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ZNF136 Gene

protein-coding   GIFtS: 52
GCID: GC19P012273

Zinc Finger Protein 136

(Previous name: zinc finger protein 136 (clone pHZ-20))
  Search for ZNF136
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 1361 2
Zinc Finger Protein 136 (Clone PHZ-20)1
pHZ-202

External Ids:    HGNC: 129201   Entrez Gene: 76952   Ensembl: ENSG000001966467   OMIM: 6040785   UniProtKB: P527373   

Export aliases for ZNF136 gene to outside databases

Previous GC identifers: GC19P012405 GC19P012496 GC19P012119 GC19P012134 GC19P012037 GC19P011848


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF136 Gene:
ZNF136 (zinc finger protein 136) is a protein-coding gene. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is ZNF669.

UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737
Function: May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused
with a heterologous protein containing a KRAB B-domain




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF136 gene promoter:
         RORalpha1   PPAR-gamma1   GCNF-1   GCNF   p300   PPAR-gamma2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF136 promoter sequence
   Search Chromatin IP Primers for ZNF136

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF136


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF136 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF136 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P012273:  view genomic region     (about GC identifiers)

Start:
12,273,872 bp from pter      End:
12,300,064 bp from pter
Size:
26,193 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737 (See protein sequence)
Recommended Name: Zinc finger protein 136  
Size: 540 amino acids; 62784 Da

Explore the universe of human proteins at neXtProt for ZNF136: NX_P52737

Explore proteomics data for ZNF136 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF136 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003428.1  
    ENSEMBL proteins: 
     ENSP00000403707   ENSP00000388759   ENSP00000344162   ENSP00000397176   ENSP00000381617  
    Reactome Protein details: P52737

    ZNF136 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P52737

    ProtoNet protein and cluster: P52737

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 14 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF136 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN136_HUMAN, P52737
    Function: May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused
    with a heterologous protein containing a KRAB B-domain

         Genatlas biochemistry entry for ZNF136:
    zinc finger protein 136 (C2H2 type,Kruppel-like,KRAB subfamily)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity TAS7649249
    GO:0005515protein binding IPI16189514
    GO:0046872metal ion binding IEA--
         
    ZNF136 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ZNF136:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF136
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    hsa-mir-26b-5p (MIRT029729)

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    8 qRT-PCR Assays for microRNAs that regulate ZNF136:
    hsa-miR-188-3p hsa-miR-135b hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-135a hsa-miR-181b hsa-miR-4262
    SwitchGear 3'UTR luciferase reporter plasmidZNF136 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN136_HUMAN, P52737: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF136 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF136 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF136
        Generic Transcription Pathway



    ZNF136 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF136
    Interactions:

        GeneGlobe Interaction Network for ZNF136

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ZNF136 (P527371, 3 ENSP000003441624) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997501, 3, ENSP000002303214EBI-749129,EBI-724076 I2D: score=5 STRING: ENSP00000230321
    CEP70Q8NHQ13, ENSP000002649824I2D: score=1 STRING: ENSP00000264982
    PPP2R2BQ000053, ENSP000003365914I2D: score=1 STRING: ENSP00000336591
    CCNDBP1O952733I2D: score=1 
    MTUS2Q5JR593I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS7649249
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS7649249

    ZNF136 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF136 (ZN136)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF136 gene: 
    NM_003437.3  

    Unigene Cluster for ZNF136:

    Zinc finger protein 136
    Hs.479874  [show with all ESTs]
    Unigene Representative Sequence: AK123008
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425827 ENST00000439995 ENST00000343979(uc002mti.3 uc010xmh.2)
    ENST00000418338 ENST00000464860 ENST00000476676 ENST00000398616
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate ZNF136:
    hsa-miR-188-3p hsa-miR-135b hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-135a hsa-miR-181b hsa-miR-4262
    SwitchGear 3'UTR luciferase reporter plasmidZNF136 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for ZNF136
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF136
      QuantiFast Probe-based Assays in human, mouse, rat ZNF136

    Additional mRNA sequence: 

    AK123008.1 AK291242.1 AK299601.1 AY500356.1 BC006421.1 U09367.1 

    4 DOTS entries:

    DT.206860  DT.91686143  DT.95366624  DT.102822301 

    Selected AceView cDNA sequences (see all 43):

