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Aliases for ZNF140 Gene

Aliases for ZNF140 Gene

  • Zinc Finger Protein 140 2 3 5
  • Zinc Finger Protein 140 (Clone PHZ-39) 2
  • EC 63
  • EC 63
  • PHZ-39 3

External Ids for ZNF140 Gene

Previous GeneCards Identifiers for ZNF140 Gene

  • GC12P131178
  • GC12P133260
  • GC12P131896
  • GC12P131391
  • GC12P132267
  • GC12P133657
  • GC12P130436

Summaries for ZNF140 Gene

GeneCards Summary for ZNF140 Gene

ZNF140 (Zinc Finger Protein 140) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF345.

UniProtKB/Swiss-Prot for ZNF140 Gene

  • May be involved in transcriptional regulation as a repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF140 Gene

Genomics for ZNF140 Gene

Regulatory Elements for ZNF140 Gene

Enhancers for ZNF140 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF140 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF140 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF140 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF140 Gene

133,079,687 bp from pter
133,108,803 bp from pter
29,117 bases
Plus strand

Genomic View for ZNF140 Gene

Genes around ZNF140 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF140 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF140 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF140 Gene

Proteins for ZNF140 Gene

  • Protein details for ZNF140 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 140
    Protein Accession:
    Secondary Accessions:
    • D3DXJ3
    • Q05CP6
    • Q8IV75

    Protein attributes for ZNF140 Gene

    457 amino acids
    Molecular mass:
    52996 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF140 Gene


neXtProt entry for ZNF140 Gene

Proteomics data for ZNF140 Gene at MOPED

Selected DME Specific Peptides for ZNF140 Gene

Post-translational modifications for ZNF140 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF140

Domains & Families for ZNF140 Gene

Gene Families for ZNF140 Gene

Protein Domains for ZNF140 Gene

Suggested Antigen Peptide Sequences for ZNF140 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF140: view

Function for ZNF140 Gene

Molecular function for ZNF140 Gene

GENATLAS Biochemistry:
zinc finger protein 140 (C2H2 type,Kruppel-like,KRAB subfamily)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation as a repressor.

Enzyme Numbers (IUBMB) for ZNF140 Gene

genes like me logo Genes that share phenotypes with ZNF140: view

Animal Model Products

CRISPR Products

miRNA for ZNF140 Gene

miRTarBase miRNAs that target ZNF140

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF140 Gene

Localization for ZNF140 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF140 Gene

Subcellular locations from

Jensen Localization Image for ZNF140 Gene COMPARTMENTS Subcellular localization image for ZNF140 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF140 Gene

Pathways & Interactions for ZNF140 Gene

SuperPathways for ZNF140 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF140: view

Pathways by source for ZNF140 Gene

2 Reactome pathways for ZNF140 Gene

Interacting Proteins for ZNF140 Gene

Gene Ontology (GO) - Biological Process for ZNF140 Gene


No data available for SIGNOR curated interactions for ZNF140 Gene

Drugs & Compounds for ZNF140 Gene

No Compound Related Data Available

Transcripts for ZNF140 Gene

Unigene Clusters for ZNF140 Gene

Zinc finger protein 140:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF140 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: -
SP7: - -

Relevant External Links for ZNF140 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF140 Gene

mRNA expression in normal human tissues for ZNF140 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF140 Gene

SOURCE GeneReport for Unigene cluster for ZNF140 Gene Hs.181552

mRNA Expression by UniProt/SwissProt for ZNF140 Gene

Tissue specificity: Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with ZNF140: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for ZNF140 Gene

Orthologs for ZNF140 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF140 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF140 35
  • 90.08 (n)
  • 89.72 (a)
ZNF140 36
  • 89 (a)
(Canis familiaris)
Mammalia ZNF140 35
  • 89.57 (n)
  • 88.99 (a)
ZNF140 36
  • 87 (a)
(Pan troglodytes)
Mammalia ZNF140 35
  • 99.64 (n)
  • 99.78 (a)
ZNF140 36
  • 100 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZAP1 36
  • 14 (a)
Species with no ortholog for ZNF140:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF140 Gene

Gene Tree for ZNF140 (if available)
Gene Tree for ZNF140 (if available)

Paralogs for ZNF140 Gene

(533) SIMAP similar genes for ZNF140 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ZNF140: view

Variants for ZNF140 Gene

Sequence variations from dbSNP and Humsavar for ZNF140 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_046562 -
rs2088683 -- 133,100,763(-) actga(A/C)cctta intron-variant
rs7134680 -- 133,097,856(+) ttttg(A/T)gatga intron-variant
rs585948 -- 133,095,783(-) ACATC(C/T)AGGCA intron-variant
rs587890 -- 133,090,857(+) gtgca(C/T)gtaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF140 Gene

Variant ID Type Subtype PubMed ID
dgv538e1 CNV Complex 17122850
dgv330e199 CNV Deletion 23128226
nsv899835 CNV Loss 21882294
nsv899836 CNV Gain 21882294
esv27162 CNV Gain+Loss 19812545
essv8522 CNV CNV 17122850
nsv470337 CNV Loss 18288195
nsv518970 CNV Gain 19592680

Variation tolerance for ZNF140 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF140 Gene

Disorders for ZNF140 Gene

Relevant External Links for ZNF140

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF140 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF140 Gene

Publications for ZNF140 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N. … Vissing H. (Genomics 1995) 2 3 4 67
  2. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF140 Gene

Sources for ZNF140 Gene