Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF135 Gene

Aliases for ZNF135 Gene

  • Zinc Finger Protein 135 2 3 5
  • Zinc Finger Protein 61 2 3 4
  • Zinc Finger Protein 135 (Clone PHZ-17) 2 3
  • ZNF78L1 3 4
  • ZNF61 3 4
  • Zinc Finger Protein 78-Like 1 (PT3) 3
  • Zinc Finger Protein 78-Like 1 4
  • PHZ-17 3
  • PT3 3

External Ids for ZNF135 Gene

Previous HGNC Symbols for ZNF135 Gene

  • ZNF61
  • ZNF78L1

Previous GeneCards Identifiers for ZNF135 Gene

  • GC19P059476
  • GC19P059025
  • GC19P063246
  • GC19P063263
  • GC19P063060
  • GC19P063264
  • GC19P058571
  • GC19P054881
  • GC19P058573
  • GC19P058577
  • GC19P058587
  • GC19P058602

Summaries for ZNF135 Gene

GeneCards Summary for ZNF135 Gene

ZNF135 (Zinc Finger Protein 135) is a Protein Coding gene. Diseases associated with ZNF135 include Rectal Neoplasm and Middle Ear Carcinoma. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF607.

UniProtKB/Swiss-Prot for ZNF135 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF135 Gene

Genomics for ZNF135 Gene

Regulatory Elements for ZNF135 Gene

Enhancers for ZNF135 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF135 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF135 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF135 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF135 Gene

58,059,239 bp from pter
58,086,310 bp from pter
27,072 bases
Plus strand

Genomic View for ZNF135 Gene

Genes around ZNF135 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF135 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF135 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF135 Gene

Proteins for ZNF135 Gene

  • Protein details for ZNF135 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 135
    Protein Accession:
    Secondary Accessions:
    • B4DHH9
    • E9PEV2
    • F5GYY9
    • I3L0B3
    • Q5U5L3
    • Q8N1I7

    Protein attributes for ZNF135 Gene

    658 amino acids
    Molecular mass:
    75261 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC50254.1; Type=Frameshift; Positions=207, 558, 563; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF135 Gene


neXtProt entry for ZNF135 Gene

Proteomics data for ZNF135 Gene at MOPED

Post-translational modifications for ZNF135 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF135 Gene

Domains & Families for ZNF135 Gene

Gene Families for ZNF135 Gene

Protein Domains for ZNF135 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF135: view

Function for ZNF135 Gene

Molecular function for ZNF135 Gene

GENATLAS Biochemistry:
zinc finger protein 135 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF135: view

Animal Model Products

CRISPR Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF135 Gene

Localization for ZNF135 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF135 Gene

Subcellular locations from

Jensen Localization Image for ZNF135 Gene COMPARTMENTS Subcellular localization image for ZNF135 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ZNF135 Gene

Pathways & Interactions for ZNF135 Gene

SuperPathways for ZNF135 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF135: view

Pathways by source for ZNF135 Gene

2 Reactome pathways for ZNF135 Gene

Gene Ontology (GO) - Biological Process for ZNF135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IMP 21834987
genes like me logo Genes that share ontologies with ZNF135: view

No data available for SIGNOR curated interactions for ZNF135 Gene

Drugs & Compounds for ZNF135 Gene

No Compound Related Data Available

Transcripts for ZNF135 Gene

Unigene Clusters for ZNF135 Gene

Zinc finger protein 135:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF135 Gene

No ASD Table

Relevant External Links for ZNF135 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF135 Gene

mRNA expression in normal human tissues for ZNF135 Gene

SOURCE GeneReport for Unigene cluster for ZNF135 Gene Hs.85863

genes like me logo Genes that share expression patterns with ZNF135: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF135 Gene

Orthologs for ZNF135 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF135 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF135 35
  • 84.88 (n)
  • 84.93 (a)
ZNF135 36
  • 41 (a)
(Canis familiaris)
Mammalia LOC102154493 35
  • 85.49 (n)
  • 85.54 (a)
-- 36
  • 48 (a)
(Pan troglodytes)
Mammalia ZNF135 35
  • 99.3 (n)
  • 98.66 (a)
ZNF135 36
  • 99 (a)
(Monodelphis domestica)
Mammalia ZNF135 36
  • 37 (a)
(Mus musculus)
Mammalia Zfp712 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10543 37
  • 34 (a)
CG12299 37
  • 41 (a)
CG3032 37
  • 32 (a)
CG7987 37
  • 31 (a)
CG9215 37
  • 37 (a)
CG9797 37
  • 40 (a)
(Caenorhabditis elegans)
Secernentea M03D4.4 37
  • 33 (a)
Species with no ortholog for ZNF135:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF135 Gene

Gene Tree for ZNF135 (if available)
Gene Tree for ZNF135 (if available)

Paralogs for ZNF135 Gene

(534) SIMAP similar genes for ZNF135 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF135: view

Variants for ZNF135 Gene

Sequence variations from dbSNP and Humsavar for ZNF135 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1469087 - 58,061,611(-) TGAAG(C/T)CCACT reference, missense, utr-variant-5-prime
rs2228277 - 58,068,004(+) CAGCT(C/T)GTCCC intron-variant, reference, missense, utr-variant-3-prime
rs2228278 - 58,068,033(+) TCCAC(A/G)CTGGG intron-variant, reference, missense, utr-variant-3-prime
rs2228279 - 58,068,219(+) CGTAT(C/G)GGTGC intron-variant, reference, missense, utr-variant-3-prime
rs2228275 - 58,068,259(+) CTCCT(C/T)GCTCA intron-variant, reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF135 Gene

Variant ID Type Subtype PubMed ID
nsv833885 CNV Loss 17160897
nsv912533 CNV Loss 21882294
nsv912534 CNV Loss 21882294
nsv458836 CNV Gain 19166990
nsv828656 CNV Gain 20364138
nsv912535 CNV Loss 21882294

Variation tolerance for ZNF135 Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.55% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF135 Gene

Disorders for ZNF135 Gene

MalaCards: The human disease database

(21) MalaCards diseases for ZNF135 Gene - From: DISEASES

Disorder Aliases PubMed IDs
rectal neoplasm
  • neoplasm of rectum
middle ear carcinoma
  • carcinoma of middle ear
bronchus cancer
  • malignant neoplasm of bronchus and lung, unspecified
renal pelvis carcinoma
  • carcinoma of kidney pelvis
ureteral benign neoplasm
  • neoplasm of ureter
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF135

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZNF135: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF135 Gene

Publications for ZNF135 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N. … Vissing H. (Genomics 1995) 2 3 4 67
  2. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P. … Ward D.C. (Genomics 1992) 2 3
  3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ZNF135 Gene

Sources for ZNF135 Gene