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Aliases for ZNF124 Gene

Aliases for ZNF124 Gene

  • Zinc Finger Protein 124 2 3
  • Zinc Finger Protein HZF-16 3 4
  • Zinc Finger Protein 124 (HZF-16) 2
  • HZF-16 3
  • HZF16 3
  • ZK7 3

External Ids for ZNF124 Gene

Previous GeneCards Identifiers for ZNF124 Gene

  • GC01P245157
  • GC01P242540
  • GC01P243386
  • GC01M244265
  • GC01M244098
  • GC01M243645
  • GC01M245386
  • GC01M247285
  • GC01M217713

Summaries for ZNF124 Gene

Entrez Gene Summary for ZNF124 Gene

  • This gene encodes a protein with an amino-terminal KRAB-A box and multiple repeated Kruppel-type (C2H2) zinc finger motifs at its carboxy terminus. The encoded protein may function as a transcription factor. Expression of this gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and results in inhibition of apoptotic cell death induced by irradiation or exposure to etoposide. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2014]

GeneCards Summary for ZNF124 Gene

ZNF124 (Zinc Finger Protein 124) is a Protein Coding gene. Diseases associated with ZNF124 include dandy-walker complex. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF558.

UniProtKB/Swiss-Prot for ZNF124 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF124 Gene

Genomics for ZNF124 Gene

Regulatory Elements for ZNF124 Gene

Genomic Location for ZNF124 Gene

247,121,975 bp from pter
247,172,016 bp from pter
50,042 bases
Minus strand

Genomic View for ZNF124 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF124 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF124 Gene

Proteins for ZNF124 Gene

  • Protein details for ZNF124 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 124
    Protein Accession:
    Secondary Accessions:
    • B3KNP3
    • J3KSE1
    • Q15974
    • Q4VAJ7
    • Q5T2V4

    Protein attributes for ZNF124 Gene

    351 amino acids
    Molecular mass:
    40217 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF124 Gene


neXtProt entry for ZNF124 Gene

Proteomics data for ZNF124 Gene at MOPED

Post-translational modifications for ZNF124 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF124 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF124 Gene

Domains for ZNF124 Gene

Gene Families for ZNF124 Gene

  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF124 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q15973
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF124: view

Function for ZNF124 Gene

Molecular function for ZNF124 Gene

GENATLAS Biochemistry:
zinc finger protein 127 (C2H2 type,Kruppel-like),from a hepatoblastoma cell line
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF124 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF124: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF124

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF124 Gene

Localization for ZNF124 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF124 Gene

Subcellular locations from

Jensen Localization Image for ZNF124 Gene COMPARTMENTS Subcellular localization image for ZNF124 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF124 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF124: view

Pathways for ZNF124 Gene

SuperPathways for ZNF124 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF124: view

Pathways by source for ZNF124 Gene

2 Reactome pathways for ZNF124 Gene

Gene Ontology (GO) - Biological Process for ZNF124 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF124: view

Transcripts for ZNF124 Gene

Unigene Clusters for ZNF124 Gene

Zinc finger protein 124:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF124

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF124 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for ZNF124 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF124 Gene

mRNA expression in normal human tissues for ZNF124 Gene

Protein differential expression in normal tissues for ZNF124 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (44.5) and Heart (24.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF124 Gene

SOURCE GeneReport for Unigene cluster for ZNF124 Gene Hs.421238

genes like me logo Genes that share expressions with ZNF124: view

Expression partners for ZNF124 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF124 Gene

Orthologs for ZNF124 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF124 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia LOC102637111 35
  • 70.66 (n)
  • 59.93 (a)
Gm20422 36
  • 20 (a)
(Pan troglodytes)
Mammalia ZNF124 35
  • 91.58 (n)
  • 88.93 (a)
ZNF124 36
  • 100 (a)
(Canis familiaris)
Mammalia ZNF124 36
  • 34 (a)
(Monodelphis domestica)
Mammalia ZNF124 36
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
(Danio rerio)
Actinopterygii ZNF557 36
  • 32 (a)
Species with no ortholog for ZNF124:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF124 Gene

Gene Tree for ZNF124 (if available)
Gene Tree for ZNF124 (if available)

Paralogs for ZNF124 Gene

Selected SIMAP similar genes for ZNF124 Gene using alignment to 2 proteins: Pseudogenes for ZNF124 Gene

genes like me logo Genes that share paralogs with ZNF124: view

Variants for ZNF124 Gene

Sequence variations from dbSNP and Humsavar for ZNF124 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs924085 -- 247,149,173(-) CTTGT(A/G)TAAGC intron-variant
rs990789 -- 247,162,451(+) taaat(C/T)tagga intron-variant
rs1059347 -- 247,157,687(-) TTTAT(C/G)TTCAA intron-variant
rs1609840 -- 247,173,424(-) CTCAC(C/T)TGAGC upstream-variant-2KB
rs2067086 -- 247,132,476(+) gatgg(C/G)taata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF124 Gene

Variant ID Type Subtype PubMed ID
nsv873424 CNV Gain 21882294
esv33129 CNV Gain+Loss 17666407
nsv873428 CNV Loss 21882294
dgv562n71 CNV Loss 21882294
nsv509779 CNV Insertion 20534489
nsv833126 CNV Loss 17160897
nsv5287 CNV Insertion 18451855
nsv873432 CNV Loss 21882294
nsv873433 CNV Loss 21882294
nsv499487 OTHER Inversion 21111241
nsv513639 OTHER Inversion 21212237
esv1225151 OTHER Inversion 17803354
nsv7192 OTHER Inversion 18451855
nsv821373 CNV Deletion 20802225
esv2727629 CNV Deletion 23290073
esv24532 CNV Gain+Loss 19812545
esv2727640 CNV Deletion 23290073
esv1201683 CNV Deletion 17803354
esv2727651 CNV Deletion 23290073
esv2727662 CNV Deletion 23290073
esv2727673 CNV Deletion 23290073
esv2675826 CNV Deletion 23128226
esv272773 CNV Insertion 20981092
nsv873434 CNV Loss 21882294
esv1441492 OTHER Inversion 17803354

Relevant External Links for ZNF124 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF124 Gene

Disorders for ZNF124 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ZNF124 Gene in MalaCards »

(1) Diseases for ZNF124 Gene including...

Relevant External Links for ZNF124

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ZNF124: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZNF124 Gene

Publications for ZNF124 Gene

  1. A novel zinc finger gene on human chromosome 1qter that is alternatively spliced in human tissues and cell lines. (PMID: 7916577) Saleh M. … Evans G.A. (Am. J. Hum. Genet. 1993) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. (PMID: 21314694) Kendler K.S. … Gejman P.V. (Alcohol. Clin. Exp. Res. 2011) 3 48

Products for ZNF124 Gene

Sources for ZNF124 Gene

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