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ZNF146 Gene

protein-coding   GIFtS: 56
GCID: GC19P036705

Zinc Finger Protein 146

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 1461 2 3
OZF2 3 5
Only Zinc Finger Protein2 3
Zinc Finger Protein OZF2

External Ids:    HGNC: 129311   Entrez Gene: 77052   Ensembl: ENSG000001676357   OMIM: 6015055   UniProtKB: Q150723   

Export aliases for ZNF146 gene to outside databases

Previous GC identifers: GC19P037373 GC19P037154 GC19P041382 GC19P041411 GC19P033211


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF146 Gene:
ZNF146 (zinc finger protein 146) is a protein-coding gene. Diseases associated with ZNF146 include tonsillitis, and pancreatic cancer. GO annotations related to this gene include heparin binding. An important paralog of this gene is ZNF260.

Gene Wiki entry for ZNF146 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF146 gene promoter:
         Max1   ER-alpha   USF1   USF2   USF-1:USF-2   HNF-4alpha1   N-Myc   Max   USF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF146 promoter sequence
   Search Chromatin IP Primers for ZNF146

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF146


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.1

ZNF146 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF146 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P036705:  view genomic region     (about GC identifiers)

Start:
36,705,504 bp from pter      End:
36,729,676 bp from pter
Size:
24,173 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OZF_HUMAN, Q15072 (See protein sequence)
Recommended Name: Zinc finger protein OZF  
Size: 292 amino acids; 33308 Da
Subunit: Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein
TERF2IP
Secondary accessions: Q2TB94

Explore the universe of human proteins at neXtProt for ZNF146: NX_Q15072

Explore proteomics data for ZNF146 at MOPED

Post-translational modifications: 

  • Sumoylated1
  • Ubiquitination2 at Lys19, Lys84, Lys112, Lys182, Lys238, Lys247
  • Modification sites at PhosphoSitePlus

  • See ZNF146 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001093108.1  NP_001093109.1  NP_009076.2  

    ENSEMBL proteins: 
     ENSP00000392095   ENSP00000400391  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q15072

    ProtoNet protein and cluster: Q15072

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: OZF_HUMAN, Q15072
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers


    ZNF146 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for ZNF146:
    only zinc finger protein 145,(C2H2 type),Kruppel-like,expressed in liver,skeletal muscle,mammary cells,amplified
    or overexpressed in pancreatic carcinoma and contributing to the progression of tumour

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0008201heparin binding TAS8665923
    GO:0008270zinc ion binding TAS8665923
    GO:0046872metal ion binding ----
         
    ZNF146 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF146:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF146
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    miRNA
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    miRTarBase miRNAs that target ZNF146:
    hsa-mir-615-3p (MIRT039766), hsa-mir-30c-5p (MIRT048005), hsa-mir-149-5p (MIRT045667)

    Block miRNA regulation of human, mouse, rat ZNF146 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF146 (see all 28):
    hsa-miR-607 hsa-miR-548k hsa-miR-513a-5p hsa-miR-1278 hsa-miR-885-5p hsa-miR-511 hsa-miR-641 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF146 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OZF_HUMAN, Q15072: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS8665923
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    ZNF146 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF146
    Interactions:

        GeneGlobe Interaction Network for ZNF146

    1 Interacting protein for ZNF146 (Q150723) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TERF2IPQ9NYB03I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IBA--

    ZNF146 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF146 (OZF)

    1 HMDB Compound for ZNF146    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF146 gene (3 alternative transcripts): 
    NM_001099638.1  NM_001099639.1  NM_007145.2  

    Unigene Cluster for ZNF146:

    Zinc finger protein 146
    Hs.643436  [show with all ESTs]
    Unigene Representative Sequence: NM_007145
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591063 ENST00000586094 ENST00000443387(uc002odq.4) ENST00000587285
    ENST00000456324(uc010eet.3 uc010eeu.3)
    miRNA
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    hsa-miR-607 hsa-miR-548k hsa-miR-513a-5p hsa-miR-1278 hsa-miR-885-5p hsa-miR-511 hsa-miR-641 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF146 3' UTR sequence
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF146
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF146
      QuantiFast Probe-based Assays in human, mouse, rat ZNF146

    Additional mRNA sequence: 

    AK311486.1 AK313460.1 BC005154.2 BC065568.1 BC110500.1 BC110501.1 X70394.1 

    17 DOTS entries:

    DT.416084  DT.91770392  DT.100025276  DT.121439287  DT.121439162  DT.100815584  DT.121439256  DT.91770391 
    DT.121439136  DT.91770389  DT.100020997  DT.100025275  DT.121439283  DT.121439290  DT.91999105  DT.65285522 
    DT.91669221 

    Selected AceView cDNA sequences (see all 212):

    BC065568 CD723352 AI167498 AI955665 BG257666 BU681882 AL119740 AA101734 
    BM717848 AI216831 AI699996 AW105599 AA774922 BF447806 AA810092 BM454645 
    AI474770 AL047710 BM682378 AI627519 BE888482 BM469259 CD724244 BU682012 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF146 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATACTGGA
    ZNF146 Expression
    About this image


    ZNF146 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Limb Bud Mesenchyme Cells Limb Bud
             Limb Bud
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Bone (Muscoskeletal System)
             Bone Marrow
    ZNF146 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF146 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643436

