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ZNF137P Gene

pseudogene   GIFtS: 34
GCID: GC19P053099

Zinc Finger Protein 137, Pseudogene

(Previous names: zinc finger protein 137 (clone pHZ-30), zinc finger protein...)
(Previous symbol: ZNF137)
  Search for ZNF137P
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 137, Pseudogene1 2     Zinc Finger Protein 137 (Pseudogene)1
ZNF1371 2 3 5     pHZ-302
Zinc Finger Protein 1371     Zinc Finger Protein 137 Pseudogene3
Zinc Finger Protein 137 (Clone PHZ-30)1     

External Ids:    HGNC: 129211   Entrez Gene: 76962   Ensembl: ENSG000001238707   OMIM: 6040795   UniProtKB: P527433   
ORGUL members:         

Export aliases for ZNF137P gene to outside databases

Previous GC identifer: GC19P049428


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF137P Gene:
ZNF137P (zinc finger protein 137, pseudogene) is a pseudogene, and is affiliated with the lncRNA class.

UniProtKB/Swiss-Prot: ZN137_HUMAN, P52743
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF137P
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF137P


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.4

ZNF137P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF137P gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P053099:  view genomic region     (about GC identifiers)

Start:
53,091,758 bp from pter      End:
53,103,405 bp from pter
Size:
11,648 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN137_HUMAN, P52743 (See protein sequence)
Recommended Name: Putative zinc finger protein 137  
Size: 207 amino acids; 24115 Da
Caution: Product of a dubious CDS prediction. May be produced at very low levels due to a premature stop codon in
the mRNA, leading to nonsense-mediated mRNA decay
Secondary accessions: Q2TBC7

Explore the universe of human proteins at neXtProt for ZNF137P: NX_P52743

Explore proteomics data for ZNF137P at MOPED


See ZNF137P Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry P52743

ProtoNet protein and cluster: P52743

1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN137_HUMAN, P52743
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 5 C2H2-type zinc fingers


ZNF137P for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN137_HUMAN, P52743
Function: May be involved in transcriptional regulation

Phenotypes:
     1 GenomeRNAi human phenotype for ZNF137P:

 Decreased POU5F1-GFP protein e 

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZN137_HUMAN, P52743: Nucleus (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF137P
Interactions:

    Search GeneGlobe Interaction Network for ZNF137P

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for ZNF137P (ZN137)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ZNF137P gene: 
NM_003438.2  

Unigene Cluster for ZNF137P:

Zinc finger protein 137, pseudogene
Hs.373648  [show with all ESTs]
Unigene Representative Sequence: NR_023311
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000597158 ENST00000456718 ENST00000333303 ENST00000406609 ENST00000446680

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Additional mRNA sequence: NR_023311.1 

3 DOTS entries:

DT.40293189  DT.92415807  DT.100008251 

Selected AceView cDNA sequences (see all 70):

BQ958705 CD244192 AI953831 AI003260 BQ690668 BQ008299 BP871716 BC067346 
BX955279 BV193457 CO250069 AI244141 BV198598 BQ060959 CF595699 BU754034 
AK001753 CO249449 BQ424683 BQ016962 NM_018260 CO245168 BV199062 CO249550 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF137P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ZNF137P Expression
About this image

ZNF137P Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF137P Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.373648
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for ZNF137P (if available)
TreeFam Gene Tree for ZNF137P (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF137P gene
Selected SIMAP similar genes for ZNF137P using alignment to 1 protein entry:     ZN137_HUMAN(see all similar genes):
ZNF845    ZNF860    ZNF808    ZNF397    ZNF675    ZNF135
ZNF813    ZNF420    HZF30    ZNF132    ZNF429    ZNF492
ZNF519    ZNF56    ZNF708    ZNF724P    ZNF78L1    ZNF93

ZNF137P for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF137P (see all 147)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1860267741,2
--53097941(+) CTGTAA/TTTTTA 1 -- us2k10--------
rs1915235291,2
--53098065(+) CTGGCC/TCGTTC 1 -- us2k10--------
rs116729991,2
C,F,A,H--53098101(+) CATCTT/CTCACT 1 -- us2k18Minor allele frequency- C:0.40NA WA CSA EA 252
rs129795461,2
C,F,A--53098186(+) TCCTAC/GGGAGG 1 -- us2k111Minor allele frequency- G:0.43NA WA CSA EA 374
rs81106861,2
C,F,A,H--53098296(+) atggcG/Atgatc 1 -- us2k14Minor allele frequency- A:0.38NA CSA 8
rs81107941,2
C,F,A,H--53098306(+) ctccaG/Ctcact 1 -- us2k16Minor allele frequency- C:0.33NA CSA 12
rs1506096451,2
C--53098514(+) AACTA-/TTAT  
        
TTACC
1 -- us2k10--------
rs65096531,2
C,F,A,H--53098551(+) GGATTC/ATTGCT 1 -- us2k17Minor allele frequency- A:0.36NA WA CSA 14
rs1480680361,2
--53098568(+) CCCAGA/GCTGGA 1 -- us2k10--------
rs113267551,2
C,F--53098690(+) GCTAAT/-TTTTT 1 -- us2k13Minor allele frequency- -:0.50NA CSA 6

HapMap Linkage Disequilibrium report for ZNF137P (53091758 - 53103405 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for ZNF137P:    About this table    
Variant IDTypeSubtypePubMed ID
esv2718787CNV Deletion23290073
esv2718786CNV Deletion23290073
nsv833874CNV Loss17160897
nsv912304CNV Loss21882294
nsv458743CNV Loss19166990
nsv510772CNV Loss20534489
dgv3981n71CNV Gain21882294
dgv3980n71CNV Gain21882294
nsv828616CNV Gain20364138

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604079    OMIM disorders: --


ZNF137P for disorders           About GeneDecksing


Export disorders for ZNF137P gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF137P gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF137P)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PubMed id 7557990)1, 2, 3 Tommerup N. and Vissing H. (Genomics 1995)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
  4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7696 HGNC: 12921 AceView: FLJ10891andZNF578andLOC388558 Ensembl:ENSG00000123870 euGenes: HUgn7696
ECgene: ZNF137P H-InvDB: ZNF137P

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF137P Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF137P gene:
Search GeneIP for patents involving ZNF137P

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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