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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF121 Gene

protein-coding   GIFtS: 41
GCID: GC19M009676

zinc finger protein 121

(Previous name: zinc finger protein 121 (clone ZHC32) )
(Previous symbol: D19S204)
 Explore 5 diseases affiliated with
ZNF121 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZNF121    

Aliases
for ZNF121 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zinc Finger Protein 1211 2
ZNF201 2 3
D19S2041 2 5
ZHC321 2
Zinc Finger Protein 121 (Clone ZHC32)1 2
Zinc Finger Protein 202 3

External Ids:    HGNC: 129041   Entrez Gene: 76752   Ensembl: ENSG000001979617   OMIM: 1946285   UniProtKB: P583173   

Export aliases for ZNF121 gene to outside databases

Previous GC identifers: GC19U990136 GC19M009538 GC19M009257


Summaries
for ZNF121 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ZN121_HUMAN, P58317
Function: May be involved in transcriptional regulation




Genomic Views
for ZNF121 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF121
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF121 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF121

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF121


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF121 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF121 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M009676:  view genomic region     (about GC identifiers)

Start:
 9,671,029 bp from pter      End:
 9,695,209 bp from pter
Size:
 24,181 bases      Orientation:
 minus strand

Proteins
for ZNF121 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZN121_HUMAN, P58317 (See protein sequence)
Recommended Name: Zinc finger protein 121  
Size: 390 amino acids; 44694 Da
Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for ZNF121: NX_P58317

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P58317

    • ZNF121 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001008727.1  
    ENSEMBL proteins: 
     ENSP00000468643   ENSP00000467491   ENSP00000467838   ENSP00000326967  

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    Uscn Proteins for ZNF121

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    ZNF121 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ZNF121 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZNF121 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P58317

    ProtoNet protein and cluster: P58317

    UniProtKB/Swiss-Prot: ZN121_HUMAN, P58317
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers


    Function
    for ZNF121 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZN121_HUMAN, P58317
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF121:
    zinc finger protein 121 (clone ZHC32),KRAB subfamily

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    ZNF121 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ZNF121 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF121

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF121 (P583173 ENSP000003269674) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    KIAA1967Q8N1633, ENSP000003106704I2D: score=1 STRING: ENSP00000310670
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    ZNF121 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZNF121 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF121
    Search CenterWatch for drugs/clinical trials and news about ZNF121 / ZN121 

    Transcripts
    for ZNF121 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for ZNF121 gene: 
    NM_001008727.2  

    Unigene Cluster for ZNF121:

    Zinc finger protein 121
    Hs.501537  [show with all ESTs]
    Unigene Representative Sequence: NM_001008727
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000590933 ENST00000586602 ENST00000588400 ENST00000591447 ENST00000320451(uc010xkp.1 uc010dwt.2 uc010xkq.1)


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    Inhib. RNA
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    Additional cDNA sequence: AK297919.1 

    3 DOTS entries:

    DT.40312111  DT.121425507  DT.100888162 

    GeneLoc Exon Structure


    Expression
    for ZNF121 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF121 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZNF121 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZNF121 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.501537
        SABiosciences Custom PCR Arrays for ZNF121
    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for ZNF121 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for ZNF121 (if available)
    TreeFam Gene Tree for ZNF121 (if available) 

    Paralogs
    for ZNF121 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF121 gene
    ZNF8122  ZNF7782  ZNF4262  ZNF2662  ZNF5602  ZNF8462  ZNF5612  ZNF5592  
    ZNF5622  
    18/503 SIMAP similar genes for ZNF121 using alignment to 3 protein entries:     ZN121_HUMAN (see all proteins) (see all similar genes):
    ZNF266    DKFZp313M0722    ZFS-4    ZSCAN22    DKFZp686H10254    ZNF566
    ZNF19    ZNF501    ZNF684    DKFZp686N14223    GLI4    HZF30
    ZNF146    ZNF383    ZNF514    ZNF516    ZNF577    ZNF662

    ZNF121 for paralogs           About GeneDecksing



    Genomic Variants
    for ZNF121 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/418 NCBI SNPs in ZNF121 are shown (see all 418)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1394723491,2
    		--9675926(+) GGCTTC/TCTGTG 1 -- ds50010--------
    rs1845988351,2
    		C,--9675949(+) TATGGC/TCCCAT 1 -- ds50010--------
    rs1424750811,2
    		--9676028(+) GACTT-/ACAA  
      AAAAAA    AAAAA     		1 -- ds50010--------
    rs2012342021,2
    		--9676028(+) GACTT-/ACAAA 
    AAAAAAAA    AAAAA     		1 -- ds50010--------
    rs776503061,2
    		C--9676029(+) ACTTAC/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1495991151,2
    		--9676087(+) ACTCCC/TATAAT 1 -- ds50010--------
    rs1442832611,2
    		--9676165(+) ACATGA/GTGAAA 1 -- ds50010--------
    rs1121376871,2
    		F,--9676253(+) GGCAGA/GATCGC 1 -- ds50013Minor allele frequency- G:0.08CSA WA 122
    rs594952451,2
    		--9676286(+) GCAGTA/GAGCTG 1 -- ds50010--------
    rs1161109071,2
    		F,--9676294(+) CTGGGA/GTCATG 1 -- ut311Minor allele frequency- G:0.09WA 118

    HapMap Linkage Disequilibrium report for ZNF121 (9671029 - 9695209 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNF121: --

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    Disorders / Diseases
    for ZNF121 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZNF121 for disorders           About GeneDecksing

    OMIM gene information: 194628    OMIM disorders: --

    5 diseases for ZNF121:    About MalaCards
    papillary thyroid carcinoma    thyroid carcinoma    neuroblastoma    thyroiditis
    carcinoma


    Export disorders for ZNF121 gene to outside databases

    Publications
    for ZNF121 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF121 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF121)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel zinc finger cDNA with a polymorphic pentanucleotide repeat (ATTTT)n maps on human chromosome 19p. (PubMed id 8468057)1, 2, 3 Chen H....Antonarakis S.E. (1993)
    2. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. (PubMed id 17314511)1 Koch H.B....Hermeking H. (2007)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    7. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
    8. Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets. (PubMed id 12934113)1 Ohira M....Nakagawara A. (2003)

    External Searches for ZNF121 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZNF121 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7675 HGNC: 12904 Ensembl:ENSG00000197961 euGenes: HUgn7675 ECgene: ZNF121
    H-InvDB: ZNF121

    Other Databases showing ZNF121 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZNF121 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF121 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZNF121 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZNF121 gene:
    Search GeneIP for patents involving ZNF121

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ZNF121 gene

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    About This Section

     
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