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Aliases for ZNF131 Gene

Aliases for ZNF131 Gene

  • Zinc Finger Protein 131 2 3
  • Zinc Finger And BTB Domain Containing 35 2 3
  • Zinc Finger Protein 131 (Clone PHZ-10) 2 3
  • ZBTB35 3
  • PHZ-10 3

External Ids for ZNF131 Gene

Previous GeneCards Identifiers for ZNF131 Gene

  • GC05P043425
  • GC05M044298
  • GC05P043161
  • GC05P043206
  • GC05P043198
  • GC05U900556
  • GC05P043066
  • GC05P043069
  • GC05P043071
  • GC05P043073
  • GC05P043088
  • GC05P043098
  • GC05P043110
  • GC05P043120

Summaries for ZNF131 Gene

GeneCards Summary for ZNF131 Gene

ZNF131 (Zinc Finger Protein 131) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is ZBTB24.

UniProtKB/Swiss-Prot for ZNF131 Gene

  • Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF131 Gene

Genomics for ZNF131 Gene

Regulatory Elements for ZNF131 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF131 Gene

Start:
43,065,176 bp from pter
End:
43,192,021 bp from pter
Size:
126,846 bases
Orientation:
Plus strand

Genomic View for ZNF131 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF131 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF131 Gene

Proteins for ZNF131 Gene

  • Protein details for ZNF131 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52739-ZN131_HUMAN
    Recommended name:
    Zinc finger protein 131
    Protein Accession:
    P52739
    Secondary Accessions:
    • B4DRL3
    • Q6PIF0

    Protein attributes for ZNF131 Gene

    Size:
    623 amino acids
    Molecular mass:
    71422 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF131 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF131 Gene

Proteomics data for ZNF131 Gene at MOPED

Post-translational modifications for ZNF131 Gene

  • Monosumoylated at Lys-601 by CBX4 and UHRF2. Sumoylation may potentiate ZNF131 inhibition of estrogen signaling. Sumoylation does not interfere with ubiquitination.
  • Ubiquitinated
  • Ubiquitination at Lys220
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF131 Gene

Domains for ZNF131 Gene

Gene Families for ZNF131 Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF131 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52739

UniProtKB/Swiss-Prot:

ZN131_HUMAN :
  • P52739
Domain:
  • Contains 1 BTB (POZ) domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF131: view

Function for ZNF131 Gene

Molecular function for ZNF131 Gene

GENATLAS Biochemistry: zinc finger protein 131 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function: Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.

Gene Ontology (GO) - Molecular Function for ZNF131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 7557990
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF131: view

Animal Model Products

CRISPR Products

miRNA for ZNF131 Gene

miRTarBase miRNAs that target ZNF131

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF131 Gene

Localization for ZNF131 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF131 Gene

Nucleus. Note=Sumoylation does not affect nuclear localization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF131 Gene COMPARTMENTS Subcellular localization image for ZNF131 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 7557990
genes like me logo Genes that share ontologies with ZNF131: view

Pathways for ZNF131 Gene

SuperPathways for ZNF131 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 7557990
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZNF131: view

No data available for Pathways by source for ZNF131 Gene

Transcripts for ZNF131 Gene

mRNA/cDNA for ZNF131 Gene

(11) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(20) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF131 Gene

Zinc finger protein 131:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF131

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF131
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF131 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP1:
SP2:
SP3:

Relevant External Links for ZNF131 Gene

GeneLoc Exon Structure for
ZNF131
ECgene alternative splicing isoforms for
ZNF131

Expression for ZNF131 Gene

mRNA expression in normal human tissues for ZNF131 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF131 Gene

SOURCE GeneReport for Unigene cluster for ZNF131 Gene Hs.535804

mRNA Expression by UniProt/SwissProt for ZNF131 Gene

P52739-ZN131_HUMAN
Tissue specificity: Predominant expression is found in different brain areas such as the occipital and temporal lobe, the nucleus caudatus, hippocampus, and the cerebellum as well as in testis and thymus.
genes like me logo Genes that share expressions with ZNF131: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF131 Gene

Orthologs for ZNF131 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF131 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF131 35
  • 99.66 (n)
  • 99.83 (a)
ZNF131 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF131 35
  • 93.04 (n)
  • 96.6 (a)
ZNF131 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF131 35
  • 93.44 (n)
  • 96.1 (a)
ZNF131 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp131 35
  • 90.88 (n)
  • 94.19 (a)
Zfp131 16
Zfp131 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF131 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF131 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp131 35
  • 89.57 (n)
  • 92.31 (a)
chicken
(Gallus gallus)
Aves ZNF131 35
  • 77.51 (n)
  • 79.41 (a)
ZNF131 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF131 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf131 35
  • 69.63 (n)
  • 69.09 (a)
zebrafish
(Danio rerio)
Actinopterygii znf131 35
  • 63.98 (n)
  • 62.42 (a)
znf131 36
  • 51 (a)
OneToOne
Species with no ortholog for ZNF131:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF131 Gene

ENSEMBL:
Gene Tree for ZNF131 (if available)
TreeFam:
Gene Tree for ZNF131 (if available)

Paralogs for ZNF131 Gene

Paralogs for ZNF131 Gene

Pseudogenes.org Pseudogenes for ZNF131 Gene

genes like me logo Genes that share paralogs with ZNF131: view

Variants for ZNF131 Gene

Sequence variations from dbSNP and Humsavar for ZNF131 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs13665 -- 43,175,851(+) TTTTG(C/G)TTATA utr-variant-3-prime, nc-transcript-variant
rs14208 -- 43,175,436(+) AAGTT(A/C)TTCCT utr-variant-3-prime, nc-transcript-variant
rs15650 -- 43,176,174(-) CCACA(A/G)TTTAG utr-variant-3-prime, nc-transcript-variant
rs482224 -- 43,123,111(+) GAAGA(C/T)CTATT intron-variant
rs487169 -- 43,134,929(-) cctga(A/G)gtcag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF131 Gene

Variant ID Type Subtype PubMed ID
nsv462126 CNV Gain 19166990
nsv830274 CNV Loss 17160897
esv2663534 CNV Deletion 23128226

Relevant External Links for ZNF131 Gene

HapMap Linkage Disequilibrium report
ZNF131

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF131 Gene

Disorders for ZNF131 Gene

(1) University of Copenhagen DISEASES for ZNF131 Gene

genes like me logo Genes that share disorders with ZNF131: view

No data available for UniProtKB/Swiss-Prot for ZNF131 Gene

Publications for ZNF131 Gene

  1. High-throughput cell-based screening reveals a role for ZNF131 as a repressor of ERalpha signaling. (PMID: 18847501) Han X. … Ma D. (BMC Genomics 2008) 3 4 23
  2. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N. … Vissing H. (Genomics 1995) 3 4
  3. The murine BTB/POZ zinc finger gene Znf131: predominant expression in the developing central nervous system, in adult brain, testis, and thymus. (PMID: 12163020) Trappe R. … Burfeind P. (Biochem. Biophys. Res. Commun. 2002) 3 4
  4. Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling. (PMID: 22467880) Oh Y. … Chung K.C. (J. Biol. Chem. 2012) 3 4
  5. UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131. (PMID: 23404503) Oh Y. … Chung K.C. (J. Biol. Chem. 2013) 3 4

Products for ZNF131 Gene

Sources for ZNF131 Gene

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