Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF14 Gene

Aliases for ZNF14 Gene

  • Zinc Finger Protein 14 2 3
  • KOX6 3 4 6
  • Gonadotropin-Inducible Ovary Transcription Repressor 4 3 4
  • Zinc Finger Protein 14 (KOX 6) 2 3
  • Zinc Finger Protein KOX6 3 4
  • GIOT-4 3 4
  • Gonadotropin Inducible Transcription Repressor-4 3
  • GIOT4 4

External Ids for ZNF14 Gene

Summaries for ZNF14 Gene

Entrez Gene Summary for ZNF14 Gene

  • The protein encoded by this gene contains a zinc finger and a Kruppel-associated box (KRAB) domain. KRAB domain is known to be involved in the transcriptional repression of a number of zinc finger proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF14 Gene

ZNF14 (Zinc Finger Protein 14) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF709.

UniProtKB/Swiss-Prot for ZNF14 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF14 Gene

Genomics for ZNF14 Gene

Genomic Location for ZNF14 Gene

Start:
19,710,471 bp from pter
End:
19,733,112 bp from pter
Size:
22,642 bases
Orientation:
Minus strand

Genomic View for ZNF14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF14 Gene

Regulatory Elements for ZNF14 Gene

Proteins for ZNF14 Gene

  • Protein details for ZNF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17017-ZNF14_HUMAN
    Recommended name:
    Zinc finger protein 14
    Protein Accession:
    P17017
    Secondary Accessions:
    • B9EGA4
    • Q9ULZ5

    Protein attributes for ZNF14 Gene

    Size:
    642 amino acids
    Molecular mass:
    75353 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF14 Gene

Proteomics data for ZNF14 Gene at MOPED

Post-translational modifications for ZNF14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF14 Gene

Domains for ZNF14 Gene

Gene Families for ZNF14 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF14 Gene

UniProtKB/Swiss-Prot:

ZNF14_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • P17017
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • P17017
Similarity:
  • Contains 19 C2H2-type zinc fingers.:
    • P17017
genes like me logo Genes that share domains with ZNF14: view

Function for ZNF14 Gene

Molecular function for ZNF14 Gene

GENATLAS Biochemistry: zinc finger protein 14 (KOX6) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF14: view

Phenotypes for ZNF14 Gene

GenomeRNAi human phenotypes for ZNF14:
genes like me logo Genes that share phenotypes with ZNF14: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF14 Gene

Localization for ZNF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF14 Gene COMPARTMENTS Subcellular localization image for ZNF14 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF14: view

Pathways for ZNF14 Gene

SuperPathways for ZNF14 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF14: view

Pathways by source for ZNF14 Gene

2 Reactome pathways for ZNF14 Gene

Interacting Proteins for ZNF14 Gene

Gene Ontology (GO) - Biological Process for ZNF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF14: view

Transcripts for ZNF14 Gene

mRNA/cDNA for ZNF14 Gene

Unigene Clusters for ZNF14 Gene

Zinc finger protein 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF14 Gene

No ASD Table

Relevant External Links for ZNF14 Gene

GeneLoc Exon Structure for
ZNF14
ECgene alternative splicing isoforms for
ZNF14

Expression for ZNF14 Gene

mRNA expression in normal human tissues for ZNF14 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF14 Gene

SOURCE GeneReport for Unigene cluster for ZNF14 Gene Hs.659932

genes like me logo Genes that share expressions with ZNF14: view

Orthologs for ZNF14 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF14 36
  • 99.17 (n)
  • 98.91 (a)
ZNF14 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 57 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm5595 36
  • 67.55 (n)
  • 56.17 (a)
Zfp709 16
fruit fly
(Drosophila melanogaster)
Insecta CG4707 38
  • 28 (a)
CG8301 38
  • 29 (a)
CG6254 38
  • 33 (a)
Species with no ortholog for ZNF14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF14 Gene

ENSEMBL:
Gene Tree for ZNF14 (if available)
TreeFam:
Gene Tree for ZNF14 (if available)

Paralogs for ZNF14 Gene

Selected SIMAP similar genes for ZNF14 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF14 Gene

genes like me logo Genes that share paralogs with ZNF14: view

Variants for ZNF14 Gene

Sequence variations from dbSNP and Humsavar for ZNF14 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs247774 -- 19,732,742(-) cccgg(C/T)cctgg intron-variant
rs247775 -- 19,732,071(-) ttttt(G/T)tgtgt intron-variant
rs247776 -- 19,731,806(-) acagg(C/G)gtgag intron-variant
rs247777 -- 19,731,327(-) aaagt(G/T)ctggg intron-variant
rs247778 -- 19,731,244(-) CATAT(C/T)TAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF14 Gene

Variant ID Type Subtype PubMed ID
nsv519533 CNV Gain 19592680
nsv2436 CNV Loss 18451855
esv33937 CNV Loss 17666407
nsv911311 CNV Loss 21882294
nsv509726 CNV Insertion 20534489
esv22084 CNV Gain+Loss 19812545
nsv828479 CNV Loss 20364138
nsv512566 CNV Loss 21212237
nsv436259 CNV Deletion 17901297
esv2718294 CNV Deletion 23290073
esv2676150 CNV Deletion 23128226
nsv498894 CNV Loss 21111241
nsv819368 CNV Gain 19587683
nsv821501 CNV Deletion 20802225
nsv828480 CNV Gain+Loss 20364138
nsv514892 CNV Loss 21397061
esv33361 CNV Loss 17666407
esv269670 CNV Insertion 20981092

Relevant External Links for ZNF14 Gene

HapMap Linkage Disequilibrium report
ZNF14

Disorders for ZNF14 Gene

No disorders were found for ZNF14 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF14 Gene

Publications for ZNF14 Gene

  1. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4
  2. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. (PMID: 7649249) Vissing H. … Thiesen H.-J. (FEBS Lett. 1995) 3
  3. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19. (PMID: 8262519) Rousseau-Merck M.F. … Berger R. (Hum. Genet. 1993) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for ZNF14 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF14
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF14
    • Block miRNA regulation of ZNF14 using miScript Target Protectors

    Sources for ZNF14 Gene

    Back to Top

    Content