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Aliases for ZNF141 Gene

Aliases for ZNF141 Gene

  • Zinc Finger Protein 141 2 3
  • D4S90 3 4 6
  • Zinc Finger Protein 141 (Clone PHZ-44) 2 3
  • PAPA6 3 6
  • PHZ-44 3

External Ids for ZNF141 Gene

Previous Symbols for ZNF141 Gene

  • D4S90

Summaries for ZNF141 Gene

GeneCards Summary for ZNF141 Gene

ZNF141 (Zinc Finger Protein 141) is a Protein Coding gene. Diseases associated with ZNF141 include polydactyly, postaxial, type a6 and postaxial polydactyly type a, bilateral. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF141 Gene

  • May be involved in transcriptional regulation as a repressor. Plays a role in limb development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF141 Gene

Genomics for ZNF141 Gene

Genomic Location for ZNF141 Gene

Start:
337,628 bp from pter
End:
384,864 bp from pter
Size:
47,237 bases
Orientation:
Plus strand

Genomic View for ZNF141 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF141 Gene

Regulatory Elements for ZNF141 Gene

Proteins for ZNF141 Gene

  • Protein details for ZNF141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15928-ZN141_HUMAN
    Recommended name:
    Zinc finger protein 141
    Protein Accession:
    Q15928
    Secondary Accessions:
    • Q6DK07

    Protein attributes for ZNF141 Gene

    Size:
    474 amino acids
    Molecular mass:
    55249 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF141 Gene

Proteomics data for ZNF141 Gene at MOPED

Post-translational modifications for ZNF141 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys256

Other Protein References for ZNF141 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF141 Gene

Domains for ZNF141 Gene

Gene Families for ZNF141 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

UniProtKB/Swiss-Prot:

ZN141_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q15928
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q15928
Similarity:
  • Contains 11 C2H2-type zinc fingers.:
    • Q15928
genes like me logo Genes that share domains with ZNF141: view

Function for ZNF141 Gene

Molecular function for ZNF141 Gene

GENATLAS Biochemistry: zinc finger protein 141,C2H2 type,Kruppel-like,KRAB subfamily
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation as a repressor. Plays a role in limb development.

Gene Ontology (GO) - Molecular Function for ZNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF141: view

Phenotypes for ZNF141 Gene

GenomeRNAi human phenotypes for ZNF141:
genes like me logo Genes that share phenotypes with ZNF141: view

miRNA for ZNF141 Gene

miRTarBase miRNAs that target ZNF141

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF141 Gene

Localization for ZNF141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF141 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF141 Gene COMPARTMENTS Subcellular localization image for ZNF141 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF141: view

Pathways for ZNF141 Gene

SuperPathways for ZNF141 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF141: view

Pathways by source for ZNF141 Gene

2 Reactome pathways for ZNF141 Gene

Interacting Proteins for ZNF141 Gene

Gene Ontology (GO) - Biological Process for ZNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 8268908
GO:0009653 anatomical structure morphogenesis TAS 8268908
GO:0035108 limb morphogenesis IMP 23160277
genes like me logo Genes that share ontologies with ZNF141: view

Transcripts for ZNF141 Gene

Unigene Clusters for ZNF141 Gene

Zinc finger protein 141:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF141 Gene

No ASD Table

Relevant External Links for ZNF141 Gene

GeneLoc Exon Structure for
ZNF141
ECgene alternative splicing isoforms for
ZNF141

Expression for ZNF141 Gene

mRNA expression in normal human tissues for ZNF141 Gene

SOURCE GeneReport for Unigene cluster for ZNF141 Gene Hs.654355

mRNA Expression by UniProt/SwissProt for ZNF141 Gene

Q15928-ZN141_HUMAN
Tissue specificity: Ubiquitously low expression
genes like me logo Genes that share expressions with ZNF141: view

Orthologs for ZNF141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF141 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF141 36
  • 99.72 (n)
  • 99.16 (a)
ZNF141 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 44 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 32 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp941 37
  • 29 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 32 (a)
ManyToMany
-- 37
  • 45 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 43 (a)
ManyToMany
-- 37
  • 27 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
-- 37
  • 31 (a)
ManyToMany
-- 37
  • 27 (a)
ManyToMany
-- 37
  • 26 (a)
ManyToMany
-- 37
  • 25 (a)
ManyToMany
-- 37
  • 24 (a)
ManyToMany
Species with no ortholog for ZNF141:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF141 Gene

ENSEMBL:
Gene Tree for ZNF141 (if available)
TreeFam:
Gene Tree for ZNF141 (if available)

Paralogs for ZNF141 Gene

Selected SIMAP similar genes for ZNF141 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ZNF141 Gene

genes like me logo Genes that share paralogs with ZNF141: view

Variants for ZNF141 Gene

Sequence variations from dbSNP and Humsavar for ZNF141 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3946 -- 374,138(-) TTACA(C/T)TCTTT downstream-variant-500B
rs955417 - 373,483(+) TTTTA(A/G)ACAGT missense, reference
rs1443076 -- 374,167(-) TCACC(A/G)GTGAG downstream-variant-500B
rs2018645 - 373,511(+) CATAA(G/T)AAAGT reference, missense
rs2229296 - 372,807(+) AGTGT(A/G)AGTTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF141 Gene

Variant ID Type Subtype PubMed ID
dgv914e199 CNV Deletion 23128226
dgv5386n71 CNV Gain 21882294
esv4769 CNV Complex 18987735
nsv469996 CNV Gain 18288195
nsv469736 CNV Loss 16826518
nsv461144 CNV Loss 19166990

Relevant External Links for ZNF141 Gene

HapMap Linkage Disequilibrium report
ZNF141
Human Gene Mutation Database (HGMD)
ZNF141

Disorders for ZNF141 Gene

(1) OMIM Diseases for ZNF141 Gene (194648)

UniProtKB/Swiss-Prot

ZN141_HUMAN
  • Polydactyly, postaxial A6 (PAPA6) [MIM:615226]: A condition characterized by the occurrence of supernumerary digits in the upper and/or lower extremities. In postaxial polydactyly type A, the extra digit is well-formed and articulates with the fifth or a sixth metacarpal/metatarsal. {ECO:0000269 PubMed:23160277}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for ZNF141 Gene

genes like me logo Genes that share disorders with ZNF141: view

Publications for ZNF141 Gene

  1. A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate gene for the Wolf-Hirschhorn (4p-) syndrome. (PMID: 8268908) Tommerup N. … Vissing H. (Hum. Mol. Genet. 1993) 2 3 4 23
  2. Whole exome sequencing identified a novel zinc-finger gene ZNF141 associated with autosomal recessive postaxial polydactyly type A. (PMID: 23160277) Kalsoom U.E. … Ahmad W. (J. Med. Genet. 2013) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers. (PMID: 15576338) Rosas-Acosta G. … Wilson V.G. (Mol. Cell Proteomics 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ZNF141 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF141
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF141
    • Block miRNA regulation of ZNF141 using miScript Target Protectors
    • antibodies-online peptides for ZNF141
    • antibodies-online antibodies for ZNF141
    • antibodies-online kits for ZNF141

    Sources for ZNF141 Gene

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