    UniProtKB/Swiss-Prot: OZF_HUMAN, Q15072
    Tissue specificity: Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and
    kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected
    in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpressed in 80% of colorectal cancers

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF146 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp1461 , 5 zinc finger protein 1461, 5 85.73(n)1
    95.55(a)1
      7 (17.29 cM)5
    264651  NM_011980.31  NP_036110.11 
     301612745 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    45(a)
    1 → many
    AAWZ02039384(4666-5910)
    zebrafish
    (Danio rerio)
    Actinopterygii ZNF1466
    zinc finger protein 146
    29(a)
    1 → many
    2(328130-337204) ENSDARG00000074146
    fruit fly
    (Drosophila melanogaster)
    Insecta CG113986
    --
    22(a)
    1 → many
    X(1106022-1109221)


    ENSEMBL Gene Tree for ZNF146 (if available)
    TreeFam Gene Tree for ZNF146 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF146 gene
    ZNF2602  
    Selected SIMAP similar genes for ZNF146 using alignment to 1 protein entry:     OZF_HUMAN(see all similar genes):
    ZNF260    ZNF569    DKFZp547L155    ZNF132    ZNF135    ZNF16
    ZNF480    ZNF78L1    kr-znf3    ZFP37    ZFS-1    ZNF300
    ZNF420    ZNF470    ZNF484    ZNF502    ZNF813    ZSCAN16

    ZNF146 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF146
    PGOHUM00000243992


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF146 (see all 499)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1849094901,2
    --36708057(+) CCCCCC/TAGGTT 3 -- int10--------
    rs1871211091,2
    --36708207(+) TGATCA/GGCCCG 3 -- int10--------
    rs104128321,2
    C--36708586(+) gtttgG/Agacca 3 -- int11Minor allele frequency- A:0.50WA 2
    rs1496627561,2
    C--36708594(+) CCAGCA/GTGACC 3 -- int10--------
    rs1923363611,2
    C--36708651(+) CGTGGC/TGGCAC 3 -- int10--------
    rs2010439031,2
    C--36708788(+) ATCTC-/AAAAAAA 3 -- int10--------
    rs1454765741,2
    C--36708820(+) ACATAC/TGAAAT 3 -- int10--------
    rs74090161,2
    C--36709015(+) tttttT/Aaatta 3 -- int12Minor allele frequency- A:0.25WA 4
    rs3687840541,2
    C--36709280(+) GCTGC-/AAAAAA 3 -- int10--------
    rs1402876101,2
    C--36709305(+) AAAATA/GTTATA 3 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF146 (36705504 - 36729676 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF146:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509739CNV Insertion20534489
    nsv520020CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF146
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601505    OMIM disorders: --

    8 diseases for ZNF146:    
    About MalaCards
    tonsillitis    pancreatic cancer    colorectal cancer    pancreatitis
    cerebritis    thyroiditis    prostatitis    endotheliitis


    ZNF146 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF146

    Export disorders for ZNF146 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF146 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with ZNF146)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and promoter identification of ZNF146, a gene encoding a protein consisting solely of zinc finger domains. (PubMed id 11306801)1, 2, 9 Pibouin L.... Goubin G. (Cytogenet. Cell Genet. 2001)
    2. Cloning, characterization, and chromosome assignment of Zfp146 the mouse ortholog of human ZNF146, a gene amplified and overexpressed in pancreatic cancer, and Zfp260 a closely related gene. (PubMed id 10449921)1, 3, 9 BlottiA"re L....Goubin G. (Cytogenet. Cell Genet. 1999)
    3. Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1. (PubMed id 15838871)1, 2 Antoine K.... Goubin G. (J. Cell. Biochem. 2005)
    4. A Kruppel zinc finger of ZNF 146 interacts with the SUMO-1 conjugating enzyme UBC9 and is sumoylated in vivo. (PubMed id 15881673)1, 2 Antoine K.... Goubin G. (Mol. Cell. Biochem. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    7. The zinc finger protein OZF (ZNF146) is overexpressed in colorectal cancer. (PubMed id 12754738)1, 2 Ferbus D.... Goubin G. (J. Pathol. 2003)
    8. Amplification and over-expression of OZF, a gene encoding a zinc finger protein, in human pancreatic carcinomas. (PubMed id 9935176)1, 2 Ferbus D.... Goubin G. (Int. J. Cancer 1999)
    9. Identification, nuclear localization, and binding activities of OZF, a human protein solely composed of zinc-finger motifs. (PubMed id 8665923)1, 2 Ferbus D.... Goubin G. (Eur. J. Biochem. 1996)
    10. Localization of ZNF164, ZNF146, GGTA1, SOX2, PRLR and EEF2 on homoeologous cattle, sheep and goat chromosomes by fluorescent in situ hybridization and comparison with the human gene map. (PubMed id 8641144)1, 3 Hayes H....Kohno K. (Cytogenet. Cell Genet. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7705 HGNC: 12931 AceView: ZNF146 Ensembl:ENSG00000167635 euGenes: HUgn7705
    ECgene: ZNF146 H-InvDB: ZNF146

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF146 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZNF146 Genetics and Cytogenetics in Oncology and Haematology

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    Patent Information for ZNF146 gene:
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