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Aliases for ZNF143 Gene

Aliases for ZNF143 Gene

  • Zinc Finger Protein 143 2 3 5
  • Selenocysteine TRNA Gene Transcription-Activating Factor 3 4
  • SPH-Binding Factor 3 4
  • HStaf 3 4
  • STAF 3 4
  • SBF 3 4
  • Zinc Finger Protein 143 (Clone PHZ-1) 2
  • Transcriptional Activator Staf 3
  • PHZ-1 3

External Ids for ZNF143 Gene

Previous GeneCards Identifiers for ZNF143 Gene

  • GC11P010122
  • GC11P009522
  • GC11P009446
  • GC11P009439
  • GC11P009153

Summaries for ZNF143 Gene

GeneCards Summary for ZNF143 Gene

ZNF143 (Zinc Finger Protein 143) is a Protein Coding gene. Diseases associated with ZNF143 include Cataract 1, Multiple Types and Split Hand-Foot Malformation 1. Among its related pathways are RNA polymerase II transcribes snRNA genes and RNA Polymerase III Transcription Initiation. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF76.

UniProtKB/Swiss-Prot for ZNF143 Gene

  • Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8.

Gene Wiki entry for ZNF143 Gene

Additional gene information for ZNF143 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF143 Gene

Genomics for ZNF143 Gene

Regulatory Elements for ZNF143 Gene

Enhancers for ZNF143 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H009458 1.4 ENCODE dbSUPER 33.7 +1.1 1080 5 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 SNORA3B RPL27A RPL21P97 TMEM9B-AS1 WEE1 TRIM66 IPO7 LOC644656 PIR40365
GH11H008681 1.7 Ensembl ENCODE dbSUPER 27.5 -774.5 -774464 8 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 TRIM66 SNORA3B EIF3F ZNF143 RPL21P97 RPL27A STK33 WEE1 RPL23AP65 ENSG00000254665
GH11H009565 1.9 FANTOM5 ENCODE dbSUPER 18 +111.9 111929 15 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 SP3 ZC3H11A NFYC MEF2D WEE1 SWAP70 ZNF143 RPL21P97 TRIM66 AKIP1 SNORA3B TMEM41B DENND5A PIR40365
GH11H009361 1.9 FANTOM5 Ensembl ENCODE 15.4 -96.8 -96804 4 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 DENND5A NRIP3 SNORA3B ZNF143 AKIP1 RPL21P97 RPL27A IPO7 TMEM41B TMEM9B
GH11H009751 2 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +299.5 299450 15 HDGF MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 ZNF766 CTR9 SBF2 ENSG00000254397 RPL21P97 ST5 SWAP70 TMEM9B-AS1 ZNF143 SBF2-AS1 ENSG00000238387
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF143 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF143 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036592 482 3200 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766

Genomic Location for ZNF143 Gene

Chromosome:
11
Start:
9,460,319 bp from pter
End:
9,528,524 bp from pter
Size:
68,206 bases
Orientation:
Plus strand

Genomic View for ZNF143 Gene

Genes around ZNF143 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF143 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF143 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF143 Gene

Proteins for ZNF143 Gene

  • Protein details for ZNF143 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52747-ZN143_HUMAN
    Recommended name:
    Zinc finger protein 143
    Protein Accession:
    P52747
    Secondary Accessions:
    • A8K518
    • B4DLY5
    • E7ER34
    • O75559
    • Q8WUK9

    Protein attributes for ZNF143 Gene

    Size:
    638 amino acids
    Molecular mass:
    68896 Da
    Quaternary structure:
    • Interacts with CHD8.
    SequenceCaution:
    • Sequence=AAC50266.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH20219.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF83822.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF143 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF143 Gene

Post-translational modifications for ZNF143 Gene

  • Ubiquitination at isoforms=2, 3375
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF143 Gene

Domains & Families for ZNF143 Gene

Gene Families for ZNF143 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF143 Gene

Suggested Antigen Peptide Sequences for ZNF143 Gene

Graphical View of Domain Structure for InterPro Entry

P52747

UniProtKB/Swiss-Prot:

ZN143_HUMAN :
  • Belongs to the GLI C2H2-type zinc-finger protein family.
Family:
  • Belongs to the GLI C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF143: view

Function for ZNF143 Gene

Molecular function for ZNF143 Gene

GENATLAS Biochemistry:
zinc finger protein 143,GLI-Kruppel family member,homolog of Xenopus laevis STAF transcriptional activator ortholog
UniProtKB/Swiss-Prot Function:
Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8.

Gene Ontology (GO) - Molecular Function for ZNF143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10893243
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 10893243
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 17938208
genes like me logo Genes that share ontologies with ZNF143: view
genes like me logo Genes that share phenotypes with ZNF143: view

Animal Model Products

CRISPR Products

miRNA for ZNF143 Gene

miRTarBase miRNAs that target ZNF143
Targeted motifs for ZNF143 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF143
  • Consensus sequence: ATTTCCCAGVAKSCY Submotif: canonical Cell Type: CUTLL GEO ID: GSE29600

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF143
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF143 Gene

Localization for ZNF143 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF143 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF143 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ZNF143: view

Pathways & Interactions for ZNF143 Gene

genes like me logo Genes that share pathways with ZNF143: view

Gene Ontology (GO) - Biological Process for ZNF143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9566884
GO:0006359 regulation of transcription from RNA polymerase III promoter TAS 9566884
GO:0006366 transcription from RNA polymerase II promoter TAS 9009278
genes like me logo Genes that share ontologies with ZNF143: view

