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Aliases for ZNF14 Gene

Aliases for ZNF14 Gene

  • Zinc Finger Protein 14 2 3 5
  • Gonadotropin-Inducible Ovary Transcription Repressor 4 3 4
  • Zinc Finger Protein 14 (KOX 6) 2 3
  • Zinc Finger Protein KOX6 3 4
  • GIOT-4 3 4
  • KOX6 3 4
  • Gonadotropin Inducible Transcription Repressor-4 3
  • GIOT4 4

External Ids for ZNF14 Gene

Previous GeneCards Identifiers for ZNF14 Gene

  • GC19M020315
  • GC19M020212
  • GC19M019666
  • GC19M019682
  • GC19M019821
  • GC19M019384

Summaries for ZNF14 Gene

Entrez Gene Summary for ZNF14 Gene

  • The protein encoded by this gene contains a zinc finger and a Kruppel-associated box (KRAB) domain. KRAB domain is known to be involved in the transcriptional repression of a number of zinc finger proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF14 Gene

ZNF14 (Zinc Finger Protein 14) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF791.

UniProtKB/Swiss-Prot for ZNF14 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF14 Gene

Genomics for ZNF14 Gene

Regulatory Elements for ZNF14 Gene

Enhancers for ZNF14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZNF14 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZNF14 Gene

Chromosome:
19
Start:
19,710,471 bp from pter
End:
19,733,112 bp from pter
Size:
22,642 bases
Orientation:
Minus strand

Genomic View for ZNF14 Gene

Genes around ZNF14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF14 Gene

Proteins for ZNF14 Gene

  • Protein details for ZNF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17017-ZNF14_HUMAN
    Recommended name:
    Zinc finger protein 14
    Protein Accession:
    P17017
    Secondary Accessions:
    • B9EGA4
    • Q9ULZ5

    Protein attributes for ZNF14 Gene

    Size:
    642 amino acids
    Molecular mass:
    75353 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF14 Gene

Post-translational modifications for ZNF14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF14 Gene

Domains & Families for ZNF14 Gene

Gene Families for ZNF14 Gene

Protein Domains for ZNF14 Gene

Suggested Antigen Peptide Sequences for ZNF14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17017

UniProtKB/Swiss-Prot:

ZNF14_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 19 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 19 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF14: view

Function for ZNF14 Gene

Molecular function for ZNF14 Gene

GENATLAS Biochemistry:
zinc finger protein 14 (KOX6) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF14: view

Phenotypes for ZNF14 Gene

genes like me logo Genes that share phenotypes with ZNF14: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF14 Gene

Localization for ZNF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF14 Gene COMPARTMENTS Subcellular localization image for ZNF14 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for ZNF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF14: view

Pathways & Interactions for ZNF14 Gene

SuperPathways for ZNF14 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF14: view

Pathways by source for ZNF14 Gene

2 Reactome pathways for ZNF14 Gene

Interacting Proteins for ZNF14 Gene

Gene Ontology (GO) - Biological Process for ZNF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF14: view

No data available for SIGNOR curated interactions for ZNF14 Gene

Drugs & Compounds for ZNF14 Gene

No Compound Related Data Available

Transcripts for ZNF14 Gene

mRNA/cDNA for ZNF14 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF14 Gene

Zinc finger protein 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF14 Gene

No ASD Table

Relevant External Links for ZNF14 Gene

GeneLoc Exon Structure for
ZNF14
ECgene alternative splicing isoforms for
ZNF14

Expression for ZNF14 Gene

mRNA expression in normal human tissues for ZNF14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF14 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF14 Gene:

ZNF14

SOURCE GeneReport for Unigene cluster for ZNF14 Gene:

Hs.659932
genes like me logo Genes that share expression patterns with ZNF14: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF14 Gene

Orthologs for ZNF14 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF14 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Gm5595 34
  • 67.55 (n)
  • 56.17 (a)
Zfp976 16
chimpanzee
(Pan troglodytes)
Mammalia ZNF14 34
  • 99.17 (n)
  • 98.91 (a)
ZNF14 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 57 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4707 36
  • 28 (a)
CG6254 36
  • 33 (a)
CG8301 36
  • 29 (a)
Species where no ortholog for ZNF14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF14 Gene

ENSEMBL:
Gene Tree for ZNF14 (if available)
TreeFam:
Gene Tree for ZNF14 (if available)

Paralogs for ZNF14 Gene

(492) SIMAP similar genes for ZNF14 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF14 Gene

genes like me logo Genes that share paralogs with ZNF14: view

Variants for ZNF14 Gene

Sequence variations from dbSNP and Humsavar for ZNF14 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12973901 - 19,712,461(+) TCCAG(A/T)GTGAG reference, missense
rs3752153 - 19,712,145(+) GCAAT(C/T)GAAGA reference, missense
rs3031866 -- 19,714,729(+) ttttt(-/TTT/TTTTT)gagac intron-variant, upstream-variant-2KB
rs10717958 -- 19,729,320(+) ACAAC(-/T)TTTTT intron-variant
rs17699333 -- 19,720,735(+) TCAAG(G/T)ACTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF14 Gene

Variant ID Type Subtype PubMed ID
dgv1731n106 CNV deletion 24896259
dgv3455n100 CNV gain 25217958
dgv6300n54 CNV gain 21841781
dgv6301n54 CNV gain 21841781
dgv6302n54 CNV loss 21841781
dgv80n73 CNV deletion 24416366
esv22084 CNV gain+loss 19812545
esv2676150 CNV deletion 23128226
esv2718294 CNV deletion 23290073
esv33361 CNV loss 17666407
esv3381770 CNV insertion 20981092
esv33937 CNV loss 17666407
esv3556149 CNV deletion 23714750
esv3643856 CNV loss 21293372
nsv1070659 CNV deletion 25765185
nsv1109172 CNV deletion 24896259
nsv1150655 CNV deletion 26484159
nsv2436 CNV deletion 18451855
nsv436259 CNV deletion 17901297
nsv498894 CNV loss 21111241
nsv509726 CNV insertion 20534489
nsv512566 CNV loss 21212237
nsv514892 CNV gain+loss 21397061
nsv519533 CNV gain 19592680
nsv578788 CNV gain 21841781
nsv578793 CNV loss 21841781
nsv578794 CNV loss 21841781
nsv578796 CNV loss 21841781
nsv819368 CNV gain 19587683
nsv821501 CNV deletion 20802225
nsv828479 CNV loss 20364138
nsv828480 CNV gain+loss 20364138

Variation tolerance for ZNF14 Gene

Residual Variation Intolerance Score: 57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.67; 78.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF14 Gene

Disorders for ZNF14 Gene

Relevant External Links for ZNF14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF14

No disorders were found for ZNF14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF14 Gene

Publications for ZNF14 Gene

  1. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4 65
  2. Genome-wide association study of selenium concentrations. (PMID: 25343990) Cornelis M.C. … He K. (Hum. Mol. Genet. 2015) 3 65
  3. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3 65
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65

Products for ZNF14 Gene

Sources for ZNF14 Gene

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