ZNF131 Gene
protein-coding GIFtS: 47
GCID: GC05P043098
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zinc finger protein 131(Previous name: zinc finger protein 131 (clone pHZ-10) )
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Aliases for ZNF131 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 1311 2 | | ZBTB351 2 | | PHZ-101 | | Zinc Finger Protein 131 (Clone PHZ-10)1 2 | | Zinc Finger And BTB Domain Containing 352 |
Export aliases for ZNF131 gene to outside databasesPrevious GC identifers: GC05P043425 GC05M044298 GC05P043161 GC05P043206 GC05P043198 GC05U900556 GC05P043066 GC05P043069 GC05P043071 GC05P043073 GC05P043088 |
Summaries for ZNF131 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ZN131_HUMAN, P52739Function: Plays a role during development and organogenesis as well as in the function of the adult central nervoussystem (By similarity). May be involved in transcriptional regulation as a repressor of ERalpha signaling
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Genomic Views for ZNF131 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006576.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF131 gene promoter: AhR USF1 Pax-6 Roaz N-Myc POU2F1 POU2F1a USF-1 LyF-1 ATF Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF131
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF131 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5p12 Ensembl cytogenetic band: 5p12 HGNC cytogenetic band: 5p12ZNF131 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P043098: view genomic region
(about GC identifiers)
Start:
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43,065,278 bp from pter |
End:
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43,192,123 bp from pter |
Size:
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126,846 bases |
Orientation:
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plus strand |
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Proteins for ZNF131 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZN131_HUMAN, P52739 (See
protein sequence)Recommended Name: Zinc finger protein 131 Size: 623 amino acids; 71422 Da
Subcellular location: Nucleus
Secondary accessions: B4DRL3 Q6PIF0Alternative splicing: 2 isoforms: P52739-1 P52739-2 Explore the universe of human proteins at neXtProt for ZNF131: NX_P52739
Post-translational modifications:
Sumoylation by CBX4 at Lys-601 by may potentiate the negative effect on estrogen signaling1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P52739 ZNF131 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003423.1 ENSEMBL proteins: ENSP00000427003 ENSP00000422079 ENSP00000425623 ENSP00000426504 ENSP00000422659 ENSP00000425139 ENSP00000305804 ENSP00000423945 ENSP00000421246 ENSP00000424771 ENSP00000425722 ENSP00000426614 ENSP00000423254 ENSP00000382450 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
ZNF131 for ontologies About GeneDecksing
ZNF131 Antibody Products: Assay Products for ZNF131: |
Protein
Domains / Families for ZNF131 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF131 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P52739ProtoNet protein and cluster: P52739 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: ZN131_HUMAN, P52739Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 6 C2H2-type zinc fingers |
Function for ZNF131 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ZN131_HUMAN, P52739Function: Plays a role during development and organogenesis as well as in the function of the adult central nervoussystem (By similarity). May be involved in transcriptional regulation as a repressor of ERalpha signaling Genatlas biochemistry entry for ZNF131:zinc finger protein 131 (C2H2 type,Kruppel-like)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF131 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF131 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF131 (NM_003432) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF131 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF131  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF131 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF131 for ontologies About GeneDecksing
|
Pathways & Interactions for ZNF131 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF131
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
 5/7 Interacting proteins for ZNF131 (P527393 ENSP000003058044) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | 7557990 |
ZNF131 for ontologies About GeneDecksing
|
Drugs & Compounds for ZNF131 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ZNF131 Search CenterWatch for drugs/clinical trials and news about ZNF131 / ZN131 
|
Transcripts for ZNF131 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZNF131 gene: NM_003432.1 Unigene Cluster for ZNF131: Zinc finger protein 131 Hs.535804 [show with all ESTs]Unigene Representative Sequence: NM_00343218/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21): ENST00000503599 ENST00000499046(uc010ivk.3) ENST00000508795 ENST00000507393 ENST00000514169 ENST00000515326 ENST00000510026(uc010ivl.1 uc003jnj.4) ENST00000504359 ENST00000509156 ENST00000508259 ENST00000507218 ENST00000306938(uc003jnk.3) ENST00000505606 ENST00000509634 ENST00000509341 ENST00000509931(uc003jnl.1) ENST00000511736(uc010ivm.1) ENST00000510037(uc003jnm.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF131 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF131 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF131 (NM_003432) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF131 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF131  |
