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Aliases for ZNF132 Gene

Aliases for ZNF132 Gene

  • Zinc Finger Protein 132 2 3 5
  • Zinc Finger Protein 132 (Clone PHZ-12) 2
  • PHZ-12 3

External Ids for ZNF132 Gene

Previous GeneCards Identifiers for ZNF132 Gene

  • GC19M059842
  • GC19M059398
  • GC19M063620
  • GC19M063635
  • GC19M058944
  • GC19M055257

Summaries for ZNF132 Gene

GeneCards Summary for ZNF132 Gene

ZNF132 (Zinc Finger Protein 132) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF16.

UniProtKB/Swiss-Prot for ZNF132 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF132 Gene

Genomics for ZNF132 Gene

Regulatory Elements for ZNF132 Gene

Enhancers for ZNF132 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G058400 1.8 FANTOM5 ENCODE dbSUPER 22.2 +38.8 38768 2.2 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A YY1 SLC30A9 ZNF143 ZNF207 ZNF584 ZNF132 LOC100506634 A1BG ZNF324 ZNF329 ZNF497 MZF1 ZNF256 CENPBD1P1
GH19G058406 1.4 ENCODE dbSUPER 25.7 +31.7 31732 3.7 HDGF CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766 ZNF584 LOC105372483 ZNF132 ZNF17 LOC100128398 ENSG00000268912 ZNF549 ZSCAN18 ZNF418 ENSG00000268201
GH19G058384 1.4 ENCODE dbSUPER 18.2 +53.6 53582 3.8 PKNOX1 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 RPS5 ZNF132 TRIM28 ZNF446 MIR4754
GH19G058474 1.1 ENCODE 18.7 -35.9 -35936 3.8 HNRNPUL1 PKNOX1 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF584 ZNF132 LOC100506634 ZNF324B CENPBD1P1 ENSG00000269106 RNU6-1337P
GH19G058439 0.8 ENCODE 25.5 +0.1 108 2.1 HDGF PKNOX1 MXI1 TBL1XR1 WRNIP1 TEAD4 MAX BMI1 ZBTB40 YY1 ZNF584 ZNF132 LOC100506634 LOC105372483 ENSG00000268912 PIR40092
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF132 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF132 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111876 -78 1001 PKNOX1 MXI1 TBL1XR1 WRNIP1 TEAD4 MAX BMI1 ZBTB40 YY1 ETS1

Genomic Location for ZNF132 Gene

Chromosome:
19
Start:
58,432,807 bp from pter
End:
58,440,222 bp from pter
Size:
7,416 bases
Orientation:
Minus strand

Genomic View for ZNF132 Gene

Genes around ZNF132 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF132 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF132 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF132 Gene

Proteins for ZNF132 Gene

  • Protein details for ZNF132 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52740-ZN132_HUMAN
    Recommended name:
    Zinc finger protein 132
    Protein Accession:
    P52740
    Secondary Accessions:
    • Q32MI9

    Protein attributes for ZNF132 Gene

    Size:
    706 amino acids
    Molecular mass:
    80623 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF132 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF132 Gene

Post-translational modifications for ZNF132 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF132 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF132 Gene

Domains & Families for ZNF132 Gene

Gene Families for ZNF132 Gene

Suggested Antigen Peptide Sequences for ZNF132 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52740

UniProtKB/Swiss-Prot:

ZN132_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF132: view

Function for ZNF132 Gene

Molecular function for ZNF132 Gene

GENATLAS Biochemistry:
zinc finger protein 132 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 7557990
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF132: view
genes like me logo Genes that share phenotypes with ZNF132: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF132 Gene

Localization for ZNF132 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF132 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF132 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF132: view

Pathways & Interactions for ZNF132 Gene

SuperPathways for ZNF132 Gene

No Data Available

Interacting Proteins for ZNF132 Gene

Gene Ontology (GO) - Biological Process for ZNF132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF132: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF132 Gene

Drugs & Compounds for ZNF132 Gene

No Compound Related Data Available

Transcripts for ZNF132 Gene

mRNA/cDNA for ZNF132 Gene

Unigene Clusters for ZNF132 Gene

Zinc finger protein 132:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF132 Gene

No ASD Table

Relevant External Links for ZNF132 Gene

GeneLoc Exon Structure for
ZNF132
ECgene alternative splicing isoforms for
ZNF132

Expression for ZNF132 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF132 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF132 Gene:

ZNF132

SOURCE GeneReport for Unigene cluster for ZNF132 Gene:

Hs.156169
genes like me logo Genes that share expression patterns with ZNF132: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF132 Gene

Orthologs for ZNF132 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF132 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF132 34 35
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia ZNF132 34 35
  • 86.04 (n)
cow
(Bos Taurus)
Mammalia ZNF132 34 35
  • 81.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15436 36
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea F35H8.3 36
  • 36 (a)
Species where no ortholog for ZNF132 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF132 Gene

ENSEMBL:
Gene Tree for ZNF132 (if available)
TreeFam:
Gene Tree for ZNF132 (if available)

Paralogs for ZNF132 Gene

(504) SIMAP similar genes for ZNF132 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF132: view

Variants for ZNF132 Gene

Sequence variations from dbSNP and Humsavar for ZNF132 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000304254 -- 58,435,991(+) TTCTA(G/T)ACACT intron-variant
rs1000786057 -- 58,438,288(+) CCATC(C/T)CTTGG intron-variant
rs1000863909 -- 58,441,361(+) TATGA(G/T)AGTGG upstream-variant-2KB
rs1001683642 -- 58,440,848(+) CTTGA(A/C)CCAGT upstream-variant-2KB
rs1002080233 -- 58,435,030(+) TTCTC(C/T)TCAGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF132 Gene

Variant ID Type Subtype PubMed ID
esv999478 CNV insertion 20482838
nsv1057077 CNV gain 25217958
nsv1160670 CNV deletion 26073780
nsv515731 CNV gain+loss 19592680
nsv833887 CNV loss 17160897
nsv833888 CNV loss 17160897

Variation tolerance for ZNF132 Gene

Residual Variation Intolerance Score: 30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF132 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF132

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF132 Gene

Disorders for ZNF132 Gene

Relevant External Links for ZNF132

Genetic Association Database (GAD)
ZNF132
Human Genome Epidemiology (HuGE) Navigator
ZNF132
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF132

No disorders were found for ZNF132 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF132 Gene

Publications for ZNF132 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N. … Vissing H. (Genomics 1995) 2 3 4 64
  2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 46 64
  3. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 46 64
  4. Downregulation of zinc finger protein 132 in prostate cancer is associated with aberrant promoter hypermethylation and poor prognosis. (PMID: 21445975) Abildgaard M.O. … rensen K.D. (Int. J. Cancer 2012) 3 64
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3 64

Products for ZNF132 Gene

Sources for ZNF132 Gene

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