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ZNF131 Gene

protein-coding   GIFtS: 50
GCID: GC05P043120

Zinc Finger Protein 131

(Previous name: zinc finger protein 131 (clone pHZ-10))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 1311 2
Zinc Finger Protein 131 (Clone PHZ-10)1 2
Zinc Finger And BTB Domain Containing 351 2
ZBTB352
pHZ-102

External Ids:    HGNC: 129151   Entrez Gene: 76902   Ensembl: ENSG000001722627   OMIM: 6040735   UniProtKB: P527393   

Export aliases for ZNF131 gene to outside databases

Previous GC identifers: GC05P043425 GC05M044298 GC05P043161 GC05P043206 GC05P043198 GC05U900556 GC05P043066 GC05P043069 GC05P043071 GC05P043073 GC05P043088 GC05P043098 GC05P043110


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF131 Gene:
ZNF131 (zinc finger protein 131) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZBTB24.

UniProtKB/Swiss-Prot: ZN131_HUMAN, P52739
Function: Plays a role during development and organogenesis as well as in the function of the adult central
nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha
signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF131 gene promoter:
         AhR   USF1   Pax-6   Roaz   N-Myc   POU2F1   POU2F1a   USF-1   LyF-1   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF131

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF131


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p12   Ensembl cytogenetic band:  5p12   HGNC cytogenetic band: 5p12

ZNF131 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF131 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P043120:  view genomic region     (about GC identifiers)

Start:
43,065,278 bp from pter      End:
43,192,123 bp from pter
Size:
126,846 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN131_HUMAN, P52739 (See protein sequence)
Recommended Name: Zinc finger protein 131  
Size: 623 amino acids; 71422 Da
Secondary accessions: B4DRL3 Q6PIF0
Alternative splicing: 2 isoforms:  P52739-1   P52739-2   

Explore the universe of human proteins at neXtProt for ZNF131: NX_P52739

Explore proteomics data for ZNF131 at MOPED

Post-translational modifications: 

  • Monosumoylated at Lys-601 by CBX4 and UHRF2. Sumoylation may potentiate ZNF131 inhibition of estrogen signaling.
    Sumoylation does not interfere with ubiquitination1
  • Ubiquitinated1
  • Ubiquitination2 at Lys220
  • Modification sites at PhosphoSitePlus

  • See ZNF131 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003423.1  
    ENSEMBL proteins: 
     ENSP00000427003   ENSP00000422079   ENSP00000425623   ENSP00000426504   ENSP00000422659  
     ENSP00000425139   ENSP00000305804   ENSP00000423945   ENSP00000421246   ENSP00000424771  
     ENSP00000425722   ENSP00000426614   ENSP00000423254   ENSP00000382450  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 8):
     IPR027758 Zfp131
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR027775 C2H2_Znf_fam

    Graphical View of Domain Structure for InterPro Entry P52739

    ProtoNet protein and cluster: P52739

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZN131_HUMAN, P52739
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 C2H2-type zinc fingers


    Find genes that share domains with ZNF131           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN131_HUMAN, P52739
    Function: Plays a role during development and organogenesis as well as in the function of the adult central
    nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha
    signaling

         Genatlas biochemistry entry for ZNF131:
    zinc finger protein 131 (C2H2 type,Kruppel-like)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS7557990
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF131           About GenesLikeMe


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    miRTarBase miRNAs that target ZNF131:
    hsa-mir-222-3p (MIRT046774)

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    hsa-miR-4291 hsa-miR-576-5p hsa-miR-631 hsa-miR-586 hsa-miR-133b hsa-miR-3661 hsa-miR-337-3p hsa-miR-9
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN131_HUMAN, P52739: Nucleus. Note=Sumoylation does not affect nuclear localization
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS7557990

    Find genes that share ontologies with ZNF131           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF131
    Interactions:

        Search GeneGlobe Interaction Network for ZNF131

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for ZNF131 (P527393 ENSP000003058044) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MORF4L1Q9UBU83, ENSP000003313104I2D: score=1 STRING: ENSP00000331310
    CTNNB1P352223I2D: score=1 
    MORF4L2Q150143I2D: score=1 
    BAP1ENSP000004171324STRING: ENSP00000417132
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated NAS7557990
    GO:0006366transcription from RNA polymerase II promoter IBA--

    Find genes that share ontologies with ZNF131           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF131 (ZN131)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF131 gene: 
    NM_003432.1  

    Unigene Cluster for ZNF131:

    Zinc finger protein 131
    Hs.535804  [show with all ESTs]
    Unigene Representative Sequence: NM_003432
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000503599 ENST00000499046(uc010ivk.3) ENST00000508795 ENST00000507393
    ENST00000514169 ENST00000515326 ENST00000510026(uc010ivl.1 uc003jnj.4)
    ENST00000504359 ENST00000509156 ENST00000508259 ENST00000507218 ENST00000306938(uc003jnk.3)
    ENST00000505606 ENST00000509634 ENST00000509341 ENST00000509931(uc003jnl.1)
    ENST00000511736(uc010ivm.1) ENST00000510037(uc003jnm.3)
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    hsa-miR-4291 hsa-miR-576-5p hsa-miR-631 hsa-miR-586 hsa-miR-133b hsa-miR-3661 hsa-miR-337-3p hsa-miR-9
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    Additional mRNA sequence: 

