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Aliases for ZNF133 Gene

Aliases for ZNF133 Gene

  • Zinc Finger Protein 133 2 3 5
  • Zinc Finger Protein 133 (Clone PHZ-13) 2 3
  • Zinc Finger Protein 150 (PHZ-66) 2 3
  • ZNF150 3 4
  • Zinc Finger Protein 150 4
  • EC 2.1.1.43 63
  • EC 2.1.1 63
  • PHZ-13 3
  • PHZ-66 3

External Ids for ZNF133 Gene

Previous HGNC Symbols for ZNF133 Gene

  • ZNF150

Previous GeneCards Identifiers for ZNF133 Gene

  • GC20P018257
  • GC20P018217

Summaries for ZNF133 Gene

GeneCards Summary for ZNF133 Gene

ZNF133 (Zinc Finger Protein 133) is a Protein Coding gene. Diseases associated with ZNF133 include osteoblastoma and bone benign neoplasm. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF169.

UniProtKB/Swiss-Prot for ZNF133 Gene

  • May be involved in transcriptional regulation as a repressor.

Gene Wiki entry for ZNF133 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF133 Gene

Genomics for ZNF133 Gene

Regulatory Elements for ZNF133 Gene

Promoters for ZNF133 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF133 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF133 Gene

Chromosome:
20
Start:
18,288,283 bp from pter
End:
18,316,996 bp from pter
Size:
28,714 bases
Orientation:
Plus strand

Genomic View for ZNF133 Gene

Genes around ZNF133 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF133 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF133 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF133 Gene

Proteins for ZNF133 Gene

  • Protein details for ZNF133 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52736-ZN133_HUMAN
    Recommended name:
    Zinc finger protein 133
    Protein Accession:
    P52736
    Secondary Accessions:
    • A8K5S4
    • B4DHU7
    • B4DIB8
    • B7ZAS1
    • F5H289
    • J3KQ11
    • J3KQJ0
    • Q53XU1
    • Q5JXV8
    • Q9BUV2
    • Q9H443

    Protein attributes for ZNF133 Gene

    Size:
    654 amino acids
    Molecular mass:
    73388 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF133 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF133 Gene

Proteomics data for ZNF133 Gene at MOPED

Selected DME Specific Peptides for ZNF133 Gene

Post-translational modifications for ZNF133 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ZNF133 Gene

Gene Families for ZNF133 Gene

Protein Domains for ZNF133 Gene

Graphical View of Domain Structure for InterPro Entry

P52736

UniProtKB/Swiss-Prot:

ZN133_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF133: view

Function for ZNF133 Gene

Molecular function for ZNF133 Gene

GENATLAS Biochemistry:
zinc finger protein 133 (C2H2 type,Kruppel-like,KRAB subfamily)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation as a repressor.

Enzyme Numbers (IUBMB) for ZNF133 Gene

Gene Ontology (GO) - Molecular Function for ZNF133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
genes like me logo Genes that share ontologies with ZNF133: view
genes like me logo Genes that share phenotypes with ZNF133: view

Animal Model Products

CRISPR Products

miRNA for ZNF133 Gene

miRTarBase miRNAs that target ZNF133

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF133 Gene

Localization for ZNF133 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF133 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF133 Gene COMPARTMENTS Subcellular localization image for ZNF133 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF133 Gene

Pathways & Interactions for ZNF133 Gene

SuperPathways for ZNF133 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF133: view

Pathways by source for ZNF133 Gene

2 Reactome pathways for ZNF133 Gene

Gene Ontology (GO) - Biological Process for ZNF133 Gene

None

No data available for SIGNOR curated interactions for ZNF133 Gene

Drugs & Compounds for ZNF133 Gene

No Compound Related Data Available

Transcripts for ZNF133 Gene

Unigene Clusters for ZNF133 Gene

Zinc finger protein 133:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF133 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d
SP1: -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4:
SP5:
SP6: - - -
SP7: - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - - - -
SP11:
SP12: - - - - - - - - - -
SP13:
SP14: - - - - - - - - - - - -
SP15: - -
SP16: - - - - - - - - - - - - - - - - -

Relevant External Links for ZNF133 Gene

GeneLoc Exon Structure for
ZNF133
ECgene alternative splicing isoforms for
ZNF133

Expression for ZNF133 Gene

mRNA expression in normal human tissues for ZNF133 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ZNF133 Gene Hs.472221

mRNA Expression by UniProt/SwissProt for ZNF133 Gene

P52736-ZN133_HUMAN
Tissue specificity: Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with ZNF133: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZNF133 Gene

Orthologs for ZNF133 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF133 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF133 35
  • 99.54 (n)
  • 99.85 (a)
ZNF133 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF133 36
  • 87 (a)
OneToOne
ZNF133 35
  • 86.45 (n)
  • 87.52 (a)
rat
(Rattus norvegicus)
Mammalia Zfp133 35
  • 83.59 (n)
  • 82.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10543 37
  • 32 (a)
fu2 37
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STP2 38
Species with no ortholog for ZNF133:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF133 Gene

ENSEMBL:
Gene Tree for ZNF133 (if available)
TreeFam:
Gene Tree for ZNF133 (if available)

Paralogs for ZNF133 Gene

Paralogs for ZNF133 Gene

(554) SIMAP similar genes for ZNF133 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ZNF133: view

Variants for ZNF133 Gene

Sequence variations from dbSNP and Humsavar for ZNF133 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_028228 -
VAR_028229 -
rs3079052 -- 18,306,814(+) AAAAA(-/A)CTGTG intron-variant
rs2103757 -- 18,293,129(+) ttgac(C/T)gctac intron-variant
rs2843441 -- 18,287,832(-) GAGAA(C/G)CAGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF133 Gene

Variant ID Type Subtype PubMed ID
dgv1316e1 CNV Complex 17122850
esv2751911 CNV Gain 17911159
nsv509763 CNV Insertion 20534489

Variation tolerance for ZNF133 Gene

Residual Variation Intolerance Score: 19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 68.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF133 Gene

HapMap Linkage Disequilibrium report
ZNF133
Human Gene Mutation Database (HGMD)
ZNF133

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF133 Gene

Disorders for ZNF133 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ZNF133 Gene - From: DISEASES

Disorder Aliases PubMed IDs
osteoblastoma
bone benign neoplasm
connective tissue benign neoplasm
  • neoplasm of soft tissue
corneal dystrophy, posterior polymorphous, 1
  • posterior polymorphous corneal dystrophy
chondroblastoma
  • chondroblastoma of bone
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF133

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF133
genes like me logo Genes that share disorders with ZNF133: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF133 Gene

Publications for ZNF133 Gene

  1. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. (PMID: 7649249) Vissing H. … Thiesen H.-J. (FEBS Lett. 1995) 2 3 4 67
  2. PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc finger motifs and regulates its transcriptional activity. (PMID: 17934332) Lee S.J. … Hahn M.J. (Exp. Mol. Med. 2007) 3 23
  3. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N. … Vissing H. (Genomics 1995) 2 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for ZNF133 Gene

Sources for ZNF133 Gene

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