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ZNF148 Gene

protein-coding   GIFtS: 55
GCID: GC03M124944

Zinc Finger Protein 148

(Previous name: zinc finger protein 148 (pHZ-52))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 1481 2     HT-BETA2
Transcription Factor ZBP-892 3     ZBP-892
Zinc Finger DNA-Binding Protein 892 3     CACCC Box-Binding Protein2
ZFP1482 5     CLL-Associated Antigen KW-102
Zinc Finger Protein 148 (PHZ-52)1     pHZ-522
BERF-12     ZBP893
BFCOL12     

External Ids:    HGNC: 129331   Entrez Gene: 77072   Ensembl: ENSG000001638487   OMIM: 6018975   UniProtKB: Q9UQR13   

Export aliases for ZNF148 gene to outside databases

Previous GC identifers: GC03M121701 GC03M124981 GC03M126232 GC03M126271 GC03M126433 GC03M122320


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF148 Gene:
ZNF148 (zinc finger protein 148) is a protein-coding gene. Diseases associated with ZNF148 include sertoli cell-only syndrome, and y chromosome infertility. GO annotations related to this gene include double-stranded DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF740.

UniProtKB/Swiss-Prot: ZN148_HUMAN, Q9UQR1
Function: Involved in transcriptional regulation. Represses the transcription of a number of genes including
gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes

Gene Wiki entry for ZNF148 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF148 gene promoter:
         E2F-4   E2F-3a   E2F-5   STAT1   STAT1beta   E2F-2   STAT1alpha   E2F   E2F-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF148

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF148


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21   Ensembl cytogenetic band:  3q21.2   HGNC cytogenetic band: 3q21.2

ZNF148 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF148 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M124944:  view genomic region     (about GC identifiers)

Start:
124,944,405 bp from pter      End:
125,094,198 bp from pter
Size:
149,794 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN148_HUMAN, Q9UQR1 (See protein sequence)
Recommended Name: Zinc finger protein 148  
Size: 794 amino acids; 88976 Da
Subunit: Interacts with HNRNPDL. Interacts with the 5FMC complex; the interaction requires association with CHTOP
Secondary accessions: D3DN27 O00389 O43591 Q58EY5

Explore the universe of human proteins at neXtProt for ZNF148: NX_Q9UQR1

Explore proteomics data for ZNF148 at MOPED

Post-translational modifications: 

  • Sumoylated with SUMO2. Desumoylated by SENP3, resulting in the stimulation of transcription of its target genes
    (By similarity)1
  • Ubiquitination2 at Lys153
  • Modification sites at PhosphoSitePlus

  • See ZNF148 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_068799.2  
    ENSEMBL proteins: 
     ENSP00000353863   ENSP00000420102   ENSP00000420335   ENSP00000419322   ENSP00000420448  
     ENSP00000417847   ENSP00000419585   ENSP00000420038   ENSP00000437916  

    ZNF148 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ZNF148
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ZNF148
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    Novus Biologicals ZNF148 Protein
    Novus Biologicals ZNF148 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF148

    ZNF148 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for ZNF148
    Cloud-Clone Corp. Antibodies for ZNF148
    ThermoFisher Antibody for ZNF148
    LSBio Antibodies in human, mouse, rat for ZNF148

    ZNF148 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZNF148
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZNF148
    Cloud-Clone Corp. CLIAs for ZNF148


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UQR1

    ProtoNet protein and cluster: Q9UQR1

    UniProtKB/Swiss-Prot: ZN148_HUMAN, Q9UQR1
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers


    ZNF148 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN148_HUMAN, Q9UQR1
    Function: Involved in transcriptional regulation. Represses the transcription of a number of genes including
    gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes

         Genatlas biochemistry entry for ZNF148:
    zinc finger protein 148 (C2H2 type,Kruppel-like),functioning as a beta enolase repressor factor 1

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
         
    ZNF148 for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Zfp148):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  immune system  integument  mortality/aging 
     nervous system  normal  reproductive system  respiratory system 

    ZNF148 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ZNF148: Zfp148tm1Kii Zfp148tm1Djl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF148
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZNF148

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF148
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF148

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZNF148:
    hsa-mir-425-5p (MIRT039326), hsa-let-7b-5p (MIRT051980), hsa-mir-186-5p (MIRT021205), hsa-mir-181a-5p (MIRT025207), hsa-mir-132-3p (MIRT021856), hsa-mir-203a (MIRT006269), hsa-mir-335-5p (MIRT018719), hsa-mir-93-5p (MIRT028179)

    Block miRNA regulation of human, mouse, rat ZNF148 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF148 (see all 265):
    hsa-miR-124* hsa-miR-411* hsa-miR-520f hsa-miR-361-5p hsa-miR-146a hsa-miR-4275 hsa-miR-3622b-3p hsa-miR-200b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZNF148
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF148

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZNF148

    Clone
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    OriGene clones in human, mouse for ZNF148 (see all 7)
    OriGene ORF clones in mouse, rat for ZNF148
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZNF148 (NM_021964)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF148
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF148

