ZNF141 Gene
protein-coding GIFtS: 49
GCID: GC04P000303
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zinc finger protein 141(Previous name: zinc finger protein 141 (clone pHZ-44) )
(Previous symbol: D4S90)
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Aliases
for ZNF141 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 1411 2 | | D4S901 2 3 5 | | PHZ-441 | | Zinc Finger Protein 141 (Clone PHZ-44)1 2 |
Export aliases for ZNF141 gene to outside databasesPrevious GC identifers: GC04P000321 GC04P000203 GC04P000204 GC04P000044 |
Summaries
for ZNF141 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN141_HUMAN, Q15928Function: May be involved in transcriptional regulation as a repressor. Candidate gene for Wolf-Hirschhorn (4p-)syndrome (WHS)
|
Genomic Views
for ZNF141 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_037622.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF141 gene promoter:
Bach1 GR USF1 HSF1 (long) USF-1 c-Myb HSF1short ZID GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF141
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF141 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3ZNF141 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P000303: view genomic region
(about GC identifiers)
Start:
|
331,596 bp from pter |
End:
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378,653 bp from pter |
Size:
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47,058 bases |
Orientation:
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plus strand |
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Proteins
for ZNF141 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN141_HUMAN, Q15928 (See
protein sequence)Recommended Name: Zinc finger protein 141 Size: 474 amino acids; 55249 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q6DK07Explore the universe of human proteins at neXtProt for ZNF141: NX_Q15928
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15928
ZNF141 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003432.1
ENSEMBL proteins: ENSP00000425799 ENSP00000424403 ENSP00000240499 Reactome Protein details: Q15928
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF141 for ontologies About GeneDecksing
ZNF141 Antibody Products:
Assay Products for ZNF141: |
Protein
Domains /
Families
for ZNF141 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF141 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15928ProtoNet protein and cluster: Q15928 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN141_HUMAN, Q15928Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 11 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF141 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN141_HUMAN, Q15928Function: May be involved in transcriptional regulation as a repressor. Candidate gene for Wolf-Hirschhorn (4p-)syndrome (WHS) Genatlas biochemistry entry for ZNF141:zinc finger protein 141,C2H2 type,Kruppel-like,KRAB subfamily
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF141
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF141 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZNF141:
|
Pathways & Interactions
for ZNF141 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF141
ZNF141 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF141
1 Interacting protein for ZNF141 (Q159283) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | 8268908 | | GO:0009653 | anatomical structure morphogenesis |
TAS | 8268908 |
ZNF141 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF141 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF141
Search CenterWatch for drugs/clinical trials and news about ZNF141 / ZN141
|
Transcripts
for ZNF141 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF141 gene: NM_003441.2 Unigene Cluster for ZNF141: Zinc finger protein 141 Hs.654355 [show with all ESTs]Unigene Representative Sequence: L153096 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000366506 ENST00000512994(uc003gab.3) ENST00000503699(uc003fzz.2)
ENST00000505939 ENST00000240499(uc003gaa.2) ENST00000579770
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF141
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF141
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF141 (NM_003441) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF141 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF141 |
Additional cDNA sequence: AK123078.1 BC036854.1 BC057244.1 BC074853.2 L15309.1 14 DOTS entries: DT.101984 DT.100015992 DT.100010494 DT.121227381 DT.100034393 DT.91842394 DT.95077054 DT.40290320 DT.423776 DT.75149597 DT.86845873 DT.91954556 DT.97793696 DT.99943253 24/59 AceView cDNA sequences (see all 59): AA617794 AI914884 AK091543 AA291302 BM800016 BF512484 BC074853 BX452265 CA312024 CR607283 BQ722919 BQ923205 BC057244 BC036854 BV204588 BQ428430 BG110742 AV714960 AA262062 BX481918 CA448053 BV204585 CB854294 AW590651
GeneLoc Exon Structure
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Expression
for ZNF141 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF141 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF141 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF141
SOURCE GeneReport for Unigene cluster: Hs.654355
UniProtKB/Swiss-Prot: ZN141_HUMAN, Q15928Tissue specificity: Ubiquitously low expression
SABiosciences Custom PCR Arrays for ZNF141
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF141
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF141 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF141 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF141 |
Orthologs
for ZNF141 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF141 gene from 1/4 species (see all 4) About this table
ENSEMBL Gene Tree for ZNF141 (if available)
TreeFam Gene Tree for ZNF141 (if available) |
Paralogs
for ZNF141 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF141 gene
- ZNF852 ZNF4932 ZNF4862 ZNF1002 ZNF922 ZNF7322 ZNF1382 ZNF6752
- ZNF5062 ZNF2732 ZNF66P2 ZNF6952 ZNF6262 ZNF6802 ZNF2532 ZNF4792
- ZNF932 ZNF4922 ZNF6822 ZNF6762 ZNF6812 ZNF6792 ZNF2572 ZNF2542
- ZNF7372 ZNF724P2 ZNF982 ZNF849P2 ZNF7162 ZNF7142 ZNF4292 ZNF4302
- ZNF7302 ZNF6782 ZNF1172 ZNF7082 ZNF1072 ZNF4312 ZNF902
18/528 SIMAP similar genes for ZNF141 using alignment to 4 protein entries: ZN141_HUMAN (see all proteins)
(see all similar genes):ZNF78L1 MGC12518 ZNF732 ZFS-4 ZNF718 ZNF818P
ZNF595 ZNF273 ZNF66 ZNF738 ZNF726 DKFZp686M04222
ZNF519 ZNF56 ZNF90 ZNF527 ZNF66P DKFZp313M0722
ZNF141 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for ZNF141
PGOHUM00000242638 PGOHUM00000250548 PGOHUM00000256898 PGOHUM00000250431
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Genomic Variants
for ZNF141 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF141
1 CNV: 2066 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF141 |
|
Disorders
/ Diseases
for ZNF141 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF141 for disorders About GeneDecksing
OMIM gene information: 194648
OMIM disorders: --
2  diseases for ZNF141: About MalaCardswolf-hirschhorn syndrome huntington's disease
1 disease from the University of Copenhagen DISEASES database for ZNF141:Huntington's disease Export disorders for ZNF141 gene to outside databases
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Publications
for ZNF141 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF141 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF141) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate gene for the Wolf-Hirschhorn (4p-) syndrome. (PubMed id 8268908)1, 2, 3, 9 Tommerup N.... Vissing H. (1993)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- A universal strategy for proteomic studies of SUMO an d other ubiquitin-like modifiers. (PubMed id 15576338)1 Rosas-Acosta G....Wilson V.G. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer. (PubMed id 9671765)1 Varrault A....Journot L. (1998)
|
External Searches for ZNF141 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF141 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF141 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF141 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF141 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF141 gene:
Search GeneIP for patents involving ZNF141
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF141 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF141 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF141 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF141 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF141 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF141 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF141 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF141 | | OriGene Custom Protein Services for ZNF141 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF141 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF141 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF141 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF141 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF141 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF141 |
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| | | | Search Tocris compounds for ZNF141 |
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 | | | ZNF141 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for ZNF141 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF141 |
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