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Aliases for ZNF138 Gene

Aliases for ZNF138 Gene

  • Zinc Finger Protein 138 2 3 5
  • Zinc Finger Protein 138 (Clone PHZ-32) 2 3
  • PHZ-32 3

External Ids for ZNF138 Gene

Previous GeneCards Identifiers for ZNF138 Gene

  • GC07P062894
  • GC07P063652
  • GC07P063684
  • GC07P063085
  • GC07P063698
  • GC07P063892
  • GC07P064254
  • GC07P060636

Summaries for ZNF138 Gene

GeneCards Summary for ZNF138 Gene

ZNF138 (Zinc Finger Protein 138) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot for ZNF138 Gene

  • May be involved in transcriptional regulation as a repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF138 Gene

Genomics for ZNF138 Gene

Regulatory Elements for ZNF138 Gene

Enhancers for ZNF138 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F064792 0.2 ENCODE 6.9 -0.2 -245 2.8 PKNOX1 ATF1 ARNT ARID4B SIN3A FEZF1 GLI4 ZNF48 ZNF2 YY1 EEF1DP4 GABPAP GTF2IP14 ZNF138 ERV3-1 ZNF107 ENSG00000234338 ENSG00000277206
GH07F064574 0.8 Ensembl ENCODE 5.5 -219.6 -219647 1.3 POLR2A NFYB SIN3A ZNF107 ZNF736 ZNF680P1 ZNF138 LOC100128885 LOC641746
GH07F064569 1 Ensembl ENCODE 5.5 -224.5 -224488 1.0 CTCF CEBPB ZNF48 EZH2 ZNF107 ZNF680P1 ZNF138 LOC100129293 LOC100133092
GH07F064541 0.4 ENCODE 5.5 -252.6 -252577 1.2 JUND ZNF107 ZNF680P1 ZNF138 BNIP3P42 HNRNPCP7
GH07F064664 0.6 ENCODE 5.4 -127.9 -127934 3.2 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 ELK1 ZNF143 ZNF107 LOC441239 ERV3-1 SEPHS1P1 ZNF138 MIR6839
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF138 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF138 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000067022 712 2201 PKNOX1 ATF1 ARNT ARID4B SIN3A FEZF1 ZNF48 ZNF2 YY1 ELK1

Genomic Location for ZNF138 Gene

Chromosome:
7
Start:
64,794,388 bp from pter
End:
64,853,800 bp from pter
Size:
59,413 bases
Orientation:
Plus strand

Genomic View for ZNF138 Gene

Genes around ZNF138 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF138 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF138 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF138 Gene

Proteins for ZNF138 Gene

  • Protein details for ZNF138 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52744-ZN138_HUMAN
    Recommended name:
    Zinc finger protein 138
    Protein Accession:
    P52744
    Secondary Accessions:
    • B4DFX2
    • B4DP87
    • E9PHI7
    • E9PHK7

    Protein attributes for ZNF138 Gene

    Size:
    262 amino acids
    Molecular mass:
    30592 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF138 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF138 Gene

Post-translational modifications for ZNF138 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF138 Gene

Domains & Families for ZNF138 Gene

Gene Families for ZNF138 Gene

Protein Domains for ZNF138 Gene

Suggested Antigen Peptide Sequences for ZNF138 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52744

UniProtKB/Swiss-Prot:

ZN138_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 6 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF138: view

Function for ZNF138 Gene

Molecular function for ZNF138 Gene

GENATLAS Biochemistry:
zinc finger protein 138 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation as a repressor.

