ZNF136 Gene
protein-coding GIFtS: 52
GCID: GC19P012273
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zinc finger protein 136(Previous name: zinc finger protein 136 (clone pHZ-20) )
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Aliases for ZNF136 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 1361 2 | | PHZ-201 | | Zinc Finger Protein 136 (Clone PHZ-20)1 |
Export aliases for ZNF136 gene to outside databasesPrevious GC identifers: GC19P012405 GC19P012496 GC19P012119 GC19P012134 GC19P012037 GC19P011848 |
Summaries for ZNF136 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737Function: May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused witha heterologous protein containing a KRAB B-domain
|
Genomic Views for ZNF136 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF136 gene promoter: RORalpha1 PPAR-gamma1 GCNF-1 GCNF p300 PPAR-gamma2 GCNF-2 Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF136
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF136 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2ZNF136 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P012273: view genomic region
(about GC identifiers)
Start:
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12,273,872 bp from pter |
End:
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12,300,064 bp from pter |
Size:
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26,193 bases |
Orientation:
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plus strand |
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Proteins for ZNF136 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737 (See
protein sequence)Recommended Name: Zinc finger protein 136 Size: 540 amino acids; 62784 Da
Subcellular location: Nucleus (Potential)Explore the universe of human proteins at neXtProt for ZNF136: NX_P52737
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P52737 ZNF136 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003428.1 ENSEMBL proteins: ENSP00000403707 ENSP00000388759 ENSP00000344162 ENSP00000397176 ENSP00000381617 Reactome Protein details: P52737 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF136 for ontologies About GeneDecksing
ZNF136 Antibody Products: Assay Products for ZNF136: |
Protein
Domains / Families for ZNF136 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF136 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P52737ProtoNet protein and cluster: P52737 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 14 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function for ZNF136 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737Function: May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused witha heterologous protein containing a KRAB B-domain Genatlas biochemistry entry for ZNF136:zinc finger protein 136 (C2H2 type,Kruppel-like,KRAB subfamily)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF136 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF136 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF136 (NM_003437) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF136 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF136  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF136 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ZNF136 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for ZNF136:
|
Pathways & Interactions for ZNF136 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
2
Reactome Pathways for ZNF136
ZNF136 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF136
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
 5 Interacting proteins for ZNF136 (P527371, 3 ENSP000003441624) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
TAS | 7649249 | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | 7649249 |
ZNF136 for ontologies About GeneDecksing
|
Drugs & Compounds for ZNF136 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ZNF136 Search CenterWatch for drugs/clinical trials and news about ZNF136 / ZN136 
|
Transcripts for ZNF136 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZNF136 gene: NM_003437.3 Unigene Cluster for ZNF136: Zinc finger protein 136 Hs.479874 [show with all ESTs]Unigene Representative Sequence: AK1230087 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000425827 ENST00000439995 ENST00000343979(uc002mti.3 uc010xmh.2) ENST00000418338 ENST00000464860 ENST00000476676 ENST00000398616
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF136 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF136 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF136 (NM_003437) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF136 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF136  |
Additional cDNA sequence: AK123008.1 AK291242.1 AK299601.1 AY500356.1 BC006421.1 U09367.1 4 DOTS entries: DT.206860 DT.91686143 DT.95366624 DT.102822301 24/43 AceView cDNA sequences (see all 43): AW949871 NM_003437 BQ574220 BM905782 BQ440904 CA417915 BU542575 BE677097 BI259319 BU541852 W67486 BM049184 BM049625 BM473019 BX420069 U09367 AI538106 AI559178 BX956550 BM457272 BM737723 AY500356 BF962022 AL710695 GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF136 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | |
| SP1: | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for ZNF136
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Expression for ZNF136 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF136 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AATTTCATAG
About this image See ZNF136 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF136
SOURCE GeneReport for Unigene cluster: Hs.479874 UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737Tissue specificity: Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney andpancreas SABiosciences Custom PCR Arrays for ZNF136
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF136 Browse OriGene validated miRNA SYBR primer pairs
| |  | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ZNF136 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF136 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF136 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF136 |
Orthologs for ZNF136 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF136 (if available) TreeFam Gene Tree for ZNF136 (if available)  |
Paralogs for ZNF136 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ZNF136 gene
- ZNF6692 ZNF4902 ZNF5642 ZNF4412 ZNF8782 ENSG000002671792 ZNF142 ENSG000001968262
- ZNF7002 ZNF692 ZNF4402 ZNF4432 ZNF442 ZNF4392 ZNF8232 ZNF4912
- ENSG000001884742 ZNF5552 ZNF7092 ZNF6252 ZNF7992 ZNF202 ZNF1012 ZNF7912
- ZNF4422 ZNF4332 ZNF572 ZNF5632 ZNF6272 ENSG000002573552 ZNF5562 ZNF6702
- ZNF7632 ZNF1242 ZNF6992 ZNF8442 ZNF772
18/510 SIMAP similar genes for ZNF136 using alignment to 5 protein entries: ZN136_HUMAN (see all proteins)
(see all similar genes):HZF16 ZNF627 ZNF709 ZNF56 ZNF55 ZNF78L1 ZNF818P ZNF625 ZNF124 ZNF433 HZF36 ZNF564 ZNF ZNF844 DKFZp313M0722 DKFZp434J0650 DKFZp666C237 DKFZp686M04222
ZNF136 for paralogs About GeneDecksing
|
Genomic Variants for ZNF136 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 19 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for ZNF136 (12273872 - 12300064 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ZNF136: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF136 |
|
Disorders
/ Diseases for ZNF136 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF136 for disorders About MalaCards
ZNF136 for disorders About GeneDecksing
OMIM gene information: 604078
OMIM disorders: --
Export disorders for ZNF136 gene to outside databases
|
Publications for ZNF136 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF136 gene, integrated from 9 sources (see all 11): (articles sorted by number of sources associating them with ZNF136) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PubMed id 7557990)1, 2, 3 Tommerup N. and Vissing H. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. (PubMed id 7649249)1, 2 Vissing H.... Thiesen H.-J. (1995)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
- An integrated workflow for charting the human interac tion proteome: insights into the PP2A system. (PubMed id 19156129)1 Glatter T....Gstaiger M. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ZNF136 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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Genome Databases showing ZNF136 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF136 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF136 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ZNF136 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF136 gene: Search GeneIP for patents involving ZNF136
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZNF136 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | OriGene Antibodies for ZNF136 | | OriGene shRNA RFP for ZNF136 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF136 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF136 | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for ZNF136 | | OriGene 3'-UTR Clone for ZNF136 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF136 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF136 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for ZNF136 | | OriGene Custom Protein Services for ZNF136 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF136 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF136 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF136 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF136 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF136 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF136 |
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| | | Search Tocris compounds for ZNF136 |
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 | | ZNF136 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF136 |
|  |  |  | | | Search ThermoFisher Antibodies for ZNF136 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF136 |
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