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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF140 Gene

protein-coding   GIFtS: 52
GCID: GC12P133657

Zinc Finger Protein 140

(Previous name: zinc finger protein 140 (clone pHZ-39))
  Search for ZNF140
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 1401 2
Zinc Finger Protein 140 (Clone PHZ-39)1
pHZ-392
EC 1.3.1.268
EC 2.1.1.438

External Ids:    HGNC: 129251   Entrez Gene: 76992   Ensembl: ENSG000001963877   OMIM: 6040825   UniProtKB: P527383   

Export aliases for ZNF140 gene to outside databases

Previous GC identifers: GC12P131178 GC12P133260 GC12P131896 GC12P131391 GC12P132267 GC12P130436


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF140 Gene: 
ZNF140 (zinc finger protein 140) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF707.

UniProtKB/Swiss-Prot: ZN140_HUMAN, P52738
Function: May be involved in transcriptional regulation as a repressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_024477.14  NC_018923.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF140
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF140 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF140

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF140


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

ZNF140 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF140 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P133657:  view genomic region     (about GC identifiers)

Start:
133,656,424 bp from pter      End:
133,684,260 bp from pter
Size:
27,837 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN140_HUMAN, P52738 (See protein sequence)
Recommended Name: Zinc finger protein 140  
Size: 457 amino acids; 52996 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: D3DXJ3 Q8IV75

Explore the universe of human proteins at neXtProt for ZNF140: NX_P52738

Explore proteomics data for ZNF140 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P52738

  • 2 DME Specific Peptides for ZNF140 (P52738)
     DVAIDFS  HQRTHTGEKPY 

    ZNF140 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF140 Protein Expression
    REFSEQ proteins: NP_003431.2  
    ENSEMBL proteins: 
     ENSP00000347755   ENSP00000444905   ENSP00000389566   ENSP00000445411   ENSP00000439805  
     ENSP00000437913   ENSP00000415016   ENSP00000375895   ENSP00000441170   ENSP00000415499  
    Reactome Protein details: P52738
    Human Recombinant Protein Products for ZNF140: 
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    Novus Biologicals ZNF140 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF140 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF140 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P52738

    ProtoNet protein and cluster: P52738

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN140_HUMAN, P52738
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF140 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN140_HUMAN, P52738
    Function: May be involved in transcriptional regulation as a repressor

         Genatlas biochemistry entry for ZNF140:
    zinc finger protein 140 (C2H2 type,Kruppel-like,KRAB subfamily)

         Enzyme Numbers (IUBMB): EC 2.1.1.432 EC 1.3.1.262

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS7557990
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF140 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF140:
     Synthetic lethal with imatinib 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF140 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF140
        Generic Transcription Pathway
    Gene Expression



    ZNF140 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF140

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----

    ZNF140 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF140 (ZN140)

    Search CenterWatch for drugs/clinical trials and news about ZNF140 / ZN140

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF140 gene: 
    NM_003440.2  

    Unigene Cluster for ZNF140:

    Zinc finger protein 140
    Hs.181552  [show with all ESTs]
    Unigene Representative Sequence: AK122741
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355557(uc001ulo.3 uc001ulp.3 uc010tbu.2) ENST00000356456
    ENST00000412146 ENST00000544426 ENST00000440984 ENST00000319849 ENST00000440550
    ENST00000392041 ENST00000536790 ENST00000429434
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF140:
    hsa-miR-3910 hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidZNF140 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK122741.1 AK296572.1 AK303240.1 AK313145.1 BC022291.1 BC040561.1 U09368.1 

    11 DOTS entries:

    DT.451633  DT.95159528  DT.121214050  DT.121214124  DT.40230959  DT.97837634  DT.121213922  DT.121214038 
    DT.75101272  DT.95337672  DT.40250234 

    24/87 AceView cDNA sequences (see all 87):

