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Aliases for ZNF135 Gene

Aliases for ZNF135 Gene

  • Zinc Finger Protein 135 2 3
  • Zinc Finger Protein 61 2 3 4
  • Zinc Finger Protein 135 (Clone PHZ-17) 2 3
  • ZNF78L1 3 4
  • ZNF61 3 4
  • Zinc Finger Protein 78-Like 1 (PT3) 3
  • Zinc Finger Protein 78-Like 1 4
  • PHZ-17 3
  • PT3 3

External Ids for ZNF135 Gene

Previous Symbols for ZNF135 Gene

  • ZNF61
  • ZNF78L1

Summaries for ZNF135 Gene

GeneCards Summary for ZNF135 Gene

ZNF135 (Zinc Finger Protein 135) is a Protein Coding gene. Diseases associated with ZNF135 include renal pelvis carcinoma and ureteral benign neoplasm. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF630.

UniProtKB/Swiss-Prot for ZNF135 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF135 Gene

Genomics for ZNF135 Gene

Genomic Location for ZNF135 Gene

Start:
58,059,239 bp from pter
End:
58,086,310 bp from pter
Size:
27,072 bases
Orientation:
Plus strand

Genomic View for ZNF135 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF135 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF135 Gene

Regulatory Elements for ZNF135 Gene

Proteins for ZNF135 Gene

  • Protein details for ZNF135 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52742-ZN135_HUMAN
    Recommended name:
    Zinc finger protein 135
    Protein Accession:
    P52742
    Secondary Accessions:
    • B4DHH9
    • E9PEV2
    • F5GYY9
    • I3L0B3
    • Q5U5L3
    • Q8N1I7

    Protein attributes for ZNF135 Gene

    Size:
    658 amino acids
    Molecular mass:
    75261 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC50254.1; Type=Frameshift; Positions=207, 558, 563; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF135 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF135 Gene

Proteomics data for ZNF135 Gene at MOPED

Post-translational modifications for ZNF135 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF135 Gene

Domains for ZNF135 Gene

Gene Families for ZNF135 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

UniProtKB/Swiss-Prot:

ZN135_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • P52742
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • P52742
Similarity:
  • Contains 16 C2H2-type zinc fingers.:
    • P52742
genes like me logo Genes that share domains with ZNF135: view

Function for ZNF135 Gene

Molecular function for ZNF135 Gene

GENATLAS Biochemistry: zinc finger protein 135 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function: Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 7557990
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF135: view

Phenotypes for ZNF135 Gene

GenomeRNAi human phenotypes for ZNF135:
genes like me logo Genes that share phenotypes with ZNF135: view

miRNA for ZNF135 Gene

miRTarBase miRNAs that target ZNF135

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF135 Gene

Localization for ZNF135 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF135 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF135 Gene COMPARTMENTS Subcellular localization image for ZNF135 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ZNF135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus NAS 7557990
genes like me logo Genes that share ontologies with ZNF135: view

Pathways for ZNF135 Gene

SuperPathways for ZNF135 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF135: view

Pathways by source for ZNF135 Gene

2 Reactome pathways for ZNF135 Gene

Gene Ontology (GO) - Biological Process for ZNF135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 7557990
GO:0007010 cytoskeleton organization IMP 21834987
GO:0022604 regulation of cell morphogenesis IMP 21834987
genes like me logo Genes that share ontologies with ZNF135: view

Transcripts for ZNF135 Gene

Unigene Clusters for ZNF135 Gene

Zinc finger protein 135:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF135 Gene

No ASD Table

Relevant External Links for ZNF135 Gene

GeneLoc Exon Structure for
ZNF135
ECgene alternative splicing isoforms for
ZNF135

Expression for ZNF135 Gene

mRNA expression in normal human tissues for ZNF135 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ZNF135 Gene Hs.85863

genes like me logo Genes that share expressions with ZNF135: view

Orthologs for ZNF135 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF135 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF135 36
  • 99.3 (n)
  • 98.66 (a)
ZNF135 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF135 36
  • 84.88 (n)
  • 84.93 (a)
ZNF135 37
  • 41 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 48 (a)
ManyToMany
LOC102154493 36
  • 85.49 (n)
  • 85.54 (a)
mouse
(Mus musculus)
Mammalia Zfp712 37
  • 45 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia ZNF135 37
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9215 38
  • 37 (a)
CG12299 38
  • 41 (a)
CG3032 38
  • 32 (a)
CG10543 38
  • 34 (a)
CG7987 38
  • 31 (a)
CG9797 38
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea M03D4.4 38
  • 33 (a)
Species with no ortholog for ZNF135:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF135 Gene

ENSEMBL:
Gene Tree for ZNF135 (if available)
TreeFam:
Gene Tree for ZNF135 (if available)

Paralogs for ZNF135 Gene

Selected SIMAP similar genes for ZNF135 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF135: view

Variants for ZNF135 Gene

Sequence variations from dbSNP and Humsavar for ZNF135 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs369802 -- 58,060,264(-) GGCAC(C/G)AGTAG intron-variant, utr-variant-5-prime
rs381801 -- 58,060,231(-) AGGTG(C/T)GCGAG intron-variant, utr-variant-5-prime
rs386336 -- 58,060,234(-) GCCAG(G/T)TGCGC intron-variant, utr-variant-5-prime
rs889154 -- 58,060,050(-) CAAGG(A/G)AGCCG intron-variant, utr-variant-5-prime
rs974182 -- 58,058,133(-) CTCGA(A/T)CTCAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF135 Gene

Variant ID Type Subtype PubMed ID
nsv833885 CNV Loss 17160897
nsv912533 CNV Loss 21882294
nsv912534 CNV Loss 21882294
nsv458836 CNV Gain 19166990
nsv828656 CNV Gain 20364138
nsv912535 CNV Loss 21882294

Relevant External Links for ZNF135 Gene

HapMap Linkage Disequilibrium report
ZNF135

Disorders for ZNF135 Gene

Relevant External Links for ZNF135

Genetic Association Database (GAD)
ZNF135
genes like me logo Genes that share disorders with ZNF135: view

No data available for UniProtKB/Swiss-Prot for ZNF135 Gene

Publications for ZNF135 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N. … Vissing H. (Genomics 1995) 2 3 4
  2. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P. … Ward D.C. (Genomics 1992) 2 3
  3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for ZNF135 Gene

Sources for ZNF135 Gene

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