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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF136 Gene

protein-coding   GIFtS: 52
GCID: GC19P012273

Zinc Finger Protein 136

(Previous name: zinc finger protein 136 (clone pHZ-20))
  Search for ZNF136
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 1361 2
Zinc Finger Protein 136 (Clone PHZ-20)1
pHZ-202

External Ids:    HGNC: 129201   Entrez Gene: 76952   Ensembl: ENSG000001966467   OMIM: 6040785   UniProtKB: P527373   

Export aliases for ZNF136 gene to outside databases

Previous GC identifers: GC19P012405 GC19P012496 GC19P012119 GC19P012134 GC19P012037 GC19P011848


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF136 Gene: 
ZNF136 (zinc finger protein 136) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and transcription corepressor activity. An important paralog of this gene is ZNF669.

UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737
Function: May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused
with a heterologous protein containing a KRAB B-domain




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF136 gene promoter:
         RORalpha1   PPAR-gamma1   GCNF-1   GCNF   p300   PPAR-gamma2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF136 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF136

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF136


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF136 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF136 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P012273:  view genomic region     (about GC identifiers)

Start:
12,273,872 bp from pter      End:
12,300,064 bp from pter
Size:
26,193 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737 (See protein sequence)
Recommended Name: Zinc finger protein 136  
Size: 540 amino acids; 62784 Da
Subcellular location: Nucleus (Potential)

Explore the universe of human proteins at neXtProt for ZNF136: NX_P52737

Explore proteomics data for ZNF136 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P52737

  • ZNF136 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF136 Protein Expression
    REFSEQ proteins: NP_003428.1  
    ENSEMBL proteins: 
     ENSP00000403707   ENSP00000388759   ENSP00000344162   ENSP00000397176   ENSP00000381617  
    Reactome Protein details: P52737
    Human Recombinant Protein Products for ZNF136: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF136 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF136 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P52737

    ProtoNet protein and cluster: P52737

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 14 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF136 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN136_HUMAN, P52737
    Function: May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused
    with a heterologous protein containing a KRAB B-domain

         Genatlas biochemistry entry for ZNF136:
    zinc finger protein 136 (C2H2 type,Kruppel-like,KRAB subfamily)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity TAS7649249
    GO:0005515protein binding IPI16189514
    GO:0008270zinc ion binding ----
         
    ZNF136 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ZNF136:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZNF136 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF136 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF136
        Generic Transcription Pathway
    Gene Expression



    ZNF136 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF136

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ZNF136 (P527371, 3 ENSP000003441624) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997501, 3, ENSP000002303214EBI-749129,EBI-724076 I2D: score=5 STRING: ENSP00000230321
    CEP70Q8NHQ13, ENSP000002649824I2D: score=1 STRING: ENSP00000264982
    PPP2R2BQ000053, ENSP000003365914I2D: score=1 STRING: ENSP00000336591
    CCNDBP1O952733I2D: score=1 
    MTUS2Q5JR593I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS7649249
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS7649249

    ZNF136 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF136 (ZN136)

    Search CenterWatch for drugs/clinical trials and news about ZNF136 / ZN136

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF136 gene: 
    NM_003437.3  

    Unigene Cluster for ZNF136:

    Zinc finger protein 136
    Hs.479874  [show with all ESTs]
    Unigene Representative Sequence: AK123008
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425827 ENST00000439995 ENST00000343979(uc002mti.3 uc010xmh.2)
    ENST00000418338 ENST00000464860 ENST00000476676 ENST00000398616
    miRNA
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    hsa-miR-188-3p hsa-miR-135b hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-135a hsa-miR-181b hsa-miR-4262
    SwitchGear 3'UTR luciferase reporter plasmidZNF136 3' UTR sequence
    Inhib. RNA
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    Primer
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    Additional mRNA sequence: 

    AK123008.1 AK291242.1 AK299601.1 AY500356.1 BC006421.1 U09367.1 

    4 DOTS entries:

    DT.206860  DT.91686143  DT.95366624  DT.102822301 

    24/43 AceView cDNA sequences (see all 43):