    AI300487 BC040561 AL709071 AA928315 BU521239 AI275779 AI272003 CA431110 
    AW152508 AW612210 BC022291 AW080105 BQ017154 CR601967 CA435627 NM_003440 
    BE073574 AI077691 AI702590 AI089705 AI887845 AW949874 BF438601 AI202058 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF140 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
    SP1:                                            -                       -     -                                       
    SP2:                                            -                       -                                             
    SP3:                                            -                       -     -                                       
    SP4:                    -     -     -           -                       -     -                                       
    SP5:                                      -     -                       -     -                                       


    ECgene alternative splicing isoforms for ZNF140

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF140 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAAGGGAT
    ZNF140 Expression
    About this image


    See ZNF140 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF140

    SOURCE GeneReport for Unigene cluster: Hs.181552

    UniProtKB/Swiss-Prot: ZN140_HUMAN, P52738
    Tissue specificity: Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and
    pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF140 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF1401 zinc finger protein 140 89.65(n)
    88.99(a)
      100855854  XM_003639924.1  XP_003639972.1 


    ENSEMBL Gene Tree for ZNF140 (if available)
    TreeFam Gene Tree for ZNF140 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF140 gene
    ZNF7072  ZFP922  ZNF3022  ZNF8292  ZNF22  ZNF5662  
    18/533 SIMAP similar genes for ZNF140 using alignment to 10 protein entries:     ZN140_HUMAN (see all proteins) (see all similar genes):
    ZNF649    ZNF283    FIK    ZNF571    ZNF624    ZFP90
    kr-znf3    ZNF780B    ZNF738    ZNF573    ZNF850    ZNF493
    ZNF569    ZNF682    ZFS-4    ZNF519    ZNF577    ZNF78L1

    ZNF140 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/471 SNPs in ZNF140 are shown (see all 471)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1419251611,2
    C--133655217(+) TGCTC-/TTTTTT 1 -- us2k10--------
    rs1165837981,2
    C--133655719(+) ACTCTA/GGCCTG 1 -- us2k10--------
    rs1995476771,2
    C--133655747(+) AAACTC/GCTGAC 1 -- us2k10--------
    rs3697531281,2
    C--133656235(-) TTAGTC/TGGCTT 1 -- us2k10--------
    rs1142735381,2
    C--133656293(+) GTGGCC/TATGGC 1 -- us2k10--------
    rs1147266391,2
    C--133656706(+) GGGCCG/TTGTGT 1 -- us2k10--------
    rs1161376991,2
    C--133656774(+) GGCGTC/GCGGCG 1 -- us2k10--------
    rs1160358621,2
    C--133656806(+) TCGCCA/GGAGCT 1 -- us2k10--------
    rs1155336611,2
    C--133656858(+) TGGGAA/GTCGTA 1 -- us2k10--------
    rs1166688901,2
    C--133656898(+) CGCACA/GGTCGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF140 (133656424 - 133684260 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZNF140:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv330e199CNV Deletion23128226
    nsv899835CNV Loss21882294
    nsv470337CNV Loss18288195
    nsv899836CNV Gain21882294
    nsv518970CNV Gain19592680
    esv27162CNV Gain+Loss19812545
    essv8522CNV CNV17122850
    dgv538e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF140 for disorders           About MalaCards
    OMIM gene information: 604082    OMIM disorders: --


    ZNF140 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF140

    Export disorders for ZNF140 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF140 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF140)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PubMed id 7557990)1, 2, 3 Tommerup N. and Vissing H. (1995)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. (PubMed id 7649249)1, 2 Vissing H.... Thiesen H.-J. (1995)
    4. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    5. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. KAP-1, a novel corepressor for the highly conserved KRAB repression domain. (PubMed id 8769649)1 Friedman J.R.... Rauscher F.J. III (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7699 HGNC: 12925 AceView: ZNF140 Ensembl:ENSG00000196387 euGenes: HUgn7699
    ECgene: ZNF140 H-InvDB: ZNF140

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF140 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF140 gene:
    Search GeneIP for patents involving ZNF140

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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