ZNF140 Gene
protein-coding GIFtS: 51
GCID: GC12P133657
|
|
zinc finger protein 140(Previous name: zinc finger protein 140 (clone pHZ-39) )
| |
Aliases
for ZNF140 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 1401 2 | | PHZ-391 | | Zinc Finger Protein 140 (Clone PHZ-39)1 | | EC 1.3.1.268 | | EC 2.1.1.438 |
Export aliases for ZNF140 gene to outside databasesPrevious GC identifers: GC12P131178 GC12P133260 GC12P131896 GC12P131391 GC12P132267 GC12P130436 |
Summaries
for ZNF140 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN140_HUMAN, P52738Function: May be involved in transcriptional regulation as a repressor
|
Genomic Views
for ZNF140 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_024477.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZNF140
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF140
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF140 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.33 Ensembl cytogenetic band: 12q24.33 HGNC cytogenetic band: 12q24.33ZNF140 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P133657: view genomic region
(about GC identifiers)
Start:
|
133,656,424 bp from pter |
End:
|
133,684,260 bp from pter |
Size:
|
27,837 bases |
Orientation:
|
plus strand |
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Proteins
for ZNF140 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN140_HUMAN, P52738 (See
protein sequence)Recommended Name: Zinc finger protein 140 Size: 457 amino acids; 52996 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: D3DXJ3 Q8IV75Explore the universe of human proteins at neXtProt for ZNF140: NX_P52738
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P52738
2 DME Specific Peptides for ZNF140 (P52738)
ZNF140 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003431.2
ENSEMBL proteins: ENSP00000347755 ENSP00000444905 ENSP00000389566 ENSP00000445411 ENSP00000439805 ENSP00000437913 ENSP00000415016 ENSP00000375895 ENSP00000441170 ENSP00000415499 Reactome Protein details: P52738
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF140 for ontologies About GeneDecksing
ZNF140 Antibody Products:
Assay Products for ZNF140: |
Protein
Domains /
Families
for ZNF140 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF140 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P52738ProtoNet protein and cluster: P52738 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN140_HUMAN, P52738Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 10 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF140 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN140_HUMAN, P52738Function: May be involved in transcriptional regulation as a repressor Genatlas biochemistry entry for ZNF140:zinc finger protein 140 (C2H2 type,Kruppel-like,KRAB subfamily)
Enzyme Numbers (IUBMB): EC 2.1.1.432 EC 1.3.1.262
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF140
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF140
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF140 (NM_003440) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF140 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF140 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF140 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZNF140 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF140:
|
Pathways & Interactions
for ZNF140 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF140
ZNF140 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF140
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- |
ZNF140 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF140 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF140
Search CenterWatch for drugs/clinical trials and news about ZNF140 / ZN140
|
Transcripts
for ZNF140 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF140 gene: NM_003440.2 Unigene Cluster for ZNF140: Zinc finger protein 140 Hs.181552 [show with all ESTs]Unigene Representative Sequence: AK12274110 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000355557(uc001ulo.3 uc001ulp.3 uc010tbu.2) ENST00000356456
ENST00000412146 ENST00000544426 ENST00000440984 ENST00000319849 ENST00000440550
ENST00000392041 ENST00000536790 ENST00000429434
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF140
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF140
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF140 (NM_003440) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF140 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF140 |
Additional cDNA sequence: AK122741.1 AK296572.1 AK303240.1 AK313145.1 BC022291.1 BC040561.1 U09368.1 11 DOTS entries: DT.451633 DT.95159528 DT.121214050 DT.121214124 DT.40230959 DT.121213922 DT.121214038 DT.97837634 DT.95337672 DT.40250234 DT.75101272 24/87 AceView cDNA sequences (see all 87): AW949874 BU521239 AA928315 AI702590 AI077691 BQ017154 BC040561 CA431110 BF438601 NM_003440 AW152508 AI089705 BC022291 AI275779 CR601967 AW080105 AI272003 AL709071 AI300487 BE073574 AW612210 CA435627 AI887845 BQ014109
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF140 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF140
|
Expression
for ZNF140 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF140 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACAAGGGAT
About this image
See ZNF140 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF140
SOURCE GeneReport for Unigene cluster: Hs.181552
UniProtKB/Swiss-Prot: ZN140_HUMAN, P52738Tissue specificity: Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney andpancreas
SABiosciences Custom PCR Arrays for ZNF140
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF140
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF140 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF140 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF140 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF140 |
Orthologs
for ZNF140 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF140 gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
19(a) |
1 → many |
GroupUn.197(18775-21878) |
ENSEMBL Gene Tree for ZNF140 (if available)
TreeFam Gene Tree for ZNF140 (if available) |
Paralogs
for ZNF140 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF140 gene
- ZNF4202 ZNF5292 ZFP302 ZNF780A2 ZNF3832 ZNF7902 ZNF5822 ZFP822
- ZNF302 ZNF5732 ZNF5402 ZNF5712 ZNF3312 ZFP142 ZNF4612 ZNF2832
- ZNF4042 ZNF8292 ZNF6072 ZNF5652 ZNF5662 ENSG000002675522
18/523 SIMAP similar genes for ZNF140 using alignment to 10 protein entries: ZN140_HUMAN (see all proteins)
(see all similar genes):ZNF283 ZNF571 ZNF624 ZFP90 kr-znf3 ZNF738
ZNF573 ZNF124 ZNF850 ZNF569 ZFS-4 ZNF519
ZNF577 ZNF78L1 ZNF818P ZNF559 ZNF527 ZNF844
ZNF140 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF140 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF140 (133656424 - 133684260 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for ZNF140
7 CNVs: 86695 29933 76243 3002 66384 3903 66386 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF140 |
|
Disorders
/ Diseases
for ZNF140 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF140 for disorders About MalaCards
ZNF140 for disorders About GeneDecksing
OMIM gene information: 604082
OMIM disorders: --
Export disorders for ZNF140 gene to outside databases
|
Publications
for ZNF140 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF140 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF140) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PubMed id 7557990)1, 2, 3 Tommerup N. and Vissing H. (1995)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. (PubMed id 7649249)1, 2 Vissing H.... Thiesen H.-J. (1995)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- KAP-1, a novel corepressor for the highly conserved KRAB repression domain. (PubMed id 8769649)1 Friedman J.R.... Rauscher F.J. III (1996)
|
External Searches for ZNF140 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF140 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF140 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF140 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF140 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF140 gene:
Search GeneIP for patents involving ZNF140
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF140 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for ZNF140 | | OriGene shRNA RFP for ZNF140 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF140 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF140 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF140 | | OriGene 3'-UTR Clone for ZNF140 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF140 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF140 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF140 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF140 |
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