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Aliases for ZNF148 Gene

Aliases for ZNF148 Gene

  • Zinc Finger Protein 148 2 3
  • Zinc Finger DNA-Binding Protein 89 3 4
  • Transcription Factor ZBP-89 3 4
  • ZFP148 3 6
  • Zinc Finger Protein 148 (PHZ-52) 2
  • CLL-Associated Antigen KW-10 3
  • CACCC Box-Binding Protein 3
  • HT-BETA 3
  • BERF-1 3
  • BFCOL1 3
  • ZBP-89 3
  • PHZ-52 3
  • ZBP89 4

External Ids for ZNF148 Gene

Summaries for ZNF148 Gene

GeneCards Summary for ZNF148 Gene

ZNF148 (Zinc Finger Protein 148) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and double-stranded DNA binding. An important paralog of this gene is ZNF740.

UniProtKB/Swiss-Prot for ZNF148 Gene

  • Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes

Gene Wiki entry for ZNF148 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF148 Gene

Genomics for ZNF148 Gene

Genomic Location for ZNF148 Gene

Start:
125,225,561 bp from pter
End:
125,375,354 bp from pter
Size:
149,794 bases
Orientation:
Minus strand

Genomic View for ZNF148 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF148 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF148 Gene

Regulatory Elements for ZNF148 Gene

Proteins for ZNF148 Gene

  • Protein details for ZNF148 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQR1-ZN148_HUMAN
    Recommended name:
    Zinc finger protein 148
    Protein Accession:
    Q9UQR1
    Secondary Accessions:
    • D3DN27
    • O00389
    • O43591
    • Q58EY5
    • Q6PJ98

    Protein attributes for ZNF148 Gene

    Size:
    794 amino acids
    Molecular mass:
    88976 Da
    Quaternary structure:
    • Interacts with HNRNPDL. Interacts with the 5FMC complex; the interaction requires association with CHTOP.

    Alternative splice isoforms for ZNF148 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF148 Gene

Proteomics data for ZNF148 Gene at MOPED

Post-translational modifications for ZNF148 Gene

  • Sumoylated with SUMO2. Desumoylated by SENP3, resulting in the stimulation of transcription of its target genes (By similarity).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys153

No data available for DME Specific Peptides for ZNF148 Gene

Domains for ZNF148 Gene

Gene Families for ZNF148 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF148 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UQR1

UniProtKB/Swiss-Prot:

ZN148_HUMAN
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q9UQR1
Similarity:
  • Contains 4 C2H2-type zinc fingers.:
    • Q9UQR1
genes like me logo Genes that share domains with ZNF148: view

Function for ZNF148 Gene

Molecular function for ZNF148 Gene

GENATLAS Biochemistry: zinc finger protein 148 (C2H2 type,Kruppel-like),functioning as a beta enolase repressor factor 1
UniProtKB/Swiss-Prot Function: Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes

Gene Ontology (GO) - Molecular Function for ZNF148 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding --
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 12771217
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 12771217
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
genes like me logo Genes that share ontologies with ZNF148: view
genes like me logo Genes that share phenotypes with ZNF148: view

Animal Models for ZNF148 Gene

MGI Knock Outs for ZNF148:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZNF148 Gene

Localization for ZNF148 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF148 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF148 Gene COMPARTMENTS Subcellular localization image for ZNF148 gene
Compartment Confidence
nucleus 5
golgi apparatus 4

Gene Ontology (GO) - Cellular Components for ZNF148 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with ZNF148: view

Pathways for ZNF148 Gene

SuperPathways for ZNF148 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF148 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 12771217
GO:0006366 transcription from RNA polymerase II promoter TAS 9685330
GO:0006461 protein complex assembly IEA --
GO:0006968 cellular defense response TAS 8355710
GO:0007276 gamete generation IEA --
genes like me logo Genes that share ontologies with ZNF148: view

No data available for Pathways by source for ZNF148 Gene

Compounds for ZNF148 Gene

(1) HMDB Compounds for ZNF148 Gene

Compound Synonyms Cas Number PubMed IDs
Zinc
  • Zinc
7440-66-6

(2) Novoseek inferred chemical compound relationships for ZNF148 Gene

Compound -log(P) Hits PubMed IDs
zinc 66.4 23
butyrate 58.2 17
genes like me logo Genes that share compounds with ZNF148: view

Transcripts for ZNF148 Gene

Unigene Clusters for ZNF148 Gene

Zinc finger protein 148:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF148 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b
SP1: - - - - - - -
SP2: - - -
SP3: - - -
SP4: -
SP5: - - - - - -
SP6: - -
SP7: -
SP8:

