (58208735 - 58220579 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF154: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF154 for disorders About MalaCards

ZNF154 for disorders About GeneDecksing

OMIM gene information: 604085 OMIM disorders: --

Export disorders for ZNF154 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF154 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF154)

Utopia: connect your pdf to the dynamic
world of online information

Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PubMed id 7557990)^{1, 2, 3} Tommerup N. and Vissing H. (1995)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7710	HGNC: 12939	AceView: ZNF154	Ensembl:ENSG00000179909	euGenes: HUgn7710
ECgene: ZNF154	H-InvDB: ZNF154

(According to HUGE)
About This Section

HUGE: KIAA2003

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF154	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF154 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF154 gene:
Search GeneIP for patents involving ZNF154

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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ZNF154 Gene

zinc finger protein 154

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ZNF154 Gene

zinc finger protein 154

Aliasesfor ZNF154 gene

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for ZNF154 gene

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for ZNF154 gene

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for ZNF154 gene

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for ZNF154 gene

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for ZNF154 gene

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for ZNF154 gene

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for ZNF154 gene

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