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Aliases for ZNF141 Gene

Aliases for ZNF141 Gene

  • Zinc Finger Protein 141 2 3 5
  • Zinc Finger Protein 141 (Clone PHZ-44) 2 3
  • D4S90 3 4
  • PHZ-44 3
  • PAPA6 3

External Ids for ZNF141 Gene

Previous HGNC Symbols for ZNF141 Gene

  • D4S90

Previous GeneCards Identifiers for ZNF141 Gene

  • GC04P000321
  • GC04P000203
  • GC04P000204
  • GC04P000044
  • GC04P000303

Summaries for ZNF141 Gene

GeneCards Summary for ZNF141 Gene

ZNF141 (Zinc Finger Protein 141) is a Protein Coding gene. Diseases associated with ZNF141 include Polydactyly, Postaxial, Type A6 and Postaxial Polydactyly Type A, Bilateral. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF732.

UniProtKB/Swiss-Prot for ZNF141 Gene

  • May be involved in transcriptional regulation as a repressor. Plays a role in limb development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF141 Gene

Genomics for ZNF141 Gene

Regulatory Elements for ZNF141 Gene

Enhancers for ZNF141 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F001040 1.4 FANTOM5 Ensembl ENCODE 18.4 +704.1 704089 1.8 RING1 SOX13 CTCF KLF1 SAP130 ZIC2 ZFHX2 NR2F6 TRIM24 E2F6 CRIPAK LOC100129917 ZNF141 CTBP1-AS2 ZNF718 ZNF876P ZNF732 LOC100288172 ABCA11P IDUA
GH04F001042 1.8 FANTOM5 Ensembl ENCODE 13.5 +706.4 706366 2.7 HDGF PKNOX1 ARNT SIN3A ZNF2 CBX5 FOS JUNB REST SMARCB1 ZNF141 MIR943 ZNF718 LOC100288172 ZNF732 PCGF3 FGFRL1 LETM1 GAK MAEA
GH04F000050 1.5 FANTOM5 Ensembl ENCODE 12.4 -284.1 -284149 6.1 HDAC1 CBX3 PKNOX1 TBL1XR1 ARNT WRNIP1 SIN3A ETS1 YY1 ELK1 ENSG00000272588 ZNF718 ZNF141 LOC100129917 IDUA ENSG00000251535 ZNF595 LOC105379580
GH04F001009 1 ENCODE 18.4 +672.5 672548 2.0 HDGF PKNOX1 ZNF48 GLIS2 FOS ZNF263 SP3 SP5 ZNF610 SMARCA4 LOC100129917 ZNF141 CRIPAK ZNF718 ZNF876P CTBP1-AS2 ZNF732 LOC100288172 ABCA11P IDUA
GH04F000704 1.1 ENCODE 13.1 +368.4 368448 2.6 HDGF PKNOX1 ZFP64 ARID4B SIN3A YBX1 ZNF2 ZNF143 ZNF207 SP3 ENSG00000207009 LOC100129917 ZNF718 ZNF141 ENSG00000272588 PCGF3 ZNF732 IDUA CTBP1-AS2 CRIPAK
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF141 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF141 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001234243 -6 3599 HDGF TBP PKNOX1 SIN3A ZBTB40 YY1 EGR1 ZNF143 ZNF207 FOS

Genomic Location for ZNF141 Gene

337,807 bp from pter
384,864 bp from pter
47,058 bases
Plus strand

Genomic View for ZNF141 Gene

Genes around ZNF141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF141 Gene

Proteins for ZNF141 Gene

  • Protein details for ZNF141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 141
    Protein Accession:
    Secondary Accessions:
    • Q6DK07

    Protein attributes for ZNF141 Gene

    474 amino acids
    Molecular mass:
    55249 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF141 Gene

Post-translational modifications for ZNF141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF141 Gene

No data available for DME Specific Peptides for ZNF141 Gene

Domains & Families for ZNF141 Gene

Gene Families for ZNF141 Gene

Suggested Antigen Peptide Sequences for ZNF141 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF141: view

Function for ZNF141 Gene

Molecular function for ZNF141 Gene

GENATLAS Biochemistry:
zinc finger protein 141,C2H2 type,Kruppel-like,KRAB subfamily
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation as a repressor. Plays a role in limb development.

