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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF142 Gene

protein-coding   GIFtS: 49
GCID: GC02M219466

Zinc Finger Protein 142

(Previous name: zinc finger protein 142 (clone pHZ-49))
  Search for ZNF142
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 1421 2
Zinc Finger Protein 142 (Clone PHZ-49)1 2
HA46542 3
pHZ-492
KIAA02363

External Ids:    HGNC: 129271   Entrez Gene: 77012   Ensembl: ENSG000001155687   OMIM: 6040835   UniProtKB: P527463   

Export aliases for ZNF142 gene to outside databases

Previous GC identifers: GC02M217518 GC02M218224 GC02M219705 GC02M219328 GC02M219210 GC02M211356


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF142 Gene:
The protein encoded by this gene belongs to the Kruppel family of C2H2-type zinc finger proteins. It contains 31
C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternatively spliced transcript
variants have been found for this gene. (provided by RefSeq, Jan 2013)

GeneCards Summary for ZNF142 Gene: 
ZNF142 (zinc finger protein 142) is a protein-coding gene. GO annotations related to this gene include DNA binding and molecular_function. An important paralog of this gene is ZNF462.

UniProtKB/Swiss-Prot: ZN142_HUMAN, P52746
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF142 gene promoter:
         CREB   AP-1   p53   deltaCREB   ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF142 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF142

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF142


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

ZNF142 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF142 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M219466:  view genomic region     (about GC identifiers)

Start:
219,502,639 bp from pter      End:
219,524,378 bp from pter
Size:
21,740 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN142_HUMAN, P52746 (See protein sequence)
Recommended Name: Zinc finger protein 142  
Size: 1687 amino acids; 187880 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAA13242.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q92510

Explore the universe of human proteins at neXtProt for ZNF142: NX_P52746

Explore proteomics data for ZNF142 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P52746

  • ZNF142 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF142 Protein Expression
    REFSEQ proteins: NP_001099007.1  
    ENSEMBL proteins: 
     ENSP00000408643   ENSP00000405477   ENSP00000397456   ENSP00000415156   ENSP00000400424  
     ENSP00000391599   ENSP00000398798  

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    Cloud-Clone Corp. Proteins for ZNF142 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--

    ZNF142 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P52746

    ProtoNet protein and cluster: P52746

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN142_HUMAN, P52746
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 31 C2H2-type zinc fingers


    ZNF142 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN142_HUMAN, P52746
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF142:
    zinc finger protein 142 (C2H2 type,Kruppel-like)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF142 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF142:
     Increased G1 DNA content 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF142

    2 Interacting proteins for ZNF142 (P527463) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK14Q165393I2D: score=3 
    CHMP5Q9NZZ33I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0008150biological_process ND--

    ZNF142 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF142 (ZN142)

    Search CenterWatch for drugs/clinical trials and news about ZNF142 / ZN142

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF142 gene (2 alternative transcripts): 
    NM_001105537.2  NM_005081.2  

    Unigene Cluster for ZNF142:

    Zinc finger protein 142
    Hs.657969  [show with all ESTs]
    Unigene Representative Sequence: BC033631
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449707(uc002vil.3 uc002vin.3) ENST00000433921 ENST00000450765(uc010fvt.3 uc002vim.3)
    ENST00000440934 ENST00000450560 ENST00000432460 ENST00000411696
    miRNA
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    hsa-miR-1252 hsa-miR-3653
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK095027.1 BC033631.1 BC038226.1 BC053849.2 D87073.1 NR_073599.1 NR_073600.1 U09849.1 

    11 DOTS entries:

    DT.70104504  DT.100036136  DT.100815149  DT.414399  DT.91709428  DT.120959234  DT.120959214  DT.97823849 
    DT.91709424  DT.91709429  DT.95216040 

    24/115 AceView cDNA sequences (see all 115):

    AI096532 AI095080 BC053849 BQ638508 BM461611 AA613879 BC033631 AW960903 
    BM684190 AA479665 BM450507 BX111275 BQ064640 BQ229763 D87073 BU621557 
    AW074561 AK095027 BC038226 AU154175 BU156288 BG254184 AA326333 AU132687 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF142    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                            -                 -     -                                                         
    SP2:                    -                       -                 -     -     -                                                   
    SP3:                                                              -                                                               
    SP4:                                -           -                 -     -                                                         
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for ZNF142

