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Aliases for ZNF121 Gene

Aliases for ZNF121 Gene

  • Zinc Finger Protein 121 2 3
  • Zinc Finger Protein 121 (Clone ZHC32) 2 3
  • Zinc Finger Protein 20 3 4
  • D19S204 3 6
  • ZNF20 3 4
  • ZHC32 3

External Ids for ZNF121 Gene

Previous Symbols for ZNF121 Gene

  • D19S204

Summaries for ZNF121 Gene

GeneCards Summary for ZNF121 Gene

ZNF121 (Zinc Finger Protein 121) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF426.

UniProtKB/Swiss-Prot for ZNF121 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF121 Gene

Genomics for ZNF121 Gene

Genomic Location for ZNF121 Gene

Start:
9,560,353 bp from pter
End:
9,584,533 bp from pter
Size:
24,181 bases
Orientation:
Minus strand

Genomic View for ZNF121 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF121 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF121 Gene

No data available for Regulatory Elements for ZNF121 Gene

Proteins for ZNF121 Gene

  • Protein details for ZNF121 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58317-ZN121_HUMAN
    Recommended name:
    Zinc finger protein 121
    Protein Accession:
    P58317
    Secondary Accessions:

    Protein attributes for ZNF121 Gene

    Size:
    390 amino acids
    Molecular mass:
    44694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF121 Gene

Proteomics data for ZNF121 Gene at MOPED

Post-translational modifications for ZNF121 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys226 and Lys385

Other Protein References for ZNF121 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF121 Gene

Domains for ZNF121 Gene

Gene Families for ZNF121 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF121 Gene

UniProtKB/Swiss-Prot:

ZN121_HUMAN
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • P58317
Similarity:
  • Contains 11 C2H2-type zinc fingers.:
    • P58317
genes like me logo Genes that share domains with ZNF121: view

Function for ZNF121 Gene

Molecular function for ZNF121 Gene

GENATLAS Biochemistry: zinc finger protein 121 (clone ZHC32),KRAB subfamily
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF121: view

miRNA for ZNF121 Gene

miRTarBase miRNAs that target ZNF121

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF121 Gene

Localization for ZNF121 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF121 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF121 Gene COMPARTMENTS Subcellular localization image for ZNF121 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF121: view

Pathways for ZNF121 Gene

SuperPathways for ZNF121 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF121: view

Pathways by source for ZNF121 Gene

2 Reactome pathways for ZNF121 Gene

Gene Ontology (GO) - Biological Process for ZNF121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF121: view

Transcripts for ZNF121 Gene

mRNA/cDNA for ZNF121 Gene

(5) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF121 Gene

Zinc finger protein 121:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF121 Gene

No ASD Table

Relevant External Links for ZNF121 Gene

GeneLoc Exon Structure for
ZNF121
ECgene alternative splicing isoforms for
ZNF121

Expression for ZNF121 Gene

mRNA expression in normal human tissues for ZNF121 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF121 Gene

SOURCE GeneReport for Unigene cluster for ZNF121 Gene Hs.501537

genes like me logo Genes that share expressions with ZNF121: view

Orthologs for ZNF121 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF121 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF121 36
  • 99.83 (n)
  • 99.74 (a)
ZNF121 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 24 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp560 37
  • 28 (a)
ManyToMany
Species with no ortholog for ZNF121:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF121 Gene

ENSEMBL:
Gene Tree for ZNF121 (if available)
TreeFam:
Gene Tree for ZNF121 (if available)

Paralogs for ZNF121 Gene

Paralogs for ZNF121 Gene

Selected SIMAP similar genes for ZNF121 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF121: view

Variants for ZNF121 Gene

Sequence variations from dbSNP and Humsavar for ZNF121 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1559200 -- 9,567,859(+) CAAGC(A/G)ATGGG intron-variant
rs2431497 -- 9,565,845(+) GTACC(A/C)ATAAA utr-variant-3-prime
rs4283331 -- 9,569,154(+) AAAAA(C/T)AACTA intron-variant
rs4804448 -- 9,568,292(+) AAAAA(A/G)TTAAA intron-variant
rs4804449 -- 9,574,179(+) ctcat(C/T)ctgtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF121 Gene

Variant ID Type Subtype PubMed ID
nsv911024 CNV Loss 21882294
esv2718156 CNV Deletion 23290073

Relevant External Links for ZNF121 Gene

HapMap Linkage Disequilibrium report
ZNF121

Disorders for ZNF121 Gene

No disorders were found for ZNF121 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF121 Gene

Publications for ZNF121 Gene

  1. A novel zinc finger cDNA with a polymorphic pentanucleotide repeat (ATTTT)n maps on human chromosome 19p. (PMID: 8468057) Chen H. … Antonarakis S.E. (Genomics 1993) 2 3 4
  2. Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets. (PMID: 12934113) Ohira M. … Nakagawara A. (Oncogene 2003) 3
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  4. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. (PMID: 17314511) Koch H.B. … Hermeking H. (Cell Cycle 2007) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for ZNF121 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF121
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF121
    • Block miRNA regulation of ZNF121 using miScript Target Protectors

    Sources for ZNF121 Gene

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