ZNF14 Gene
protein-coding GIFtS: 49
GCID: GC19M019821
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zinc finger protein 14(Previous name: zinc finger protein 14 (KOX 6) )
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Aliases
for ZNF14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 141 2 | | Gonadotropin-Inducible Ovary Transcription Repressor 42 3 | | KOX61 2 3 5 | | Zinc Finger Protein KOX62 3 | | GIOT-41 2 3 | | Gonadotropin Inducible Transcription Repressor-42 | | Zinc Finger Protein 14 (KOX 6)1 2 | | GIOT43 |
Export aliases for ZNF14 gene to outside databasesPrevious GC identifers: GC19M020315 GC19M020212 GC19M019666 GC19M019682 GC19M019384 |
Summaries
for ZNF14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF14:
The protein encoded by this gene contains a zinc finger and a Kruppel-associated box (KRAB) domain. KRAB domain isknown to be involved in the transcriptional repression of a number of zinc finger proteins. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: ZNF14_HUMAN, P17017Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF14 gene promoter:
NF-1 HTF GCNF ATF-2 CRE-BP1 PPAR-gamma1 CP2 GCNF-1 PPAR-gamma2 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11ZNF14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M019821: view genomic region
(about GC identifiers)
Start:
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19,821,280 bp from pter |
End:
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19,843,921 bp from pter |
Size:
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22,642 bases |
Orientation:
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minus strand |
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Proteins
for ZNF14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNF14_HUMAN, P17017 (See
protein sequence)Recommended Name: Zinc finger protein 14 Size: 642 amino acids; 75353 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B9EGA4 Q9ULZ5Explore the universe of human proteins at neXtProt for ZNF14: NX_P17017
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P17017
ZNF14 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066358.2
ENSEMBL proteins: ENSP00000340514 Reactome Protein details: P17017
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF14 for ontologies About GeneDecksing
ZNF14 Antibody Products:
Assay Products for ZNF14: |
Protein
Domains /
Families
for ZNF14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF14 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P17017ProtoNet protein and cluster: P17017 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZNF14_HUMAN, P17017Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 19 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZNF14_HUMAN, P17017Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF14:zinc finger protein 14 (KOX6) (C2H2 type,Kruppel-like)
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF14 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF14 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF14:
|
Pathways & Interactions
for ZNF14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF14
ZNF14 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF14
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for ZNF14 (ENSP000003405144) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF14 for ontologies About GeneDecksing
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Drugs & Compounds
for ZNF14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF14
Search CenterWatch for drugs/clinical trials and news about ZNF14
|
Transcripts
for ZNF14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF14 gene: NM_021030.2 Unigene Cluster for ZNF14: Zinc finger protein 14 Hs.659932 [show with all ESTs]Unigene Representative Sequence: NM_0210301 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000344099(uc002nnk.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF14
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF14 (NM_021030) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF14 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF14 |
Additional cDNA sequence: AB021644.1 AK074832.1 AK125668.1 BC136323.1 X52337.1 3 DOTS entries: DT.95156486 DT.101971328 DT.91749745 24/32 AceView cDNA sequences (see all 32): N92176 X52337 NM_021030 BX506330 AA286756 BM836276 BX282058 BF958556 BE889413 CD358782 CA414092 BE392040 AA599140 AW675436 AB021644 AA354794 AK074832 CB147796 AI708304 AW748353 AV735076 BX506331 CD630568 AW858468
GeneLoc Exon Structure
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Expression
for ZNF14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAACAGCCC
About this image
See ZNF14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF14
SOURCE GeneReport for Unigene cluster: Hs.659932
SABiosciences Custom PCR Arrays for ZNF14
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF14
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF14 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF14 |
Orthologs
for ZNF14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for ZNF14 gene from 1/7 species (see all 7) About this table
ENSEMBL Gene Tree for ZNF14 (if available)
TreeFam Gene Tree for ZNF14 (if available) |
Paralogs
for ZNF14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF14 gene
- ZNF6692 ZNF4902 ZNF5642 ZNF4412 ZNF8782 ENSG000002671792 ENSG000001968262 ZNF7002
- ZNF692 ZNF4402 ZNF4432 ZNF442 ZNF4392 ZNF8232 ZNF4912 ENSG000001884742
- ZNF5552 ZNF7092 ZNF6252 ZNF7992 ZNF202 ZNF1012 ZNF7912 ZNF4422
- ZNF4332 ZNF572 ZNF5632 ZNF6272 ENSG000002573552 ZNF1362 ZNF5562 ZNF6702
- ZNF7632 ZNF1242 ZNF6992 ZNF8442 ZNF772
18/491 SIMAP similar genes for ZNF14 using alignment to 1 protein entry: ZNF14_HUMAN(see all similar genes):ZFS-4 ZNF78L1 ZNF669 HZF36 ZNF709 DKFZp313M0722
ZNF818P ZNF833P DKFZp434J0650 DKFZp666C237 DKFZp666M039 ZFP41
ZNF558 ZNF586 ZNF81 DKFZp686M04222 DKFZp686N14223 HZF16
ZNF14 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF14
PGOHUM00000263091
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Genomic Variants
for ZNF14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF14 (19821280 - 19843921 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for ZNF14
10 CNVs: 22740 35615 58865 7193 35613 67490 78133 7194 89151 35614 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF14 |
|
Disorders
/ Diseases
for ZNF14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF14 for disorders About MalaCards
ZNF14 for disorders About GeneDecksing
OMIM gene information: 194556
OMIM disorders: --
Export disorders for ZNF14 gene to outside databases
|
Publications
for ZNF14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF14 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ZNF14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Coactivation of estrogen receptor beta by gonadotropin-induced cofactor GIOT-4. (PubMed id 18981223)1 Kouzu-Fujita M....Kato S. (2009)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. (PubMed id 7649249)1 Vissing H.... Thiesen H.-J. (1995)
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External Searches for ZNF14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF14 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF14 gene:
Search GeneIP for patents involving ZNF14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF14 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF14 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF14 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF14 |
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 | | | ZNF14 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF14 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF14 |
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