Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF146 Gene

Aliases for ZNF146 Gene

  • Zinc Finger Protein 146 2 3 4 5
  • Only Zinc Finger Protein 3 4
  • OZF 3 4
  • Zinc Finger Protein OZF 3

External Ids for ZNF146 Gene

Previous GeneCards Identifiers for ZNF146 Gene

  • GC19P037373
  • GC19P037154
  • GC19P041382
  • GC19P041411
  • GC19P036705
  • GC19P033211

Summaries for ZNF146 Gene

GeneCards Summary for ZNF146 Gene

ZNF146 (Zinc Finger Protein 146) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and heparin binding. An important paralog of this gene is ZNF260.

Gene Wiki entry for ZNF146 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF146 Gene

Genomics for ZNF146 Gene

Regulatory Elements for ZNF146 Gene

Enhancers for ZNF146 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F035882 0.7 Ensembl ENCODE 42.5 -332.2 -332202 0.4 ZFP64 ZNF493 ARID4B FEZF1 ZNF121 ZNF302 KLF7 ZNF202 SP3 MIER2 ZNF345 TMEM147-AS1 ZNF850 ZNF567 HAUS5 KMT2B ZNF790-AS1 ZNF146 ZNF792 ZNF790
GH19F035322 0.9 Ensembl ENCODE 42.4 -890.8 -890781 2.6 HDGF PKNOX1 ZFP64 ZNF493 ZNF121 ZNF302 KLF7 ZNF548 ZNF202 SP3 TMEM147-AS1 HAUS5 KMT2B ZNF792 RBM42 ZNF146 ENSG00000267049 SDHAF1 WTIP LINC01766
GH19F035946 1.2 FANTOM5 Ensembl ENCODE 41.8 -267.1 -267110 1.0 HDGF ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF302 ZNF416 ZNF143 ZNF548 ZNF345 ZNF850 ZNF567 TMEM147-AS1 KMT2B HAUS5 ZNF792 RBM42 ZNF146 ZNF790-AS1
GH19F036052 0.2 ENCODE 35.9 -159.8 -159798 3.9 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC MEF2D ZNF610 ZNF345 ZNF850 RBM42 ZNF568 ZFP82 KMT2B ZNF146 ZNF461 ZNF790-AS1 ZNF529
GH19F035627 0.6 ENCODE 35.8 -585.7 -585738 2.3 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF146 ZFP82 ZNF792 RBM42 ZNF529 TMEM147-AS1 ZNF260 HAUS5 KMT2B LINC01801
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF146 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF146 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000346044 698 3401 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A YBX1 DMAP1 ZNF2

Genomic Location for ZNF146 Gene

Chromosome:
19
Start:
36,214,602 bp from pter
End:
36,238,774 bp from pter
Size:
24,173 bases
Orientation:
Plus strand

Genomic View for ZNF146 Gene

Genes around ZNF146 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF146 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF146 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF146 Gene

Proteins for ZNF146 Gene

  • Protein details for ZNF146 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15072-OZF_HUMAN
    Recommended name:
    Zinc finger protein OZF
    Protein Accession:
    Q15072
    Secondary Accessions:
    • Q2TB94

    Protein attributes for ZNF146 Gene

    Size:
    292 amino acids
    Molecular mass:
    33308 Da
    Quaternary structure:
    • Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP.

neXtProt entry for ZNF146 Gene

Post-translational modifications for ZNF146 Gene

No data available for DME Specific Peptides for ZNF146 Gene

Domains & Families for ZNF146 Gene

Gene Families for ZNF146 Gene

Protein Domains for ZNF146 Gene

Suggested Antigen Peptide Sequences for ZNF146 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15072

UniProtKB/Swiss-Prot:

OZF_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF146: view

Function for ZNF146 Gene

Molecular function for ZNF146 Gene

GENATLAS Biochemistry:
only zinc finger protein 145,(C2H2 type),Kruppel-like,expressed in liver,skeletal muscle,mammary cells,amplified or overexpressed in pancreatic carcinoma and contributing to the progression of tumour

Gene Ontology (GO) - Molecular Function for ZNF146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,TAS --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0008201 heparin binding TAS 8665923
GO:0008270 zinc ion binding TAS 8665923
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF146: view
genes like me logo Genes that share phenotypes with ZNF146: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF146 Gene

Localization for ZNF146 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF146 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF146 Gene COMPARTMENTS Subcellular localization image for ZNF146 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8665923
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZNF146: view

