Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF124 Gene

Aliases for ZNF124 Gene

  • Zinc Finger Protein 124 2 3 5
  • Zinc Finger Protein HZF-16 3 4
  • Zinc Finger Protein 124 (HZF-16) 2
  • HZF-16 3
  • HZF16 3
  • ZK7 3

External Ids for ZNF124 Gene

Previous GeneCards Identifiers for ZNF124 Gene

  • GC01P245157
  • GC01P242540
  • GC01P243386
  • GC01M244265
  • GC01M244098
  • GC01M243645
  • GC01M245386
  • GC01M247285
  • GC01M217713

Summaries for ZNF124 Gene

Entrez Gene Summary for ZNF124 Gene

  • This gene encodes a protein with an amino-terminal KRAB-A box and multiple repeated Kruppel-type (C2H2) zinc finger motifs at its carboxy terminus. The encoded protein may function as a transcription factor. Expression of this gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and results in inhibition of apoptotic cell death induced by irradiation or exposure to etoposide. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2014]

GeneCards Summary for ZNF124 Gene

ZNF124 (Zinc Finger Protein 124) is a Protein Coding gene. Diseases associated with ZNF124 include dandy-walker complex. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000196826.

UniProtKB/Swiss-Prot for ZNF124 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF124 Gene

Genomics for ZNF124 Gene

Regulatory Elements for ZNF124 Gene

Promoters for ZNF124 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF124 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF124 Gene

Chromosome:
1
Start:
247,121,975 bp from pter
End:
247,172,438 bp from pter
Size:
50,464 bases
Orientation:
Minus strand

Genomic View for ZNF124 Gene

Genes around ZNF124 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF124 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF124 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF124 Gene

Proteins for ZNF124 Gene

  • Protein details for ZNF124 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15973-ZN124_HUMAN
    Recommended name:
    Zinc finger protein 124
    Protein Accession:
    Q15973
    Secondary Accessions:
    • B3KNP3
    • J3KSE1
    • Q15974
    • Q4VAJ7
    • Q5T2V4

    Protein attributes for ZNF124 Gene

    Size:
    351 amino acids
    Molecular mass:
    40217 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF124 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF124 Gene

Proteomics data for ZNF124 Gene at MOPED

Post-translational modifications for ZNF124 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF124 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF124 Gene

Domains & Families for ZNF124 Gene

Gene Families for ZNF124 Gene

Protein Domains for ZNF124 Gene

Suggested Antigen Peptide Sequences for ZNF124 Gene

Graphical View of Domain Structure for InterPro Entry

Q15973

UniProtKB/Swiss-Prot:

ZN124_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF124: view

Function for ZNF124 Gene

Molecular function for ZNF124 Gene

GENATLAS Biochemistry:
zinc finger protein 127 (C2H2 type,Kruppel-like),from a hepatoblastoma cell line
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF124: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF124 Gene

Localization for ZNF124 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF124 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF124 Gene COMPARTMENTS Subcellular localization image for ZNF124 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF124 Gene

Pathways & Interactions for ZNF124 Gene

SuperPathways for ZNF124 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF124: view

Pathways by source for ZNF124 Gene

2 Reactome pathways for ZNF124 Gene

Gene Ontology (GO) - Biological Process for ZNF124 Gene

None

No data available for SIGNOR curated interactions for ZNF124 Gene

Drugs & Compounds for ZNF124 Gene

No Compound Related Data Available

Transcripts for ZNF124 Gene

Unigene Clusters for ZNF124 Gene

Zinc finger protein 124:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF124 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for ZNF124 Gene

GeneLoc Exon Structure for
ZNF124
ECgene alternative splicing isoforms for
ZNF124

Expression for ZNF124 Gene

mRNA expression in normal human tissues for ZNF124 Gene

Protein differential expression in normal tissues from HIPED for ZNF124 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (44.5) and Heart (24.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF124 Gene



SOURCE GeneReport for Unigene cluster for ZNF124 Gene Hs.421238

genes like me logo Genes that share expression patterns with ZNF124: view

Protein tissue co-expression partners for ZNF124 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF124 Gene

Orthologs for ZNF124 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF124 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia LOC102637111 35
  • 70.66 (n)
  • 59.93 (a)
Gm20541 16
Gm20422 36
  • 20 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF124 35
  • 91.58 (n)
  • 88.93 (a)
ZNF124 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF124 36
  • 34 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF124 36
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF557 36
  • 32 (a)
OneToMany
Species with no ortholog for ZNF124:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF124 Gene

ENSEMBL:
Gene Tree for ZNF124 (if available)
TreeFam:
Gene Tree for ZNF124 (if available)

Paralogs for ZNF124 Gene

(503) SIMAP similar genes for ZNF124 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF124 Gene

genes like me logo Genes that share paralogs with ZNF124: view

Variants for ZNF124 Gene

Sequence variations from dbSNP and Humsavar for ZNF124 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1059347 -- 247,157,687(-) TTTAT(C/G)TTCAA intron-variant
rs924085 -- 247,149,173(-) CTTGT(A/G)TAAGC intron-variant
rs990789 -- 247,162,451(+) taaat(C/T)tagga intron-variant
rs2067086 -- 247,132,476(+) gatgg(C/G)taata intron-variant
rs2890107 -- 247,123,595(+) ttcca(A/C)gttct utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF124 Gene

Variant ID Type Subtype PubMed ID
nsv873424 CNV Gain 21882294
esv33129 CNV Gain+Loss 17666407
nsv873428 CNV Loss 21882294
dgv562n71 CNV Loss 21882294
nsv509779 CNV Insertion 20534489
nsv833126 CNV Loss 17160897
nsv5287 CNV Insertion 18451855
nsv873432 CNV Loss 21882294
nsv873433 CNV Loss 21882294
nsv499487 OTHER Inversion 21111241
nsv513639 OTHER Inversion 21212237
esv1225151 OTHER Inversion 17803354
nsv7192 OTHER Inversion 18451855
nsv821373 CNV Deletion 20802225
esv2727629 CNV Deletion 23290073
esv24532 CNV Gain+Loss 19812545
esv2727640 CNV Deletion 23290073
esv1201683 CNV Deletion 17803354
esv2727651 CNV Deletion 23290073
esv2727662 CNV Deletion 23290073
esv2727673 CNV Deletion 23290073
esv2675826 CNV Deletion 23128226
esv272773 CNV Insertion 20981092
nsv873434 CNV Loss 21882294
esv1441492 OTHER Inversion 17803354

Variation tolerance for ZNF124 Gene

Residual Variation Intolerance Score: 70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF124 Gene

HapMap Linkage Disequilibrium report
ZNF124

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF124 Gene

Disorders for ZNF124 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF124 Gene - From: GeneCards

Disorder Aliases PubMed IDs
dandy-walker complex
  • dandy-walker syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF124

Genetic Association Database (GAD)
ZNF124
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF124
genes like me logo Genes that share disorders with ZNF124: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF124 Gene

Publications for ZNF124 Gene

  1. A novel zinc finger gene on human chromosome 1qter that is alternatively spliced in human tissues and cell lines. (PMID: 7916577) Saleh M. … Evans G.A. (Am. J. Hum. Genet. 1993) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3
  4. Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. (PMID: 21314694) Kendler K.S. … Gejman P.V. (Alcohol. Clin. Exp. Res. 2011) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for ZNF124 Gene

Sources for ZNF124 Gene

Back to Top

Content