Additional cDNA sequence: AK057343.1 AK299315.1 AK307963.1 AK307974.1 AK307977.1 AK310735.1 AL832081.1 BC017923.1 BC035875.2 U09410.1 10 DOTS entries: DT.315974 DT.91961053 DT.100714068 DT.95274391 DT.97765558 DT.100780607 DT.100780606 DT.120828639 DT.315977 DT.95075907 GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF131 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for ZNF131
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Expression for ZNF131 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF131 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: ATGAAAAGTG
About this image See ZNF131 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF131
SOURCE GeneReport for Unigene cluster: Hs.535804 UniProtKB/Swiss-Prot: ZN131_HUMAN, P52739Tissue specificity: Predominant expression is found in different brain areas such as the occipital and temporal lobe,the nucleus caudatus, hippocampus, and the cerebellum as well as in testis and thymus SABiosciences Custom PCR Arrays for ZNF131
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF131 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF131 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF131 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF131 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF131 |
Orthologs for ZNF131 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF131 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for ZNF131 (if available) TreeFam Gene Tree for ZNF131 (if available)  |
Paralogs for ZNF131 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ZNF131 gene
- ZBTB142
18/25 SIMAP similar genes for ZNF131 using alignment to 10 protein entries: ZN131_HUMAN (see all proteins)
(see all similar genes):ZBTB7C BACH2 KLHL2 BACH1 ZBTB20 ZBTB10 KLHL36 KLHL24 ZBTB14 KLHL14 ZBTB3 MYNN HIC1 ZBTB16 BCL6 NACC1 KLHL32 ZBTB25
ZNF131 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for ZNF131 PGOHUM00000244807 PGOHUM00000243407 PGOHUM00000232994
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Genomic Variants for ZNF131 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 5 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for ZNF131 (43065278 - 43192123 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ZNF131: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF131 |
|
Disorders
/ Diseases for ZNF131 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF131 for disorders About GeneDecksing
OMIM gene information: 604073
OMIM disorders: --
5 diseases for ZNF131: About MalaCardsbeckwith-wiedemann syndrome alagille syndrome thyroid adenoma adenoma thyroiditis 1 disease from the University of Copenhagen DISEASES database for ZNF131:Alagille syndrome Export disorders for ZNF131 gene to outside databases
|
Publications for ZNF131 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF131 gene, integrated from 9 sources (see all 15): (articles sorted by number of sources associating them with ZNF131) | |  | Utopia: connect your pdf to the dynamic world of online information |
- High-throughput cell-based screening reveals a role for ZNF131 as a repressor of ERalpha signaling. (PubMed id 18847501)1, 2, 9 Han X....Ma D. (2008)
- Small ubiquitin-like modifier (SUMO) modification of z inc finger protein 131 potentiates its negative effect on estrogen signaling. (PubMed id 22467880)1, 2 Oh Y. and Chung K.C. (2012)
- Nuclear trafficking of the POZ-ZF protein Znf131. (PubMed id 17306895)1, 2 Donaldson N.S....Daniel J.M. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)
- The murine BTB/POZ zinc finger gene Znf131: predominant expression in the developing central nervous system, in adult brain, testis, and thymus. (PubMed id 12163020)1, 2 Trappe R....Burfeind P. (2002)
- Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PubMed id 7557990)1, 2 Tommerup N. and Vissing H. (1995)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
|
External Searches for ZNF131 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZNF131 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF131 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF131 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ZNF131 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF131 gene: Search GeneIP for patents involving ZNF131
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZNF131 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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 | |
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 | | ZNF131 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF131 |
|  |  |  | | | Search ThermoFisher Antibodies for ZNF131 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF131 |
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