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Aliases for ZNF132 Gene

Aliases for ZNF132 Gene

  • Zinc Finger Protein 132 2 3
  • Zinc Finger Protein 132 (Clone PHZ-12) 2
  • PHZ-12 3

External Ids for ZNF132 Gene

Summaries for ZNF132 Gene

GeneCards Summary for ZNF132 Gene

ZNF132 (Zinc Finger Protein 132) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZNF132 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF132 Gene

Genomics for ZNF132 Gene

Genomic Location for ZNF132 Gene

Start:
58,432,814 bp from pter
End:
58,440,222 bp from pter
Size:
7,409 bases
Orientation:
Minus strand

Genomic View for ZNF132 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF132 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF132 Gene

Regulatory Elements for ZNF132 Gene

Proteins for ZNF132 Gene

  • Protein details for ZNF132 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52740-ZN132_HUMAN
    Recommended name:
    Zinc finger protein 132
    Protein Accession:
    P52740
    Secondary Accessions:
    • Q32MI9

    Protein attributes for ZNF132 Gene

    Size:
    706 amino acids
    Molecular mass:
    80623 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF132 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF132 Gene

Proteomics data for ZNF132 Gene at MOPED

Post-translational modifications for ZNF132 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF132 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF132 Gene

Domains for ZNF132 Gene

Gene Families for ZNF132 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

UniProtKB/Swiss-Prot:

ZN132_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • P52740
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • P52740
Similarity:
  • Contains 18 C2H2-type zinc fingers.:
    • P52740
genes like me logo Genes that share domains with ZNF132: view

Function for ZNF132 Gene

Molecular function for ZNF132 Gene

GENATLAS Biochemistry: zinc finger protein 132 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF132: view

Phenotypes for ZNF132 Gene

GenomeRNAi human phenotypes for ZNF132:
genes like me logo Genes that share phenotypes with ZNF132: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF132 Gene

Localization for ZNF132 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF132 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF132 Gene COMPARTMENTS Subcellular localization image for ZNF132 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ZNF132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF132: view

Pathways for ZNF132 Gene

SuperPathways for ZNF132 Gene

No Data Available

Interacting Proteins for ZNF132 Gene

Gene Ontology (GO) - Biological Process for ZNF132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF132: view

No data available for Pathways by source for ZNF132 Gene

Transcripts for ZNF132 Gene

mRNA/cDNA for ZNF132 Gene

Unigene Clusters for ZNF132 Gene

Zinc finger protein 132:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF132 Gene

No ASD Table

Relevant External Links for ZNF132 Gene

GeneLoc Exon Structure for
ZNF132
ECgene alternative splicing isoforms for
ZNF132

Expression for ZNF132 Gene

mRNA expression in normal human tissues for ZNF132 Gene

SOURCE GeneReport for Unigene cluster for ZNF132 Gene Hs.156169

genes like me logo Genes that share expressions with ZNF132: view

Orthologs for ZNF132 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF132 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF132 36
  • 99.24 (n)
  • 98.73 (a)
ZNF132 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF132 36
  • 81.01 (n)
  • 73.84 (a)
ZNF132 37
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF132 36
  • 86.04 (n)
  • 79.58 (a)
ZNF132 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp132 16
fruit fly
(Drosophila melanogaster)
Insecta CG15436 38
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea F35H8.3 38
  • 36 (a)
Species with no ortholog for ZNF132:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF132 Gene

ENSEMBL:
Gene Tree for ZNF132 (if available)
TreeFam:
Gene Tree for ZNF132 (if available)

Paralogs for ZNF132 Gene

Selected SIMAP similar genes for ZNF132 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF132: view

Variants for ZNF132 Gene

Sequence variations from dbSNP and Humsavar for ZNF132 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1005050 -- 58,438,212(+) CTACT(C/T)TCTGC intron-variant, upstream-variant-2KB
rs1051500 -- 58,433,035(-) TGTGT(C/T)CTCTA utr-variant-3-prime
rs1122955 - 58,434,836(-) CCTGG(A/G)CAGCT missense, reference
rs1465789 - 58,434,689(-) TCTCC(C/T)CAACC reference, missense
rs3764529 -- 58,433,722(-) TGCAA(C/T)GAATG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for ZNF132 Gene

Variant ID Type Subtype PubMed ID
nsv833887 CNV Loss 17160897
nsv515731 CNV Gain+Loss 19592680
nsv833888 CNV Loss 17160897
esv999478 CNV Insertion 20482838

Relevant External Links for ZNF132 Gene

HapMap Linkage Disequilibrium report
ZNF132

Disorders for ZNF132 Gene

Relevant External Links for ZNF132

Genetic Association Database (GAD)
ZNF132
Human Genome Epidemiology (HuGE) Navigator
ZNF132
genes like me logo Genes that share disorders with ZNF132: view

No data available for UniProtKB/Swiss-Prot for ZNF132 Gene

Publications for ZNF132 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N. … Vissing H. (Genomics 1995) 2 3 4
  2. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 49
  3. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 49
  4. Downregulation of zinc finger protein 132 in prostate cancer is associated with aberrant promoter hypermethylation and poor prognosis. (PMID: 21445975) Abildgaard M.O. … rensen K.D. (Int. J. Cancer 2012) 3
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4

Products for ZNF132 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF132
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF132
  • Block miRNA regulation of ZNF132 using miScript Target Protectors

Sources for ZNF132 Gene

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