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Aliases for ZNF142 Gene

Aliases for ZNF142 Gene

  • Zinc Finger Protein 142 2 3
  • Zinc Finger Protein 142 (Clone PHZ-49) 2 3
  • HA4654 3 4
  • KIAA0236 4
  • PHZ-49 3

External Ids for ZNF142 Gene

Previous GeneCards Identifiers for ZNF142 Gene

  • GC02M217518
  • GC02M218224
  • GC02M219466
  • GC02M219705
  • GC02M219328
  • GC02M219210
  • GC02M211356

Summaries for ZNF142 Gene

Entrez Gene Summary for ZNF142 Gene

  • The protein encoded by this gene belongs to the Kruppel family of C2H2-type zinc finger proteins. It contains 31 C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for ZNF142 Gene

ZNF142 (Zinc Finger Protein 142) is a Protein Coding gene. An important paralog of this gene is ZNF513.

UniProtKB/Swiss-Prot for ZNF142 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF142 Gene

Genomics for ZNF142 Gene

Regulatory Elements for ZNF142 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF142 Gene

Chromosome:
2
Start:
218,637,916 bp from pter
End:
218,659,655 bp from pter
Size:
21,740 bases
Orientation:
Minus strand

Genomic View for ZNF142 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF142 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF142 Gene

Proteins for ZNF142 Gene

  • Protein details for ZNF142 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52746-ZN142_HUMAN
    Recommended name:
    Zinc finger protein 142
    Protein Accession:
    P52746
    Secondary Accessions:
    • Q92510

    Protein attributes for ZNF142 Gene

    Size:
    1687 amino acids
    Molecular mass:
    187880 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13242.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZNF142 Gene

Proteomics data for ZNF142 Gene at MOPED

Post-translational modifications for ZNF142 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF142 Gene

No data available for DME Specific Peptides for ZNF142 Gene

Domains & Families for ZNF142 Gene

Gene Families for ZNF142 Gene

Protein Domains for ZNF142 Gene

Suggested Antigen Peptide Sequences for ZNF142 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52746

UniProtKB/Swiss-Prot:

ZN142_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 31 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 31 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF142: view

Function for ZNF142 Gene

Molecular function for ZNF142 Gene

GENATLAS Biochemistry:
zinc finger protein 142 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF142: view
genes like me logo Genes that share phenotypes with ZNF142: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF142

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF142 Gene

Localization for ZNF142 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF142 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF142 Gene COMPARTMENTS Subcellular localization image for ZNF142 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF142: view

Pathways & Interactions for ZNF142 Gene

SuperPathways for ZNF142 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF142: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF142 Gene

Drugs & Compounds for ZNF142 Gene

No Compound Related Data Available

Transcripts for ZNF142 Gene

Unigene Clusters for ZNF142 Gene

Zinc finger protein 142:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF142

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF142 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - -
SP2: - - - - -
SP3: -
SP4: - - - -
SP5:

Relevant External Links for ZNF142 Gene

GeneLoc Exon Structure for
ZNF142
ECgene alternative splicing isoforms for
ZNF142

Expression for ZNF142 Gene

mRNA expression in normal human tissues for ZNF142 Gene

Protein differential expression in normal tissues from HIPED for ZNF142 Gene

This gene is overexpressed in Adipocyte (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF142 Gene



SOURCE GeneReport for Unigene cluster for ZNF142 Gene Hs.657969

genes like me logo Genes that share expression patterns with ZNF142: view

Protein tissue co-expression partners for ZNF142 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF142 Gene

Orthologs for ZNF142 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF142 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF142 35
  • 86.49 (n)
  • 87.83 (a)
ZNF142 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF142 35
  • 85.54 (n)
  • 87.06 (a)
ZNF142 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp142 35
  • 85.2 (n)
  • 85.5 (a)
Zfp142 16
Zfp142 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF142 35
  • 95.79 (n)
  • 94.61 (a)
ZNF142 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp142 35
  • 84.52 (n)
  • 85.67 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF142 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF142 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF142 35
  • 66.46 (n)
  • 64.2 (a)
ZNF142 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF142 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf142 35
  • 60.59 (n)
  • 57.64 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.17315 35
znf142 35
  • 54.29 (n)
  • 50.24 (a)
znf142 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta hb 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hbl-1 36
  • 12 (a)
OneToMany
Species with no ortholog for ZNF142:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF142 Gene

ENSEMBL:
Gene Tree for ZNF142 (if available)
TreeFam:
Gene Tree for ZNF142 (if available)

Paralogs for ZNF142 Gene

Paralogs for ZNF142 Gene

genes like me logo Genes that share paralogs with ZNF142: view

Variants for ZNF142 Gene

Sequence variations from dbSNP and Humsavar for ZNF142 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1055517 -- 218,652,621(-) TTTTC(C/T)TTTGG intron-variant
rs2230115 -- 218,644,895(-) CACCG(A/G/T)CCCCA reference, missense, nc-transcript-variant
rs3074285 -- 218,651,004(+) ttttt(-/T/TT/TTA)gagac intron-variant
rs3731871 -- 218,640,358(+) AATCT(A/G)CCCTT intron-variant
rs3731872 -- 218,656,172(+) GCACC(C/T)GGGGT reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF142 Gene

Variant ID Type Subtype PubMed ID
nsv875862 CNV Gain 21882294
esv2662860 CNV Deletion 23128226

Variation tolerance for ZNF142 Gene

Residual Variation Intolerance Score: 80.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.28; 88.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF142 Gene

HapMap Linkage Disequilibrium report
ZNF142

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF142 Gene

Disorders for ZNF142 Gene

Relevant External Links for ZNF142

Genetic Association Database (GAD)
ZNF142
Human Genome Epidemiology (HuGE) Navigator
ZNF142
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF142
genes like me logo Genes that share disorders with ZNF142: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF142 Gene

Publications for ZNF142 Gene

  1. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 67
  2. Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. (PMID: 22959728) . … Zheng J.G. (Neurobiol. Aging 2013) 67
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  5. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 67

Products for ZNF142 Gene

Sources for ZNF142 Gene

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