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Aliases for ZNF140 Gene

Aliases for ZNF140 Gene

  • Zinc Finger Protein 140 2 3
  • Zinc Finger Protein 140 (Clone PHZ-39) 2
  • EC 2.1.1.43 63
  • EC 1.3.1.26 63
  • PHZ-39 3

External Ids for ZNF140 Gene

Previous GeneCards Identifiers for ZNF140 Gene

  • GC12P131178
  • GC12P133260
  • GC12P131896
  • GC12P131391
  • GC12P132267
  • GC12P133657
  • GC12P130436

Summaries for ZNF140 Gene

GeneCards Summary for ZNF140 Gene

ZNF140 (Zinc Finger Protein 140) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZFP92.

UniProtKB/Swiss-Prot for ZNF140 Gene

  • May be involved in transcriptional regulation as a repressor

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF140 Gene

Genomics for ZNF140 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF140 Gene

Start:
133,079,838 bp from pter
End:
133,108,976 bp from pter
Size:
29,139 bases
Orientation:
Plus strand

Genomic View for ZNF140 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF140 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF140 Gene

No data available for Regulatory Elements for ZNF140 Gene

Proteins for ZNF140 Gene

  • Protein details for ZNF140 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52738-ZN140_HUMAN
    Recommended name:
    Zinc finger protein 140
    Protein Accession:
    P52738
    Secondary Accessions:
    • D3DXJ3
    • Q05CP6
    • Q8IV75

    Protein attributes for ZNF140 Gene

    Size:
    457 amino acids
    Molecular mass:
    52996 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF140 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF140 Gene

Proteomics data for ZNF140 Gene at MOPED

Selected DME Specific Peptides for ZNF140 Gene

Post-translational modifications for ZNF140 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for ZNF140 Gene

Gene Families for ZNF140 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF140 Gene

Graphical View of Domain Structure for InterPro Entry

P52738

UniProtKB/Swiss-Prot:

ZN140_HUMAN :
  • P52738
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF140: view

Function for ZNF140 Gene

Molecular function for ZNF140 Gene

GENATLAS Biochemistry: zinc finger protein 140 (C2H2 type,Kruppel-like,KRAB subfamily)
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation as a repressor

Enzyme Numbers (IUBMB) for ZNF140 Gene

Gene Ontology (GO) - Molecular Function for ZNF140 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF140: view

Phenotypes for ZNF140 Gene

GenomeRNAi human phenotypes for ZNF140:
genes like me logo Genes that share phenotypes with ZNF140: view

Animal Model Products

CRISPR Products

miRNA for ZNF140 Gene

miRTarBase miRNAs that target ZNF140

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF140 Gene

Localization for ZNF140 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF140 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF140 Gene COMPARTMENTS Subcellular localization image for ZNF140 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF140 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF140: view

Pathways for ZNF140 Gene

SuperPathways for ZNF140 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF140: view

Pathways by source for ZNF140 Gene

2 Reactome pathways for ZNF140 Gene

Interacting Proteins for ZNF140 Gene

Gene Ontology (GO) - Biological Process for ZNF140 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF140: view

Transcripts for ZNF140 Gene

Unigene Clusters for ZNF140 Gene

Zinc finger protein 140:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF140

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF140 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: -
SP7: - -

Relevant External Links for ZNF140 Gene

GeneLoc Exon Structure for
ZNF140
ECgene alternative splicing isoforms for
ZNF140

Expression for ZNF140 Gene

mRNA expression in normal human tissues for ZNF140 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF140 Gene

SOURCE GeneReport for Unigene cluster for ZNF140 Gene Hs.181552

mRNA Expression by UniProt/SwissProt for ZNF140 Gene

P52738-ZN140_HUMAN
Tissue specificity: Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
genes like me logo Genes that share expressions with ZNF140: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF140 Gene

Orthologs for ZNF140 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF140 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF140 35
  • 99.64 (n)
  • 99.78 (a)
ZNF140 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF140 35
  • 90.08 (n)
  • 89.72 (a)
ZNF140 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF140 35
  • 89.57 (n)
  • 88.99 (a)
ZNF140 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZAP1 36
  • 14 (a)
OneToMany
Species with no ortholog for ZNF140:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF140 Gene

ENSEMBL:
Gene Tree for ZNF140 (if available)
TreeFam:
Gene Tree for ZNF140 (if available)

Paralogs for ZNF140 Gene

Paralogs for ZNF140 Gene

Selected SIMAP similar genes for ZNF140 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ZNF140: view

Variants for ZNF140 Gene

Sequence variations from dbSNP and Humsavar for ZNF140 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1025 -- 133,107,042(-) CATGC(A/T)TTCTG utr-variant-3-prime, nc-transcript-variant
rs1026 -- 133,107,164(+) ACTTA(A/C)ATTTT utr-variant-3-prime, intron-variant
rs585948 -- 133,095,783(-) ACATC(C/T)AGGCA intron-variant
rs653143 -- 133,088,220(-) AACAA(C/T)AATGG intron-variant
rs679145 -- 133,096,024(+) TACCA(A/G)TCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF140 Gene

Variant ID Type Subtype PubMed ID
dgv538e1 CNV Complex 17122850
dgv330e199 CNV Deletion 23128226
nsv899835 CNV Loss 21882294
nsv899836 CNV Gain 21882294
esv27162 CNV Gain+Loss 19812545
essv8522 CNV CNV 17122850
nsv470337 CNV Loss 18288195
nsv518970 CNV Gain 19592680

Relevant External Links for ZNF140 Gene

HapMap Linkage Disequilibrium report
ZNF140

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF140 Gene

Disorders for ZNF140 Gene

Relevant External Links for ZNF140

Genetic Association Database (GAD)
ZNF140
genes like me logo Genes that share disorders with ZNF140: view

No data available for UniProtKB/Swiss-Prot for ZNF140 Gene

Publications for ZNF140 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N. … Vissing H. (Genomics 1995) 2 3 4
  2. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. (PMID: 7649249) Vissing H. … Thiesen H.-J. (FEBS Lett. 1995) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for ZNF140 Gene

Sources for ZNF140 Gene

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