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF142 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAACAGAA
    ZNF142 Expression
    About this image


    See ZNF142 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF142

    SOURCE GeneReport for Unigene cluster: Hs.657969
        SABiosciences Custom PCR Arrays for ZNF142
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF142 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp1421 , 5 zinc finger protein 1421, 5 85.63(n)1
    86.39(a)1
      1 (38.54 cM)5
    772641  NM_029888.21  NP_084164.11 
     745651275 
    chicken
    (Gallus gallus)
    Aves ZNF1421 zinc finger protein 142 65.97(n)
    63.69(a)
      424213  XM_422062.2  XP_422062.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF1426
    Uncharacterized protein
    56(a)
    1 ↔ 1
    1(88369994-88388755)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.173152 Transcribed sequence with moderate similarity to protein more 75.58(n)    BM777854.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG52046
    CG99326
    --
    7(a)
    4(a)
    many ↔ many
    many ↔ many
    2L(13160527-13163153)
    2L(13021866-13060115)
    worm
    (Caenorhabditis elegans)
    Secernentea hbl-16
    Hunchback-like protein
    4(a)
    1 → many
    X(5822277-5826434)


    ENSEMBL Gene Tree for ZNF142 (if available)
    TreeFam Gene Tree for ZNF142 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF142 gene
    ZNF4622  ENSG000002426312  ZNF5132  
    18 SIMAP similar genes for ZNF142 using alignment to 5 protein entries:     ZN142_HUMAN (see all proteins):
    kr-znf3    ZNF55    ZNF    ZNF808    DKFZp686N0199    ZFS-5
    ZNF72    ZNF78L1    ZNF22    ZNF32    A-328A3.4    DKFZp434J0650
    ZFS-2    ZNF234    ZNF331    ZNF449    ZNF663    ZNF844

    ZNF142 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/614 SNPs in ZNF142 are shown (see all 614)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105830411,2
    C--211366350(+) AGAAG-/AC/CA 
            
    AGTTA
    3 -- int10--------
    rs1124805971,2
    C--211371473(+) GGCCAAG/-AGAGA 3 -- int11Minor allele frequency- -:0.50CSA 2
    rs344919631,2
    C--211371789(+) ATCTC-/A/AA  
            
    AAAAA
    3 -- int10--------
    rs563586191,2
    C--211372585(+) TTTTT-/TTGAGAC 3 -- int10--------
    rs359958861,2
    C--211372997(+) AAAAA-/AGGTTT 3 -- int11Minor allele frequency- A:0.50NA 2
    rs714030571,2
    C--211375047(+) TTTTT-/T/TT  
            
    GAGAC
    3 -- int11NA 2
    rs67287011,2
    C,F--218885822(+) CCAGCA/GTAATT 3 -- ds50015Minor allele frequency- G:0.13WA CSA NA EA 362
    rs1878017111,2
    --218885922(+) CAGTTA/GTAGAA 3 -- ds50010--------
    rs769789451,2
    F--218885981(+) CCTTGG/TGCTTT 3 -- ds50011Minor allele frequency- T:0.50NA 4
    rs1402613541,2
    --218886399(+) AGGAAA/TTGACA 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for ZNF142 (219502639 - 219524378 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF142:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662860CNV Deletion23128226
    nsv875862CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF142 for disorders           About MalaCards
    OMIM gene information: 604083    OMIM disorders: --


    ZNF142 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF142
    Human Genome Epidemiology (HuGE) Navigator: ZNF142 (1 document)

    Export disorders for ZNF142 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF142 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ZNF142)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    3. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PubMed id 7557990)1, 2 Tommerup N. and Vissing H. (1995)
    4. Age of onset of amyotrophic lateral sclerosis is modul ated by a locus on 1p34.1. (PubMed id 22959728)1  ....Zheng J.G. (2013)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7701 HGNC: 12927 AceView: ZNF142 Ensembl:ENSG00000115568 euGenes: HUgn7701
    ECgene: ZNF142 H-InvDB: ZNF142

    (According to HUGE)
    About This Section
    HUGE: KIAA0236

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF142 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF142 gene:
    Search GeneIP for patents involving ZNF142

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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