    AK057343.1 AK299315.1 AK307963.1 AK307974.1 AK307977.1 AK310735.1 AL832081.1 BC017923.1 
    BC035875.2 U09410.1 

    10 DOTS entries:

    DT.315974  DT.91961053  DT.100714068  DT.95274391  DT.97765558  DT.100780607  DT.100780606  DT.120828639 
    DT.315977  DT.95075907 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF131    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
    SP1:                                                
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for ZNF131

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF131 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAAAAGTG
    ZNF131 Expression
    About this image

    ZNF131 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF131 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.535804

    UniProtKB/Swiss-Prot: ZN131_HUMAN, P52739
    Tissue specificity: Predominant expression is found in different brain areas such as the occipital and temporal
    lobe, the nucleus caudatus, hippocampus, and the cerebellum as well as in testis and thymus

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF131 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp1311 , 5 zinc finger protein 1311, 5 90.88(n)1
    94.19(a)1
      135
    724651  NM_028245.31  NP_082521.11 
     1197651875 
    chicken
    (Gallus gallus)
    Aves ZNF1311 zinc finger protein 131 77.51(n)
    79.41(a)
      431588  XM_429143.4  XP_429143.4 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF1316
    zinc finger protein 131
    66(a)
    1 ↔ 1
    2(6211638-6229101)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia znf1311 zinc finger protein 131 69.63(n)
    69.09(a)
      100491098  XM_004910441.1  XP_004910498.1 
    zebrafish
    (Danio rerio)
    Actinopterygii znf1311 zinc finger protein 131 63.98(n)
    62.42(a)
      393477  NM_200505.1  NP_956799.1 


    ENSEMBL Gene Tree for ZNF131 (if available)
    TreeFam Gene Tree for ZNF131 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF131 gene
    ZBTB242  
    Selected SIMAP similar genes for ZNF131 using alignment to 10 protein entries:     ZN131_HUMAN (see all proteins) (see all similar genes):
    ZBTB7C    BACH2    Bach2    KLHL2    BACH1    ZBTB20
    KLHL36    KLHL24    ZBTB14    KLHL14    ZBTB3    MYNN
    HIC1    ZBTB16    BCL6    NACC1    KLHL32    ZBTB25

    Find genes that share paralogs with ZNF131           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for ZNF131
    PGOHUM00000244807 PGOHUM00000243407 PGOHUM00000232994


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF131 (see all 1406)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs557802261,2
    C,F--43119659(+) CAGCCT/CATCTC 1 -- us2k12Minor allele frequency- C:0.13WA NA 238
    rs1807837871,2
    C--43119733(+) TCCCAG/TTTGAT 1 -- us2k10--------
    rs768034321,2
    C,F--43119753(+) TAGCAG/ACTTGT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs5003221,2
    F--43119814(-) CCTAAG/AATGTA 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs5002551,2
    F--43119833(-) GCCTTG/CGCGCA 1 -- us2k12Minor allele frequency- C:0.50NA 4
    rs1913803191,2
    --43119908(+) ATCCAA/GCAACA 1 -- us2k10--------
    rs18454851,2
    C,F,A,H--43119928(+) TTTCCT/CGAATG 1 -- us2k1 tfbs327Minor allele frequency- C:0.10NS EA NA WA 3120
    rs8782341,2
    C,F,H--43119950(-) TGCAAA/TGGCAC 1 -- us2k1 tfbs320Minor allele frequency- T:0.06NS EA NA 2020
    rs1458833181,2
    --43120005(+) AAAAAC/TATTTT 1 -- us2k10--------
    rs1811242471,2
    --43120088(+) CCAACG/TCGGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF131 (43065278 - 43192123 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF131:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663534CNV Deletion23128226
    nsv830274CNV Loss17160897
    nsv462126CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604073    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for ZNF131:
    Alagille syndrome

    Find genes that share disorders with ZNF131           About GenesLikeMe


    Export disorders for ZNF131 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF131 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ZNF131)
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    1. High-throughput cell-based screening reveals a role for ZNF131 as a repressor of ERalpha signaling. (PubMed id 18847501)1, 2, 9 Han X.... Ma D. (BMC Genomics 2008)
    2. UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131. (PubMed id 23404503)1, 2 Oh Y. and Chung K.C. (J. Biol. Chem. 2013)
    3. Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling. (PubMed id 22467880)1, 2 Oh Y. and Chung K.C. (J. Biol. Chem. 2012)
    4. Nuclear trafficking of the POZ-ZF protein Znf131. (PubMed id 17306895)1, 2 Donaldson N.S.... Daniel J.M. (Biochim. Biophys. Acta 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (Nature 2004)
    8. The murine BTB/POZ zinc finger gene Znf131: predominant expression in the developing central nervous system, in adult brain, testis, and thymus. (PubMed id 12163020)1, 2 Trappe R....Burfeind P. (Biochem. Biophys. Res. Commun. 2002)
    9. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PubMed id 7557990)1, 2 Tommerup N. and Vissing H. (Genomics 1995)
    10. Zinc finger protein 131 inhibits estrogen signaling by suppressing estrogen receptor I+ homo-dimerization. (PubMed id 23159625)1 Oh Y. and Chung K.C. (Biochem. Biophys. Res. Commun. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7690 HGNC: 12915 Ensembl:ENSG00000172262 euGenes: HUgn7690 ECgene: ZNF131
    H-InvDB: ZNF131

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF131 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF131 gene:
    Search GeneIP for patents involving ZNF131

    GeneCards and IP:
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