Pathways & Interactions for ZNF146 Gene

SuperPathways for ZNF146 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 8107129
genes like me logo Genes that share ontologies with ZNF146: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF146 Gene

Drugs & Compounds for ZNF146 Gene

(1) Drugs for ZNF146 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2231
genes like me logo Genes that share compounds with ZNF146: view

Transcripts for ZNF146 Gene

Unigene Clusters for ZNF146 Gene

Zinc finger protein 146:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF146 Gene

No ASD Table

Relevant External Links for ZNF146 Gene

GeneLoc Exon Structure for
ZNF146
ECgene alternative splicing isoforms for
ZNF146

Expression for ZNF146 Gene

mRNA expression in normal human tissues for ZNF146 Gene

Protein differential expression in normal tissues from HIPED for ZNF146 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (50.8), Blymphocyte (10.8), and Fetal testis (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF146 Gene



Protein tissue co-expression partners for ZNF146 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF146 Gene:

ZNF146

SOURCE GeneReport for Unigene cluster for ZNF146 Gene:

Hs.643436

mRNA Expression by UniProt/SwissProt for ZNF146 Gene:

Q15072-OZF_HUMAN
Tissue specificity: Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpressed in 80% of colorectal cancers.
genes like me logo Genes that share expression patterns with ZNF146: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF146 Gene

Orthologs for ZNF146 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF146 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF146 34 35
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 98 (a)
OneToMany
-- 35
  • 97 (a)
OneToMany
ZNF146 34
  • 93.15 (n)
dog
(Canis familiaris)
Mammalia ZNF146 34 35
  • 93.49 (n)
rat
(Rattus norvegicus)
Mammalia LOC102555183 34
  • 87.56 (n)
mouse
(Mus musculus)
Mammalia Zfp146 34 16 35
  • 85.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 45 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 45 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF146 35
  • 29 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11398 35
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F35H8.3 36
  • 35 (a)
Species where no ortholog for ZNF146 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF146 Gene

ENSEMBL:
Gene Tree for ZNF146 (if available)
TreeFam:
Gene Tree for ZNF146 (if available)

Paralogs for ZNF146 Gene

Paralogs for ZNF146 Gene

(546) SIMAP similar genes for ZNF146 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF146 Gene

genes like me logo Genes that share paralogs with ZNF146: view

Variants for ZNF146 Gene

Sequence variations from dbSNP and Humsavar for ZNF146 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10403738 -- 36,233,954(+) ttccc(A/G)cgggg intron-variant
rs10405434 -- 36,216,776(+) GACTG(A/T)GAAAG intron-variant, upstream-variant-2KB
rs10407835 -- 36,220,630(+) caaag(C/T)gctgg intron-variant
rs10407850 -- 36,222,554(+) TATTT(A/G)GTATT intron-variant
rs10409983 -- 36,225,904(+) tacag(A/G)catgt intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF146 Gene

Variant ID Type Subtype PubMed ID
esv3644249 CNV loss 21293372
nsv509739 CNV insertion 20534489
nsv520020 CNV loss 19592680

Variation tolerance for ZNF146 Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.20; 87.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF146 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF146

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF146 Gene

Disorders for ZNF146 Gene

Relevant External Links for ZNF146

Genetic Association Database (GAD)
ZNF146
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF146

No disorders were found for ZNF146 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF146 Gene

Publications for ZNF146 Gene

  1. Genomic organization and promoter identification of ZNF146, a gene encoding a protein consisting solely of zinc finger domains. (PMID: 11306801) Pibouin L. … Goubin G. (Cytogenet. Cell Genet. 2001) 3 4 22 64
  2. Cloning, characterization, and chromosome assignment of Zfp146 the mouse ortholog of human ZNF146, a gene amplified and overexpressed in pancreatic cancer, and Zfp260 a closely related gene. (PMID: 10449921) BlottiA"re L. … Goubin G. (Cytogenet. Cell Genet. 1999) 2 3 22 64
  3. Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1. (PMID: 15838871) Antoine K. … Goubin G. (J. Cell. Biochem. 2005) 3 4 64
  4. A Kruppel zinc finger of ZNF 146 interacts with the SUMO-1 conjugating enzyme UBC9 and is sumoylated in vivo. (PMID: 15881673) Antoine K. … Goubin G. (Mol. Cell. Biochem. 2005) 3 4 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64

Products for ZNF146 Gene

Sources for ZNF146 Gene

Content
Loading form....