No data available for SIGNOR curated interactions for ZNF143 Gene

Drugs & Compounds for ZNF143 Gene

(1) Drugs for ZNF143 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF143: view

Transcripts for ZNF143 Gene

Unigene Clusters for ZNF143 Gene

Zinc finger protein 143:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF143
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF143 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17
SP1: - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for ZNF143 Gene

GeneLoc Exon Structure for
ZNF143
ECgene alternative splicing isoforms for
ZNF143

Expression for ZNF143 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF143 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF143 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.4), CD8 Tcells (10.6), Retina (7.6), Fetal Liver (7.3), and NK cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF143 Gene



Protein tissue co-expression partners for ZNF143 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF143 Gene:

ZNF143

SOURCE GeneReport for Unigene cluster for ZNF143 Gene:

Hs.523471

mRNA Expression by UniProt/SwissProt for ZNF143 Gene:

P52747-ZN143_HUMAN
Tissue specificity: Expressed in all tissues tested, with the strongest expression in ovary.

Evidence on tissue expression from TISSUES for ZNF143 Gene

  • Nervous system(4.6)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with ZNF143: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF143 Gene

Orthologs for ZNF143 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF143 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF143 33 34
  • 99.42 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF143 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF143 33 34
  • 93.5 (n)
cow
(Bos Taurus)
Mammalia ZNF143 33 34
  • 93.14 (n)
mouse
(Mus musculus)
Mammalia Zfp143 33 16 34
  • 90.63 (n)
rat
(Rattus norvegicus)
Mammalia Zfp143 33
  • 90.4 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF143 34
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF143 33 34
  • 82.26 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF143 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf143 33
  • 73.03 (n)
Str.3450 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23822 33
zebrafish
(Danio rerio)
Actinopterygii wee1 34
  • 74 (a)
OneToMany
znf143b 33 34
  • 70.1 (n)
znf143a 34
  • 64 (a)
OneToMany
zgc66276 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13634 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
OneToMany
Species where no ortholog for ZNF143 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF143 Gene

ENSEMBL:
Gene Tree for ZNF143 (if available)
TreeFam:
Gene Tree for ZNF143 (if available)

Paralogs for ZNF143 Gene

Paralogs for ZNF143 Gene

genes like me logo Genes that share paralogs with ZNF143: view

Variants for ZNF143 Gene

Sequence variations from dbSNP and Humsavar for ZNF143 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000140102 -- 9,526,009(+) GGTGA(C/T)GGCTG intron-variant
rs1000157718 -- 9,461,468(+) CGCCG(C/T)CGAGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000180202 -- 9,464,466(+) TGGGG(C/T)GGCCC intron-variant
rs1000204026 -- 9,500,459(+) GATGG(A/C)GTCTC intron-variant
rs1000245420 -- 9,506,865(+) TATGT(A/T)ACTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF143 Gene

Variant ID Type Subtype PubMed ID
dgv584n106 CNV deletion 24896259
esv24739 CNV loss 19812545
esv2486941 CNV deletion 19546169
esv2675320 CNV deletion 23128226
esv2744093 CNV deletion 23290073
esv3547301 CNV deletion 23714750
esv3625334 CNV loss 21293372
esv3625335 CNV loss 21293372
esv3625336 CNV loss 21293372
nsv1039537 CNV gain 25217958
nsv1055078 CNV gain 25217958
nsv1069561 CNV deletion 25765185
nsv1119859 CNV deletion 24896259
nsv1122583 CNV deletion 24896259
nsv1148850 CNV deletion 26484159
nsv499766 OTHER inversion 21111241
nsv512209 CNV loss 21212237
nsv553467 CNV loss 21841781
nsv7215 OTHER inversion 18451855
nsv7670 CNV deletion 18451855
nsv7671 CNV insertion 18451855
nsv957161 CNV deletion 24416366

Variation tolerance for ZNF143 Gene

Residual Variation Intolerance Score: 4.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF143 Gene

Human Gene Mutation Database (HGMD)
ZNF143
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF143

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF143 Gene

Disorders for ZNF143 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF143 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
cataract 1, multiple types
  • cataract 1 multiple types
split hand-foot malformation 1
  • shfd1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF143

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF143
genes like me logo Genes that share disorders with ZNF143: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF143 Gene

Publications for ZNF143 Gene

  1. CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription. (PMID: 17938208) Yuan CC … Hernandez N (Molecular and cellular biology 2007) 3 4 22 60
  2. Molecular cloning of a cDNA encoding human SPH-binding factor, a conserved protein that binds to the enhancer-like region of the U6 small nuclear RNA gene promoter. (PMID: 9776743) Rincon JC … Kunkel GR (Nucleic acids research 1998) 3 4 22 60
  3. Transcriptional regulation of the human establishment of cohesion 1 homolog 2 gene. (PMID: 20116366) Nishihara M … Yanagihara I (Biochemical and biophysical research communications 2010) 3 22 60
  4. ZNF143 interacts with p73 and is involved in cisplatin resistance through the transcriptional regulation of DNA repair genes. (PMID: 17297437) Wakasugi T … Kohno K (Oncogene 2007) 3 22 60
  5. ZNF143 mediates basal and tissue-specific expression of human transaldolase. (PMID: 14702349) Grossman CE … Perl A (The Journal of biological chemistry 2004) 3 22 60

Products for ZNF143 Gene

Sources for ZNF143 Gene

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