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Aliases for ZNF138 Gene

Aliases for ZNF138 Gene

  • Zinc Finger Protein 138 2 3
  • Zinc Finger Protein 138 (Clone PHZ-32) 2 3
  • PHZ-32 3

External Ids for ZNF138 Gene

Summaries for ZNF138 Gene

GeneCards Summary for ZNF138 Gene

ZNF138 (Zinc Finger Protein 138) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF138 Gene

  • May be involved in transcriptional regulation as a repressor

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF138 Gene

Genomics for ZNF138 Gene

Genomic Location for ZNF138 Gene

Start:
64,794,388 bp from pter
End:
64,853,800 bp from pter
Size:
59,413 bases
Orientation:
Plus strand

Genomic View for ZNF138 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF138 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF138 Gene

No data available for Regulatory Elements for ZNF138 Gene

Proteins for ZNF138 Gene

  • Protein details for ZNF138 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52744-ZN138_HUMAN
    Recommended name:
    Zinc finger protein 138
    Protein Accession:
    P52744
    Secondary Accessions:
    • B4DFX2
    • B4DP87
    • E9PHI7
    • E9PHK7

    Protein attributes for ZNF138 Gene

    Size:
    262 amino acids
    Molecular mass:
    30592 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF138 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF138 Gene

Proteomics data for ZNF138 Gene at MOPED

Post-translational modifications for ZNF138 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF138 Gene

Domains for ZNF138 Gene

Gene Families for ZNF138 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF138 Gene

Suggested Antigen Peptide Sequences for ZNF138 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52744

UniProtKB/Swiss-Prot:

ZN138_HUMAN
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • P52744
Similarity:
  • Contains 6 C2H2-type zinc fingers.:
    • P52744
genes like me logo Genes that share domains with ZNF138: view

Function for ZNF138 Gene

Molecular function for ZNF138 Gene

GENATLAS Biochemistry: zinc finger protein 138 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation as a repressor

Gene Ontology (GO) - Molecular Function for ZNF138 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 7557990
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF138: view

Phenotypes for ZNF138 Gene

genes like me logo Genes that share phenotypes with ZNF138: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF138 Gene

Localization for ZNF138 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF138 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF138 Gene COMPARTMENTS Subcellular localization image for ZNF138 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF138 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus NAS 7557990
genes like me logo Genes that share ontologies with ZNF138: view

Pathways for ZNF138 Gene

SuperPathways for ZNF138 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF138: view

Pathways by source for ZNF138 Gene

2 Reactome pathways for ZNF138 Gene

Gene Ontology (GO) - Biological Process for ZNF138 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 7557990
genes like me logo Genes that share ontologies with ZNF138: view

Transcripts for ZNF138 Gene

Unigene Clusters for ZNF138 Gene

Zinc finger protein 138:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF138 Gene

ExUns: 1 ^ 2 ^ 3
SP1:
SP2:

Relevant External Links for ZNF138 Gene

GeneLoc Exon Structure for
ZNF138
ECgene alternative splicing isoforms for
ZNF138

Expression for ZNF138 Gene

mRNA expression in normal human tissues for ZNF138 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF138 Gene

SOURCE GeneReport for Unigene cluster for ZNF138 Gene Hs.184080

genes like me logo Genes that share expressions with ZNF138: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF138 Gene

Orthologs for ZNF138 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF138 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 54 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 27 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 20 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp493 36
  • 28 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 18 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 20 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
-- 36
  • 18 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
-- 36
  • 14 (a)
ManyToMany
-- 36
  • 13 (a)
ManyToMany
-- 36
  • 14 (a)
ManyToMany
-- 36
  • 13 (a)
ManyToMany
Species with no ortholog for ZNF138:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF138 Gene

ENSEMBL:
Gene Tree for ZNF138 (if available)
TreeFam:
Gene Tree for ZNF138 (if available)

Paralogs for ZNF138 Gene

Selected SIMAP similar genes for ZNF138 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF138: view

Variants for ZNF138 Gene

Sequence variations from dbSNP and Humsavar for ZNF138 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1358004 -- 64,844,602(+) TTTTT(A/T)TTTTT intron-variant
rs1464925 -- 64,833,114(+) ACTTA(C/T)AATCC utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1464926 -- 64,833,160(+) GAAAC(A/C)CCACA utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1464927 -- 64,833,197(+) AACAA(A/G)TCTTC utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1464928 -- 64,833,353(+) TTTAA(A/C)AAAAC utr-variant-3-prime, intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF138 Gene

Variant ID Type Subtype PubMed ID
dgv1147e201 CNV Deletion 23290073
esv2422405 CNV Duplication 17116639
nsv464518 CNV Gain 19166990
dgv7307n71 CNV Gain 21882294
dgv7308n71 CNV Gain 21882294
nsv888279 CNV Loss 21882294
nsv888281 CNV Loss 21882294
esv33896 CNV Gain 17666407
esv2734581 CNV Deletion 23290073
esv2677316 CNV Deletion 23128226
esv2675483 CNV Deletion 23128226
nsv508457 CNV Loss 20534489
esv2478591 CNV Insertion 19546169

Relevant External Links for ZNF138 Gene

HapMap Linkage Disequilibrium report
ZNF138

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF138 Gene

Disorders for ZNF138 Gene

(1) University of Copenhagen DISEASES for ZNF138 Gene

Relevant External Links for ZNF138

Genetic Association Database (GAD)
ZNF138
Human Genome Epidemiology (HuGE) Navigator
ZNF138
genes like me logo Genes that share disorders with ZNF138: view

No data available for UniProtKB/Swiss-Prot for ZNF138 Gene

Publications for ZNF138 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N. … Vissing H. (Genomics 1995) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Genome-wide and candidate gene association study of cigarette smoking behaviors. (PMID: 19247474) Caporaso N. … Bergen A.W. (PLoS ONE 2009) 3 48
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for ZNF138 Gene

Sources for ZNF138 Gene

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