Aliases for ZNF148 Gene
External Ids for ZNF148 Gene
Previous GeneCards Identifiers for ZNF148 Gene
The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer, while mutations in this gene have been associated with global developmental delay, hypoplastic corpus callosum, and dysmorphic facies. [provided by RefSeq, Feb 2017]
GeneCards Summary for ZNF148 Gene
ZNF148 (Zinc Finger Protein 148) is a Protein Coding gene. Diseases associated with ZNF148 include Global Developmental Delay, Absent Or Hypoplastic Corpus Callosum, And Dysmorphic Facies and Split Hand-Foot Malformation 1. GO annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ZNF281.
UniProtKB/Swiss-Prot for ZNF148 Gene
Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.