Gene Ontology (GO) - Molecular Function for ZNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF141: view
genes like me logo Genes that share phenotypes with ZNF141: view

Human Phenotype Ontology for ZNF141 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF141 Gene

Localization for ZNF141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF141 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF141 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZNF141: view

Pathways & Interactions for ZNF141 Gene

SuperPathways for ZNF141 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF141: view

Pathways by source for ZNF141 Gene

2 Reactome pathways for ZNF141 Gene

Gene Ontology (GO) - Biological Process for ZNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006366 transcription from RNA polymerase II promoter TAS 8268908
GO:0007275 multicellular organism development IEA --
GO:0009653 anatomical structure morphogenesis TAS 8268908
genes like me logo Genes that share ontologies with ZNF141: view

No data available for SIGNOR curated interactions for ZNF141 Gene

Transcripts for ZNF141 Gene

Unigene Clusters for ZNF141 Gene

Zinc finger protein 141:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF141 Gene

No ASD Table

Relevant External Links for ZNF141 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF141 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF141 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF141 Gene:


SOURCE GeneReport for Unigene cluster for ZNF141 Gene:


mRNA Expression by UniProt/SwissProt for ZNF141 Gene:

Tissue specificity: Ubiquitously low expression.
genes like me logo Genes that share expression patterns with ZNF141: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZNF141 Gene

Orthologs for ZNF141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF141 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF141 34 35
  • 99.72 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 45 (a)
-- 35
  • 32 (a)
(Bos Taurus)
Mammalia -- 35
  • 44 (a)
(Canis familiaris)
Mammalia -- 35
  • 32 (a)
(Mus musculus)
Mammalia Zfp941 35
  • 29 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 43 (a)
-- 35
  • 33 (a)
-- 35
  • 31 (a)
-- 35
  • 27 (a)
-- 35
  • 27 (a)
-- 35
  • 26 (a)
-- 35
  • 25 (a)
-- 35
  • 24 (a)
Species where no ortholog for ZNF141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF141 Gene

Gene Tree for ZNF141 (if available)
Gene Tree for ZNF141 (if available)

Paralogs for ZNF141 Gene

(533) SIMAP similar genes for ZNF141 Gene using alignment to 4 proteins: Pseudogenes for ZNF141 Gene

genes like me logo Genes that share paralogs with ZNF141: view

Variants for ZNF141 Gene

Sequence variations from dbSNP and Humsavar for ZNF141 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs587776959 Polydactyly, postaxial A6 (PAPA6) [MIM:615226], other 373,858(+) TCATA(C/T)TTGAG reference, missense
rs10015733 -- 369,766(+) tatat(A/T)ttttt intron-variant
rs10212688 -- 357,255(+) agtcA(C/T)TTCTT intron-variant
rs111227600 -- 336,392(+) CTGCC(-/G)GGGGG upstream-variant-2KB
rs111369004 -- 344,382(-) CTCTT(C/T)TCTTT intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF141 Gene

Variant ID Type Subtype PubMed ID
nsv980176 CNV duplication 23825009
nsv593199 CNV loss 21841781
nsv593198 CNV loss 21841781
nsv469996 CNV gain 18288195
nsv469736 CNV loss 16826518
nsv461144 CNV loss 19166990
nsv1161026 CNV duplication 26073780
nsv1150471 CNV deletion 26484159
nsv1074123 CNV deletion 25765185
nsv1009336 CNV gain 25217958
nsv1006781 CNV gain 25217958
nsv1001899 CNV loss 25217958
esv4769 OTHER complex 18987735
esv3893862 CNV gain 25118596
esv3599369 CNV loss 21293372
esv2763816 CNV gain+loss 21179565
dgv971e214 CNV gain 21293372
dgv914e199 CNV deletion 23128226
dgv8875n54 CNV loss 21841781
dgv5077n100 CNV loss 25217958
dgv5076n100 CNV gain 25217958
dgv2697n106 CNV deletion 24896259

Variation tolerance for ZNF141 Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF141 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF141 Gene

Disorders for ZNF141 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF141 Gene - From: OMIM, ClinVar, Orphanet, and Swiss-Prot

Disorder Aliases PubMed IDs
polydactyly, postaxial, type a6
  • polydactyly, postaxial a6
postaxial polydactyly type a, bilateral
- elite association - COSMIC cancer census association via MalaCards


  • Polydactyly, postaxial A6 (PAPA6) [MIM:615226]: A condition characterized by the occurrence of supernumerary digits in the upper and/or lower extremities. In postaxial polydactyly type A, the extra digit is well-formed and articulates with the fifth or a sixth metacarpal/metatarsal. {ECO:0000269 PubMed:23160277}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZNF141

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZNF141: view

No data available for Genatlas for ZNF141 Gene

Publications for ZNF141 Gene

  1. A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate gene for the Wolf-Hirschhorn (4p-) syndrome. (PMID: 8268908) Tommerup N. … Vissing H. (Hum. Mol. Genet. 1993) 2 3 4 22 64
  2. Whole exome sequencing identified a novel zinc-finger gene ZNF141 associated with autosomal recessive postaxial polydactyly type A. (PMID: 23160277) Kalsoom U.E. … Ahmad W. (J. Med. Genet. 2013) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Advances in the molecular genetics of non-syndromic polydactyly. (PMID: 26515020) Deng H. … Yuan L. (Expert Rev Mol Med 2015) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for ZNF141 Gene

Sources for ZNF141 Gene

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