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ZNF143 Gene

protein-coding   GIFtS: 62
GCID: GC11P009483

Zinc Finger Protein 143

(Previous name: zinc finger protein 143 (clone pHZ-1))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 1431 2     SPH-Binding Factor2 3
SBF2 3 5     Zinc Finger Protein 143 (Clone PHZ-1)1
Selenocysteine TRNA Gene Transcription-Activating Factor2 3     pHZ-12
STAF2 3     Transcriptional Activator Staf2
hStaf2 3     

External Ids:    HGNC: 129281   Entrez Gene: 77022   Ensembl: ENSG000001664787   OMIM: 6034335   UniProtKB: P527473   

Export aliases for ZNF143 gene to outside databases

Previous GC identifers: GC11P010122 GC11P009522 GC11P009446 GC11P009439 GC11P009153


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF143 Gene:
ZNF143 (zinc finger protein 143) is a protein-coding gene. Diseases associated with ZNF143 include compartment syndrome, and roberts syndrome. An important paralog of this gene is MTF1.

UniProtKB/Swiss-Prot: ZN143_HUMAN, P52747
Function: Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif
of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via
its interaction with CHD8

Gene Wiki entry for ZNF143 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF143 gene promoter:
         MEF-2A   AML1a   AP-1   HFH-1   Brachyury   ATF-2   aMEF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF143 promoter sequence
   Search Chromatin IP Primers for ZNF143

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF143


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

ZNF143 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF143 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P009483:  view genomic region     (about GC identifiers)

Start:
9,481,866 bp from pter      End:
9,550,071 bp from pter
Size:
68,206 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN143_HUMAN, P52747 (See protein sequence)
Recommended Name: Zinc finger protein 143  
Size: 638 amino acids; 68896 Da
Subunit: Interacts with CHD8
Sequence caution: Sequence=AAC50266.1; Type=Erroneous initiation; Sequence=AAH20219.1; Type=Erroneous initiation;
Sequence=BAF83822.1; Type=Erroneous initiation;
Secondary accessions: A8K518 B4DLY5 O75559 Q8WUK9
Alternative splicing: 2 isoforms:  P52747-1   P52747-2   

Explore the universe of human proteins at neXtProt for ZNF143: NX_P52747

Explore proteomics data for ZNF143 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys375
  • Modification sites at PhosphoSitePlus

  • See ZNF143 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269585.1  NP_001269586.1  NP_003433.3  

    ENSEMBL proteins: 
     ENSP00000434638   ENSP00000379849   ENSP00000379847   ENSP00000432154   ENSP00000434922  
     ENSP00000433221   ENSP00000379843   ENSP00000409432   ENSP00000431306   ENSP00000435881  
     ENSP00000299606   ENSP00000433743   ENSP00000388628   ENSP00000395221   ENSP00000392323  
     ENSP00000401493  
    Reactome Protein details: P52747

    ZNF143 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P52747

    ProtoNet protein and cluster: P52747

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN143_HUMAN, P52747
    Similarity: Belongs to the GLI C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers


    ZNF143 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN143_HUMAN, P52747
    Function: Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif
    of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via
    its interaction with CHD8

         Genatlas biochemistry entry for ZNF143:
    zinc finger protein 143,GLI-Kruppel family member,homolog of Xenopus laevis STAF transcriptional activator
    ortholog

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI17938208
    GO:0046872metal ion binding IEA--
         
    ZNF143 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Zfp143):
     reproductive system 

    ZNF143 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF143
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF143
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    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  ATTTCCCAGVAKSCY 

    miRNA
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    miRTarBase miRNAs that target ZNF143:
    hsa-mir-93-5p (MIRT028153)

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    1 qRT-PCR Assays for microRNA that regulate ZNF143:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF143 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN143_HUMAN, P52747: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--

    ZNF143 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF143 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase III Transcription Initiation
    RNA Polymerase III Transcription Initiation0.88
    RNA Polymerase III Transcription0.88
    RNA Polymerase III Abortive And Retractive Initiation0.88
    RNA Polymerase III Transcription Initiation From Type 3 Promoter0.80
    2RNA Polymerase I Promoter Opening
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    3Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for ZNF143
        RNA Polymerase III Transcription Initiation From Type 3 Promoter
    RNA Polymerase III Abortive And Retractive Initiation