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF148


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN148_HUMAN, Q9UQR1: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005794Golgi apparatus ----

    ZNF148 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including ZNF148: 
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ZNF148

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for ZNF148 (Q9UQR12, 3 ENSP000003538634) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC3O153792, 3, ENSP000003029674MINT-7144469 MINT-7144499 MINT-7144482 I2D: score=2 STRING: ENSP00000302967
    HDAC4P565242, 3, ENSP000002646064MINT-7144512 I2D: score=1 STRING: ENSP00000264606
    PTRFQ6NZI23, ENSP000003495414I2D: score=3 STRING: ENSP00000349541
    TP53P046373, ENSP000002693054I2D: score=3 STRING: ENSP00000269305
    EP300Q094723, ENSP000002632534I2D: score=2 STRING: ENSP00000263253
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS9685330
    GO:0006461protein complex assembly IEA--
    GO:0006968cellular defense response TAS8355710
    GO:0007276gamete generation IEA--

    ZNF148 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF148 (ZN148)

    1 HMDB Compound for ZNF148    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    2 Novoseek inferred chemical compound relationships for ZNF148 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 66.4 30 8943318 (2), 9144414 (2), 10777586 (2), 9268691 (2) (see all 17)
    butyrate 58.2 22 10899165 (7), 12840224 (5), 17560543 (3), 12622418 (2)



    ZNF148 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF148 gene: 
    NM_021964.2  

    Unigene Cluster for ZNF148:

    Zinc finger protein 148
    Hs.592591  [show with all ESTs]
    Unigene Representative Sequence: NM_021964
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360647(uc003ehx.4 uc003ehz.4 uc010hsa.3 uc003eia.4 uc003ehy.3)
    ENST00000468369 ENST00000484491 ENST00000492394 ENST00000485866 ENST00000497929
    ENST00000496732 ENST00000465763 ENST00000495019 ENST00000471196 ENST00000544464

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF148 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF148 (see all 265):
    hsa-miR-124* hsa-miR-411* hsa-miR-520f hsa-miR-361-5p hsa-miR-146a hsa-miR-4275 hsa-miR-3622b-3p hsa-miR-200b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF148
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF148
    Clone
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    OriGene clones in human, mouse for ZNF148 (see all 7)
    OriGene ORF clones in mouse, rat for ZNF148
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZNF148 (NM_021964)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF148
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF148
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF148
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF148
      QuantiFast Probe-based Assays in human, mouse, rat ZNF148

    Additional mRNA sequence: 

    AF039019.1 AF432210.1 AJ236885.1 AK310654.1 AK314203.1 AL833616.1 BC016316.1 BC018971.2 
    BC035591.1 BC050260.1 BC128582.1 DQ090088.1 L04282.1 U09851.1 

    12 DOTS entries:

    DT.99932689  DT.411207  DT.91738209  DT.95376273  DT.314455  DT.210145  DT.212644  DT.100817050 
    DT.120909104  DT.120909147  DT.95376271  DT.97765131 

    Selected AceView cDNA sequences (see all 314):

    CA440516 AA412235 CA336516 AA588715 BU902868 BI093600 AU121036 BQ573990 
    BM702502 AA968968 AW089063 AI467973 NM_024628 AA399260 BM771821 BM665217 
    AI263859 AI718907 BX369282 BQ441085 BM874671 AW594167 AA169362 CA866727 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF148 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b
    SP1:                          -     -           -     -           -           -                                                           -               
    SP2:                                                              -           -                                                           -               
    SP3:                                                  -           -           -                                                                           
    SP4:                                                                                                                                -                     
    SP5:                                            -     -     -     -     -     -                                                                           


    ECgene alternative splicing isoforms for ZNF148

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF148 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTCACCTT
    ZNF148 Expression
    About this image


    ZNF148 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ZNF148 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF148 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592591
        Pathway & Disease-focused RT2 Profiler PCR Array including ZNF148: 
              Cardiotoxicity in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF148
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF148
    QuantiTect SYBR Green Assays in human, mouse, rat ZNF148
    QuantiFast Probe-based Assays in human, mouse, rat ZNF148
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF148

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF148 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp1481 , 5 zinc finger protein 1481, 5 92.99(n)1
    97.61(a)1
      16 (23.93 cM)5
    226611  NM_011749.41  NP_035879.11 
     333807755 
    chicken
    (Gallus gallus)
    Aves ZNF1481 zinc finger protein 148 85.08(n)
    88.62(a)
      424259  XM_004942947.1  XP_004943004.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF1486
    zinc finger protein 148
    81(a)
    1 ↔ 1
    1(77867145-77890913)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004871271 zinc finger protein 148-like 64.98(n)
    66.75(a)
      100487127  XM_002942594.2  XP_002942640.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb06h052 Transcribed sequence with weak similarity to protein more 79.15(n)    57037214 


