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Aliases for ZNF142 Gene

Aliases for ZNF142 Gene

  • Zinc Finger Protein 142 2 3 5
  • Zinc Finger Protein 142 (Clone PHZ-49) 2 3
  • HA4654 3 4
  • KIAA0236 4
  • PHZ-49 3

External Ids for ZNF142 Gene

Previous GeneCards Identifiers for ZNF142 Gene

  • GC02M217518
  • GC02M218224
  • GC02M219466
  • GC02M219705
  • GC02M219328
  • GC02M219210
  • GC02M211356

Summaries for ZNF142 Gene

Entrez Gene Summary for ZNF142 Gene

  • The protein encoded by this gene belongs to the Kruppel family of C2H2-type zinc finger proteins. It contains 31 C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for ZNF142 Gene

ZNF142 (Zinc Finger Protein 142) is a Protein Coding gene. An important paralog of this gene is ZNF462.

UniProtKB/Swiss-Prot for ZNF142 Gene

  • May be involved in transcriptional regulation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF142 Gene

Genomics for ZNF142 Gene

Regulatory Elements for ZNF142 Gene

Enhancers for ZNF142 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G218730 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -73.0 -73035 4.6 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 SLC11A1 CYP27A1 PLCD4 USP37 NHEJ1 RNF25 ZNF142 BCS1L AAMP PNKD
GH02G218566 1.8 FANTOM5 ENCODE dbSUPER 10.1 +90.3 90338 4.7 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC CNOT9 PLCD4 BCS1L USP37 SLC23A3 NHEJ1 AAMP ZNF142 RNF25 CNPPD1
GH02G218819 1.6 FANTOM5 ENCODE dbSUPER 9.8 -161.8 -161756 4.7 PKNOX1 ATF1 ZFP64 SIN3A KLF13 PAF1 ZNF263 SP3 CAVIN1 NFYC WNT6 PLCD4 RNF25 MIR375 LOC100129175 ZNF142 BCS1L SLC11A1 PNKD GC02P218820
GH02G218687 1.2 Ensembl ENCODE 11.4 -27.9 -27946 0.4 ELF3 RB1 ARID4B SIN3A RAD21 ZNF335 ZNF143 CREM MIXL1 THAP11 BCS1L ZNF142 WNT6 PLCD4 RNF25 TTLL4
GH02G218753 0.8 dbSUPER 10.3 -95.0 -95026 1.6 SOX13 CTCF FOXA2 THRB ZNF48 RAD21 KAT2B TEAD3 RARA POLR2A CYP27A1 RNF25 ZNF142 BCS1L PLCD4 GC02P218766 TTLL4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF142 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF142 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000130436 155 1801 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9

Genomic Location for ZNF142 Gene

Chromosome:
2
Start:
218,637,916 bp from pter
End:
218,659,655 bp from pter
Size:
21,740 bases
Orientation:
Minus strand

Genomic View for ZNF142 Gene

Genes around ZNF142 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF142 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF142 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF142 Gene

Proteins for ZNF142 Gene

  • Protein details for ZNF142 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52746-ZN142_HUMAN
    Recommended name:
    Zinc finger protein 142
    Protein Accession:
    P52746
    Secondary Accessions:
    • Q92510

    Protein attributes for ZNF142 Gene

    Size:
    1687 amino acids
    Molecular mass:
    187880 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13242.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZNF142 Gene

Post-translational modifications for ZNF142 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF142 Gene

Domains & Families for ZNF142 Gene

Gene Families for ZNF142 Gene

Protein Domains for ZNF142 Gene

Suggested Antigen Peptide Sequences for ZNF142 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52746

UniProtKB/Swiss-Prot:

ZN142_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF142: view

Function for ZNF142 Gene

Molecular function for ZNF142 Gene

GENATLAS Biochemistry:
zinc finger protein 142 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF142: view
genes like me logo Genes that share phenotypes with ZNF142: view

Animal Models for ZNF142 Gene

MGI Knock Outs for ZNF142:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF142 Gene

Localization for ZNF142 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF142 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF142 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF142: view

Pathways & Interactions for ZNF142 Gene

SuperPathways for ZNF142 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF142: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF142 Gene

Drugs & Compounds for ZNF142 Gene

No Compound Related Data Available

Transcripts for ZNF142 Gene

Unigene Clusters for ZNF142 Gene

Zinc finger protein 142:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF142 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - -
SP2: - - - - -
SP3: -
SP4: - - - -
SP5:

Relevant External Links for ZNF142 Gene

GeneLoc Exon Structure for
ZNF142
ECgene alternative splicing isoforms for
ZNF142

Expression for ZNF142 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF142 Gene

Protein differential expression in normal tissues from HIPED for ZNF142 Gene

This gene is overexpressed in Adipocyte (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF142 Gene



Protein tissue co-expression partners for ZNF142 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF142 Gene:

ZNF142

SOURCE GeneReport for Unigene cluster for ZNF142 Gene:

Hs.657969

Evidence on tissue expression from TISSUES for ZNF142 Gene

  • Bone marrow(4.2)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with ZNF142: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF142 Gene

Orthologs for ZNF142 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF142 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF142 34 35
  • 95.79 (n)
cow
(Bos Taurus)
Mammalia ZNF142 34 35
  • 86.49 (n)
dog
(Canis familiaris)
Mammalia ZNF142 34 35
  • 85.54 (n)
mouse
(Mus musculus)
Mammalia Zfp142 34 16 35
  • 85.2 (n)
rat
(Rattus norvegicus)
Mammalia Zfp142 34
  • 84.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF142 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF142 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF142 34 35
  • 66.46 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF142 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf142 34
  • 60.59 (n)
zebrafish
(Danio rerio)
Actinopterygii znf142 34 35
  • 54.29 (n)
Dr.17315 34
fruit fly
(Drosophila melanogaster)
Insecta hb 35
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hbl-1 35
  • 12 (a)
OneToMany
Species where no ortholog for ZNF142 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF142 Gene

ENSEMBL:
Gene Tree for ZNF142 (if available)
TreeFam:
Gene Tree for ZNF142 (if available)

Paralogs for ZNF142 Gene

Paralogs for ZNF142 Gene

genes like me logo Genes that share paralogs with ZNF142: view

Variants for ZNF142 Gene

Sequence variations from dbSNP and Humsavar for ZNF142 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs121908572 Pathogenic 218,661,283(+) TGTCC(C/T)CAGCC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs121908575 Pathogenic 218,661,120(+) TCCGG(C/G/T)GCCAT intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs121908576 Pathogenic 218,661,153(+) CTGCT(C/T)GAGAC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, stop-gained, utr-variant-5-prime
rs121908579 Pathogenic 218,661,090(+) GGAAG(C/G)GTGTC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs121908580 Pathogenic 218,661,135(+) TGATC(A/G)CACTG intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF142 Gene

Variant ID Type Subtype PubMed ID
esv2662860 CNV deletion 23128226
esv3594346 CNV loss 21293372
esv3594347 CNV loss 21293372

Variation tolerance for ZNF142 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.28; 88.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF142 Gene

Human Gene Mutation Database (HGMD)
ZNF142
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF142

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF142 Gene

Disorders for ZNF142 Gene

Relevant External Links for ZNF142

Genetic Association Database (GAD)
ZNF142
Human Genome Epidemiology (HuGE) Navigator
ZNF142
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF142

No disorders were found for ZNF142 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF142 Gene

Publications for ZNF142 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4 64
  3. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N. … Vissing H. (Genomics 1995) 3 4 64
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
  5. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 4 64

Products for ZNF142 Gene

Sources for ZNF142 Gene

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