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Aliases for ZNF131 Gene

Aliases for ZNF131 Gene

  • Zinc Finger Protein 131 2 3 5
  • Zinc Finger And BTB Domain Containing 35 2 3
  • Zinc Finger Protein 131 (Clone PHZ-10) 2 3
  • ZBTB35 3
  • PHZ-10 3

External Ids for ZNF131 Gene

Previous GeneCards Identifiers for ZNF131 Gene

  • GC05P043425
  • GC05M044298
  • GC05P043161
  • GC05P043206
  • GC05P043198
  • GC05U900556
  • GC05P043066
  • GC05P043069
  • GC05P043071
  • GC05P043073
  • GC05P043088
  • GC05P043098
  • GC05P043110
  • GC05P043120
  • GC05P043104
  • GC05P043128

Summaries for ZNF131 Gene

GeneCards Summary for ZNF131 Gene

ZNF131 (Zinc Finger Protein 131) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZBTB24.

UniProtKB/Swiss-Prot for ZNF131 Gene

  • Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF131 Gene

Genomics for ZNF131 Gene

Regulatory Elements for ZNF131 Gene

Enhancers for ZNF131 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF131 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF131 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF131 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF131 Gene

Chromosome:
5
Start:
43,065,176 bp from pter
End:
43,192,021 bp from pter
Size:
126,846 bases
Orientation:
Plus strand

Genomic View for ZNF131 Gene

Genes around ZNF131 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF131 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF131 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF131 Gene

Proteins for ZNF131 Gene

  • Protein details for ZNF131 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52739-ZN131_HUMAN
    Recommended name:
    Zinc finger protein 131
    Protein Accession:
    P52739
    Secondary Accessions:
    • B4DRL3
    • Q6PIF0

    Protein attributes for ZNF131 Gene

    Size:
    623 amino acids
    Molecular mass:
    71422 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF131 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF131 Gene

Proteomics data for ZNF131 Gene at MOPED

Post-translational modifications for ZNF131 Gene

  • Monosumoylated at Lys-601 by CBX4 and UHRF2. Sumoylation may potentiate ZNF131 inhibition of estrogen signaling. Sumoylation does not interfere with ubiquitination.
  • Ubiquitinated.
  • Ubiquitination at Lys 220
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF131 Gene

Domains & Families for ZNF131 Gene

Gene Families for ZNF131 Gene

Suggested Antigen Peptide Sequences for ZNF131 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52739

UniProtKB/Swiss-Prot:

ZN131_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 6 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF131: view

Function for ZNF131 Gene

Molecular function for ZNF131 Gene

GENATLAS Biochemistry:
zinc finger protein 131 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.

Gene Ontology (GO) - Molecular Function for ZNF131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with ZNF131: view
genes like me logo Genes that share phenotypes with ZNF131: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF131 Gene

Localization for ZNF131 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF131 Gene

Nucleus. Note=Sumoylation does not affect nuclear localization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF131 Gene COMPARTMENTS Subcellular localization image for ZNF131 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF131 Gene

Pathways & Interactions for ZNF131 Gene

SuperPathways for ZNF131 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF131 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 7557990
genes like me logo Genes that share ontologies with ZNF131: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF131 Gene

Drugs & Compounds for ZNF131 Gene

No Compound Related Data Available

Transcripts for ZNF131 Gene

mRNA/cDNA for ZNF131 Gene

(11) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(20) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF131 Gene

Zinc finger protein 131:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF131 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP1:
SP2:
SP3:

Relevant External Links for ZNF131 Gene

GeneLoc Exon Structure for
ZNF131
ECgene alternative splicing isoforms for
ZNF131

Expression for ZNF131 Gene

mRNA expression in normal human tissues for ZNF131 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF131 Gene

This gene is overexpressed in Adrenal (38.6), Cervix (18.2), and Blymphocyte (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF131 Gene



SOURCE GeneReport for Unigene cluster for ZNF131 Gene Hs.535804

mRNA Expression by UniProt/SwissProt for ZNF131 Gene

P52739-ZN131_HUMAN
Tissue specificity: Predominant expression is found in different brain areas such as the occipital and temporal lobe, the nucleus caudatus, hippocampus, and the cerebellum as well as in testis and thymus.
genes like me logo Genes that share expression patterns with ZNF131: view

Protein tissue co-expression partners for ZNF131 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for ZNF131 Gene

Orthologs for ZNF131 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF131 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF131 35
  • 93.04 (n)
  • 96.6 (a)
ZNF131 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF131 35
  • 93.44 (n)
  • 96.1 (a)
ZNF131 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp131 35
  • 90.88 (n)
  • 94.19 (a)
Zfp131 16
Zfp131 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF131 35
  • 99.66 (n)
  • 99.83 (a)
ZNF131 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp131 35
  • 89.57 (n)
  • 92.31 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF131 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF131 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF131 35
  • 77.51 (n)
  • 79.41 (a)
ZNF131 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF131 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf131 35
  • 69.63 (n)
  • 69.09 (a)
zebrafish
(Danio rerio)
Actinopterygii znf131 35
  • 63.98 (n)
  • 62.42 (a)
znf131 36
  • 51 (a)
OneToOne
Species with no ortholog for ZNF131:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF131 Gene

ENSEMBL:
Gene Tree for ZNF131 (if available)
TreeFam:
Gene Tree for ZNF131 (if available)

Paralogs for ZNF131 Gene

Paralogs for ZNF131 Gene

Pseudogenes.org Pseudogenes for ZNF131 Gene

genes like me logo Genes that share paralogs with ZNF131: view

Variants for ZNF131 Gene

Sequence variations from dbSNP and Humsavar for ZNF131 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs13665 -- 43,175,851(+) TTTTG(C/G)TTATA nc-transcript-variant, utr-variant-3-prime
rs14208 -- 43,175,436(+) AAGTT(A/C)TTCCT nc-transcript-variant, utr-variant-3-prime
rs15650 -- 43,176,174(-) CCACA(A/G)TTTAG nc-transcript-variant, utr-variant-3-prime
rs782971 -- 43,124,586(+) AACTT(A/G)ATAAA intron-variant
rs782976 -- 43,145,567(+) AGAAT(C/T)GCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF131 Gene

Variant ID Type Subtype PubMed ID
nsv462126 CNV Gain 19166990
nsv830274 CNV Loss 17160897
esv2663534 CNV Deletion 23128226

Variation tolerance for ZNF131 Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF131 Gene

Disorders for ZNF131 Gene

Relevant External Links for ZNF131

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF131

No disorders were found for ZNF131 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF131 Gene

Publications for ZNF131 Gene

  1. High-throughput cell-based screening reveals a role for ZNF131 as a repressor of ERalpha signaling. (PMID: 18847501) Han X. … Ma D. (BMC Genomics 2008) 3 4 23 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry J.R. … Ong K.K. (Nature 2014) 3

Products for ZNF131 Gene

Sources for ZNF131 Gene

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