    ENSEMBL Gene Tree for ZNF148 (if available)
    TreeFam Gene Tree for ZNF148 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF148 gene
    ZNF7402  ZNF2812  
    Selected SIMAP similar genes for ZNF148 using alignment to 9 protein entries:     ZN148_HUMAN (see all proteins) (see all similar genes):
    tb protein    HKR3    ZNF441    ZBTB47    ZNF652    REST
    DKFZp686G16228    ZNF12    ZNF28    ZNF320    ZNF442    ZNF701
    ZNF888    ZNF468    ZNF479    ZNF78L1    HKR1    ZNF263

    ZNF148 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF148 (see all 2653)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs593094621,2
    C--122350487(+) TTTTT-/T/TT  
            
    GAGAC
    1 -- int11NA 2
    rs105676311,2
    C--122367866(+) ATATA-/TTTA  
            
    ATTAC
    1 -- int11Minor allele frequency- TTTA:0.00NA 2
    rs9360791,2
    C,F,O,A,H--124944143(-) ATTTCG/AAAGTG 1 -- int121Minor allele frequency- A:0.37MN NA NS EA WA CSA 1120
    rs1456035851,2
    C--124944165(+) TTACAA/GTATCA 1 -- int10--------
    rs9360781,2
    C,F,O,A,H--124944178(-) GGGATA/GTGAAA 1 -- int115Minor allele frequency- G:0.33NA WA CSA EA 400
    rs1393884081,2
    --124944209(+) TGCAGC/TTGTGT 1 -- int10--------
    rs1436272371,2
    --124944292(+) TTTTAG/TCTTTA 1 -- int10--------
    rs738591491,2
    C,F--124944417(+) AAAAAA/TTTTTT 1 -- int12Minor allele frequency- T:0.09WA 120
    rs1467845421,2
    --124944423(+) TTTTTA/TAATTC 1 -- int10--------
    rs1177867071,2
    C,F--124944439(+) AAACAT/CATAAT 1 -- int11Minor allele frequency- C:0.02EA 120

    HapMap Linkage Disequilibrium report for ZNF148 (124944405 - 125094198 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ZNF148:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1126785CNV Deletion17803354
    esv994465CNV Deletion20482838
    esv2657697CNV Deletion23128226
    esv2725855CNV Deletion23290073
    esv2651756CNV Deletion19546169
    nsv509849CNV Loss20534489
    nsv508239CNV Loss20534489
    nsv829713CNV Gain17160897
    nsv877406CNV Gain21882294
    nsv10311CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF148
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF148

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601897    OMIM disorders: --

    17 diseases for ZNF148:    
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    sertoli cell-only syndrome    y chromosome infertility    clear cell renal cell carcinoma    renal cell carcinoma
    infertility    psoriasis    hepatocellular carcinoma    tonsillitis
    pancreatic cancer    adenocarcinoma    pancreatitis    colorectal cancer
    thyroiditis    cerebritis    prostatitis    neuronitis
    endotheliitis


    ZNF148 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ZNF148 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma 0 1 12622418 (1)

    Genetic Association Database (GAD): ZNF148
    Human Genome Epidemiology (HuGE) Navigator: ZNF148 (3 documents)

    Export disorders for ZNF148 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF148 gene, integrated from 10 sources (see all 73):
    (articles sorted by number of sources associating them with ZNF148)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human stromelysin gene promoter activity is modulated by transcription factor ZBP-89. (PubMed id 10359087)1, 2, 9 Ye S.... Henney A. (FEBS Lett. 1999)
    2. The gene encoding the transcriptional repressor BERF-1 maps to a region of conserved synteny on mouse chromosome 16 and human chromosome 3 and a related pseudogene maps to mouse chromosome 8. (PubMed id 9925940)1, 3, 9 Antona V....Feo S. (Cytogenet. Cell Genet. 1998)
    3. Association analysis of cystatin A and zinc finger protein 148, two genes located at the psoriasis susceptibility locus PSORS5. (PubMed id 15175029)1, 4, 9 Samuelsson L....WahlstrAPm J. (J. Invest. Dermatol. 2004)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The human ZBP-89 homolog, located at chromosome 3q21, represses gastrin gene expression. (PubMed id 9457682)1, 2 Law D.J.... Merchant J.L. (Mamm. Genome 1998)
    8. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PubMed id 7557990)1, 3 Tommerup N. and Vissing H. (Genomics 1995)
    9. Transcription factor ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21waf1 transcription in human cells. (PubMed id 10899165)1, 9 Bai L. and Merchant J.L. (J. Biol. Chem. 2000)
    10. Intestinal alkaline phosphatase gene expression is activated by ZBP-89. (PubMed id 16384873)1, 9 Malo M.S....Hodin R.A. (Am. J. Physiol. Gastrointest. Liver Physiol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7707 HGNC: 12933 AceView: ZNF148andSLC12A8 Ensembl:ENSG00000163848 euGenes: HUgn7707
    ECgene: ZNF148 H-InvDB: ZNF148

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF148 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF148 gene:
    Search GeneIP for patents involving ZNF148

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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