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ZNF121 Gene

protein-coding   GIFtS: 44
GCID: GC19M009676

Zinc Finger Protein 121

(Previous name: zinc finger protein 121 (clone ZHC32))
(Previous symbol: D19S204)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 1211 2
D19S2041 2 5
Zinc Finger Protein 121 (Clone ZHC32)1 2
Zinc Finger Protein 202 3
ZNF202 3
ZHC322

External Ids:    HGNC: 129041   Entrez Gene: 76752   Ensembl: ENSG000001979617   OMIM: 1946285   UniProtKB: P583173   

Export aliases for ZNF121 gene to outside databases

Previous GC identifers: GC19U990136 GC19M009538 GC19M009257


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF121 Gene:
ZNF121 (zinc finger protein 121) is a protein-coding gene. Diseases associated with ZNF121 include papillary thyroid carcinoma, and neuroblastoma. An important paralog of this gene is ZNF812.

UniProtKB/Swiss-Prot: ZN121_HUMAN, P58317
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF121
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF121 promoter sequence
   Search Chromatin IP Primers for ZNF121

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF121


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF121 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF121 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M009676:  view genomic region     (about GC identifiers)

Start:
9,671,029 bp from pter      End:
9,695,209 bp from pter
Size:
24,181 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN121_HUMAN, P58317 (See protein sequence)
Recommended Name: Zinc finger protein 121  
Size: 390 amino acids; 44694 Da

Explore the universe of human proteins at neXtProt for ZNF121: NX_P58317

Explore proteomics data for ZNF121 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys226, Lys385
  • Modification sites at PhosphoSitePlus

  • See ZNF121 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001008727.1  
    ENSEMBL proteins: 
     ENSP00000468643   ENSP00000326967   ENSP00000467838  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P58317

    ProtoNet protein and cluster: P58317

    UniProtKB/Swiss-Prot: ZN121_HUMAN, P58317
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers


    ZNF121 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN121_HUMAN, P58317
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF121:
    zinc finger protein 121 (clone ZHC32),KRAB subfamily

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    ZNF121 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-mir-484 (MIRT041775)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN121_HUMAN, P58317: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF121 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF121
    Interactions:

        Search GeneGlobe Interaction Network for ZNF121

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF121 (P583173 ENSP000003269674) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    CCAR2Q8N1633, ENSP000003106704I2D: score=1 STRING: ENSP00000310670
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    ZNF121 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF121 (ZN121)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF121 gene: 
    NM_001008727.2  

    Unigene Cluster for ZNF121:

    Zinc finger protein 121
    Hs.501537  [show with all ESTs]
    Unigene Representative Sequence: NM_001008727
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000590933 ENST00000586602 ENST00000320451(uc010xkp.1 uc010dwt.2 uc010xkq.1)
    ENST00000591447
    miRNA
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    Additional mRNA sequence: AK297919.1 

    3 DOTS entries:

    DT.40312111  DT.121425507  DT.100888162 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF121 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF121 Expression
    About this image

    ZNF121 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF121 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501537
        Custom PCR Arrays for ZNF121
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF121

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for ZNF121 (if available)
    TreeFam Gene Tree for ZNF121 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF121 gene
    ZNF8122  ZNF7782  ZNF2662  ZNF4262  ZNF5602  ZNF8462  ZNF5612  ZNF5592  
    ZNF5622  
    Selected SIMAP similar genes for ZNF121 using alignment to 2 protein entries:     ZN121_HUMAN (see all proteins) (see all similar genes):
    ZNF778    ZNF266    DKFZp313M0722    ZNF323    HZF36    ZFS-4
    ZSCAN22    DKFZp666C237    DKFZp686H10254    ZFS-2    ZNF566    ZSCAN21
    ZNF19    ZNF501    ZNF684    smap-7    DKFZp686N14223    GLI4

    ZNF121 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF121 (see all 492)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394723491,2
    --9675926(+) GGCTTC/TCTGTG 1 -- ds50010--------
    rs1845988351,2
    C--9675949(+) TATGGC/TCCCAT 1 -- ds50010--------
    rs1424750811,2
    C--9676028(+) GACTT-/ACAA  
      AAAAAA
    AAAAA
    1 -- ds50010--------
    rs2012342021,2
    --9676028(+) GACTT-/ACAAA 
    AAAAAAAA
    AAAAA
    1 -- ds50010--------
    rs776503061,2
    C--9676029(+) ACTTAC/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1495991151,2
    C--9676087(+) ACTCCC/TATAAT 1 -- ds50010--------
    rs1442832611,2
    --9676165(+) ACATGA/GTGAAA 1 -- ds50010--------
    rs1121376871,2
    C,F--9676253(+) GGCAGA/GATCGC 1 -- ds50013Minor allele frequency- G:0.08CSA WA 122
    rs594952451,2
    --9676286(+) GCAGTA/GAGCTG 1 -- ds50010--------
    rs1161109071,2
    C,F--9676294(+) CTGGGA/GTCATG 1 -- ut311Minor allele frequency- G:0.09WA 118

    HapMap Linkage Disequilibrium report for ZNF121 (9671029 - 9695209 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF121:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718156CNV Deletion23290073
    nsv911024CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 194628    OMIM disorders: --

    3 diseases for ZNF121:    
    About MalaCards
    papillary thyroid carcinoma    neuroblastoma    thyroiditis


    ZNF121 for disorders           About GeneDecksing


    Export disorders for ZNF121 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF121 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF121)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel zinc finger cDNA with a polymorphic pentanucleotide repeat (ATTTT)n maps on human chromosome 19p. (PubMed id 8468057)1, 2, 3 Chen H....Antonarakis S.E. (Genomics 1993)
    2. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    5. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. (PubMed id 17314511)1 Koch H.B....Hermeking H. (Cell Cycle 2007)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    7. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    8. Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets. (PubMed id 12934113)1 Ohira M....Nakagawara A. (Oncogene 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7675 HGNC: 12904 Ensembl:ENSG00000197961 euGenes: HUgn7675 ECgene: ZNF121
    H-InvDB: ZNF121

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF121 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF121 gene:
    Search GeneIP for patents involving ZNF121

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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