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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF124 Gene

protein-coding   GIFtS: 52
GCID: GC01M247285

Zinc Finger Protein 124

(Previous name: zinc finger protein 124 (HZF-16))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 1241 2
Zinc Finger Protein HZF-162 3
Zinc Finger Protein 124 (HZF-16)1
HZF-162
HZF162
ZK72

External Ids:    HGNC: 129071   Entrez Gene: 76782   Ensembl: ENSG000001964187   OMIM: 1946315   UniProtKB: Q159733   
ORGUL members:         
NONCODE14:n381378 n338620 n342379 n381379      

Export aliases for ZNF124 gene to outside databases

Previous GC identifers: GC01P245157 GC01P242540 GC01P243386 GC01M244265 GC01M244098 GC01M243645 GC01M245386 GC01M217713


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF124 Gene:
This gene encodes a member of the Kruppel-type (C2H2) zinc finger protein family. It has a KRAB-A box at its amino
terminus and seven consecutively repeated zinc finger motifs at its carboxy terminus. Expression of this gene is
increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and its
expression inhibits apoptotic cell death induced by irradiation or exposure to etoposide. These attributes
suggest that this protein may act as a transcription factor. Alternative splicing results in multiple transcript
variants encoding distinct proteins. Additional transcript variants have been described for this gene but their
biological validity has not been confirmed. This gene has a pseudogene on chromosome 14. (provided by RefSeq, Aug
2011)

GeneCards Summary for ZNF124 Gene: 
ZNF124 (zinc finger protein 124) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with ZNF124 include dandy-walker complex, and hepatoblastoma, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF669.

UniProtKB/Swiss-Prot: ZN124_HUMAN, Q15973
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF124 gene promoter:
         HFH-3   AML1a   NCX/Ncx   AREB6   FOXI1   MEF-2A   HEN1   Msx-1   aMEF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF124 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF124

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF124


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

ZNF124 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF124 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M247285:  view genomic region     (about GC identifiers)

Start:
247,285,277 bp from pter      End:
247,335,318 bp from pter
Size:
50,042 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ZNF124

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN124_HUMAN, Q15973 (See protein sequence)
Recommended Name: Zinc finger protein 124  
Size: 351 amino acids; 40217 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: B3KNP3 J3KSE1 Q15974 Q4VAJ7 Q5T2V4
Alternative splicing: 5 isoforms:  Q15973-3   Q15973-4   Q15973-1   Q15973-2   Q15973-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF124: NX_Q15973

Explore proteomics data for ZNF124 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15973

  • ZNF124 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF124 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001230669.1  NP_003422.2  

    ENSEMBL proteins: 
     ENSP00000462445   ENSP00000463191   ENSP00000340749   ENSP00000440365  
    Reactome Protein details: Q15973
    Human Recombinant Protein Products for ZNF124: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for ZNF124 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF124 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q15973

    ProtoNet protein and cluster: Q15973

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN124_HUMAN, Q15973
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 8 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF124 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN124_HUMAN, Q15973
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF124:
    zinc finger protein 127 (C2H2 type,Kruppel-like),from a hepatoblastoma cell line

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF124 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF124 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF124
        Generic Transcription Pathway
    Gene Expression



    ZNF124 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF124

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF124 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF124 (ZN124)

    Search CenterWatch for drugs/clinical trials and news about ZNF124 / ZN124

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF124 gene (2 alternative transcripts): 
    NM_001243740.1  NM_003431.2  

    Unigene Clusters for ZNF124:

    Zinc finger protein 124
    Hs.421238  [show with all ESTs], Hs.655205  [show with all ESTs], Hs.743338  [show with all ESTs]
    Unigene Representative Sequences: BG777901, S54641, NM_001243740
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472531(uc001ich.3 uc001ici.3) ENST00000476312 ENST00000491356
    ENST00000482970 ENST00000340684(uc001icj.1) ENST00000543802(uc001ick.3)
    ENST00000491848
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK054647.1 BC013605.1 BC032514.1 BC096349.4 BC096350.4 BC096351.2 BC099661.3 

    9 DOTS entries:

    DT.95264037  DT.40112015  DT.121463197  DT.99949212  DT.207536  DT.75100025  DT.91895679  DT.75106378 
    DT.91919497 

    24/33 AceView cDNA sequences (see all 33):

    AW197626 AA868224 S54641 BX951708 AW137277 AA629263 AK054647 NM_003431 
    AI024680 AA873762 AK131017 BG257604 AW615127 AA393367 BX477982 AA744900 
    T28214 BI767963 BX107933 AI014542 BC013605 BM791773 AI638722 AA398712 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF124    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f
    SP1:                          -                 -                                 
    SP2:                                            -                                 
    SP3:                          -                 -     -                           
    SP4:                          -                                                   