Gene Ontology (GO) - Molecular Function for ZNF138 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 7557990
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF138: view
genes like me logo Genes that share phenotypes with ZNF138: view

Animal Model Products

miRNA for ZNF138 Gene

miRTarBase miRNAs that target ZNF138

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF138 Gene

Localization for ZNF138 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF138 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF138 Gene COMPARTMENTS Subcellular localization image for ZNF138 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF138 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus NAS 7557990
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF138: view

Pathways & Interactions for ZNF138 Gene

SuperPathways for ZNF138 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF138: view

Pathways by source for ZNF138 Gene

2 Reactome pathways for ZNF138 Gene

Gene Ontology (GO) - Biological Process for ZNF138 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 7557990
genes like me logo Genes that share ontologies with ZNF138: view

No data available for SIGNOR curated interactions for ZNF138 Gene

Transcripts for ZNF138 Gene

Unigene Clusters for ZNF138 Gene

Zinc finger protein 138:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF138 Gene

ExUns: 1 ^ 2 ^ 3
SP1:
SP2:

Relevant External Links for ZNF138 Gene

GeneLoc Exon Structure for
ZNF138
ECgene alternative splicing isoforms for
ZNF138

Expression for ZNF138 Gene

mRNA expression in normal human tissues for ZNF138 Gene

Protein differential expression in normal tissues from HIPED for ZNF138 Gene

This gene is overexpressed in Breast (56.3) and Prostate (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF138 Gene



Protein tissue co-expression partners for ZNF138 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF138 Gene:

ZNF138

SOURCE GeneReport for Unigene cluster for ZNF138 Gene:

Hs.184080
genes like me logo Genes that share expression patterns with ZNF138: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF138 Gene

Orthologs for ZNF138 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF138 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 54 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp493 35
  • 28 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 27 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 24 (a)
ManyToMany
-- 35
  • 18 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 20 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 20 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
-- 35
  • 18 (a)
ManyToMany
-- 35
  • 15 (a)
ManyToMany
-- 35
  • 14 (a)
ManyToMany
-- 35
  • 14 (a)
ManyToMany
-- 35
  • 13 (a)
ManyToMany
-- 35
  • 13 (a)
ManyToMany
Species where no ortholog for ZNF138 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF138 Gene

ENSEMBL:
Gene Tree for ZNF138 (if available)
TreeFam:
Gene Tree for ZNF138 (if available)

Paralogs for ZNF138 Gene

(485) SIMAP similar genes for ZNF138 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF138: view

Variants for ZNF138 Gene

Sequence variations from dbSNP and Humsavar for ZNF138 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10085758 -- 64,801,471(+) ggttt(C/T)aagtg intron-variant
rs10155953 -- 64,807,378(+) CAAAG(C/T)GCAGA intron-variant
rs10215071 -- 64,813,334(+) TATTA(A/G)GAGAT intron-variant
rs10225171 -- 64,839,071(+) CTGAC(A/G)AGAGC intron-variant
rs10227053 -- 64,806,195(+) actca(C/T)ggttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF138 Gene

Variant ID Type Subtype PubMed ID
dgv1099e201 CNV deletion 23290073
esv23796 CNV loss 19812545
esv2422405 CNV duplication 17116639
esv2478591 CNV insertion 19546169
esv2675483 CNV deletion 23128226
esv2677316 CNV deletion 23128226
esv2764000 CNV gain+loss 21179565
esv33896 CNV gain 17666407
esv3541774 CNV deletion 23714750
esv3571879 CNV loss 25503493
esv3613425 CNV loss 21293372
nsv1022042 CNV gain 25217958
nsv1026390 CNV gain 25217958
nsv1137583 CNV deletion 24896259
nsv436564 CNV deletion 17901297
nsv464518 CNV gain 19166990
nsv508457 CNV deletion 20534489
nsv607312 CNV gain 21841781
nsv607313 CNV loss 21841781
nsv607314 CNV gain 21841781
nsv970857 CNV duplication 23825009
nsv970858 CNV duplication 23825009
nsv970859 CNV duplication 23825009

Variation tolerance for ZNF138 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF138 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF138

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF138 Gene

Disorders for ZNF138 Gene

Relevant External Links for ZNF138

Genetic Association Database (GAD)
ZNF138
Human Genome Epidemiology (HuGE) Navigator
ZNF138
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF138

No disorders were found for ZNF138 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF138 Gene

Publications for ZNF138 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Genome-wide and candidate gene association study of cigarette smoking behaviors. (PMID: 19247474) Caporaso N. … Bergen A.W. (PLoS ONE 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N. … Vissing H. (Genomics 1995) 3 4 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for ZNF138 Gene

Sources for ZNF138 Gene

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