Relevant External Links for ZNF148 Gene

GeneLoc Exon Structure for
ZNF148
ECgene alternative splicing isoforms for
ZNF148

Expression for ZNF148 Gene

mRNA expression in normal human tissues for ZNF148 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF148 Gene

SOURCE GeneReport for Unigene cluster for ZNF148 Gene Hs.592591

genes like me logo Genes that share expressions with ZNF148: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF148 Gene

Orthologs for ZNF148 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF148 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF148 35
  • 99.79 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia ZNF148 35
  • 95.8 (n)
  • 99.24 (a)
ZNF148 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF148 35
  • 94.75 (n)
  • 98.99 (a)
ZNF148 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp148 35
  • 92.99 (n)
  • 97.61 (a)
Zfp148 16
Zfp148 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF148 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp148 35
  • 92.02 (n)
  • 97.23 (a)
chicken
(Gallus gallus)
Aves ZNF148 35
  • 85.08 (n)
  • 88.62 (a)
ZNF148 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF148 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487127 35
  • 64.98 (n)
  • 66.75 (a)
zebrafish
(Danio rerio)
Actinopterygii wufb06h05 35
znf148 35
  • 65.64 (n)
  • 63.06 (a)
znf148 36
  • 58 (a)
OneToOne
Species with no ortholog for ZNF148:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF148 Gene

ENSEMBL:
Gene Tree for ZNF148 (if available)
TreeFam:
Gene Tree for ZNF148 (if available)

Paralogs for ZNF148 Gene

Paralogs for ZNF148 Gene

genes like me logo Genes that share paralogs with ZNF148: view

Variants for ZNF148 Gene

Sequence variations from dbSNP and Humsavar for ZNF148 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs13573 -- 125,229,552(+) AGATA(C/T)TGCCT utr-variant-3-prime
rs510232 -- 125,231,279(-) CTTTG(A/G)AACTG utr-variant-3-prime
rs592528 -- 125,229,156(-) TCTTA(A/G)AACAT utr-variant-3-prime
rs592559 -- 125,229,141(-) AACTA(A/G)AACTC utr-variant-3-prime
rs897323 -- 125,289,761(+) GGCAA(C/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF148 Gene

Variant ID Type Subtype PubMed ID
nsv10311 CNV Gain 18304495
nsv877406 CNV Gain 21882294
esv2657697 CNV Deletion 23128226
esv2651756 CNV Deletion 19546169
nsv508239 CNV Loss 20534489
nsv509849 CNV Loss 20534489
esv2725855 CNV Deletion 23290073
esv994465 CNV Deletion 20482838
esv1126785 CNV Deletion 17803354
nsv829713 CNV Gain 17160897

Relevant External Links for ZNF148 Gene

HapMap Linkage Disequilibrium report
ZNF148

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF148 Gene

Disorders for ZNF148 Gene

(1) Novoseek inferred disease relationships for ZNF148 Gene

Disease -log(P) Hits PubMed IDs
adenocarcinoma 0 1

Relevant External Links for ZNF148

Genetic Association Database (GAD)
ZNF148
Human Genome Epidemiology (HuGE) Navigator
ZNF148
genes like me logo Genes that share disorders with ZNF148: view

No data available for UniProtKB/Swiss-Prot for ZNF148 Gene

Publications for ZNF148 Gene

  1. The gene encoding the transcriptional repressor BERF-1 maps to a region of conserved synteny on mouse chromosome 16 and human chromosome 3 and a related pseudogene maps to mouse chromosome 8. (PMID: 9925940) Antona V. … Feo S. (Cytogenet. Cell Genet. 1998) 2 3 23
  2. Human stromelysin gene promoter activity is modulated by transcription factor ZBP-89. (PMID: 10359087) Ye S. … Henney A. (FEBS Lett. 1999) 3 4 23
  3. Association analysis of cystatin A and zinc finger protein 148, two genes located at the psoriasis susceptibility locus PSORS5. (PMID: 15175029) Samuelsson L. … WahlstrAPm J. (J. Invest. Dermatol. 2004) 3 23 48
  4. Intestinal alkaline phosphatase gene expression is activated by ZBP-89. (PMID: 16384873) Malo M.S. … Hodin R.A. (Am. J. Physiol. Gastrointest. Liver Physiol. 2006) 3 23
  5. Inhibition of growth hormone receptor gene expression by saturated fatty acids: role of Kruppel-like zinc finger factor, ZBP-89. (PMID: 16825291) Thimmarayappa J. … Menon R.K. (Mol. Endocrinol. 2006) 3 23

Products for ZNF148 Gene

Sources for ZNF148 Gene

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