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Aliases for ZNF121 Gene

Aliases for ZNF121 Gene

  • Zinc Finger Protein 121 2 3 5
  • Zinc Finger Protein 121 (Clone ZHC32) 2 3
  • Zinc Finger Protein 20 3 4
  • ZNF20 3 4
  • D19S204 3
  • ZHC32 3

External Ids for ZNF121 Gene

Previous HGNC Symbols for ZNF121 Gene

  • D19S204

Previous GeneCards Identifiers for ZNF121 Gene

  • GC19U990136
  • GC19M009676
  • GC19M009257

Summaries for ZNF121 Gene

GeneCards Summary for ZNF121 Gene

ZNF121 (Zinc Finger Protein 121) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF562.

UniProtKB/Swiss-Prot for ZNF121 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF121 Gene

Genomics for ZNF121 Gene

Regulatory Elements for ZNF121 Gene

Enhancers for ZNF121 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF121 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF121 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF121 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF121 Gene

9,560,353 bp from pter
9,584,545 bp from pter
24,193 bases
Minus strand

Genomic View for ZNF121 Gene

Genes around ZNF121 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF121 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF121 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF121 Gene

Proteins for ZNF121 Gene

  • Protein details for ZNF121 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 121
    Protein Accession:

    Protein attributes for ZNF121 Gene

    390 amino acids
    Molecular mass:
    44694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF121 Gene

Proteomics data for ZNF121 Gene at MOPED

Post-translational modifications for ZNF121 Gene

  • Ubiquitination at Lys 385
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF121 Gene

No data available for DME Specific Peptides for ZNF121 Gene

Domains & Families for ZNF121 Gene

Gene Families for ZNF121 Gene

Protein Domains for ZNF121 Gene

Suggested Antigen Peptide Sequences for ZNF121 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF121: view

Function for ZNF121 Gene

Molecular function for ZNF121 Gene

GENATLAS Biochemistry:
zinc finger protein 121 (clone ZHC32),KRAB subfamily
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF121: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF121 Gene

Localization for ZNF121 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF121 Gene

Subcellular locations from

Jensen Localization Image for ZNF121 Gene COMPARTMENTS Subcellular localization image for ZNF121 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF121 Gene

Pathways & Interactions for ZNF121 Gene

SuperPathways for ZNF121 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF121 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF121 Gene

Drugs & Compounds for ZNF121 Gene

No Compound Related Data Available

Transcripts for ZNF121 Gene

mRNA/cDNA for ZNF121 Gene

(6) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF121 Gene

Zinc finger protein 121:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF121 Gene

No ASD Table

Relevant External Links for ZNF121 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF121 Gene

mRNA expression in normal human tissues for ZNF121 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF121 Gene

SOURCE GeneReport for Unigene cluster for ZNF121 Gene Hs.501537

genes like me logo Genes that share expression patterns with ZNF121: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF121 Gene

Orthologs for ZNF121 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF121 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF121 35
  • 99.83 (n)
  • 99.74 (a)
ZNF121 36
  • 100 (a)
(Bos Taurus)
Mammalia -- 36
  • 24 (a)
(Mus musculus)
Mammalia Zfp560 36
  • 28 (a)
Species with no ortholog for ZNF121:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF121 Gene

Gene Tree for ZNF121 (if available)
Gene Tree for ZNF121 (if available)

Paralogs for ZNF121 Gene

Paralogs for ZNF121 Gene

(503) SIMAP similar genes for ZNF121 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF121: view

Variants for ZNF121 Gene

Sequence variations from dbSNP and Humsavar for ZNF121 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7257616 -- 9,582,175(+) atggc(A/G)gcatg intron-variant
rs7258752 -- 9,571,884(+) ccgag(C/T)atgtg intron-variant
rs12982118 -- 9,568,582(+) GTTGG(C/T)CAGGC intron-variant
rs8102702 -- 9,581,881(+) AGTGC(C/T)ATTTT intron-variant
rs8104779 -- 9,568,344(+) CAATC(A/G)TAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF121 Gene

Variant ID Type Subtype PubMed ID
nsv911024 CNV Loss 21882294
esv2718156 CNV Deletion 23290073

Variation tolerance for ZNF121 Gene

Residual Variation Intolerance Score: 17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF121 Gene

Disorders for ZNF121 Gene

Relevant External Links for ZNF121

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF121 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF121 Gene

Publications for ZNF121 Gene

  1. A novel zinc finger cDNA with a polymorphic pentanucleotide repeat (ATTTT)n maps on human chromosome 19p. (PMID: 8468057) Chen H. … Antonarakis S.E. (Genomics 1993) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3
  5. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. (PMID: 17314511) Koch H.B. … Hermeking H. (Cell Cycle 2007) 3

Products for ZNF121 Gene

Sources for ZNF121 Gene