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Aliases for ZNF121 Gene

Aliases for ZNF121 Gene

  • Zinc Finger Protein 121 2 3 5
  • Zinc Finger Protein 121 (Clone ZHC32) 2 3
  • Zinc Finger Protein 20 3 4
  • ZNF20 3 4
  • D19S204 3
  • ZHC32 3

External Ids for ZNF121 Gene

Previous HGNC Symbols for ZNF121 Gene

  • D19S204

Previous GeneCards Identifiers for ZNF121 Gene

  • GC19U990136
  • GC19M009676
  • GC19M009257

Summaries for ZNF121 Gene

GeneCards Summary for ZNF121 Gene

ZNF121 (Zinc Finger Protein 121) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF560.

UniProtKB/Swiss-Prot for ZNF121 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF121 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF121 Gene

Genomics for ZNF121 Gene

Regulatory Elements for ZNF121 Gene

Enhancers for ZNF121 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H010100 1.8 FANTOM5 ENCODE dbSUPER 58.2 -519.8 -519843 8.3 HDGF FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 ILF3 ZNF699 ZNF317 KRI1 FBXL12 LOC100419831 ZNF561 ZNF559 PPAN ZNF562
GH19H010379 1.1 ENCODE 39.4 -796.0 -795982 1.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ZNF207 ILF3 KRI1 FBXL12 PPAN RAVER1 DNMT1 LOC100419831 ZNF561 ZNF426 TIMM29
GH19H010415 1.5 FANTOM5 ENCODE 20.4 -832.1 -832101 2 MLX DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 ZNF610 LOC100419831 ZNF266 ILF3 FBXL12 KRI1 DNMT1 PPAN RAVER1 ZNF426 ZNF561
GH19H010005 1.2 FANTOM5 ENCODE 17.3 -423.8 -423768 4.8 HDGF PKNOX1 FEZF1 GLI4 GLIS2 FOS SP3 TSHZ1 MIER2 REST LOC100419831 ZNF559 COL5A3 ZNF699 ZNF177 ILF3 FBXL12 ZNF266 KRI1 ZNF121
GH19H010427 1.7 FANTOM5 Ensembl ENCODE 11.7 -846.0 -846020 6.5 HDGF PKNOX1 ATF1 FOXA2 ARNT YBX1 GTF3C2 ELK1 ZNF143 ATF7 EIF3G ZNF266 KRI1 ILF3 PPAN ZNF561 PDE4A RAVER1 FBXL12 TIMM29
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF121 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF121 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106903 545 2001 ATF1 MLX ARID4B SIN3A DMAP1 BRCA1 YY1 ETS1 GTF3C2 ELK1

Genomic Locations for ZNF121 Gene

Genomic Locations for ZNF121 Gene
24,193 bases
Minus strand

Genomic View for ZNF121 Gene

Genes around ZNF121 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF121 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF121 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF121 Gene

Proteins for ZNF121 Gene

  • Protein details for ZNF121 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 121
    Protein Accession:

    Protein attributes for ZNF121 Gene

    390 amino acids
    Molecular mass:
    44694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF121 Gene

Post-translational modifications for ZNF121 Gene

  • Ubiquitination at isoforms=385
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF121 Gene

No data available for DME Specific Peptides for ZNF121 Gene

Domains & Families for ZNF121 Gene

Gene Families for ZNF121 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF121 Gene

Suggested Antigen Peptide Sequences for ZNF121 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF121: view

Function for ZNF121 Gene

Molecular function for ZNF121 Gene

GENATLAS Biochemistry:
zinc finger protein 121 (clone ZHC32),KRAB subfamily
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF121 Gene

Gene Ontology (GO) - Molecular Function for ZNF121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF121: view
genes like me logo Genes that share phenotypes with ZNF121: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF121 Gene

Localization for ZNF121 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF121 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF121 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (1)
  • Nucleoli (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF121: view

Pathways & Interactions for ZNF121 Gene

SuperPathways for ZNF121 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF121: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF121 Gene

Drugs & Compounds for ZNF121 Gene

No Compound Related Data Available

Transcripts for ZNF121 Gene

mRNA/cDNA for ZNF121 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF121 Gene

Zinc finger protein 121:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF121 Gene

No ASD Table

Relevant External Links for ZNF121 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF121 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF121 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF121 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF121 Gene:


SOURCE GeneReport for Unigene cluster for ZNF121 Gene:


Evidence on tissue expression from TISSUES for ZNF121 Gene

  • Spleen(2)
genes like me logo Genes that share expression patterns with ZNF121: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF121 Gene

Orthologs for ZNF121 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF121 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF121 33 34
  • 99.83 (n)
(Mus musculus)
Mammalia Zfp560 34
  • 28 (a)
(Bos Taurus)
Mammalia -- 34
  • 24 (a)
Species where no ortholog for ZNF121 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF121 Gene

Gene Tree for ZNF121 (if available)
Gene Tree for ZNF121 (if available)

Paralogs for ZNF121 Gene

(503) SIMAP similar genes for ZNF121 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF121: view

Variants for ZNF121 Gene

Sequence variations from dbSNP and Humsavar for ZNF121 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000014409 -- 9,584,516(+) GCGGA(G/T)CCAGC utr-variant-5-prime
rs1000069908 -- 9,569,263(+) CCCAC(C/T)ATTCA intron-variant
rs1000093531 -- 9,582,964(+) TAATC(C/T)CAGCT intron-variant
rs1000166167 -- 9,574,682(+) GGAGG(A/C)AGTAA intron-variant
rs1000375271 -- 9,579,683(+) AGAGG(C/T)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF121 Gene

Variant ID Type Subtype PubMed ID
nsv1060112 CNV gain 25217958
esv2718156 CNV deletion 23290073

Variation tolerance for ZNF121 Gene

Residual Variation Intolerance Score: 17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF121 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF121 Gene

Disorders for ZNF121 Gene

Relevant External Links for ZNF121

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF121 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF121 Gene

Publications for ZNF121 Gene

  1. A novel zinc finger cDNA with a polymorphic pentanucleotide repeat (ATTTT)n maps on human chromosome 19p. (PMID: 8468057) Chen H … Antonarakis SE (Genomics 1993) 2 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods NT … Monteiro AN (Science signaling 2012) 3 60

Products for ZNF121 Gene

Sources for ZNF121 Gene

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