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Aliases for ZNF133 Gene

Aliases for ZNF133 Gene

  • Zinc Finger Protein 133 2 3
  • Zinc Finger Protein 133 (Clone PHZ-13) 2 3
  • Zinc Finger Protein 150 (PHZ-66) 2 3
  • ZNF150 3 4
  • Zinc Finger Protein 150 4
  • EC 2.1.1.43 63
  • EC 2.1.1 63
  • PHZ-13 3
  • PHZ-66 3

External Ids for ZNF133 Gene

Previous HGNC Symbols for ZNF133 Gene

  • ZNF150

Previous GeneCards Identifiers for ZNF133 Gene

  • GC20P018257
  • GC20P018217

Summaries for ZNF133 Gene

GeneCards Summary for ZNF133 Gene

ZNF133 (Zinc Finger Protein 133) is a Protein Coding gene. Diseases associated with ZNF133 include osteoblastoma. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF169.

UniProtKB/Swiss-Prot for ZNF133 Gene

  • May be involved in transcriptional regulation as a repressor

Gene Wiki entry for ZNF133 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF133 Gene

Genomics for ZNF133 Gene

Regulatory Elements for ZNF133 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF133 Gene

Start:
18,288,283 bp from pter
End:
18,316,996 bp from pter
Size:
28,714 bases
Orientation:
Plus strand

Genomic View for ZNF133 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF133 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF133 Gene

Proteins for ZNF133 Gene

  • Protein details for ZNF133 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52736-ZN133_HUMAN
    Recommended name:
    Zinc finger protein 133
    Protein Accession:
    P52736
    Secondary Accessions:
    • A8K5S4
    • B4DHU7
    • B4DIB8
    • B7ZAS1
    • F5H289
    • J3KQ11
    • J3KQJ0
    • Q53XU1
    • Q5JXV8
    • Q9BUV2
    • Q9H443

    Protein attributes for ZNF133 Gene

    Size:
    654 amino acids
    Molecular mass:
    73388 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF133 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF133 Gene

Proteomics data for ZNF133 Gene at MOPED

Selected DME Specific Peptides for ZNF133 Gene

Post-translational modifications for ZNF133 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for ZNF133 Gene

Gene Families for ZNF133 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Graphical View of Domain Structure for InterPro Entry

P52736

UniProtKB/Swiss-Prot:

ZN133_HUMAN :
  • P52736
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF133: view

Function for ZNF133 Gene

Molecular function for ZNF133 Gene

GENATLAS Biochemistry: zinc finger protein 133 (C2H2 type,Kruppel-like,KRAB subfamily)
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation as a repressor

Enzyme Numbers (IUBMB) for ZNF133 Gene

Gene Ontology (GO) - Molecular Function for ZNF133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 7557990
GO:0005515 protein binding IPI 20195357
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF133: view

Phenotypes for ZNF133 Gene

GenomeRNAi human phenotypes for ZNF133:
genes like me logo Genes that share phenotypes with ZNF133: view

Animal Model Products

CRISPR Products

miRNA for ZNF133 Gene

miRTarBase miRNAs that target ZNF133

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF133 Gene

Localization for ZNF133 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF133 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF133 Gene COMPARTMENTS Subcellular localization image for ZNF133 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF133: view

Pathways for ZNF133 Gene

SuperPathways for ZNF133 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF133: view

Pathways by source for ZNF133 Gene

2 Reactome pathways for ZNF133 Gene

Gene Ontology (GO) - Biological Process for ZNF133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF133: view

Transcripts for ZNF133 Gene

Unigene Clusters for ZNF133 Gene

Zinc finger protein 133:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF133

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF133 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d
SP1: -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4:
SP5:
SP6: - - -
SP7: - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - - - -
SP11:
SP12: - - - - - - - - - -
SP13:
SP14: - - - - - - - - - - - -
SP15: - -
SP16: - - - - - - - - - - - - - - - - -

Relevant External Links for ZNF133 Gene

GeneLoc Exon Structure for
ZNF133
ECgene alternative splicing isoforms for
ZNF133

Expression for ZNF133 Gene

mRNA expression in normal human tissues for ZNF133 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ZNF133 Gene Hs.472221

mRNA Expression by UniProt/SwissProt for ZNF133 Gene

P52736-ZN133_HUMAN
Tissue specificity: Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
genes like me logo Genes that share expressions with ZNF133: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein expression for ZNF133 Gene

Orthologs for ZNF133 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF133 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF133 35
  • 99.54 (n)
  • 99.85 (a)
ZNF133 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF133 35
  • 86.45 (n)
  • 87.52 (a)
ZNF133 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp133-ps 16
rat
(Rattus norvegicus)
Mammalia Zfp133 35
  • 83.59 (n)
  • 82.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10543 37
  • 32 (a)
fu2 37
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STP2 38
Species with no ortholog for ZNF133:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF133 Gene

ENSEMBL:
Gene Tree for ZNF133 (if available)
TreeFam:
Gene Tree for ZNF133 (if available)

Paralogs for ZNF133 Gene

Paralogs for ZNF133 Gene

Selected SIMAP similar genes for ZNF133 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ZNF133: view

Variants for ZNF133 Gene

Sequence variations from dbSNP and Humsavar for ZNF133 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs761459 -- 18,289,666(-) CCAAT(A/G)CGATA intron-variant, upstream-variant-2KB
rs910246 -- 18,286,719(-) CTTGG(A/G)AGCTT upstream-variant-2KB
rs910247 -- 18,286,609(-) AAGAT(A/G)TTGTG upstream-variant-2KB
rs926716 -- 18,292,988(-) CAAAC(C/G)AATTA intron-variant
rs926717 -- 18,292,955(-) CTGCC(A/G)ACTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF133 Gene

Variant ID Type Subtype PubMed ID
dgv1316e1 CNV Complex 17122850
esv2751911 CNV Gain 17911159
nsv509763 CNV Insertion 20534489

Relevant External Links for ZNF133 Gene

HapMap Linkage Disequilibrium report
ZNF133
Human Gene Mutation Database (HGMD)
ZNF133

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF133 Gene

Disorders for ZNF133 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZNF133 Gene including...

Search for ZNF133 Gene in MalaCards »

(2) University of Copenhagen DISEASES for ZNF133 Gene

genes like me logo Genes that share disorders with ZNF133: view

No data available for UniProtKB/Swiss-Prot for ZNF133 Gene

Publications for ZNF133 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N. … Vissing H. (Genomics 1995) 2 3 4
  2. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. (PMID: 7649249) Vissing H. … Thiesen H.-J. (FEBS Lett. 1995) 2 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc finger motifs and regulates its transcriptional activity. (PMID: 17934332) Lee S.J. … Hahn M.J. (Exp. Mol. Med. 2007) 3 23

Products for ZNF133 Gene

Sources for ZNF133 Gene

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