    ZNF143 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF143
    Interactions:

        GeneGlobe Interaction Network for ZNF143

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZNF143 (P527473 ENSP000003798474) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235068Q018603, ENSP000004050414I2D: score=2 STRING: ENSP00000405041
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    ENSG00000230336Q018603I2D: score=2 
    ENSG00000233911Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9566884
    GO:0006359regulation of transcription from RNA polymerase III promoter TAS9566884
    GO:0006366transcription from RNA polymerase II promoter TAS9009278
    GO:0006383transcription from RNA polymerase III promoter TAS--
    GO:0010467gene expression TAS--

    ZNF143 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF143 (ZN143)

    1 Novoseek inferred chemical compound relationship for ZNF143 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 55.7 30 10455183 (6), 10773080 (6), 10446199 (4), 7641696 (1) (see all 7)



    ZNF143 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF143 gene (3 alternative transcripts): 
    NM_001282656.1  NM_001282657.1  NM_003442.5  

    Unigene Cluster for ZNF143:

    Zinc finger protein 143
    Hs.523471  [show with all ESTs]
    Unigene Representative Sequence: NM_003442
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531943 ENST00000396604 ENST00000396602(uc001mhr.3 uc009yfu.3 uc010rby.2)
    ENST00000530463 ENST00000533542 ENST00000532577 ENST00000396597 ENST00000438144
    ENST00000496276 ENST00000526657 ENST00000299606 ENST00000534265 ENST00000412390
    ENST00000414370 ENST00000417726 ENST00000527597 ENST00000447186 ENST00000532305

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ZNF143:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF143 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF143

    Additional mRNA sequence: 

    AF071771.1 AK291133.1 AK297214.1 AK313330.1 BC014458.1 BC020219.1 

    7 DOTS entries:

    DT.100778990  DT.415261  DT.75179267  DT.100706459  DT.100778994  DT.120714730  DT.91699532 

    Selected AceView cDNA sequences (see all 114):

    AA307188 AW469528 BC020219 BQ215739 BM994492 AF071771 CB135037 BX348933 
    AU126271 BF515092 AU130559 AW088124 NM_003442 AI815854 AW162015 AL528459 
    BE899024 AW160395 AA741400 BP371286 AL550896 BM788276 BX350205 R91349 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF143    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17
    SP1:              -                                                                                                           -         
    SP2:                                                                                                                                    
    SP3:              -                                                                                                                     
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for ZNF143

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF143 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAAACGGA
    ZNF143 Expression
    About this image


    ZNF143 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebellum
    ZNF143 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF143 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523471

    UniProtKB/Swiss-Prot: ZN143_HUMAN, P52747
    Tissue specificity: Expressed in all tissues tested, with the strongest expression in ovary

        Custom PCR Arrays for ZNF143
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF143

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF143 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp1431 , 5 zinc finger protein 1431, 5 90.63(n)1
    97.02(a)1
      7 (57.70 cM)5
    208411  NM_009281.31  NP_033307.21 
     1100617025 
    chicken
    (Gallus gallus)
    Aves ZNF1431 zinc finger protein 143 82.26(n)
    93.72(a)
      428845  XM_004941378.1  XP_004941435.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF1436
    zinc finger protein 143
    92(a)
    1 ↔ 1
    1(64167261-64186932)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238222 X.laevis mRNA for selenocysteine tRNA acting factor more 78.39(n)    X84996.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc662762 similar to zinc finger protein 143 74.51(n)   393954  AY331976.1 


    ENSEMBL Gene Tree for ZNF143 (if available)
    TreeFam Gene Tree for ZNF143 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF143 gene
    MTF12  ZIC32  ZNF4102  ZNF762  GLI12  ZIC22  ZIC12  GLIS22  
    GLI22  ZIC42  GLIS12  GLIS32  ZIC52  GLI32  
    Selected SIMAP similar genes for ZNF143 using alignment to 16 protein entries:     ZN143_HUMAN (see all proteins) (see all similar genes):
    ZNF76    HZF16    ZNF664    ZNF826P    ZNF436    ZNF627
    ZNF697    ZNF75A    ZNF782    ZNF78L1    DKFZp666C237    HZF14
    ZNF180    ZNF239    ZNF558    ZNF670    ZNF833P    ZSCAN2