    ECgene alternative splicing isoforms for ZNF124

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF124 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCTCTGCA
    ZNF124 Expression
    About this image


    See ZNF124 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF124

    SOURCE GeneReport for Unigene clusters: Hs.421238 Hs.655205 Hs.743338
        SABiosciences Custom PCR Arrays for ZNF124
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ZNF124 (if available)
    TreeFam Gene Tree for ZNF124 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF124 gene
    ZNF6692  ZNF5642  ZNF4902  ZNF4412  ZNF625-ZNF202  ZNF8782  ENSG000002671792  ZNF142  
    ENSG000002697552  ENSG000001968262  ZNF7002  ZNF692  ZNF4402  ZNF4432  ZNF442  ZNF4392  
    ZNF8232  ENSG000001884742  ZNF4912  ZNF5552  ENSG000002688702  ZNF7092  ZNF6252  ZNF7992  
    ZNF202  ZNF7882  ZNF1012  ZNF7912  ZNF4422  ZNF4332  ZNF572  ZNF5632  
    ZNF6272  ENSG000002573552  ZNF1362  ZNF5562  ZNF6702  ZNF7632  ENSG000002687442  ZNF6992  
    ZNF8442  ZNF772  
    18/501 SIMAP similar genes for ZNF124 using alignment to 2 protein entries:     ZN124_HUMAN (see all proteins) (see all similar genes):
    ZNF761    ZNF846    ZNF669    ZNF229    ZNF235    ZNF625
    ZNF83    FIK    ZNF208    ZNF224    ZNF225    ZNF788
    ZNF320    ZNF527    ZNF624    ZNF573    ZNF616    ZNF596

    ZNF124 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ZNF124
    PGOHUM00000248166 PGOHUM00000263153 PGOHUM00000249257


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1192 SNPs in ZNF124 are shown (see all 1192)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819482601,2
    --247284815(+) ATTTAG/TTCTGC 1 -- ds50010--------
    rs66800331,2
    C,F,A--247285021(+) CTCCCG/AGGTTC 1 -- ds50014Minor allele frequency- A:0.43NA WA CSA 7
    rs2015567491,2
    C--247285029(+) TTCTA-/GCAATT 1 -- ds50010--------
    rs574187901,2
    C,F--247285040(+) CTCCTG/CCCTCA 1 -- ds50011Minor allele frequency- C:0.50WA 2
    rs49257011,2
    C,F,A--247285147(+) AGTCTT/CGAACT 1 -- ds50013Minor allele frequency- C:0.17NA WA 6
    rs49257021,2
    C,A--247285155(+) ACTCCC/TGAGCT 1 -- ds50010--------
    rs571734931,2
    F--247285223(+) GTGCCC/TAGTGA 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs49257031,2
    C,F,A,H--247285224(+) TGCCCA/GGTGAC 1 -- ds500119Minor allele frequency- G:0.30NS EA NA WA CSA 2339
    rs783380391,2
    F--247285239(+) AGTTTT/CCTCTG 1 -- ds50011Minor allele frequency- C:0.12WA 118
    rs1874125121,2
    --247285286(+) TAATAC/TTCATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF124 (247285277 - 247335318 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/25 variations for ZNF124 (see all 25):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1201683CNV Deletion17803354
    nsv821373CNV Deletion20802225
    esv2675826CNV Deletion23128226
    esv2727651CNV Deletion23290073
    esv2727640CNV Deletion23290073
    esv2727629CNV Deletion23290073
    esv2727662CNV Deletion23290073
    esv2727673CNV Deletion23290073
    nsv5287CNV Insertion18451855
    nsv509779CNV Insertion20534489

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 194631    OMIM disorders: --

    6 diseases for ZNF124:    About MalaCards
    dandy-walker complex    hepatoblastoma    endotheliitis    leukemia
    schizophrenia    squamous cell carcinoma


    ZNF124 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF124

    Export disorders for ZNF124 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF124 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with ZNF124)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel zinc finger gene on human chromosome 1qter that is alternatively spliced in human tissues and cell lines. (PubMed id 7916577)1, 2, 3 Saleh M.... Evans G.A. (1993)
    2. Genomewide association analysis of symptoms of alcoho l dependence in the molecular genetics of schizophrenia (MGS2) control sample. (PubMed id 21314694)1, 4 Kendler K.S....Gejman P.V. (2011)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
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    7. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    8. Dandy-Walker complex in a boy with a 5 Mb deletion of region 1q44 due to a paternal t(1;20)(q44;q13.33). (PubMed id 17431901)1 Poot M....Hochstenbach R. (2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7678 HGNC: 12907 AceView: ZNF124 Ensembl:ENSG00000196418 euGenes: HUgn7678
    ECgene: ZNF124 H-InvDB: ZNF124

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF124 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF124 gene:
    Search GeneIP for patents involving ZNF124

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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