    BQ440904 BM905782 BI259319 AW949871 CA417915 NM_003437 BE677097 W67486 
    BQ574220 BU541852 BU542575 AI559178 AI149238 BM737723 BX956550 U09367 
    BM457272 BM049625 AI538106 BF183055 AL710695 AY500356 BM049184 BI035607 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF136    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for ZNF136

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF136 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTCATAG
    ZNF136 Expression
    About this image


    See ZNF136 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF136

    SOURCE GeneReport for Unigene cluster: Hs.479874

    UniProtKB/Swiss-Prot: ZN136_HUMAN, P52737
    Tissue specificity: Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and
    pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF136 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    --
    48(a)
    possible ortholog
    20(49458696-49539566)


    ENSEMBL Gene Tree for ZNF136 (if available)
    TreeFam Gene Tree for ZNF136 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF136 gene
    ZNF6692  ZNF5642  ZNF4902  ZNF4412  ZNF625-ZNF202  ZNF8782  ENSG000002671792  ZNF142  
    ENSG000002697552  ENSG000001968262  ZNF7002  ZNF692  ZNF4402  ZNF4432  ZNF442  ZNF4392  
    ZNF8232  ENSG000001884742  ZNF4912  ZNF5552  ENSG000002688702  ZNF7092  ZNF6252  ZNF7992  
    ZNF202  ZNF7882  ZNF1012  ZNF7912  ZNF4422  ZNF4332  ZNF572  ZNF5632  
    ZNF6272  ENSG000002573552  ZNF5562  ZNF6702  ZNF7632  ZNF1242  ENSG000002687442  ZNF6992  
    ZNF8442  ZNF772  
    18/511 SIMAP similar genes for ZNF136 using alignment to 5 protein entries:     ZN136_HUMAN (see all proteins) (see all similar genes):
    HZF16    ZNF564    ZNF627    ZNF709    ZNF56    ZNF55
    ZNF78L1    ZNF818P    ZNF625    ZNF763    ZNF433    HZF36
    ZNF    ZNF844    DKFZp313M0722    DKFZp434J0650    DKFZp666C237    DKFZp686M04222

    ZNF136 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/616 SNPs in ZNF136 are shown (see all 616)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483821611,2
    --12271890(+) GGATTC/GAGGGT 1 -- us2k10--------
    rs1431733131,2
    --12272028(+) TCCCCC/TGATTG 1 -- us2k10--------
    rs1125782471,2
    C--12272083(+) CCGAACAGCTC/-
            
    CAGCT
    1 -- cds11Minor allele frequency- -:0.50CSA 2
    rs1888688051,2
    --12272090(+) AGCTCC/TAGCTC 1 -- us2k10--------
    rs2002924041,2
    --12272228(+) AAAAC-/TTTTTT 1 -- us2k10--------
    rs2698091,2
    C,A,H--12272234(-) AAAAAC/AAAAAA 1 -- us2k12Minor allele frequency- A:0.25NA WA 4
    rs2016873691,2
    --12272234(+) TTTTT-/GTTTTT 1 -- us2k10--------
    rs1387106211,2
    --12272267(+) ACCCAC/GGCTGG 1 -- us2k10--------
    rs1427773761,2
    C--12272395(+) TAGTAA/GAGACG 1 -- us2k10--------
    rs1507167821,2
    --12272421(+) GGCCAA/GGCTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF136 (12273872 - 12300064 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZNF136:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677508CNV Deletion23128226
    nsv911069CNV Loss21882294
    nsv510754CNV Loss20534489
    nsv833753CNV Loss17160897
    nsv911068CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF136 for disorders           About MalaCards
    OMIM gene information: 604078    OMIM disorders: --


    ZNF136 for disorders           About GeneDecksing


    Export disorders for ZNF136 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF136 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF136)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PubMed id 7557990)1, 2, 3 Tommerup N. and Vissing H. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. (PubMed id 7649249)1, 2 Vissing H.... Thiesen H.-J. (1995)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
    6. An integrated workflow for charting the human interac tion proteome: insights into the PP2A system. (PubMed id 19156129)1 Glatter T....Gstaiger M. (2009)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7695 HGNC: 12920 AceView: ZNF136 Ensembl:ENSG00000196646 euGenes: HUgn7695
    ECgene: ZNF136 H-InvDB: ZNF136

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF136 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF136 gene:
    Search GeneIP for patents involving ZNF136

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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