    BU541852 BI259319 CA417915 BE677097 BM905782 BQ440904 W67486 BQ574220 
    NM_003437 AW949871 BU542575 AI559178 BX452164 BM473019 BX956550 AL710695 
    AI538106 BX420069 AY500356 BM737723 AI149238 BM457272 BI035607 BF962022 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF136    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for ZNF136

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF136 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTCATAG
    ZNF136 Expression
    About this image

    ZNF136 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF136 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.479874

    UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737
    Tissue specificity: Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and
    pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF136 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    cow
    (Bos taurus)
    Mammalia --
    Uncharacterized protein
    52(a)
    many ↔ many
    7(14307682-14311244)


    ENSEMBL Gene Tree for ZNF136 (if available)
    TreeFam Gene Tree for ZNF136 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF136 gene
    ZNF6692  ZNF5642  ZNF4902  ZNF4412  ZNF625-ZNF202  ZNF8782  ENSG000002671792  ZNF142  
    ENSG000002697552  ENSG000001968262  ZNF7002  ZNF692  ZNF4402  ZNF4432  ZNF670-ZNF6952  ZNF442  
    ZNF4392  ZNF8232  ENSG000001884742  ZNF4912  ZNF5552  ENSG000002688702  ZNF7092  ZNF6252  
    ZNF7992  ZNF202  ZNF7882  ZNF1012  ZNF7912  ZNF4422  ZNF4332  ZNF572  
    ZNF6272  ZNF5632  ENSG000002573552  ZNF5562  ZNF7632  ENSG000002687442  ZNF8442  ZNF772  
    Selected SIMAP similar genes for ZNF136 using alignment to 5 protein entries:     ZN136_HUMAN (see all proteins) (see all similar genes):
    HZF16    ZNF627    ZNF564    ZNF709    ZNF56    ZNF55
    ZNF78L1    ZNF818P    ZNF625    ZNF763    ZNF433    HZF36
    ZNF    ZNF844    DKFZp313M0722    DKFZp434J0650    DKFZp666C237    DKFZp686M04222

    ZNF136 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF136 (see all 616)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483821611,2
    --12271890(+) GGATTC/GAGGGT 1 -- us2k10--------
    rs1431733131,2
    --12272028(+) TCCCCC/TGATTG 1 -- us2k10--------
    rs1125782471,2
    C--12272083(+) CCGAACAGCTC/-
            
    CAGCT
    1 -- cds11Minor allele frequency- -:0.50CSA 2
    rs1888688051,2
    --12272090(+) AGCTCC/TAGCTC 1 -- us2k10--------
    rs2002924041,2
    --12272228(+) AAAAC-/TTTTTT 1 -- us2k10--------
    rs2698091,2
    C,A,H--12272234(-) AAAAAC/AAAAAA 1 -- us2k12Minor allele frequency- A:0.25NA WA 4
    rs2016873691,2
    --12272234(+) TTTTT-/GTTTTT 1 -- us2k10--------
    rs1387106211,2
    --12272267(+) ACCCAC/GGCTGG 1 -- us2k10--------
    rs1427773761,2
    C--12272395(+) TAGTAA/GAGACG 1 -- us2k10--------
    rs1507167821,2
    --12272421(+) GGCCAA/GGCTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF136 (12273872 - 12300064 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZNF136:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677508CNV Deletion23128226
    nsv911069CNV Loss21882294
    nsv510754CNV Loss20534489
    nsv833753CNV Loss17160897
    nsv911068CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604078    OMIM disorders: --


    ZNF136 for disorders           About GeneDecksing


    Export disorders for ZNF136 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF136 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF136)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PubMed id 7557990)1, 2, 3 Tommerup N. and Vissing H. (Genomics 1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. (PubMed id 7649249)1, 2 Vissing H.... Thiesen H.-J. (FEBS Lett. 1995)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. An empirical framework for binary interactome mapping. (PubMed id 19060904)1 Venkatesan K....Vidal M. (Nat. Methods 2009)
    6. An integrated workflow for charting the human interaction proteome: insights into the PP2A system. (PubMed id 19156129)1 Glatter T....Gstaiger M. (Mol. Syst. Biol. 2009)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7695 HGNC: 12920 AceView: ZNF136 Ensembl:ENSG00000196646 euGenes: HUgn7695
    ECgene: ZNF136 H-InvDB: ZNF136

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF136 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF136 gene:
    Search GeneIP for patents involving ZNF136

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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