    ZNF143 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF143 (see all 1504)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1914266181,2
    --9151847(+) CTGGGC/TTACTT 1 -- us2k10--------
    rs1837939491,2
    --9151864(+) AACAGA/CGAATG 1 -- us2k10--------
    rs1390590571,2
    C--9484268(+) AATACA/GAAAAT 1 -- int10--------
    rs1907234481,2
    --9484339(+) ATCGCC/TTGAAC 1 -- int10--------
    rs1810611081,2
    C--9484537(+) ATTTCA/CTCTCA 1 -- int10--------
    rs586029531,2
    C,F--9484573(+) TTTGCA/TTGTTT 1 -- int14Minor allele frequency- T:0.10WA CSA 124
    rs1863425771,2
    --9484597(+) TTTCAC/TATAAA 1 -- int10--------
    rs10748521,2
    F--9484689(+) tatttC/Aattgt 1 -- int12Minor allele frequency- A:0.00NA 4
    rs1498830821,2
    --9484794(+) TGTACA/GAAAGT 1 -- int10--------
    rs728529641,2
    --9485023(+) TTCTAA/GTGTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF143 (9481866 - 9550071 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZNF143:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675320CNV Deletion23128226
    esv2486941CNV Deletion19546169
    esv2744093CNV Deletion23290073
    nsv7671CNV Insertion18451855
    nsv512209CNV Loss21212237
    nsv7670CNV Loss18451855
    esv24739CNV Loss19812545
    nsv7215OTHER Inversion18451855
    nsv499766OTHER Inversion21111241

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603433    OMIM disorders: --

    6 diseases for ZNF143:    
    About MalaCards
    compartment syndrome    roberts syndrome    beckwith-wiedemann syndrome    tonsillitis
    thyroiditis    endotheliitis

    2 diseases from the University of Copenhagen DISEASES database for ZNF143:
    Roberts syndrome     Beckwith-Wiedemann syndrome

    ZNF143 for disorders           About GeneDecksing


    Export disorders for ZNF143 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF143 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with ZNF143)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription. (PubMed id 17938208)1, 2, 9 Yuan C.-C....Hernandez N. (Mol. Cell. Biol. 2007)
    2. Molecular cloning of a cDNA encoding human SPH-binding factor, a conserved protein that binds to the enhancer-like region of the U6 small nuclear RNA gene promoter. (PubMed id 9776743)1, 2, 9 Rincon J.C.... Kunkel G.R. (Nucleic Acids Res. 1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PubMed id 7557990)1, 2 Tommerup N. and Vissing H. (Genomics 1995)
    5. ZNF76 and ZNF143 are two human homologs of the transcriptional activator Staf. (PubMed id 9705341)1, 9 Myslinski E....Carbon P. (J. Biol. Chem. 1998)
    6. ZNF143 interacts with p73 and is involved in cisplatin resistance through the transcriptional regulation of DNA repair genes. (PubMed id 17297437)1, 9 Wakasugi T....Kohno K. (Oncogene 2007)
    7. ZNF143 mediates basal and tissue-specific expression of human transaldolase. (PubMed id 14702349)1, 9 Grossman C.E....Perl A. (J. Biol. Chem. 2004)
    8. Staf, a promiscuous activator for enhanced transcription by RNA polymerases II and III. (PubMed id 9009278)1, 9 Schaub M....Carbon P. (EMBO J. 1997)
    9. Transcriptional regulation of the human establishment of cohesion 1 homolog 2 gene. (PubMed id 20116366)1, 9 Nishihara M....Yanagihara I. (Biochem. Biophys. Res. Commun. 2010)
    10. Two distinct domains in Staf to selectively activate small nuclear RNA-type and mRNA promoters. (PubMed id 9566884)1, 9 Schuster C....Carbon P. (Mol. Cell. Biol. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7702 HGNC: 12928 AceView: ZNF143 Ensembl:ENSG00000166478 euGenes: HUgn7702
    ECgene: ZNF143 H-InvDB: ZNF143

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZNF143 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZNF143 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZNF143 gene:
    Search GeneIP for patents involving ZNF143

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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