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Aliases for ZNF121 Gene

Aliases for ZNF121 Gene

  • Zinc Finger Protein 121 2 3
  • Zinc Finger Protein 121 (Clone ZHC32) 2 3
  • Zinc Finger Protein 20 3 4
  • ZNF20 3 4
  • D19S204 3
  • ZHC32 3

External Ids for ZNF121 Gene

Previous HGNC Symbols for ZNF121 Gene

  • D19S204

Previous GeneCards Identifiers for ZNF121 Gene

  • GC19U990136
  • GC19M009676
  • GC19M009257

Summaries for ZNF121 Gene

GeneCards Summary for ZNF121 Gene

ZNF121 (Zinc Finger Protein 121) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF426.

UniProtKB/Swiss-Prot for ZNF121 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF121 Gene

Genomics for ZNF121 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF121 Gene

Chromosome:
19
Start:
9,560,353 bp from pter
End:
9,584,545 bp from pter
Size:
24,193 bases
Orientation:
Minus strand

Genomic View for ZNF121 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF121 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF121 Gene

No data available for Regulatory Elements for ZNF121 Gene

Proteins for ZNF121 Gene

  • Protein details for ZNF121 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58317-ZN121_HUMAN
    Recommended name:
    Zinc finger protein 121
    Protein Accession:
    P58317

    Protein attributes for ZNF121 Gene

    Size:
    390 amino acids
    Molecular mass:
    44694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF121 Gene

Proteomics data for ZNF121 Gene at MOPED

Post-translational modifications for ZNF121 Gene

  • Ubiquitination at Lys 385
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF121 Gene

No data available for DME Specific Peptides for ZNF121 Gene

Domains & Families for ZNF121 Gene

Gene Families for ZNF121 Gene

Protein Domains for ZNF121 Gene

Suggested Antigen Peptide Sequences for ZNF121 Gene

Graphical View of Domain Structure for InterPro Entry

P58317

UniProtKB/Swiss-Prot:

ZN121_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF121: view

Function for ZNF121 Gene

Molecular function for ZNF121 Gene

GENATLAS Biochemistry:
zinc finger protein 121 (clone ZHC32),KRAB subfamily
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF121: view

Phenotypes for ZNF121 Gene

GenomeRNAi human phenotypes for ZNF121:
genes like me logo Genes that share phenotypes with ZNF121: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF121

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF121 Gene

Localization for ZNF121 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF121 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF121 Gene COMPARTMENTS Subcellular localization image for ZNF121 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF121: view

Pathways & Interactions for ZNF121 Gene

SuperPathways for ZNF121 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF121: view

Pathways by source for ZNF121 Gene

2 Reactome pathways for ZNF121 Gene

Gene Ontology (GO) - Biological Process for ZNF121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF121: view

No data available for SIGNOR curated interactions for ZNF121 Gene

Drugs & Compounds for ZNF121 Gene

No Compound Related Data Available

Transcripts for ZNF121 Gene

mRNA/cDNA for ZNF121 Gene

(6) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF121 Gene

Zinc finger protein 121:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF121

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF121 Gene

No ASD Table

Relevant External Links for ZNF121 Gene

GeneLoc Exon Structure for
ZNF121
ECgene alternative splicing isoforms for
ZNF121

Expression for ZNF121 Gene

mRNA expression in normal human tissues for ZNF121 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF121 Gene



SOURCE GeneReport for Unigene cluster for ZNF121 Gene Hs.501537

genes like me logo Genes that share expression patterns with ZNF121: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF121 Gene

Orthologs for ZNF121 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF121 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF121 35
  • 99.83 (n)
  • 99.74 (a)
ZNF121 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 24 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp560 36
  • 28 (a)
ManyToMany
Species with no ortholog for ZNF121:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF121 Gene

ENSEMBL:
Gene Tree for ZNF121 (if available)
TreeFam:
Gene Tree for ZNF121 (if available)

Paralogs for ZNF121 Gene

Paralogs for ZNF121 Gene

(503) SIMAP similar genes for ZNF121 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF121: view

Variants for ZNF121 Gene

Sequence variations from dbSNP and Humsavar for ZNF121 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1559200 -- 9,567,859(+) CAAGC(A/G)ATGGG intron-variant
rs2431497 -- 9,565,845(+) GTACC(A/C)ATAAA utr-variant-3-prime
rs12460745 -- 9,573,786(+) tccag(C/G)tggtc intron-variant
rs12461440 -- 9,586,249(+) ATACT(A/C)TAAAG upstream-variant-2KB
rs12461500 -- 9,568,478(+) TCAAG(C/T)GATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF121 Gene

Variant ID Type Subtype PubMed ID
nsv911024 CNV Loss 21882294
esv2718156 CNV Deletion 23290073

Variation tolerance for ZNF121 Gene

Residual Variation Intolerance Score: 17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF121 Gene

HapMap Linkage Disequilibrium report
ZNF121

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF121 Gene

Disorders for ZNF121 Gene

Relevant External Links for ZNF121

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF121
genes like me logo Genes that share disorders with ZNF121: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF121 Gene

Publications for ZNF121 Gene

  1. A novel zinc finger cDNA with a polymorphic pentanucleotide repeat (ATTTT)n maps on human chromosome 19p. (PMID: 8468057) Chen H. … Antonarakis S.E. (Genomics 1993) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 67
  4. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. (PMID: 17314511) Koch H.B. … Hermeking H. (Cell Cycle 2007) 67
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 67

Products for ZNF121 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF121
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF121
    • Block miRNA regulation of ZNF121 using miScript Target Protectors

    Sources for ZNF121 Gene

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